Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGFLR1 Gene

Aliases for IGFLR1 Gene

  • IGF Like Family Receptor 1 2 3 5
  • Transmembrane Protein 149 2 3 4
  • TMEM149 3 4
  • U2(RNU2) Small Nuclear RNA Auxiliary Factor 1-Like 4 2
  • U2 Small Nuclear RNA Auxiliary Factor 1-Like 4 4
  • IGF-Like Family Receptor 1 3
  • U2AF1L4 4

External Ids for IGFLR1 Gene

Previous HGNC Symbols for IGFLR1 Gene

  • U2AF1L4
  • TMEM149

Previous GeneCards Identifiers for IGFLR1 Gene

  • GC19M036231
  • GC19M036361
  • GC19M036542
  • GC19M037060
  • GC19M035771
  • GC19M035910
  • GC19M035936
  • GC19M036801
  • GC19M037404
  • GC19M037733
  • GC19M038029

Summaries for IGFLR1 Gene

GeneCards Summary for IGFLR1 Gene

IGFLR1 (IGF Like Family Receptor 1) is a Protein Coding gene. Diseases associated with IGFLR1 include Skin Conditions.

UniProtKB/Swiss-Prot for IGFLR1 Gene

  • Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.

Additional gene information for IGFLR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFLR1 Gene

Genomics for IGFLR1 Gene

GeneHancer (GH) Regulatory Elements for IGFLR1 Gene

Promoters and enhancers for IGFLR1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I035739 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.0 1024 3.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 IGFLR1 U2AF1L4 ZNF567 COX6B1 ENSG00000267049 TMEM147-AS1 ZNF599 LINC01534 HAUS5 ZNF461
GH19I035783 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12 -42.0 -42034 2.3 CTCF KLF1 SAP130 ARID4B RAD21 RARA ZFHX2 GLIS2 POLR2A PATZ1 U2AF1L4 ENSG00000267049 LINC01529 IGFLR1 UPK1A GAPDHS ETV2 ARHGAP33 WDR62
GH19I035897 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.7 -161.6 -161605 13 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC ZFP41 NFKBID TYROBP HCST ENSG00000280194 ZNF567 ZNF566 ZNF790 ZNF529 TMEM147-AS1 ZNF260
GH19I035316 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +423.8 423765 5 HDGF PKNOX1 CLOCK FOXA2 MLX NEUROD1 SIN3A ZNF2 ZBTB7B SLC30A9 CD22 MAG TMEM147-AS1 HAUS5 ZNF792 KMT2B ZNF599 U2AF1L4 ZNF146 PROSER3
GH19I035927 Enhancer 1.6 FANTOM5 Ensembl ENCODE 2.7 -188.0 -187980 5.2 HDGF FOXA2 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF850 ZNF345 KMT2B TMEM147-AS1 ZNF792 HAUS5 ZNF567 RBM42 U2AF1L4 TYROBP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGFLR1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGFLR1 Gene

Genomic Locations for IGFLR1 Gene
3,653 bases
Minus strand

Genomic View for IGFLR1 Gene

Genes around IGFLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFLR1 Gene

Proteins for IGFLR1 Gene

  • Protein details for IGFLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IGF-like family receptor 1
    Protein Accession:
    Secondary Accessions:
    • Q8N5X0

    Protein attributes for IGFLR1 Gene

    355 amino acids
    Molecular mass:
    37895 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGFLR1 Gene


neXtProt entry for IGFLR1 Gene

Post-translational modifications for IGFLR1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGFLR1 Gene

Domains & Families for IGFLR1 Gene

Gene Families for IGFLR1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IGFLR1 Gene


Suggested Antigen Peptide Sequences for IGFLR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFLR1: view

No data available for UniProtKB/Swiss-Prot for IGFLR1 Gene

Function for IGFLR1 Gene

Molecular function for IGFLR1 Gene

UniProtKB/Swiss-Prot Function:
Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.
UniProtKB/Swiss-Prot Induction:
Up-regulated by the proinflammatory cytokine TNFA and in skin upon tissue inflammation.

Gene Ontology (GO) - Molecular Function for IGFLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21454693
genes like me logo Genes that share ontologies with IGFLR1: view

Phenotypes for IGFLR1 Gene

GenomeRNAi human phenotypes for IGFLR1:
genes like me logo Genes that share phenotypes with IGFLR1: view

Animal Model Products

CRISPR Products

miRNA for IGFLR1 Gene

miRTarBase miRNAs that target IGFLR1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFLR1 Gene

Localization for IGFLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFLR1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFLR1 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 21454693
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGFLR1: view

Pathways & Interactions for IGFLR1 Gene

SuperPathways for IGFLR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGFLR1 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGFLR1 Gene

Drugs & Compounds for IGFLR1 Gene

No Compound Related Data Available

Transcripts for IGFLR1 Gene

Unigene Clusters for IGFLR1 Gene

IGF-like family receptor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFLR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP11: - - -

Relevant External Links for IGFLR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFLR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFLR1 Gene

This gene is overexpressed in Whole Blood (x8.9).

Protein differential expression in normal tissues from HIPED for IGFLR1 Gene

This gene is overexpressed in Urine (49.7) and Adipocyte (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFLR1 Gene

Protein tissue co-expression partners for IGFLR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGFLR1 Gene:


SOURCE GeneReport for Unigene cluster for IGFLR1 Gene:


Evidence on tissue expression from TISSUES for IGFLR1 Gene

  • Intestine(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with IGFLR1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFLR1 Gene

Orthologs for IGFLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFLR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGFLR1 33 34
  • 93.08 (n)
(Bos Taurus)
Mammalia IGFLR1 33 34
  • 75.54 (n)
(Rattus norvegicus)
Mammalia Igflr1 33
  • 68.72 (n)
(Mus musculus)
Mammalia Igflr1 33 16 34
  • 67.4 (n)
(Canis familiaris)
Mammalia IGFLR1 34
  • 66 (a)
(Monodelphis domestica)
Mammalia IGFLR1 34
  • 45 (a)
(Danio rerio)
Actinopterygii LOC793825 33
  • 41.69 (n)
igflr1 34
  • 25 (a)
Species where no ortholog for IGFLR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFLR1 Gene

Gene Tree for IGFLR1 (if available)
Gene Tree for IGFLR1 (if available)

Paralogs for IGFLR1 Gene Pseudogenes for IGFLR1 Gene

genes like me logo Genes that share paralogs with IGFLR1: view

No data available for Paralogs for IGFLR1 Gene

Variants for IGFLR1 Gene

Sequence variations from dbSNP and Humsavar for IGFLR1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000971736 -- 35,740,802(-) G/A/T intron_variant
rs1001911955 -- 35,740,214(-) G/A intron_variant
rs1002970843 -- 35,739,116(-) C/T downstream_transcript_variant
rs1003090496 -- 35,743,423(-) G/A upstream_transcript_variant
rs1003120808 -- 35,744,197(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IGFLR1 Gene

Variant ID Type Subtype PubMed ID
nsv515536 CNV loss 19592680
nsv579422 CNV loss 21841781
nsv579423 CNV loss 21841781

Variation tolerance for IGFLR1 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFLR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFLR1 Gene

Disorders for IGFLR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGFLR1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFLR1

genes like me logo Genes that share disorders with IGFLR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFLR1 Gene

Publications for IGFLR1 Gene

  1. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. (PMID: 21454693) Lobito AA … Gonzalez LC (The Journal of biological chemistry 2011) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for IGFLR1 Gene

Sources for IGFLR1 Gene

Loading form....