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Aliases for IGFL4 Gene

Aliases for IGFL4 Gene

  • IGF Like Family Member 4 2 3 5
  • Insulin Growth Factor-Like Family Member 4 3

External Ids for IGFL4 Gene

Previous GeneCards Identifiers for IGFL4 Gene

  • GC19M051317
  • GC00U921541
  • GC19M051234
  • GC19M046543
  • GC19M042971

Summaries for IGFL4 Gene

GeneCards Summary for IGFL4 Gene

IGFL4 (IGF Like Family Member 4) is a Protein Coding gene. An important paralog of this gene is IGFL3.

Additional gene information for IGFL4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFL4 Gene

Genomics for IGFL4 Gene

GeneHancer (GH) Regulatory Elements for IGFL4 Gene

Promoters and enhancers for IGFL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046077 Enhancer 1.3 Ensembl ENCODE dbSUPER 650.7 -0.6 -602 0.6 ARID4B SIN3A ZNF2 YY1 GLIS2 ARID2 ZNF143 ATF7 YY2 REST IGFL2 IGFL4 GC19P046077 LOC400706 PIR37387 IGFL3 HIF3A FOXA3 SYMPK
GH19J046078 Promoter/Enhancer 1.1 EPDnew dbSUPER 650.7 0.0 -21 0.1 MXI1 ZNF777 GFI1B ZNF501 ZEB1 ZNF335 ZFHX2 SCRT2 KLF9 EZH2 IGFL2 IGFL4 GC19P046077 LOC400706 HIF3A FOXA3 SYMPK
GH19J046080 Enhancer 0.6 ENCODE 650.7 -1.6 -1630 0.1 CTCF ZNF654 NRF1 REST ZNF623 RAD21 CREB1 SMC3 ZNF143 ZBTB33 IGFL2 IGFL4 GC19P046077 LOC400706 PIR37387 HIF3A SYMPK FOXA3
GH19J046782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 -708.7 -708664 6.8 MLX FEZF1 DMAP1 ZNF213 E2F8 ZNF143 ZNF263 SP3 NFYC ZFP41 SLC1A5 ZC3H4 CCDC61 BICRA CCDC9 ENSG00000268810 NOP53-AS1 ENSG00000269148 PRKD2 SYMPK
GH19J045466 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 +608.0 608022 4.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B FOSB GC19P045469 ZNF180 CCDC61 CLASRP FBXO46 ENSG00000269148 CD3EAP RPS16P9 ENSG00000267614
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGFL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGFL4 gene promoter:

Genomic Locations for IGFL4 Gene

Genomic Locations for IGFL4 Gene
chr19:46,039,748-46,077,118
(GRCh38/hg38)
Size:
37,371 bases
Orientation:
Minus strand
chr19:46,543,006-46,580,376
(GRCh37/hg19)

Genomic View for IGFL4 Gene

Genes around IGFL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL4 Gene

Proteins for IGFL4 Gene

  • Protein details for IGFL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6B9Z1-IGFL4_HUMAN
    Recommended name:
    Insulin growth factor-like family member 4
    Protein Accession:
    Q6B9Z1

    Protein attributes for IGFL4 Gene

    Size:
    124 amino acids
    Molecular mass:
    13885 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFL4 Gene

Post-translational modifications for IGFL4 Gene

  • Glycosylation at Asn84 and isoforms=57

Other Protein References for IGFL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFL4 Gene

Domains & Families for IGFL4 Gene

Gene Families for IGFL4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IGFL4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGFL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6B9Z1

UniProtKB/Swiss-Prot:

IGFL4_HUMAN :
  • Belongs to the IGFL family.
Family:
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL4: view

Function for IGFL4 Gene

genes like me logo Genes that share phenotypes with IGFL4: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL4 Gene

Localization for IGFL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFL4 gene
Compartment Confidence
extracellular 4
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IGFL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGFL4: view

Pathways & Interactions for IGFL4 Gene

SuperPathways for IGFL4 Gene

No Data Available

Interacting Proteins for IGFL4 Gene

Gene Ontology (GO) - Biological Process for IGFL4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGFL4 Gene

Drugs & Compounds for IGFL4 Gene

No Compound Related Data Available

Transcripts for IGFL4 Gene

mRNA/cDNA for IGFL4 Gene

(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFL4 Gene

IGF-like family member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL4 Gene

No ASD Table

Relevant External Links for IGFL4 Gene

GeneLoc Exon Structure for
IGFL4
ECgene alternative splicing isoforms for
IGFL4

Expression for IGFL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFL4 Gene

mRNA differential expression in normal tissues according to GTEx for IGFL4 Gene

This gene is overexpressed in Brain - Cortex (x5.1) and Brain - Frontal Cortex (BA9) (x4.5).

Protein differential expression in normal tissues from HIPED for IGFL4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFL4 Gene



Protein tissue co-expression partners for IGFL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGFL4 Gene:

IGFL4

SOURCE GeneReport for Unigene cluster for IGFL4 Gene:

Hs.531310

mRNA Expression by UniProt/SwissProt for IGFL4 Gene:

Q6B9Z1-IGFL4_HUMAN
Tissue specificity: Detected in the cerebellum.
genes like me logo Genes that share expression patterns with IGFL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFL4 Gene

Orthologs for IGFL4 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for IGFL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFL4 34
  • 64 (a)
OneToOne
Species where no ortholog for IGFL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFL4 Gene

ENSEMBL:
Gene Tree for IGFL4 (if available)
TreeFam:
Gene Tree for IGFL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGFL4: view image

Paralogs for IGFL4 Gene

Paralogs for IGFL4 Gene

(3) SIMAP similar genes for IGFL4 Gene using alignment to 2 proteins:

  • IGFL4_HUMAN
  • M0QYY9_HUMAN

Pseudogenes.org Pseudogenes for IGFL4 Gene

genes like me logo Genes that share paralogs with IGFL4: view

Variants for IGFL4 Gene

Sequence variations from dbSNP and Humsavar for IGFL4 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000215602 -- 46,042,646(-) ACACA/A upstream_transcript_variant
rs1001290873 -- 46,041,327(-) T/C upstream_transcript_variant
rs1002171845 -- 46,041,587(-) A/C upstream_transcript_variant
rs1002677831 -- 46,042,025(-) G/C upstream_transcript_variant
rs1003392343 -- 46,042,269(-) C/G/T upstream_transcript_variant

Variation tolerance for IGFL4 Gene

Residual Variation Intolerance Score: 76.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFL4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGFL4 Gene

Disorders for IGFL4 Gene

Additional Disease Information for IGFL4

No disorders were found for IGFL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGFL4 Gene

Publications for IGFL4 Gene

  1. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P … Tang YT (Genomics 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. Chemical synthesis of a Zwitterhormon, insulaxin, and of a relaxin-like bombyxin derivative. (PMID: 8703947) Büllesbach EE … Schwabe C (Biochemistry 1996) 22 58
  5. Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. (PMID: 8686573) Omura Y … Beckman SL (Acupuncture & electro-therapeutics research 1995) 22 58

Products for IGFL4 Gene

Sources for IGFL4 Gene

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