IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008] See more...

Aliases for IGFL3 Gene

Aliases for IGFL3 Gene

  • IGF Like Family Member 3 2 3 5
  • Insulin Growth Factor-Like Family Member 3 3 4
  • UNQ483 2 3
  • RPRC483 3
  • IGFL3 5

External Ids for IGFL3 Gene

Previous GeneCards Identifiers for IGFL3 Gene

  • GC19M051318
  • GC19M046627
  • GC19M043050

Summaries for IGFL3 Gene

Entrez Gene Summary for IGFL3 Gene

  • IGFL3 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL3 Gene

IGFL3 (IGF Like Family Member 3) is a Protein Coding gene. Diseases associated with IGFL3 include Testicular Disease and Cryptorchidism, Unilateral Or Bilateral. An important paralog of this gene is IGFL2.

UniProtKB/Swiss-Prot Summary for IGFL3 Gene

Additional gene information for IGFL3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFL3 Gene

Genomics for IGFL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGFL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGFL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFL3

Top Transcription factor binding sites by QIAGEN in the IGFL3 gene promoter:
  • c-Myc
  • HOXA9
  • HOXA9B
  • Max1
  • Meis-1
  • Meis-1a
  • RSRFC4
  • STAT3
  • STAT5B
  • USF1

Genomic Locations for IGFL3 Gene

Genomic Locations for IGFL3 Gene
chr19:46,119,778-46,127,101
(GRCh38/hg38)
Size:
7,324 bases
Orientation:
Minus strand
chr19:46,623,328-46,627,931
(GRCh37/hg19)
Size:
4,604 bases
Orientation:
Minus strand

Genomic View for IGFL3 Gene

Genes around IGFL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL3 Gene

Proteins for IGFL3 Gene

  • Protein details for IGFL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXB1-IGFL3_HUMAN
    Recommended name:
    Insulin growth factor-like family member 3
    Protein Accession:
    Q6UXB1

    Protein attributes for IGFL3 Gene

    Size:
    125 amino acids
    Molecular mass:
    14198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGFL3 Gene

Post-translational modifications for IGFL3 Gene

No Post-translational modifications

Other Protein References for IGFL3 Gene

No data available for DME Specific Peptides for IGFL3 Gene

Domains & Families for IGFL3 Gene

Gene Families for IGFL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IGFL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGFL3 Gene

GenScript: Design optimal peptide antigens:
  • Insulin growth factor-like family member 3 (IGFL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UXB1

UniProtKB/Swiss-Prot:

IGFL3_HUMAN :
  • Belongs to the IGFL family.
Family:
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL3: view

Function for IGFL3 Gene

Molecular function for IGFL3 Gene

UniProtKB/Swiss-Prot Function:
Potential ligand of the IGFLR1 cell membrane receptor.

Phenotypes From GWAS Catalog for IGFL3 Gene

Gene Ontology (GO) - Molecular Function for IGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA,IPI 21454693
genes like me logo Genes that share ontologies with IGFL3: view

Phenotypes for IGFL3 Gene

genes like me logo Genes that share phenotypes with IGFL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFL3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL3 Gene

Localization for IGFL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFL3 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IDA 21454693
genes like me logo Genes that share ontologies with IGFL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGFL3 Gene

Pathways & Interactions for IGFL3 Gene

PathCards logo

SuperPathways for IGFL3 Gene

No Data Available

Interacting Proteins for IGFL3 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000344860 Q6UXB1-IGFL3_HUMAN for IGFL3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for IGFL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IGFL3: view

No data available for Pathways by source and SIGNOR curated interactions for IGFL3 Gene

Drugs & Compounds for IGFL3 Gene

(1) Drugs for IGFL3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IGFL3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFL3: view

Transcripts for IGFL3 Gene

mRNA/cDNA for IGFL3 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFL3

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL3 Gene

No ASD Table

Relevant External Links for IGFL3 Gene

GeneLoc Exon Structure for
IGFL3

Expression for IGFL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGFL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFL3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x26.5) and Skin - Not Sun Exposed (Suprapubic) (x25.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFL3

SOURCE GeneReport for Unigene cluster for IGFL3 Gene:

Hs.365496

mRNA Expression by UniProt/SwissProt for IGFL3 Gene:

Q6UXB1-IGFL3_HUMAN
Tissue specificity: Detected in the cerebellum.
genes like me logo Genes that share expression patterns with IGFL3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFL3 Gene

Orthologs for IGFL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGFL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IGFL3 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IGFL3 30 31
  • 75.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100362729 30
  • 66.67 (n)
Mouse
(Mus musculus)
Mammalia Igfl3 30 17 31
  • 64.22 (n)
OneToMany
Species where no ortholog for IGFL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IGFL3 Gene

ENSEMBL:
Gene Tree for IGFL3 (if available)
TreeFam:
Gene Tree for IGFL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGFL3: view image

Paralogs for IGFL3 Gene

Paralogs for IGFL3 Gene

(3) SIMAP similar genes for IGFL3 Gene using alignment to 1 proteins:

  • IGFL3_HUMAN
genes like me logo Genes that share paralogs with IGFL3: view

Variants for IGFL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFL3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10406448 - p.Thr66Ser

Additional dbSNP identifiers (rs#s) for IGFL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGFL3 Gene

Variant ID Type Subtype PubMed ID
dgv225e215 CNV deletion 23714750
dgv591n67 CNV loss 20364138
dgv6504n54 CNV loss 21841781
dgv6505n54 CNV loss 21841781
esv2664945 CNV deletion 23128226
esv2718646 CNV deletion 23290073
esv28290 CNV loss 19812545
esv3644520 CNV loss 21293372
nsv498902 CNV loss 21111241
nsv528826 CNV gain 19592680
nsv828567 CNV loss 20364138
nsv978830 CNV duplication 23825009

Variation tolerance for IGFL3 Gene

Residual Variation Intolerance Score: 58.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFL3 Gene

Disorders for IGFL3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGFL3 Gene - From: Novoseek

Disorder Aliases PubMed IDs
testicular disease
  • disorder of testis
cryptorchidism, unilateral or bilateral
  • undescended testis
- elite association - COSMIC cancer census association via MalaCards
Search IGFL3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with IGFL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFL3 Gene

Publications for IGFL3 Gene

  1. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. (PMID: 21454693) Lobito AA … Gonzalez LC (The Journal of biological chemistry 2011) 3 4
  2. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P … Tang YT (Genomics 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for IGFL3 Gene

Sources for IGFL3 Gene