IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008] See more...

Aliases for IGFL2 Gene

Aliases for IGFL2 Gene

  • IGF Like Family Member 2 2 3 5
  • Insulin Growth Factor-Like Family Member 2 3 4
  • UNQ645 2 3
  • VPRI645 3
  • IGFL2 5

External Ids for IGFL2 Gene

Previous GeneCards Identifiers for IGFL2 Gene

  • GC19P051344
  • GC19P046651
  • GC19P043078
  • GC19P046143

Summaries for IGFL2 Gene

Entrez Gene Summary for IGFL2 Gene

  • IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]

GeneCards Summary for IGFL2 Gene

IGFL2 (IGF Like Family Member 2) is a Protein Coding gene. An important paralog of this gene is IGFL3.

UniProtKB/Swiss-Prot Summary for IGFL2 Gene

Additional gene information for IGFL2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFL2 Gene

Genomics for IGFL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGFL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J046077 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 600.7 -1.0 -977 0.7 HNRNPL GATAD2A CTCF TEAD4 ZNF629 PRDM10 ZNF512 ZNF692 PRDM1 ZIC2 IGFL2 IGFL4 lnc-IGFL4-1 piR-44388 IGFL3 HIF3A FOXA3 SYMPK piR-42317 PGLYRP1
GH19J046078 Promoter/Enhancer 0.9 EPDnew dbSUPER 600.7 -1.4 -1374 0.1 HNRNPL ZNF501 EZH2 SCRT2 KLF9 ZBTB20 ZEB1 ZBTB17 ZFHX2 ZNF777 IGFL2 IGFL4 lnc-IGFL4-1 HIF3A FOXA3 SYMPK lnc-CCDC61-4 piR-42317 PGLYRP1
GH19J046147 Promoter/Enhancer 0.8 EPDnew Ensembl 600.2 +69.3 69312 0.8 ZBTB44 PRDM4 FEZF1 ZNF664 IGFL2 LOC105376901 TGIF1P1 IGFL3 ENSG00000267922 IGFL1
GH19J046080 Enhancer 0.6 ENCODE 600.7 +0.2 235 0.1 CREB1 CTCF ZHX2 REST RAD21 SMC3 PKNOX1 ZNF623 ZNF654 ZNF143 IGFL2 IGFL4 lnc-IGFL4-1 piR-44388 HIF3A SYMPK FOXA3 IGFL3
GH19J046200 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11.3 +124.1 124138 4 TEAD4 ZNF512 JUND PKNOX1 ZNF24 HDAC1 SOX6 TCF12 EP300 MGA ENSG00000268460 IGFL2-AS1 IGFL1 IGFL2 HIF3A IGFL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGFL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFL2

Top Transcription factor binding sites by QIAGEN in the IGFL2 gene promoter:
  • c-Myc
  • HOXA9
  • HOXA9B
  • Max1
  • Meis-1

Genomic Locations for IGFL2 Gene

Genomic Locations for IGFL2 Gene
chr19:46,078,513-46,215,362
(GRCh38/hg38)
Size:
136,850 bases
Orientation:
Plus strand
chr19:46,646,363-46,664,561
(GRCh37/hg19)
Size:
18,199 bases
Orientation:
Plus strand

Genomic View for IGFL2 Gene

Genes around IGFL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFL2 Gene

Proteins for IGFL2 Gene

  • Protein details for IGFL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWQ7-IGFL2_HUMAN
    Recommended name:
    Insulin growth factor-like family member 2
    Protein Accession:
    Q6UWQ7
    Secondary Accessions:
    • E9PAV1
    • Q6B9Z3

    Protein attributes for IGFL2 Gene

    Size:
    119 amino acids
    Molecular mass:
    13248 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAT77786.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for IGFL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFL2 Gene

Post-translational modifications for IGFL2 Gene

No Post-translational modifications

Other Protein References for IGFL2 Gene

No data available for DME Specific Peptides for IGFL2 Gene

Domains & Families for IGFL2 Gene

Gene Families for IGFL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IGFL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGFL2 Gene

GenScript: Design optimal peptide antigens:
  • Insulin growth factor-like family member 2 (IGFL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UWQ7

UniProtKB/Swiss-Prot:

IGFL2_HUMAN :
  • Belongs to the IGFL family.
Family:
  • Belongs to the IGFL family.
genes like me logo Genes that share domains with IGFL2: view

Function for IGFL2 Gene

Molecular function for IGFL2 Gene

UniProtKB/Swiss-Prot Function:
Potential ligand of the IGFLR1 cell membrane receptor.

Gene Ontology (GO) - Molecular Function for IGFL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA,IPI 21454693
genes like me logo Genes that share ontologies with IGFL2: view

Phenotypes for IGFL2 Gene

genes like me logo Genes that share phenotypes with IGFL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFL2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGFL2 Gene

Localization for IGFL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFL2 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,IDA 21454693
genes like me logo Genes that share ontologies with IGFL2: view

Pathways & Interactions for IGFL2 Gene

PathCards logo

SuperPathways for IGFL2 Gene

No Data Available

Interacting Proteins for IGFL2 Gene

Gene Ontology (GO) - Biological Process for IGFL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IGFL2: view

No data available for Pathways by source and SIGNOR curated interactions for IGFL2 Gene

Drugs & Compounds for IGFL2 Gene

No Compound Related Data Available

Transcripts for IGFL2 Gene

mRNA/cDNA for IGFL2 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFL2

Alternative Splicing Database (ASD) splice patterns (SP) for IGFL2 Gene

No ASD Table

Relevant External Links for IGFL2 Gene

GeneLoc Exon Structure for
IGFL2

Expression for IGFL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGFL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFL2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x21.9) and Skin - Not Sun Exposed (Suprapubic) (x21.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFL2

SOURCE GeneReport for Unigene cluster for IGFL2 Gene:

Hs.99376

mRNA Expression by UniProt/SwissProt for IGFL2 Gene:

Q6UWQ7-IGFL2_HUMAN
Tissue specificity: Detected in cerebellum, heart, placenta, spleen, stomach, testis and thymus.
genes like me logo Genes that share expression patterns with IGFL2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFL2 Gene

Orthologs for IGFL2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for IGFL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IGFL2 30 31
  • 97.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Igfl3 31
  • 34 (a)
OneToMany
Species where no ortholog for IGFL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IGFL2 Gene

ENSEMBL:
Gene Tree for IGFL2 (if available)
TreeFam:
Gene Tree for IGFL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGFL2: view image

Paralogs for IGFL2 Gene

Paralogs for IGFL2 Gene

(3) SIMAP similar genes for IGFL2 Gene using alignment to 2 proteins:

  • IGFL2_HUMAN
  • M0R089_HUMAN
genes like me logo Genes that share paralogs with IGFL2: view

Variants for IGFL2 Gene

Additional dbSNP identifiers (rs#s) for IGFL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGFL2 Gene

Variant ID Type Subtype PubMed ID
dgv147n111 CNV duplication 26073780
dgv665e214 CNV gain 21293372
esv3644523 CNV gain 21293372
esv3893222 CNV gain 25118596
nsv2511 CNV insertion 18451855
nsv458713 CNV gain 19166990
nsv470147 CNV gain 18288195
nsv579886 CNV gain 21841781

Variation tolerance for IGFL2 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFL2 Gene

Disorders for IGFL2 Gene

No disorders were found for IGFL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGFL2 Gene

Publications for IGFL2 Gene

  1. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. (PMID: 21454693) Lobito AA … Gonzalez LC (The Journal of biological chemistry 2011) 3 4
  2. IGFL: A secreted family with conserved cysteine residues and similarities to the IGF superfamily. (PMID: 16890402) Emtage P … Tang YT (Genomics 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for IGFL2 Gene

Sources for IGFL2 Gene