Aliases for IGFBP5 Gene

Aliases for IGFBP5 Gene

  • Insulin Like Growth Factor Binding Protein 5 2 3 5
  • Insulin-Like Growth Factor-Binding Protein 5 3 4
  • IGF-Binding Protein 5 3 4
  • IGFBP-5 3 4
  • IBP-5 3 4
  • IBP5 3 4
  • Insulin-Like Growth Factor Binding Protein 5 2
  • IGFBP5 5

External Ids for IGFBP5 Gene

Previous GeneCards Identifiers for IGFBP5 Gene

  • GC02M215637
  • GC02M216262
  • GC02M217504
  • GC02M217743
  • GC02M217362
  • GC02M217245
  • GC02M209391

Summaries for IGFBP5 Gene

GeneCards Summary for IGFBP5 Gene

IGFBP5 (Insulin Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include Insulin-Like Growth Factor I and Renal Osteodystrophy. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP3.

UniProtKB/Swiss-Prot Summary for IGFBP5 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP5 Gene

Additional gene information for IGFBP5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFBP5 Gene

Genomics for IGFBP5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGFBP5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGFBP5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFBP5

Top Transcription factor binding sites by QIAGEN in the IGFBP5 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Myb
  • NF-kappaB1
  • Nkx2-5
  • STAT3
  • STAT5A

Genomic Locations for IGFBP5 Gene

Genomic Locations for IGFBP5 Gene
chr2:216,672,105-216,695,549
(GRCh38/hg38)
Size:
23,445 bases
Orientation:
Minus strand
chr2:217,536,828-217,560,272
(GRCh37/hg19)
Size:
23,445 bases
Orientation:
Minus strand

Genomic View for IGFBP5 Gene

Genes around IGFBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP5 Gene

Proteins for IGFBP5 Gene

  • Protein details for IGFBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24593-IBP5_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 5
    Protein Accession:
    P24593
    Secondary Accessions:
    • Q5U0A3

    Protein attributes for IGFBP5 Gene

    Size:
    272 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGFBP5 Gene

neXtProt entry for IGFBP5 Gene

Post-translational modifications for IGFBP5 Gene

  • Glycosylation at Thr123, Thr131, and Thr172
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBP5 Gene

Domains & Families for IGFBP5 Gene

Gene Families for IGFBP5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IGFBP5 Gene

InterPro:
Blocks:
  • Insulin-like growth factor-binding protein, IGFBP
  • Thyroglobulin type-1
ProtoNet:

Suggested Antigen Peptide Sequences for IGFBP5 Gene

GenScript: Design optimal peptide antigens:
  • Insulin-like growth factor-binding protein 5 (IBP5_HUMAN)
  • IGFBP5 protein (Q8WV97_HUMAN)
  • IGFBP5 protein (Q96HT5_HUMAN)
genes like me logo Genes that share domains with IGFBP5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGFBP5 Gene

Function for IGFBP5 Gene

Molecular function for IGFBP5 Gene

UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GENATLAS Biochemistry:
insulin-like growth factor binding protein 5,high affinity,complexing with IGF1 and IGF2 and acid labile subunit expressed predominantly in kidney,fetal tissues,adult conective tissues and CSF,present in the serum but decreasing with age after puberty. Binding to bone cells (skeletal growth factor)

Phenotypes From GWAS Catalog for IGFBP5 Gene

Gene Ontology (GO) - Molecular Function for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IEA,IBA 21873635
GO:0005515 protein binding IPI 15700281
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IBA,IPI 10766744
genes like me logo Genes that share ontologies with IGFBP5: view
genes like me logo Genes that share phenotypes with IGFBP5: view

Animal Models for IGFBP5 Gene

MGI Knock Outs for IGFBP5:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBP5

CRISPR Products

miRNA for IGFBP5 Gene

miRTarBase miRNAs that target IGFBP5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP5 Gene

Localization for IGFBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP5 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear bodies (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016942 insulin-like growth factor binding protein complex IC 10766744
GO:0042567 insulin-like growth factor ternary complex IDA 9497324
genes like me logo Genes that share ontologies with IGFBP5: view

Pathways & Interactions for IGFBP5 Gene

genes like me logo Genes that share pathways with IGFBP5: view

Pathways by source for IGFBP5 Gene

Gene Ontology (GO) - Biological Process for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0007165 signal transduction NAS 7525452
GO:0007565 female pregnancy IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with IGFBP5: view

No data available for SIGNOR curated interactions for IGFBP5 Gene

Drugs & Compounds for IGFBP5 Gene

(31) Drugs for IGFBP5 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mecasermin Approved, Investigational Pharma Carrier 36

(19) Additional Compounds for IGFBP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP5: view

Transcripts for IGFBP5 Gene

mRNA/cDNA for IGFBP5 Gene

1 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP5

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP5 Gene

No ASD Table

Relevant External Links for IGFBP5 Gene

GeneLoc Exon Structure for
IGFBP5

Expression for IGFBP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGFBP5 Gene

mRNA differential expression in normal tissues according to GTEx for IGFBP5 Gene

This gene is overexpressed in Ovary (x5.9) and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for IGFBP5 Gene

This gene is overexpressed in Amniocyte (27.1), Cerebral cortex (15.8), and Serum (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFBP5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFBP5

SOURCE GeneReport for Unigene cluster for IGFBP5 Gene:

Hs.607212

mRNA Expression by UniProt/SwissProt for IGFBP5 Gene:

P24593-IBP5_HUMAN
Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain.

Evidence on tissue expression from TISSUES for IGFBP5 Gene

  • Nervous system(5)
  • Lung(4.6)
  • Eye(4.4)
  • Bone marrow(4.3)
  • Kidney(3.7)
  • Intestine(3.7)
  • Pancreas(3.6)
  • Muscle(3.5)
  • Heart(3.3)
  • Thyroid gland(3.2)
  • Liver(3.1)
  • Skin(3)
  • Adrenal gland(2.7)
  • Stomach(2.6)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Blood(2.4)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with IGFBP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP5 Gene

Orthologs for IGFBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IGFBP5 30 31
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IGFBP5 30 31
  • 95.87 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IGFBP5 30 31
  • 95.54 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Igfbp5 30 17 31
  • 91.47 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Igfbp5 30
  • 91.21 (n)
Oppossum
(Monodelphis domestica)
Mammalia IGFBP5 31
  • 90 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP5 31
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IGFBP5 30 31
  • 80.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IGFBP5 31
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia igfbp5 30
  • 75.63 (n)
Str.15961 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.5266 30
Zebrafish
(Danio rerio)
Actinopterygii igfbp5a 30 31
  • 64.08 (n)
OneToMany
igfbp5b 31
  • 53 (a)
OneToMany
Dr.24976 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 28 (a)
OneToMany
Species where no ortholog for IGFBP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IGFBP5 Gene

ENSEMBL:
Gene Tree for IGFBP5 (if available)
TreeFam:
Gene Tree for IGFBP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGFBP5: view image

Paralogs for IGFBP5 Gene

Paralogs for IGFBP5 Gene

(2) SIMAP similar genes for IGFBP5 Gene using alignment to 4 proteins:

  • IBP5_HUMAN
  • C9JXX4_HUMAN
  • Q8WV97_HUMAN
  • Q96HT5_HUMAN
genes like me logo Genes that share paralogs with IGFBP5: view

Variants for IGFBP5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFBP5 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs11575194 - p.Arg138Trp

Additional dbSNP identifiers (rs#s) for IGFBP5 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGFBP5 Gene

Variant ID Type Subtype PubMed ID
esv3584350 CNV loss 25503493
nsv1072069 CNV deletion 25765185
nsv460098 CNV loss 19166990
nsv522718 CNV loss 19592680
nsv584454 CNV loss 21841781
nsv584455 CNV loss 21841781

Variation tolerance for IGFBP5 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP5 Gene

Human Gene Mutation Database (HGMD)
IGFBP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP5 Gene

Disorders for IGFBP5 Gene

MalaCards: The human disease database

(8) MalaCards diseases for IGFBP5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
renal osteodystrophy
  • renal rickets
type 1 diabetes mellitus 13
  • diabetes mellitus, insulin-dependent, 13
pulmonary fibrosis, idiopathic
  • ipf
osteoporosis
  • bone mineral density quantitative trait locus; bmnd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFBP5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IGFBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP5 Gene

Publications for IGFBP5 Gene

  1. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PMID: 7511611) Allander SV … Powell DR (The Journal of biological chemistry 1994) 2 3 4 23
  2. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PMID: 19843326) Neuhausen SL … Gillen DL (Breast cancer research : BCR 2009) 3 23 41
  3. Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. (PMID: 18210156) Garner CP … Neuhausen SL (Human genetics 2008) 3 23 41
  4. OBSL1 mutations in 3-M syndrome are associated with a modulation of IGFBP2 and IGFBP5 expression levels. (PMID: 19877176) Huber C … Cormier-Daire V (Human mutation 2010) 3 23
  5. Genetic screen identifies insulin-like growth factor binding protein 5 as a modulator of tamoxifen resistance in breast cancer. (PMID: 20354179) Ahn BY … Kim SW (Cancer research 2010) 3 23

Products for IGFBP5 Gene

Sources for IGFBP5 Gene