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Aliases for IGFBP5 Gene

Aliases for IGFBP5 Gene

  • Insulin Like Growth Factor Binding Protein 5 2 3 5
  • IGF-Binding Protein 5 3 4
  • IGFBP-5 3 4
  • IBP-5 3 4
  • IBP5 3 4
  • Insulin-Like Growth Factor Binding Protein 5 2
  • Insulin-Like Growth Factor-Binding Protein 5 3

External Ids for IGFBP5 Gene

Previous GeneCards Identifiers for IGFBP5 Gene

  • GC02M215637
  • GC02M216262
  • GC02M217504
  • GC02M217743
  • GC02M217362
  • GC02M217245
  • GC02M209391

Summaries for IGFBP5 Gene

GeneCards Summary for IGFBP5 Gene

IGFBP5 (Insulin Like Growth Factor Binding Protein 5) is a Protein Coding gene. Diseases associated with IGFBP5 include Insulin-Like Growth Factor I and Renal Osteodystrophy. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP3.

UniProtKB/Swiss-Prot for IGFBP5 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP5 Gene

Additional gene information for IGFBP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP5 Gene

Genomics for IGFBP5 Gene

GeneHancer (GH) Regulatory Elements for IGFBP5 Gene

Promoters and enhancers for IGFBP5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I216690 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +1.7 1718 7.5 PKNOX1 FEZF1 GLI4 ZNF2 GLIS2 ZNF143 KLF7 ATF7 ZNF263 SP3 ENSG00000236886 IGFBP5 IGFBP2
GH02I217162 Enhancer 1.4 FANTOM5 Ensembl ENCODE 11.1 -467.2 -467193 1.2 PKNOX1 ATF1 FOXA2 FEZF1 ZNF2 FOS ATF7 RUNX3 JUNB TSHZ1 ENSG00000236886 IGFBP5 ENSG00000231597 LOC105373872 LOC105373873 LOC101928278
GH02I215868 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.6 +825.9 825948 3 ATF1 ZNF766 ATF7 CAVIN1 REST ZNF592 KAT8 MEF2D NFIL3 SSRP1 ENSG00000227824 IGFBP5 LINC00607
GH02I216618 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.5 +75.1 75063 3.3 HDGF FOXA2 ZNF2 YY1 TCF12 ZNF766 RXRA NFIL3 ATF4 SMARCA4 IGFBP2 XRCC5 SMARCAL1 ENSG00000236886 IGFBP5 PSMB3P2
GH02I216649 Enhancer 1.2 Ensembl ENCODE dbSUPER 11 +43.1 43095 6.2 ELF3 RAD21 THRB RARA ZSCAN5C SCRT2 ATF7 FOS RXRA ELF1 ENSG00000225794 LINC01280 IGFBP5 ENSG00000236886 IGFBP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGFBP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGFBP5 gene promoter:

Genomic Locations for IGFBP5 Gene

Genomic Locations for IGFBP5 Gene
23,445 bases
Minus strand

Genomic View for IGFBP5 Gene

Genes around IGFBP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP5 Gene

Proteins for IGFBP5 Gene

  • Protein details for IGFBP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin-like growth factor-binding protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5U0A3

    Protein attributes for IGFBP5 Gene

    272 amino acids
    Molecular mass:
    30570 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGFBP5 Gene

neXtProt entry for IGFBP5 Gene

Post-translational modifications for IGFBP5 Gene

  • Glycosylation at isoforms=123, posLast=131131, and posLast=172172
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBP5 Gene

Domains & Families for IGFBP5 Gene

Gene Families for IGFBP5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IGFBP5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFBP5: view

No data available for UniProtKB/Swiss-Prot for IGFBP5 Gene

Function for IGFBP5 Gene

Molecular function for IGFBP5 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 5,high affinity,complexing with IGF1 and IGF2 and acid labile subunit expressed predominantly in kidney,fetal tissues,adult conective tissues and CSF,present in the serum but decreasing with age after puberty. Binding to bone cells (skeletal growth factor)
UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Phenotypes From GWAS Catalog for IGFBP5 Gene

Gene Ontology (GO) - Molecular Function for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IBA,IEA --
GO:0005515 protein binding IPI 15700281
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IPI 10766744
genes like me logo Genes that share ontologies with IGFBP5: view
genes like me logo Genes that share phenotypes with IGFBP5: view

Animal Models for IGFBP5 Gene

MGI Knock Outs for IGFBP5:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBP5

miRNA for IGFBP5 Gene

miRTarBase miRNAs that target IGFBP5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP5 Gene

Localization for IGFBP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP5 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear bodies (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005622 intracellular IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016942 insulin-like growth factor binding protein complex IC 10766744
GO:0042567 insulin-like growth factor ternary complex IDA 9497324
genes like me logo Genes that share ontologies with IGFBP5: view

Pathways & Interactions for IGFBP5 Gene

genes like me logo Genes that share pathways with IGFBP5: view

Gene Ontology (GO) - Biological Process for IGFBP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0006006 glucose metabolic process IEA --
GO:0007165 signal transduction NAS 7525452
GO:0007565 female pregnancy IEA --
genes like me logo Genes that share ontologies with IGFBP5: view

No data available for SIGNOR curated interactions for IGFBP5 Gene

Drugs & Compounds for IGFBP5 Gene

(30) Drugs for IGFBP5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(19) Additional Compounds for IGFBP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP5: view

Transcripts for IGFBP5 Gene

mRNA/cDNA for IGFBP5 Gene

Unigene Clusters for IGFBP5 Gene

Insulin-like growth factor binding protein 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP5 Gene

No ASD Table

Relevant External Links for IGFBP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGFBP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBP5 Gene

mRNA differential expression in normal tissues according to GTEx for IGFBP5 Gene

This gene is overexpressed in Ovary (x5.9) and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for IGFBP5 Gene

This gene is overexpressed in Amniocyte (27.1), Cerebral cortex (15.8), and Serum (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFBP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGFBP5 Gene:


SOURCE GeneReport for Unigene cluster for IGFBP5 Gene:


mRNA Expression by UniProt/SwissProt for IGFBP5 Gene:

Tissue specificity: Osteosarcoma, and at lower levels in liver, kidney and brain.

Evidence on tissue expression from TISSUES for IGFBP5 Gene

  • Nervous system(5)
  • Lung(4.5)
  • Eye(4.3)
  • Bone marrow(4)
  • Kidney(3.5)
  • Intestine(3.4)
  • Muscle(3.3)
  • Pancreas(2.9)
  • Thyroid gland(2.8)
  • Heart(2.7)
  • Liver(2.6)
  • Skin(2.4)
  • Bone(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with IGFBP5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP5 Gene

Orthologs for IGFBP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGFBP5 33 34
  • 99.75 (n)
(Canis familiaris)
Mammalia IGFBP5 33 34
  • 95.87 (n)
(Bos Taurus)
Mammalia IGFBP5 33 34
  • 95.54 (n)
(Mus musculus)
Mammalia Igfbp5 33 16 34
  • 91.47 (n)
(Rattus norvegicus)
Mammalia Igfbp5 33
  • 91.21 (n)
(Monodelphis domestica)
Mammalia IGFBP5 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia IGFBP5 34
  • 78 (a)
(Gallus gallus)
Aves IGFBP5 33 34
  • 80.61 (n)
(Anolis carolinensis)
Reptilia IGFBP5 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp5 33
  • 75.63 (n)
Str.15961 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5266 33
(Danio rerio)
Actinopterygii igfbp5a 33 34
  • 64.08 (n)
igfbp5b 34
  • 53 (a)
Dr.24976 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for IGFBP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP5 Gene

Gene Tree for IGFBP5 (if available)
Gene Tree for IGFBP5 (if available)

Paralogs for IGFBP5 Gene

Paralogs for IGFBP5 Gene

(2) SIMAP similar genes for IGFBP5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IGFBP5: view

Variants for IGFBP5 Gene

Sequence variations from dbSNP and Humsavar for IGFBP5 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000002503 -- 216,682,757(-) G/A intron_variant
rs1000191345 -- 216,678,284(-) G/A intron_variant
rs1000194504 -- 216,694,821(-) A/G 5_prime_UTR_variant
rs1000308028 -- 216,695,193(-) C/G 5_prime_UTR_variant
rs1000403432 -- 216,683,216(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP5 Gene

Variant ID Type Subtype PubMed ID
esv3584350 CNV loss 25503493
nsv1072069 CNV deletion 25765185
nsv460098 CNV loss 19166990
nsv522718 CNV loss 19592680
nsv584454 CNV loss 21841781
nsv584455 CNV loss 21841781

Variation tolerance for IGFBP5 Gene

Residual Variation Intolerance Score: 70.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP5 Gene

Disorders for IGFBP5 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IGFBP5 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
renal osteodystrophy
  • renal rickets
type 1 diabetes mellitus 13
  • diabetes mellitus, insulin-dependent, 13
uv-sensitive syndrome
  • uv sensitive syndrome
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFBP5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IGFBP5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP5 Gene

Publications for IGFBP5 Gene

  1. Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5. (PMID: 7511611) Allander SV … Powell DR (The Journal of biological chemistry 1994) 2 3 4 22 58
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58

Products for IGFBP5 Gene

Sources for IGFBP5 Gene

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