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Aliases for IGFBP4 Gene

Aliases for IGFBP4 Gene

  • Insulin Like Growth Factor Binding Protein 4 2 3 5
  • IGF-Binding Protein 4 2 3 4
  • Insulin-Like Growth Factor-Binding Protein 4 2 3
  • IGFBP-4 3 4
  • IBP-4 3 4
  • IBP4 3 4
  • Insulin-Like Growth Factor Binding Protein 4 2
  • HT29-IGFBP 3
  • BP-4 3

External Ids for IGFBP4 Gene

Previous GeneCards Identifiers for IGFBP4 Gene

  • GC17P038099
  • GC17P040775
  • GC17P038508
  • GC17P038972
  • GC17P035854
  • GC17P038599
  • GC17P034392

Summaries for IGFBP4 Gene

Entrez Gene Summary for IGFBP4 Gene

  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGFBP4 Gene

IGFBP4 (Insulin Like Growth Factor Binding Protein 4) is a Protein Coding gene. Diseases associated with IGFBP4 include Insulin-Like Growth Factor I and Renal Osteodystrophy. Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot for IGFBP4 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP4 Gene

Additional gene information for IGFBP4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP4 Gene

Genomics for IGFBP4 Gene

GeneHancer (GH) Regulatory Elements for IGFBP4 Gene

Promoters and enhancers for IGFBP4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I040442 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.2 +0.8 828 3.9 HDGF ZFP64 ARID4B SIN3A YY1 ZNF143 REST ZNF592 KAT8 SREBF1 IGFBP4 MED1 SMARCE1 CDK12 SNORD124 TOP2A CCR7 ENSG00000264968 RARA ENSG00000266208
GH17I040528 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.4 +93.2 93182 15.8 IRF4 YY1 SLC30A9 E2F8 ZNF416 ZNF143 MCM3 MEF2D GLIS1 RCOR2 SMARCE1 IGFBP4 MED24 CCR7 SNORD124 RARA TOP2A RPL23AP75 CDC6 GRB7
GH17I040138 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.1 -303.1 -303085 3.2 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 MCM3 CASC3 GC17M040140 MED1 SNORD124 SMARCE1 CDK12 MED24 MSL1 STARD3 IGFBP4
GH17I040478 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.8 +47.0 47034 24 PKNOX1 CLOCK SMAD1 FOXA2 ZFP64 SIN3A FEZF1 IRF4 YY1 ZNF143 TNS4 SNORD124 SMARCE1 MED24 IGFBP4 KRT10 RPL23AP75 TOP2A RAPGEFL1 CDC6
GH17I040306 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -125.9 -125899 22.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RARA MED1 SMARCE1 SNORD124 CDK12 MED24 MSL1 TMEM99 CDC6 WIPF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGFBP4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGFBP4 gene promoter:

Genomic Locations for IGFBP4 Gene

Genomic Locations for IGFBP4 Gene
chr17:40,443,424-40,457,731
(GRCh38/hg38)
Size:
14,308 bases
Orientation:
Plus strand
chr17:38,599,676-38,613,983
(GRCh37/hg19)

Genomic View for IGFBP4 Gene

Genes around IGFBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP4 Gene

Proteins for IGFBP4 Gene

  • Protein details for IGFBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22692-IBP4_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 4
    Protein Accession:
    P22692
    Secondary Accessions:
    • A0N9W2
    • B4E351
    • Q5U012
    • Q9UCL6

    Protein attributes for IGFBP4 Gene

    Size:
    258 amino acids
    Molecular mass:
    27934 Da
    Quaternary structure:
    • Binds IGF2 more than IGF1.

    Three dimensional structures from OCA and Proteopedia for IGFBP4 Gene

    Alternative splice isoforms for IGFBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFBP4 Gene

Post-translational modifications for IGFBP4 Gene

  • Glycosylation at posLast=125125 and posLast=173173

Other Protein References for IGFBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBP4 Gene

Domains & Families for IGFBP4 Gene

Gene Families for IGFBP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFBP4: view

No data available for UniProtKB/Swiss-Prot for IGFBP4 Gene

Function for IGFBP4 Gene

Molecular function for IGFBP4 Gene

GENATLAS Biochemistry:
insulin-like growth factor binding protein 4 ,high affinity,functionnal antagonist of IGF1. Enhancer of apoptosis in malignant prostate cells
UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UniProtKB/Swiss-Prot Induction:
By forskolin and N6,O2dibutyryl adenosine 3,5-cyclic monophosphate, but not by 1,9 dideoxyforskolin.

Phenotypes From GWAS Catalog for IGFBP4 Gene

Gene Ontology (GO) - Molecular Function for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 24431302
GO:0005515 protein binding IPI 15642270
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IBA --
genes like me logo Genes that share ontologies with IGFBP4: view
genes like me logo Genes that share phenotypes with IGFBP4: view

Animal Models for IGFBP4 Gene

MGI Knock Outs for IGFBP4:

Animal Model Products

miRNA for IGFBP4 Gene

miRTarBase miRNAs that target IGFBP4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP4 Gene

Localization for IGFBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with IGFBP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGFBP4 Gene

Pathways & Interactions for IGFBP4 Gene

genes like me logo Genes that share pathways with IGFBP4: view

Gene Ontology (GO) - Biological Process for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 1377672
GO:0001558 regulation of cell growth IEA --
GO:0006259 DNA metabolic process TAS 1377672
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 1377672
genes like me logo Genes that share ontologies with IGFBP4: view

No data available for SIGNOR curated interactions for IGFBP4 Gene

Drugs & Compounds for IGFBP4 Gene

(26) Drugs for IGFBP4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for IGFBP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP4: view

Transcripts for IGFBP4 Gene

mRNA/cDNA for IGFBP4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1457) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGFBP4 Gene

Insulin-like growth factor binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP4 Gene

No ASD Table

Relevant External Links for IGFBP4 Gene

GeneLoc Exon Structure for
IGFBP4
ECgene alternative splicing isoforms for
IGFBP4

Expression for IGFBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IGFBP4 Gene

This gene is overexpressed in Amniocyte (29.3), Serum (13.5), and Vitreous humor (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGFBP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGFBP4 Gene:

IGFBP4

SOURCE GeneReport for Unigene cluster for IGFBP4 Gene:

Hs.462998

Evidence on tissue expression from TISSUES for IGFBP4 Gene

  • Intestine(4.7)
  • Liver(4.7)
  • Lung(4.7)
  • Stomach(4.7)
  • Nervous system(4.3)
  • Bone(3.2)
  • Kidney(3.2)
  • Eye(3.1)
  • Muscle(3)
  • Pancreas(3)
  • Thyroid gland(2.8)
  • Heart(2.5)
  • Gall bladder(2.4)
  • Skin(2.4)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with IGFBP4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP4 Gene

Orthologs for IGFBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFBP4 33 34
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia IGFBP4 34 33
  • 95.22 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IGFBP4 33 34
  • 93.99 (n)
mouse
(Mus musculus)
Mammalia Igfbp4 33 16 34
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Igfbp4 33
  • 89.17 (n)
oppossum
(Monodelphis domestica)
Mammalia IGFBP4 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP4 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGFBP4 34 33
  • 79.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFBP4 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igfbp4 33
  • 63.19 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12229 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
Species where no ortholog for IGFBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGFBP4 Gene

ENSEMBL:
Gene Tree for IGFBP4 (if available)
TreeFam:
Gene Tree for IGFBP4 (if available)

Paralogs for IGFBP4 Gene

Paralogs for IGFBP4 Gene

(4) SIMAP similar genes for IGFBP4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGFBP4: view

Variants for IGFBP4 Gene

Sequence variations from dbSNP and Humsavar for IGFBP4 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs563069739 likely-pathogenic, Abnormality of brain morphology 40,456,504(+) C/T coding_sequence_variant, missense_variant
rs1000004900 -- 40,444,108(+) T/C intron_variant
rs1000041195 -- 40,445,720(+) G/A intron_variant
rs1000112456 -- 40,444,003(+) C/T coding_sequence_variant, synonymous_variant
rs1000710890 -- 40,445,876(+) TTT/TT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP4 Gene

Variant ID Type Subtype PubMed ID
nsv833445 CNV loss 17160897
nsv1146669 OTHER inversion 26484159
nsv1144801 CNV deletion 24896259

Variation tolerance for IGFBP4 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP4 Gene

Human Gene Mutation Database (HGMD)
IGFBP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP4 Gene

Disorders for IGFBP4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IGFBP4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
renal osteodystrophy
  • renal rickets
osteoporosis
  • bone mineral density quantitative trait locus; bmnd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFBP4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IGFBP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP4 Gene

Publications for IGFBP4 Gene

  1. Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. (PMID: 1707125) LaTour D … Strong DD (Molecular endocrinology (Baltimore, Md.) 1990) 2 3 4 58
  2. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. (PMID: 1704481) Shimasaki S … Ling N (Molecular endocrinology (Baltimore, Md.) 1990) 2 3 4 58
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 44 58
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  5. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PMID: 20634197) Canzian F … Feigelson HS (Human molecular genetics 2010) 3 44 58

Products for IGFBP4 Gene

Sources for IGFBP4 Gene