This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters ... See more...

Aliases for IGFBP4 Gene

Aliases for IGFBP4 Gene

  • Insulin Like Growth Factor Binding Protein 4 2 3 5
  • Insulin-Like Growth Factor-Binding Protein 4 2 3 4
  • IGF-Binding Protein 4 2 3 4
  • IGFBP-4 2 3 4
  • IBP4 2 3 4
  • HT29-IGFBP 2 3
  • IBP-4 3 4
  • BP-4 2 3
  • Insulin-Like Growth Factor Binding Protein 4 2
  • IGFBP4 5

External Ids for IGFBP4 Gene

Previous GeneCards Identifiers for IGFBP4 Gene

  • GC17P038099
  • GC17P040775
  • GC17P038508
  • GC17P038972
  • GC17P035854
  • GC17P038599
  • GC17P034392

Summaries for IGFBP4 Gene

Entrez Gene Summary for IGFBP4 Gene

  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGFBP4 Gene

IGFBP4 (Insulin Like Growth Factor Binding Protein 4) is a Protein Coding gene. Diseases associated with IGFBP4 include Insulin-Like Growth Factor I and Renal Osteodystrophy. Among its related pathways are Cell adhesion_ECM remodeling and Myometrial Relaxation and Contraction Pathways. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP2.

UniProtKB/Swiss-Prot Summary for IGFBP4 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFBP4 Gene

Genomics for IGFBP4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGFBP4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGFBP4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFBP4

Top Transcription factor binding sites by QIAGEN in the IGFBP4 gene promoter:
  • AML1a
  • Arnt
  • Egr-4
  • GATA-1
  • GATA-2
  • Nkx2-5
  • Pax-5
  • Zic3

Genomic Locations for IGFBP4 Gene

Latest Assembly
chr17:40,443,450-40,457,725
(GRCh38/hg38)
Size:
14,276 bases
Orientation:
Plus strand

Previous Assembly
chr17:38,599,702-38,613,977
(GRCh37/hg19 by Entrez Gene)
Size:
14,276 bases
Orientation:
Plus strand

chr17:38,599,702-38,613,983
(GRCh37/hg19 by Ensembl)
Size:
14,282 bases
Orientation:
Plus strand

Genomic View for IGFBP4 Gene

Genes around IGFBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP4 Gene

Proteins for IGFBP4 Gene

  • Protein details for IGFBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22692-IBP4_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 4
    Protein Accession:
    P22692
    Secondary Accessions:
    • A0N9W2
    • B4E351
    • Q5U012
    • Q9UCL6

    Protein attributes for IGFBP4 Gene

    Size:
    258 amino acids
    Molecular mass:
    27934 Da
    Quaternary structure:
    • Binds IGF2 more than IGF1.

    Three dimensional structures from OCA and Proteopedia for IGFBP4 Gene

    Alternative splice isoforms for IGFBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFBP4 Gene

Post-translational modifications for IGFBP4 Gene

  • Glycosylation at Asn125 and Ser173
  • Modification sites at PhosphoSitePlus

Other Protein References for IGFBP4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGFBP4 Gene

Domains & Families for IGFBP4 Gene

Gene Families for IGFBP4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IGFBP4 Gene

InterPro:
Blocks:
  • Insulin-like growth factor-binding protein, IGFBP
  • Thyroglobulin type-1

Suggested Antigen Peptide Sequences for IGFBP4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52130, highly similar to Insulin-like growth factor-binding protein 4 (B4E351_HUMAN)
  • Insulin-like growth factor-binding protein 4 (IBP4_HUMAN)
genes like me logo Genes that share domains with IGFBP4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGFBP4 Gene

Function for IGFBP4 Gene

Molecular function for IGFBP4 Gene

UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UniProtKB/Swiss-Prot Induction:
By forskolin and N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate, but not by 1,9 dideoxyforskolin.
GENATLAS Biochemistry:
insulin-like growth factor binding protein 4 ,high affinity,functionnal antagonist of IGF1. Enhancer of apoptosis in malignant prostate cells

Phenotypes From GWAS Catalog for IGFBP4 Gene

Gene Ontology (GO) - Molecular Function for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 24431302
GO:0005515 protein binding IPI 15642270
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IBA 21873635
genes like me logo Genes that share ontologies with IGFBP4: view
genes like me logo Genes that share phenotypes with IGFBP4: view

Animal Models for IGFBP4 Gene

MGI Knock Outs for IGFBP4:

Animal Models for research

  • Taconic Biosciences Mouse Models for IGFBP4

miRNA for IGFBP4 Gene

miRTarBase miRNAs that target IGFBP4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP4 Gene

Localization for IGFBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
cytoskeleton 2
nucleus 2
mitochondrion 1
peroxisome 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with IGFBP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGFBP4 Gene

Pathways & Interactions for IGFBP4 Gene

genes like me logo Genes that share pathways with IGFBP4: view

Pathways by source for IGFBP4 Gene

2 GeneGo (Thomson Reuters) pathways for IGFBP4 Gene
  • Cell adhesion_ECM remodeling
  • Development IGF-1 receptor signaling

Gene Ontology (GO) - Biological Process for IGFBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 1377672
GO:0010906 regulation of glucose metabolic process IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with IGFBP4: view

No data available for SIGNOR curated interactions for IGFBP4 Gene

Drugs & Compounds for IGFBP4 Gene

(27) Drugs for IGFBP4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mecasermin Approved, Investigational Pharma Carrier 36

(11) Additional Compounds for IGFBP4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP4: view

Transcripts for IGFBP4 Gene

mRNA/cDNA for IGFBP4 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP4

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP4 Gene

No ASD Table

Relevant External Links for IGFBP4 Gene

GeneLoc Exon Structure for
IGFBP4

Expression for IGFBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGFBP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IGFBP4 Gene

This gene is overexpressed in Amniocyte (29.3), Serum (13.5), and Vitreous humor (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGFBP4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFBP4

SOURCE GeneReport for Unigene cluster for IGFBP4 Gene:

Hs.462998

Evidence on tissue expression from TISSUES for IGFBP4 Gene

  • Stomach(4.8)
  • Intestine(4.8)
  • Lung(4.7)
  • Liver(4.7)
  • Nervous system(4.3)
  • Pancreas(3.5)
  • Eye(3.5)
  • Kidney(3.3)
  • Bone(3.1)
  • Muscle(3.1)
  • Thyroid gland(3)
  • Heart(2.8)
  • Skin(2.8)
  • Spleen(2.5)
  • Adrenal gland(2.5)
  • Gall bladder(2.4)
  • Lymph node(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with IGFBP4: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP4 Gene

Orthologs for IGFBP4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IGFBP4 29 30
  • 99.35 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IGFBP4 29 30
  • 95.22 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IGFBP4 29 30
  • 93.99 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Igfbp4 29 16 30
  • 90 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Igfbp4 29
  • 89.17 (n)
Oppossum
(Monodelphis domestica)
Mammalia IGFBP4 30
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP4 30
  • 77 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IGFBP4 29 30
  • 79.13 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IGFBP4 30
  • 73 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia igfbp4 29
  • 63.19 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12229 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 27 (a)
OneToMany
Species where no ortholog for IGFBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IGFBP4 Gene

ENSEMBL:
Gene Tree for IGFBP4 (if available)
TreeFam:
Gene Tree for IGFBP4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGFBP4: view image
Alliance of Genome Resources:
Additional Orthologs for IGFBP4

Paralogs for IGFBP4 Gene

Paralogs for IGFBP4 Gene

(4) SIMAP similar genes for IGFBP4 Gene using alignment to 2 proteins:

  • IBP4_HUMAN
  • B4E351_HUMAN
genes like me logo Genes that share paralogs with IGFBP4: view

Variants for IGFBP4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFBP4 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs563069739 Likely Pathogenic: Abnormality of brain morphology 40,456,504(+) C/T
NM_001552.3(IGFBP4):c.698C>T (p.Thr233Met)
MISSENSE
rs79982277 Benign: not provided 40,452,992(+) C/T
NM_001552.3(IGFBP4):c.357C>T (p.Asp119=)
SYNONYMOUS
rs599199 -- p.Val42Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IGFBP4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IGFBP4 Gene

Variant ID Type Subtype PubMed ID
nsv1144801 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv833445 CNV loss 17160897

Variation tolerance for IGFBP4 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP4 Gene

Human Gene Mutation Database (HGMD)
IGFBP4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP4
Leiden Open Variation Database (LOVD)
IGFBP4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP4 Gene

Disorders for IGFBP4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for IGFBP4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
renal osteodystrophy
  • renal rickets
ovarian disease
  • ovarian dysfunction
osteoporosis
  • bone mineral density quantitative trait locus; bmnd
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFBP4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IGFBP4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP4 Gene

Publications for IGFBP4 Gene

  1. Molecular cloning of the cDNAs encoding a novel insulin-like growth factor-binding protein from rat and human. (PMID: 1704481) Shimasaki S … Ling N (Molecular endocrinology (Baltimore, Md.) 1990) 2 3 4 22
  2. Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. (PMID: 16924115) Sitar T … Holak TA (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22
  3. Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss. (PMID: 16540175) Suzuki K … Kishi R (Journal of reproductive immunology 2006) 3 22 40
  4. Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. (PMID: 1709585) Culouscou JM … Shoyab M (Cancer research 1991) 3 4 22
  5. Inhibitory insulin-like growth factor-binding protein: cloning, complete sequence, and physiological regulation. (PMID: 1707125) LaTour D … Strong DD (Molecular endocrinology (Baltimore, Md.) 1990) 2 3 4

Products for IGFBP4 Gene

  • Boster Bio Antibodies for IGFBP4
  • Boster Bio ELISA Kits for IGFBP4

Sources for IGFBP4 Gene