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This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
IGFBP3 (Insulin Like Growth Factor Binding Protein 3) is a Protein Coding gene. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Laron Syndrome. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Senescence and Autophagy in Cancer. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001968 | fibronectin binding | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 9388210 |
GO:0005520 | insulin-like growth factor binding | IEA,NAS | 12599210 |
GO:0008160 | protein tyrosine phosphatase activator activity | IDA | 11940579 |
GO:0019838 | growth factor binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | IEA,IDA | 17119061 |
GO:0005634 | nucleus | IDA | 17434920 |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0016942 | insulin-like growth factor binding protein complex | IC | 10766744 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
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2 | TP53 Regulates Transcription of Cell Death Genes | ||
3 | Glucose / Energy Metabolism | ||
4 | Cellular senescence (KEGG) | ||
5 | Relaxin signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001558 | regulation of cell growth | IEA | -- |
GO:0001649 | osteoblast differentiation | IEA | -- |
GO:0001933 | negative regulation of protein phosphorylation | IDA | 17591901 |
GO:0006468 | protein phosphorylation | IDA | 17434920 |
GO:0006915 | apoptotic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · | 9c | · | 9d | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: |
ExUns: | 9e | ^ | 10 | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|
SP1: | |||||||
SP2: | |||||||
SP3: | |||||||
SP4: | |||||||
SP5: | |||||||
SP6: | |||||||
SP7: | |||||||
SP8: | |||||||
SP9: | |||||||
SP10: | |||||||
SP11: | |||||||
SP12: | |||||||
SP13: | |||||||
SP14: | - | ||||||
SP15: | |||||||
SP16: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IGFBP3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IGFBP3 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Igfbp3 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Igfbp3 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IGFBP3 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IGFBP3 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IGFBP3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IGFBP3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IGFBP3 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | igfbp3 30 31 |
|
OneToOne | |
Dr.12583 30 |
|
||||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs149155055 | Benign: not provided | 45,917,447(-) |
C/T NM_001013398.2(IGFBP3):c.422-8G>A |
INTRON | |
rs150156575 | Benign: not provided | 45,917,261(-) |
G/A NM_001013398.2(IGFBP3):c.600C>T (p.Ser200=) |
SYNONYMOUS | |
rs35712717 | Benign: not provided. - | 45,916,598(-) |
C/Tp.Gly234Ser NM_001013398.2(IGFBP3):c.718G>A (p.Gly240Ser) |
MISSENSE | |
rs538312081 | A colorectal cancer sample |
p.Arg252Cys |
|||
VAR_036279 | A colorectal cancer sample |
p.Thr7Met |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1145131 | CNV | deletion | 24896259 |
nsv950212 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
insulin-like growth factor i |
|
|
laron syndrome |
|
|
acid-labile subunit deficiency |
|
|
acromegaly |
|
|
47,xyy |
|
|