IGFBP3 Gene (Protein Coding)

Insulin Like Growth Factor Binding Protein 3

GC07M045912
GIFtS:
46
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-li... See more...

Aliases for IGFBP3 Gene

Aliases for IGFBP3 Gene

  • Insulin Like Growth Factor Binding Protein 3 2 3 5
  • IGF-Binding Protein 3 2 3 4
  • Insulin-Like Growth Factor-Binding Protein 3 3 4
  • Acid Stable Subunit Of The 140 K IGF Complex 2 3
  • Growth Hormone-Dependent Binding Protein 2 3
  • Binding Protein 29 2 3
  • Binding Protein 53 2 3
  • IGFBP-3 3 4
  • IBP-3 3 4
  • IBP3 3 4
  • Insulin-Like Growth Factor Binding Protein 3 2
  • BP-53 3

External Ids for IGFBP3 Gene

Previous GeneCards Identifiers for IGFBP3 Gene

  • GC07M045598
  • GC07M045692
  • GC07M045725
  • GC07M045918
  • GC07M045836

Summaries for IGFBP3 Gene

Entrez Gene Summary for IGFBP3 Gene

  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGFBP3 Gene

IGFBP3 (Insulin Like Growth Factor Binding Protein 3) is a Protein Coding gene. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency. Among its related pathways are Development IGF-1 receptor signaling and TP53 Regulates Transcription of Cell Death Genes. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot Summary for IGFBP3 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Gene Wiki entry for IGFBP3 Gene

Additional gene information for IGFBP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFBP3 Gene

Genomics for IGFBP3 Gene

GeneHancer (GH) Regulatory Elements for IGFBP3 Gene

Promoters and enhancers for IGFBP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGFBP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGFBP3 gene promoter:
  • AML1a
  • TBP

Genomic Locations for IGFBP3 Gene

Genomic Locations for IGFBP3 Gene
chr7:45,912,245-45,921,874
(GRCh38/hg38)
Size:
9,630 bases
Orientation:
Minus strand
chr7:45,951,844-45,961,473
(GRCh37/hg19)
Size:
9,630 bases
Orientation:
Minus strand

Genomic View for IGFBP3 Gene

Genes around IGFBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGFBP3 Gene

Proteins for IGFBP3 Gene

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  • Protein details for IGFBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17936-IBP3_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 3
    Protein Accession:
    P17936
    Secondary Accessions:
    • A4D2F5
    • D3DVM0
    • Q2V509
    • Q6P1M6
    • Q9UCL4

    Protein attributes for IGFBP3 Gene

    Size:
    291 amino acids
    Molecular mass:
    31674 Da
    Quaternary structure:
    • Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219.

    Alternative splice isoforms for IGFBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFBP3 Gene

Protein Expression for IGFBP3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IGFBP3 Gene

  • Phosphorylated by FAM20C in the extracellular medium.
  • Glycosylation at Asn116, Asn136, Ser148, Ser151, Ser153, Ser155, Ser156, Thr157, Ser161, Ser192, Thr195, Asn199, and Thr277
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for IGFBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IGFBP3

No data available for DME Specific Peptides for IGFBP3 Gene

Domains & Families for IGFBP3 Gene

Gene Families for IGFBP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IGFBP3 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGFBP3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ35128 fis, clone PLACE6008768, moderately similar to Insulin-like growth factor-binding protein 3 (B3KRZ1_HUMAN)
  • cDNA FLJ38655 fis, clone HHDPC2009208, highly similar to Insulin-like growth factor-binding protein 3 (B3KTS0_HUMAN)
  • cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 (B3KWK7_HUMAN)
  • Insulin-like growth factor-binding protein 3 (IBP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17936

UniProtKB/Swiss-Prot:

IBP3_HUMAN :
  • The thyroglobulin type-1 domain mediates interaction with HN.
Domain:
  • The thyroglobulin type-1 domain mediates interaction with HN.
genes like me logo Genes that share domains with IGFBP3: view

Function for IGFBP3 Gene

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Molecular function for IGFBP3 Gene

UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
UniProtKB/Swiss-Prot Induction:
Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters.
GENATLAS Biochemistry:
insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic tissues,principal serum IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly regulated by GH. Regulator of cell somatic growth and cellular proliferation,either IGF dependent or IGF independent,parameter of GH activity in acromegalic patients

Phenotypes From GWAS Catalog for IGFBP3 Gene

Gene Ontology (GO) - Molecular Function for IGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IEA,IBA 21873635
GO:0005515 protein binding IPI 9388210
GO:0005520 insulin-like growth factor binding NAS,IEA 12599210
GO:0008160 protein tyrosine phosphatase activator activity IDA 11940579
GO:0019838 growth factor binding IEA --
genes like me logo Genes that share ontologies with IGFBP3: view
genes like me logo Genes that share phenotypes with IGFBP3: view

Animal Models for IGFBP3 Gene

MGI Knock Outs for IGFBP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFBP3

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP3 Gene

Localization for IGFBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP3 gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 4
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 17119061
GO:0005634 nucleus IDA 17434920
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0016942 insulin-like growth factor binding protein complex IC 10766744
genes like me logo Genes that share ontologies with IGFBP3: view

Pathways & Interactions for IGFBP3 Gene

genes like me logo Genes that share pathways with IGFBP3: view

SIGNOR curated interactions for IGFBP3 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001933 negative regulation of protein phosphorylation IDA 17591901
GO:0006468 protein phosphorylation IDA 17434920
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with IGFBP3: view

Drugs & Compounds for IGFBP3 Gene

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  1. Drug

(93) Drugs for IGFBP3 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alitretinoin Approved, Investigational Pharma Agonist, Target 17
Mecasermin Approved, Investigational Pharma Target, Carrier, carrier 108
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2212
Lonafarnib Investigational Pharma Target Ftase inhibitor,potent and selective 36

(43) Additional Compounds for IGFBP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP3: view

Transcripts for IGFBP3 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for IGFBP3 Gene

(2) REFSEQ mRNAs :
(37) Additional mRNA sequences :
(1222) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ·
SP1: - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - -
SP13: -
SP14: -
SP15: - -
SP16:

ExUns: 9e ^ 10 ^ 11a · 11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:

Relevant External Links for IGFBP3 Gene

GeneLoc Exon Structure for
IGFBP3
ECgene alternative splicing isoforms for
IGFBP3

Expression for IGFBP3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFBP3 Gene

mRNA expression in normal human tissues for IGFBP3 Gene
mRNA expression by BioGPS for IGFBP3 GenemRNA expression by GTEx for IGFBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP3 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for IGFBP3 Gene

This gene is overexpressed in Amniocyte (35.3), Testis (12.7), and Serum (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGFBP3 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGFBP3 Gene:

IGFBP3

SOURCE GeneReport for Unigene cluster for IGFBP3 Gene:

Hs.450230

mRNA Expression by UniProt/SwissProt for IGFBP3 Gene:

P17936-IBP3_HUMAN
Tissue specificity: Expressed by most tissues. Present in plasma.

Evidence on tissue expression from TISSUES for IGFBP3 Gene

  • Kidney(5)
  • Nervous system(5)
  • Liver(4.8)
  • Skin(4.8)
  • Intestine(4.5)
  • Spleen(4.5)
  • Bone marrow(4.3)
  • Lung(4.3)
  • Pancreas(4.2)
  • Stomach(4.1)
  • Eye(3.5)
  • Heart(3.5)
  • Blood(3.4)
  • Muscle(3.2)
  • Bone(2.8)
  • Thyroid gland(2.8)
  • Adrenal gland(2.2)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with IGFBP3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP3 Gene

Orthologs for IGFBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IGFBP3 33 32
  • 99.44 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia IGFBP3 33 32
  • 83.62 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Igfbp3 32
  • 83.56 (n)
mouse
(Mus musculus)
 Mammalia Igfbp3 17 33 32
  • 83.1 (n)
dog
(Canis familiaris)
 Mammalia IGFBP3 33 32
  • 82.61 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IGFBP3 33
  • 72 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia IGFBP3 33
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves IGFBP3 33 32
  • 74.19 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia IGFBP3 33
  • 62 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii igfbp3 33 32
  • 61.94 (n)
 OneToOne
Dr.12583 32
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 26 (a)
 OneToMany
Species where no ortholog for IGFBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFBP3 Gene

ENSEMBL:
Gene Tree for IGFBP3 (if available)
TreeFam:
Gene Tree for IGFBP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGFBP3: view image

Paralogs for IGFBP3 Gene

Paralogs for IGFBP3 Gene

(3) SIMAP similar genes for IGFBP3 Gene using alignment to 5 proteins:

  • IBP3_HUMAN
  • B3KWK7_HUMAN
  • C9JMX4_HUMAN
  • H0Y485_HUMAN
  • H0Y5K2_HUMAN
genes like me logo Genes that share paralogs with IGFBP3: view

Variants for IGFBP3 Gene

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Sequence variations from dbSNP and Humsavar for IGFBP3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs538312081 A colorectal cancer sample 45,914,942(-) G/A/C coding_sequence_variant, missense_variant
VAR_036279 A colorectal cancer sample p.Thr7Met
rs1000074147 -- 45,919,101(-) C/T intron_variant
rs1000241348 -- 45,919,927(-) /G/T intron_variant
rs1000366084 -- 45,913,019(-) T/A/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for IGFBP3 Gene

Variant ID Type Subtype PubMed ID
nsv1145131 CNV deletion 24896259
nsv950212 CNV deletion 24416366

Variation tolerance for IGFBP3 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP3 Gene

Human Gene Mutation Database (HGMD)
IGFBP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP3 Gene

Disorders for IGFBP3 Gene

MalaCards: The human disease database

(57) MalaCards diseases for IGFBP3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
acid-labile subunit deficiency
  • aclsd
laron syndrome
  • growth hormone insensitivity syndrome
47,xyy
  • camptodactyly-arthropathy-coxa vara-pericarditis syndrome
marasmus
  • nutritional atrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFBP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IGFBP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP3 Gene

Publications for IGFBP3 Gene

  1. Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PMID: 1695633) Cubbage ML … Powell DR (The Journal of biological chemistry 1990) 2 3 4 23 56
  2. Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C … Maher ER (PloS one 2009) 3 23 43 56
  3. Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): correlation with serum IGFBP-3 levels and growth in short children born small for gestational age. (PMID: 18929499) van der Kaay DC … Deal CL (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2009) 3 23 43 56
  4. IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. (PMID: 19240240) D'Aloisio AA … Baird DD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 43 56
  5. Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. (PMID: 18059035) Slattery ML … Potter JD (International journal of cancer 2008) 3 23 43 56

ExternalLinks

View latest publications for IGFBP3 gene in Mastermind

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