Aliases for IGFBP3 Gene
Aliases for IGFBP3 Gene
External Ids for IGFBP3 Gene
- HGNC: 5472
- Entrez Gene: 3486
- Ensembl: ENSG00000146674
- OMIM: 146732
- UniProtKB: P17936
Previous GeneCards Identifiers for IGFBP3 Gene
- GC07M045598
- GC07M045692
- GC07M045725
- GC07M045918
- GC07M045836
Summaries for IGFBP3 Gene
-
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for IGFBP3 Gene
IGFBP3 (Insulin Like Growth Factor Binding Protein 3) is a Protein Coding gene. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency. Among its related pathways are Gene Expression and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP5.
UniProtKB/Swiss-Prot for IGFBP3 Gene
-
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Additional gene information for IGFBP3 Gene
- Monarch Initiative
- Search for IGFBP3 at DataMed
- Search for IGFBP3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP3 Gene
Genomics for IGFBP3 Gene
GeneHancer (GH) Regulatory Elements for IGFBP3 Gene
Promoters and enhancers for IGFBP3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J045918 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | +0.2 | 159 | 6.8 | RB1 SIN3A BMI1 RAD21 RFX5 ZNF143 RCOR1 FOS DEK EGR2 | IGFBP3 ENSG00000237471 TTC4P1 IGFBP1 RNU7-76P ENSG00000229628 GC07P046345 | |
| GH07J046352 | Enhancer | 0.7 | ENCODE | 12.3 | -430.7 | -430654 | 0.1 | CTCF MAX EBF1 RAD21 TEAD3 ZBTB48 ZNF143 SMC3 FOSL2 DEK | IGFBP3 GC07P046371 LOC105375265 | |
| GH07J046143 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 2.1 | -223.7 | -223729 | 4.1 | PKNOX1 SIN3A RAD21 RARA ETS1 ATF7 RCOR1 FOS RXRA USF2 | GC07P046343 ZNF619P1 ENSG00000237471 RNU7-76P TTC4P1 IGFBP3 GC07M046242 | |
| GH07J045917 | Enhancer | 0.8 | ENCODE dbSUPER | 0.7 | +4.1 | 4107 | 0.2 | CTCF ZNF3 ZNF654 ZNF10 TRIM22 REST RAD21 ZNF335 XRCC5 SCRT2 | IGFBP3 GC07P046345 | |
| GH07J045908 | Enhancer | 0.2 | FANTOM5 | 0.4 | +13.5 | 13479 | 0.2 | GC07P046345 IGFBP3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IGFBP3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IGFBP3 gene promoter:
-
- TBP
- AML1a
Regulatory Element Products
Genomic Locations for IGFBP3 Gene
Genomic Locations for IGFBP3 Gene
- chr7:45,912,245-45,921,874
- (GRCh38/hg38)
- Size:
- 9,630 bases
- Orientation:
- Minus strand
- chr7:45,951,844-45,961,473
- (GRCh37/hg19)
- Size:
- 9,630 bases
- Orientation:
- Minus strand
Genomic View for IGFBP3 Gene
Genes around IGFBP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p12.3 by Entrez Gene
- 7p12.3 by HGNC
- 7p12.3 by Ensembl
IGFBP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFBP3 Gene
Proteins for IGFBP3 Gene
-
Protein details for IGFBP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17936-IBP3_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein 3
- Protein Accession:
- P17936
- A4D2F5
- D3DVM0
- Q2V509
- Q6P1M6
- Q9UCL4
Protein attributes for IGFBP3 Gene
- Size:
- 291 amino acids
- Molecular mass:
- 31674 Da
- Quaternary structure:
-
- Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219.
Protein Expression for IGFBP3 Gene
Post-translational modifications for IGFBP3 Gene
- Phosphorylated by FAM20C in the extracellular medium.
- Glycosylation at isoforms=2277, isoforms=2199, Thr195, Ser192, Ser161, Thr157, isoforms=2156, isoforms=2155, isoforms=2153, isoforms=2151, Ser148, Asn136, and isoforms=2116
- Modification sites at PhosphoSitePlus
Other Protein References for IGFBP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IGFBP3 (IGFBP-3)
- Novus Biologicals Antibodies for IGFBP3
-
Abcam antibodies for IGFBP3
- Invitrogen Antibodies for IGFBP3 (AFLGC-IGFBP3)
- antibodies-online: Search results for 236 available IGFBP3 Antibodies ranked by validation data
- Compare Top IGFBP3 Antibodies
-
Recommended
- 154 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 DB Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 60 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 28 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- GeneTex IGFBP3 Antibody for IGFBP3
-
Custom Antibody ServicesProSci Antibodies for IGFBP3
-
Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP3
- Sino Biological Antibodies for IGFBP3
Protein Products
- R&D Systems Proteins and Enzymes for IGFBP3 (IGFBP-3)
-
OriGene Purified Proteins for IGFBP3
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBP3
- Origene Custom Protein Services for IGFBP3
- Sino Biological Recombinant Proteins for IGFBP3
- Sino Biological Cell Lysates for IGFBP3
- ProSpec Recombinant Proteins for IGFBP3
- GeneTex Proteins for IGFBP3
-
Abcam proteins for IGFBP3
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for IGFBP3
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for IGFBP3 (IGFBP-3)
- Novus Biologicals ELISA Kits for IGFBP3
- antibodies-online: Search results for 113 available IGFBP3 Elisa Kits ranked by validation data
- Compare Top IGFBP3 Elisa Kits
-
Recommended
- 5 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Fish ELISA Kit
- 3 Goat ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Helicobacter pylori ELISA Kit
- 1 Horse (Equine) ELISA Kit
- 38 Human ELISA Kits
- 2 Monkey ELISA Kits
- 24 Mouse (Murine) ELISA Kits
- 12 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- Sino Biological Assays for IGFBP3
No data available for DME Specific Peptides for IGFBP3 Gene
Domains & Families for IGFBP3 Gene
Gene Families for IGFBP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for IGFBP3 Gene
Suggested Antigen Peptide Sequences for IGFBP3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ35128 fis, clone PLACE6008768, moderately similar to Insulin-like growth factor-binding protein 3 (B3KRZ1_HUMAN)
- cDNA FLJ38655 fis, clone HHDPC2009208, highly similar to Insulin-like growth factor-binding protein 3 (B3KTS0_HUMAN)
- cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 (B3KWK7_HUMAN)
- Insulin-like growth factor-binding protein 3 (IBP3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P17936- Domain:
-
- The thyroglobulin type-1 domain mediates interaction with HN.
Function for IGFBP3 Gene
Molecular function for IGFBP3 Gene
- UniProtKB/Swiss-Prot Function:
- IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters.
- GENATLAS Biochemistry:
- insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic tissues,principal serum IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly regulated by GH. Regulator of cell somatic growth and cellular proliferation,either IGF dependent or IGF independent,parameter of GH activity in acromegalic patients
Phenotypes From GWAS Catalog for IGFBP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IEA,IBA | -- |
| GO:0005515 | protein binding | IPI | 9388210 |
| GO:0005520 | insulin-like growth factor binding | IEA,NAS | 12599210 |
| GO:0008160 | protein tyrosine phosphatase activator activity | IDA | 11940579 |
| GO:0019838 | growth factor binding | IEA | -- |
Phenotypes for IGFBP3 Gene
- MGI mutant phenotypes for IGFBP3:
-
inferred from 3 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- pigmentation phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- muscle phenotype
- liver/biliary system phenotype
- skeleton phenotype
- renal/urinary system phenotype
- adipose tissue phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for IGFBP3:
Animal Models for IGFBP3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for IGFBP3
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGFBP3
-
CRISPR Products
-
OriGene CRISPR knockouts for IGFBP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP3
- genomics-online: gRNA clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
- Applied Biological Materials CRISPR for IGFBP3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP3
- GenScript: Design CRISPR guide RNA sequences for IGFBP3
miRNA for IGFBP3 Gene
- miRTarBase miRNAs that target IGFBP3
-
- hsa-mir-375 (MIRT019713)
- hsa-mir-124-3p (MIRT022363)
- hsa-mir-210-3p (MIRT054206)
- hsa-mir-3157-3p (MIRT702743)
- hsa-mir-7977 (MIRT702744)
- hsa-mir-18b-3p (MIRT702745)
- hsa-mir-1909-5p (MIRT702746)
- hsa-mir-759 (MIRT702747)
- hsa-mir-371b-3p (MIRT702748)
- hsa-mir-4773 (MIRT702749)
- hsa-mir-5580-3p (MIRT702750)
- hsa-mir-17-5p (MIRT734603)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP3
- Browse OriGene Inhibitory RNA Products For IGFBP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP3
- genomics-online: shRNA clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IGFBP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP3
- Applied Biological Materials Clones for IGFBP3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IGFBP3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP3 Gene
Localization for IGFBP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFBP3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Cytosol (2)
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 17119061 |
| GO:0005634 | nucleus | IDA | 17434920 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0016942 | insulin-like growth factor binding protein complex | IC | 10766744 |
Pathways & Interactions for IGFBP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | TP53 Regulates Transcription of Cell Death Genes | ||
| 3 | Cellular senescence (KEGG) | ||
| 4 | DNA Damage Response | ||
| 5 | Transcriptional misregulation in cancer | ||
Pathways by source for IGFBP3 Gene
4 BioSystems pathways for IGFBP3 Gene
7 Reactome pathways for IGFBP3 Gene
1 PharmGKB pathway for IGFBP3 Gene
3 KEGG pathways for IGFBP3 Gene
2 GeneGo (Thomson Reuters) pathways for IGFBP3 Gene
1 Cell Signaling Technology pathway for IGFBP3 Gene
Interacting Proteins for IGFBP3 Gene
Selected Interacting proteins:
ENSP00000370473
P17936-IBP3_HUMAN
for IGFBP3 Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for IGFBP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0001649 | osteoblast differentiation | IEA | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IDA | 17591901 |
| GO:0006468 | protein phosphorylation | IDA | 17434920 |
| GO:0006915 | apoptotic process | IEA | -- |
No data available for SIGNOR curated interactions for IGFBP3 Gene
Drugs & Compounds for IGFBP3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Alitretinoin | Approved, Investigational | Pharma | Agonist, Target | 17 | ||
| Mecasermin | Approved, Investigational | Pharma | Target | 0 | ||
| Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 1970 | ||
| Lonafarnib | Investigational | Pharma | Target | Ftase inhibitor,potent and selective | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for IGFBP3 Gene
mRNA/cDNA for IGFBP3 Gene
- (2) REFSEQ mRNAs :
- (33) Additional mRNA sequences :
- (1222) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000381086 2322 bps (uc003tnt.3)
- ENST00000275521 2262 bps (uc003tns.4)
- ENST00000460209 583 bps (uc064dmj.1)
- ENST00000381083 1050 bps (uc003tnr.4)
- ENST00000428530 894 bps (uc064dmk.1)
Unigene Clusters for IGFBP3 Gene
- Insulin-like growth factor binding protein 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for IGFBP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP3
- genomics-online: gRNA clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
- Applied Biological Materials CRISPR for IGFBP3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP3
- GenScript: Design CRISPR guide RNA sequences for IGFBP3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP3
- Browse OriGene Inhibitory RNA Products For IGFBP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP3
- genomics-online: shRNA clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IGFBP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP3
- Applied Biological Materials Clones for IGFBP3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · | 9c | · | 9d | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 9e | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | |||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: | |||||||
| SP14: | - | ||||||
| SP15: | |||||||
| SP16: |
Expression for IGFBP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Basal Keratinocytes Embryonic Epidermis
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Detroit 551
- NULL (Integumentary System)
- Bone (Muscoskeletal System)
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Heart Tube
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Floor plate-like cells(Fasano CA et. al. 2010)
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- N2/LSB/S/F8-induced cells(Kriks S et. al. 2011)
- Mesenchymal Stem Cells
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Chorion (Extraembryonic Tissues)
- Chorionic Mesoderm Cells Chorion Bilayer
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
- Eye (Sensory Organs)
- Placenta (Extraembryonic Tissues)
- Liver (Hepatobiliary System)
- Adipose (Muscoskeletal System)
- Uncategorized
- Fibroblasts
- Cartilage (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for IGFBP3 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).
This gene is overexpressed in Amniocyte (35.3), Testis (12.7), and Serum (12.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGFBP3 Gene
NURSA nuclear receptor signaling pathways regulating expression of IGFBP3 Gene:
IGFBP3SOURCE GeneReport for Unigene cluster for IGFBP3 Gene:
Hs.450230mRNA Expression by UniProt/SwissProt for IGFBP3 Gene:
P17936-IBP3_HUMAN
Tissue specificity:
Expressed by most tissues. Present in plasma.
Evidence on tissue expression from TISSUES for IGFBP3 Gene
- Kidney(5)
- Nervous system(5)
- Liver(4.8)
- Skin(4.8)
- Intestine(4.5)
- Spleen(4.5)
- Bone marrow(4.3)
- Lung(4.3)
- Pancreas(4.2)
- Stomach(4.1)
- Eye(3.5)
- Heart(3.5)
- Blood(3.4)
- Muscle(3.2)
- Bone(2.8)
- Thyroid gland(2.8)
- Adrenal gland(2.2)
- Lymph node(2.2)
Primer Products
-
OriGene qPCR primer pairs for IGFBP3
-
OriGene qPCR primer pairs and template standards for IGFBP3
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP3 Gene
Orthologs for IGFBP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IGFBP3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IGFBP3 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Igfbp3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Igfbp3 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | IGFBP3 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IGFBP3 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | IGFBP3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IGFBP3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | IGFBP3 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | igfbp3 34 33 |
|
OneToOne | |
| Dr.12583 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for IGFBP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IGFBP3 Gene
- ENSEMBL:
- Gene Tree for IGFBP3 (if available)
- TreeFam:
- Gene Tree for IGFBP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IGFBP3: view image
Paralogs for IGFBP3 Gene
Variants for IGFBP3 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs538312081 | A colorectal cancer sample | 45,914,942(-) | G/A/C | coding_sequence_variant, missense_variant | |
| VAR_036279 | A colorectal cancer sample | p.Thr7Met | |||
| rs1000074147 | -- | 45,919,101(-) | C/T | intron_variant | |
| rs1000241348 | -- | 45,919,927(-) | /G | intron_variant | |
| rs1000366084 | -- | 45,913,019(-) | T/A/C | 3_prime_UTR_variant, genic_downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1145131 | CNV | deletion | 24896259 |
| nsv950212 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.44;
85.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGFBP3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP3 Gene
Disorders for IGFBP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| insulin-like growth factor i |
|
|
| acid-labile subunit deficiency |
|
|
| laron syndrome |
|
|
| 47,xyy |
|
|
| diffuse idiopathic skeletal hyperostosis |
|
|
Search IGFBP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IGFBP3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP3 Gene
Publications for IGFBP3 Gene
- Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PMID: 1695633) Cubbage ML … Powell DR (The Journal of biological chemistry 1990) 2 3 4 22 58
- IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. (PMID: 19240240) D'Aloisio AA … Baird DD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 44 58
- Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C … Maher ER (PloS one 2009) 3 22 44 58
- Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): correlation with serum IGFBP-3 levels and growth in short children born small for gestational age. (PMID: 18929499) van der Kaay DC … Deal CL (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2009) 3 22 44 58
- Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. (PMID: 18059035) Slattery ML … Potter JD (International journal of cancer 2008) 3 22 44 58
Products for IGFBP3 Gene
- R&D Systems Antibodies for IGFBP3 (IGFBP-3)
- R&D Systems Proteins and Enzymes for IGFBP3 (IGFBP-3)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for IGFBP3 (IGFBP-3)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IGFBP3
- Custom Assay ServicesOriGene ELISA Kits for IGFBP3
- OriGene Purified Proteins for IGFBP3
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBP3
- Origene Custom Protein Services for IGFBP3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP3
- Browse OriGene Inhibitory RNA Products For IGFBP3
- OriGene qPCR primer pairs for IGFBP3
- OriGene qPCR primer pairs and template standards for IGFBP3
- OriGene CRISPR knockouts for IGFBP3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IGFBP3
- GenScript: Next-day shipping of latest version cDNA ORF clones for IGFBP3 in any vector
- GenScript Purified and Recombinant Proteins for IGFBP3
- GenScript Custom Purified and Recombinant Proteins Services for IGFBP3
- GenScript Custom Assay Services for IGFBP3
- GenScript Custom overexpressing Cell Line Services for IGFBP3
- GenScript: Design CRISPR guide RNA sequences for IGFBP3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IGFBP3
- Sino Biological Human cDNA Clone for IGFBP3
- Sino Biological Recombinant Proteins for IGFBP3
- Sino Biological Cell Lysates for IGFBP3
- Sino Biological Antibodies for IGFBP3
- Sino Biological Assays for IGFBP3
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IGFBP3
- Novus Biologicals lysates and proteins for IGFBP3
- Novus Biologicals ELISA Kits for IGFBP3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IGFBP3
- Abcam proteins for IGFBP3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for IGFBP3
- Taconic Biosciences Mouse Models for IGFBP3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IGFBP3 (AFLGC-IGFBP3)
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGFBP3
- antibodies-online: Search results for 236 available IGFBP3 Antibodies ranked by validation data
- Compare Top IGFBP3 Antibodies
- Recommended
- 154 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 CC Antibody (anti-human)
- 1 DB Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 60 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 28 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Search results for 113 available IGFBP3 Elisa Kits ranked by validation data
- Compare Top IGFBP3 Elisa Kits
- Recommended
- 5 Chicken ELISA Kits
- 7 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Fish ELISA Kit
- 3 Goat ELISA Kits
- 1 Guinea Pig ELISA Kit
- 1 Helicobacter pylori ELISA Kit
- 1 Horse (Equine) ELISA Kit
- 38 Human ELISA Kits
- 2 Monkey ELISA Kits
- 24 Mouse (Murine) ELISA Kits
- 12 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 49 available IGFBP3 Proteins ranked by validation data
- Compare Top IGFBP3 Proteins
- GeneTex IGFBP3 Antibody for IGFBP3
- GeneTex Proteins for IGFBP3
- Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP3
- Search Santa Cruz Biotechnology (SCBT) for IGFBP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP3
- Custom Antibody ServicesProSci Antibodies for IGFBP3
- Horizon Cell Lines for IGFBP3
- genomics-online: cdna clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
- orf clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
- genomics-online: gRNA clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
- genomics-online: primer clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
- genomics-online: shRNA clones - Search results for 124 available IGFBP3 gene related products
- Overview of 124 available IGFBP3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP3
- GeneCopoeia miRNA 3'UTR Target clone products for IGFBP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP3
Sources for IGFBP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt