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This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-li... See more...
Aliases for IGFBP3 Gene
Aliases for IGFBP3 Gene
External Ids for IGFBP3 Gene
- HGNC: 5472
- Entrez Gene: 3486
- Ensembl: ENSG00000146674
- OMIM: 146732
- UniProtKB: P17936
Previous GeneCards Identifiers for IGFBP3 Gene
- GC07M045598
- GC07M045692
- GC07M045725
- GC07M045918
- GC07M045836
Summaries for IGFBP3 Gene
-
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for IGFBP3 Gene
IGFBP3 (Insulin Like Growth Factor Binding Protein 3) is a Protein Coding gene. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency. Among its related pathways are Transcriptional misregulation in cancer and Celecoxib Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP5.
UniProtKB/Swiss-Prot Summary for IGFBP3 Gene
-
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Additional gene information for IGFBP3 Gene
- HGNC(5472)
- Entrez Gene(3486)
- Ensembl(ENSG00000146674)
- OMIM(146732)
- UniProtKB(P17936)
- Open Targets Platform(ENSG00000146674)
- Monarch Initiative
- Search for IGFBP3 at DataMed
- Search for IGFBP3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFBP3 Gene
Genomics for IGFBP3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IGFBP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IGFBP3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFBP3
- Top Transcription factor binding sites by QIAGEN in the IGFBP3 gene promoter:
-
- AML1a
- TBP
Genomic Locations for IGFBP3 Gene
Genomic Locations for IGFBP3 Gene
- chr7:45,912,245-45,921,874
- (GRCh38/hg38)
- Size:
- 9,630 bases
- Orientation:
- Minus strand
- chr7:45,951,844-45,961,473
- (GRCh37/hg19)
- Size:
- 9,630 bases
- Orientation:
- Minus strand
Genomic View for IGFBP3 Gene
Genes around IGFBP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p12.3 by HGNC
- 7p12.3 by Entrez Gene
- 7p12.3 by Ensembl
IGFBP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFBP3 Gene
Proteins for IGFBP3 Gene
-
Protein details for IGFBP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17936-IBP3_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein 3
- Protein Accession:
- P17936
- A4D2F5
- D3DVM0
- Q2V509
- Q6P1M6
- Q9UCL4
Protein attributes for IGFBP3 Gene
- Size:
- 291 amino acids
- Molecular mass:
- 31674 Da
- Quaternary structure:
-
- Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219.
Protein Expression for IGFBP3 Gene
Post-translational modifications for IGFBP3 Gene
Other Protein References for IGFBP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Phospho-IGFBP-3 (Ser183) Antibody and Immunotag™ IGFBP-3 Antibody
- GeneTex Anti-IGFBP3 antibody [N2C3]
- NSJ Bioreagents IGFBP3 Antibody
- BioLegend IGFBP-3 Antibody
- Novus Biologicals Antibodies for IGFBP3
-
Abcam antibodies for IGFBP3
- Invitrogen Antibodies for IGFBP3 (AFLGC-IGFBP3)
- antibodies-online: Show 65 available IGFBP3 Antibodies ranked by validation data
- Compare Top IGFBP3 Antibodies
-
Recommended
- 175 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 77 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 40 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
-
Boster Bio Antibodies for IGFBP3
-
Custom Antibody ServicesProSci Antibodies for IGFBP3
-
Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP3
- Sino Biological Antibodies for IGFBP3
Protein Products
-
OriGene Purified Proteins for IGFBP3
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBP3
- Origene Custom Protein Services for IGFBP3
- Sino Biological Recombinant Proteins for IGFBP3
- Sino Biological Cell Lysates for IGFBP3
- ProSpec Recombinant Proteins for IGFBP3
-
Abcam proteins for IGFBP3
Assay Products
- RayBiotech Human IGFBP-3 ELISA
-
Custom Assay ServicesOriGene ELISA Kits for IGFBP3
- Novus Biologicals ELISA Kits for IGFBP3
- antibodies-online: Show 127 available IGFBP3 Elisa Kits ranked by validation data
- Compare Top IGFBP3 Elisa Kits
-
Quality Products:
- ABIN624999
- ABIN1115524
- ABIN2212648
- ABIN411290
- ABIN414870
- ABIN365320
- ABIN3032935
- ABIN1028910
- ABIN1380035
- ABIN3198552
- ABIN1115545
- ABIN625402
- ABIN415501
- ABIN1672736
- ABIN3032808
- ABIN1570539
- ABIN5523421
- ABIN2708527
- ABIN6719869
- ABIN5596289
- ABIN1115546
- ABIN416321
- ABIN365596
- ABIN1570541
- ABIN5523423
- ABIN579320
- ABIN5670765
- ABIN627200
- ABIN5593833
- ABIN5655434
- ABIN413977
- ABIN1570534
- ABIN364596
- ABIN993099
- ABIN5655429
- ABIN2535072
- ABIN4970202
- ABIN6218591
- ABIN1138183
-
Abcam assays for IGFBP3
- Sino Biological Assays for IGFBP3
No data available for DME Specific Peptides for IGFBP3 Gene
Domains & Families for IGFBP3 Gene
Gene Families for IGFBP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for IGFBP3 Gene
- InterPro:
- Blocks:
-
- Insulin-like growth factor-binding protein, IGFBP
- Thyroglobulin type-1
- ProtoNet:
Suggested Antigen Peptide Sequences for IGFBP3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ35128 fis, clone PLACE6008768, moderately similar to Insulin-like growth factor-binding protein 3 (B3KRZ1_HUMAN)
- cDNA FLJ38655 fis, clone HHDPC2009208, highly similar to Insulin-like growth factor-binding protein 3 (B3KTS0_HUMAN)
- cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 (B3KWK7_HUMAN)
- Insulin-like growth factor-binding protein 3 (IBP3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P17936- Domain:
-
- The thyroglobulin type-1 domain mediates interaction with HN.
Function for IGFBP3 Gene
Molecular function for IGFBP3 Gene
- UniProtKB/Swiss-Prot Function:
- IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters.
- GENATLAS Biochemistry:
- insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic tissues,principal serum IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly regulated by GH. Regulator of cell somatic growth and cellular proliferation,either IGF dependent or IGF independent,parameter of GH activity in acromegalic patients
Phenotypes From GWAS Catalog for IGFBP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001968 | fibronectin binding | IEA,IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 9388210 |
| GO:0005520 | insulin-like growth factor binding | IEA,NAS | 12599210 |
| GO:0008160 | protein tyrosine phosphatase activator activity | IDA | 11940579 |
| GO:0019838 | growth factor binding | IEA | -- |
Phenotypes for IGFBP3 Gene
- MGI mutant phenotypes for IGFBP3:
-
inferred from 3 alleles
- nervous system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- integument phenotype
- pigmentation phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for IGFBP3:
Animal Models for IGFBP3 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for IGFBP3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IGFBP3 - Select products 50% OFF >
- * IGFBP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IGFBP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP3
miRNA for IGFBP3 Gene
- miRTarBase miRNAs that target IGFBP3
-
- mmu-miR-340-5p (MIRT010326)
- mmu-miR-15a-5p (MIRT011617)
- mmu-miR-19b-3p (MIRT012413)
- mmu-miR-34b-5p (MIRT012718)
- hsa-miR-375 (MIRT019713)
- hsa-miR-124-3p (MIRT022363)
- hsa-miR-210-3p (MIRT054206)
- mmu-miR-342-3p (MIRT578513)
- mmu-miR-377-3p (MIRT578514)
- mmu-miR-344e-3p (MIRT578515)
- mmu-miR-344d-3p (MIRT578516)
- mmu-miR-410-3p (MIRT578517)
- mmu-miR-466l-3p (MIRT578518)
- hsa-miR-3157-3p (MIRT702743)
- hsa-miR-7977 (MIRT702744)
- hsa-miR-18b-3p (MIRT702745)
- hsa-miR-1909-5p (MIRT702746)
- hsa-miR-759 (MIRT702747)
- hsa-miR-371b-3p (MIRT702748)
- hsa-miR-4773 (MIRT702749)
- hsa-miR-5580-3p (MIRT702750)
- hsa-miR-17-5p (MIRT734603)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP3
- Browse OriGene Inhibitory RNA Products For IGFBP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP3
Clone Products
- Applied Biological Materials (abm): Clones for IGFBP3 - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204018
- MR204018
- MR204018L3
- MR204018L4
- RC209150
- RC209150L1
- RC209150L2
- RC209150L3
- RC209150L4
- RC216898
- RC216898L1
- RC216898L2
- RC216898L3
- RC216898L4
- RG209150
- RG216898
- RR204906
- RR204906L3
- RR204906L4
- MR204018L3V
- MR204018L4V
- RC209150L1V
- RC209150L2V
- RC209150L3V
- RC209150L4V
- RC216898L1V
- RC216898L2V
- RC216898L3V
- RC216898L4V
- RR204906L3V
- RR204906L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IGFBP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP3
Cell Line Products
-
Horizon Cell Lines for IGFBP3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP3 Gene
Localization for IGFBP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFBP3 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 4 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (2)
- Nucleoplasm (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | IEA,IDA | 17119061 |
| GO:0005634 | nucleus | IDA | 17434920 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0016942 | insulin-like growth factor binding protein complex | IC | 10766744 |
Pathways & Interactions for IGFBP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | TP53 Regulates Transcription of Cell Death Genes | ||
| 3 | Glucose / Energy Metabolism | ||
| 4 | Cellular senescence (KEGG) | ||
| 5 | Relaxin signaling pathway | ||
Pathways by source for IGFBP3 Gene
4 BioSystems pathways for IGFBP3 Gene
7 Reactome pathways for IGFBP3 Gene
1 PharmGKB pathway for IGFBP3 Gene
4 KEGG pathways for IGFBP3 Gene
2 GeneGo (Thomson Reuters) pathways for IGFBP3 Gene
- Development IGF-1 receptor signaling
- Transcription Receptor-mediated HIF regulation
1 R&D Systems pathway for IGFBP3 Gene
1 Cell Signaling Technology pathway for IGFBP3 Gene
Interacting Proteins for IGFBP3 Gene
Selected Interacting proteins:
P17936-IBP3_HUMAN
ENSP00000370473
for IGFBP3 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IGFBP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0001649 | osteoblast differentiation | IEA | -- |
| GO:0001933 | negative regulation of protein phosphorylation | IDA | 17591901 |
| GO:0006468 | protein phosphorylation | IDA | 17434920 |
| GO:0006915 | apoptotic process | IEA | -- |
Drugs & Compounds for IGFBP3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Alitretinoin | Approved, Investigational | Pharma | Agonist, Target | 17 | ||
| Mecasermin | Approved, Investigational | Pharma | Target, Carrier, carrier | 36 | ||
| Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 2338 | ||
| Lonafarnib | Investigational | Pharma | Target | Ftase inhibitor,potent and selective | 36 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for IGFBP3 Gene
mRNA/cDNA for IGFBP3 Gene
- 2 REFSEQ mRNAs :
- 37 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000275521 2262 nts (view in UCSC)
- ENST00000381083 2631 nts (view in UCSC)
- ENST00000381086 2322 nts (view in UCSC)
- ENST00000417621 810 nts (view in UCSC)
- ENST00000428530 894 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IGFBP3 - Select products 50% OFF >
- * IGFBP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IGFBP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP3
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP3
- Browse OriGene Inhibitory RNA Products For IGFBP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP3
Clone Products
- Applied Biological Materials (abm): Clones for IGFBP3 - Select products 50% OFF >
- * IGFBP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204018
- MR204018
- MR204018L3
- MR204018L4
- RC209150
- RC209150L1
- RC209150L2
- RC209150L3
- RC209150L4
- RC216898
- RC216898L1
- RC216898L2
- RC216898L3
- RC216898L4
- RG209150
- RG216898
- RR204906
- RR204906L3
- RR204906L4
- MR204018L3V
- MR204018L4V
- RC209150L1V
- RC209150L2V
- RC209150L3V
- RC209150L4V
- RC216898L1V
- RC216898L2V
- RC216898L3V
- RC216898L4V
- RR204906L3V
- RR204906L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IGFBP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP3
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9a | · | 9b | · | 9c | · | 9d | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: |
| ExUns: | 9e | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | |||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: | |||||||
| SP14: | - | ||||||
| SP15: | |||||||
| SP16: |
Relevant External Links for IGFBP3 Gene
- GeneLoc Exon Structure for
- IGFBP3
Expression for IGFBP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Basal Keratinocytes Embryonic Epidermis
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Detroit 551
- NULL (Integumentary System)
- Bone (Muscoskeletal System)
-
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Heart Tube
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Floor plate-like cells(Fasano CA et. al. 2010)
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- N2/LSB/S/F8-induced cells(Kriks S et. al. 2011)
- Mesenchymal Stem Cells
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Chorion (Extraembryonic Tissues)
- Chorionic Mesoderm Cells Chorion Bilayer
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
- Kidney (Urinary System)
- Intestine (Gastrointestinal Tract)
- Eye (Sensory Organs)
- Placenta (Extraembryonic Tissues)
- Liver (Hepatobiliary System)
- Adipose (Muscoskeletal System)
- Uncategorized
- Fibroblasts
- Cartilage (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Prostate (Endocrine System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for IGFBP3 Gene
This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).
This gene is overexpressed in Amniocyte (35.3), Testis (12.7), and Serum (12.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGFBP3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFBP3
SOURCE GeneReport for Unigene cluster for IGFBP3 Gene:
Hs.450230mRNA Expression by UniProt/SwissProt for IGFBP3 Gene:
P17936-IBP3_HUMAN
Tissue specificity:
Expressed by most tissues. Present in plasma.
Evidence on tissue expression from TISSUES for IGFBP3 Gene
- Nervous system(5)
- Kidney(5)
- Skin(4.9)
- Liver(4.8)
- Spleen(4.6)
- Intestine(4.6)
- Bone marrow(4.4)
- Pancreas(4.4)
- Lung(4.4)
- Stomach(4.3)
- Heart(3.8)
- Eye(3.7)
- Blood(3.6)
- Muscle(3.5)
- Thyroid gland(3.2)
- Bone(3)
- Lymph node(2.9)
- Adrenal gland(2.7)
- Gall bladder(2.3)
- Urine(2.2)
Primer Products
-
OriGene qPCR primer pairs for IGFBP3
-
OriGene qPCR primer pairs and template standards for IGFBP3
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP3 Gene
Orthologs for IGFBP3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IGFBP3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IGFBP3 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Igfbp3 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Igfbp3 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IGFBP3 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IGFBP3 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IGFBP3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IGFBP3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IGFBP3 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | igfbp3 30 31 |
|
OneToOne | |
| Dr.12583 30 |
|
||||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for IGFBP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IGFBP3 Gene
- ENSEMBL:
- Gene Tree for IGFBP3 (if available)
- TreeFam:
- Gene Tree for IGFBP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IGFBP3: view image
Paralogs for IGFBP3 Gene
Variants for IGFBP3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFBP3 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 716144 | Benign: not provided | 45,916,598(-) | C/T | MISSENSE_VARIANT | |
| 736283 | Benign: not provided | 45,917,261(-) | G/A | SYNONYMOUS_VARIANT | |
| 792074 | Benign: not provided | 45,917,447(-) | C/T | INTRON_VARIANT | |
| rs538312081 | A colorectal cancer sample | p.Arg252Cys | |||
| VAR_036279 | A colorectal cancer sample | p.Thr7Met |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1145131 | CNV | deletion | 24896259 |
| nsv950212 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.44;
85.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGFBP3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP3 Gene
Disorders for IGFBP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| insulin-like growth factor i |
|
|
| acid-labile subunit deficiency |
|
|
| laron syndrome |
|
|
| acromegaly |
|
|
| marasmus |
|
Search IGFBP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IGFBP3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP3 Gene
Publications for IGFBP3 Gene
- Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PMID: 1695633) Cubbage ML … Powell DR (The Journal of biological chemistry 1990) 2 3 4 23
- Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density. (PMID: 20302654) Biong M … Kristensen VN (BMC medical genomics 2010) 3 23 41
- Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C … Maher ER (PloS one 2009) 3 23 41
- IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. (PMID: 19240240) D'Aloisio AA … Baird DD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 23 41
- Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): correlation with serum IGFBP-3 levels and growth in short children born small for gestational age. (PMID: 18929499) van der Kaay DC … Deal CL (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2009) 3 23 41
ExternalLinks
Products for IGFBP3 Gene
- View all 14 R&D Systems IGFBP3 (IGFBP-3) Products
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- OriGene qPCR primer pairs for IGFBP3
- OriGene qPCR primer pairs and template standards for IGFBP3
- OriGene CRISPR knockouts for IGFBP3
- MG204018
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- RC209150
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- ProSpec Recombinant Proteins for IGFBP3
- Taconic Biosciences Mouse Models for IGFBP3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IGFBP3 (AFLGC-IGFBP3)
- VectorBuilder Custom and pre-made DNA vectors for IGFBP3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IGFBP3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IGFBP3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IGFBP3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IGFBP3
- antibodies-online: Show 65 available IGFBP3 Antibodies ranked by validation data
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- Recommended
- 175 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 DB Antibody (anti-human)
- 77 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 40 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- antibodies-online: Show 127 available IGFBP3 Elisa Kits ranked by validation data
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- ABIN624999
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- ABIN1380035
- ABIN3198552
- ABIN1115545
- ABIN625402
- ABIN415501
- ABIN1672736
- ABIN3032808
- ABIN1570539
- ABIN5523421
- ABIN2708527
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- ABIN5596289
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- antibodies-online: Show 54 available IGFBP3 Proteins ranked by validation data
- Compare Top IGFBP3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP3
- Search Santa Cruz Biotechnology (SCBT) for IGFBP3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP3
- Custom Antibody ServicesProSci Antibodies for IGFBP3
- Horizon Cell Lines for IGFBP3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP3
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- Boster Bio Antibodies for IGFBP3
Sources for IGFBP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
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- (103) SIGNOR
- (104) diseasecard
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
- (170) snOPY
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- (175) Open Targets Platform
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- (178) MirGeneDB