IGFBP3 Gene (Protein Coding)

Insulin Like Growth Factor Binding Protein 3

GCID:: GC07M045912

GIFtS:: 45

Genes Participants

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-li... See more...

Aliases for IGFBP3 Gene

Insulin Like Growth Factor Binding Protein 3 ² ³ ⁵
IGF-Binding Protein 3 ² ³ ⁴
IBP3 ² ³ ⁴
Acid Stable Subunit Of The 140 K IGF Complex ² ³
Insulin-Like Growth Factor-Binding Protein 3 ³ ⁴
Growth Hormone-Dependent Binding Protein ² ³

Binding Protein 53 ² ³
Binding Protein 29 ² ³
IGFBP-3 ³ ⁴
BP-53 ² ³
IBP-3 ³ ⁴
Insulin-Like Growth Factor Binding Protein 3 ²
IGFBP3 ⁵

External Ids for IGFBP3 Gene

HGNC: 5472
Entrez Gene: 3486
Ensembl: ENSG00000146674
OMIM: 146732
UniProtKB: P17936

Previous GeneCards Identifiers for IGFBP3 Gene

GC07M045598
GC07M045692
GC07M045725
GC07M045918
GC07M045836

Search aliases for IGFBP3 gene in PubMed and other databases

Summaries for IGFBP3 Gene

Entrez Gene Summary for IGFBP3 Gene

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGFBP3 Gene

IGFBP3 (Insulin Like Growth Factor Binding Protein 3) is a Protein Coding gene. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency. Among its related pathways are Transcriptional misregulation in cancer and Celecoxib Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include fibronectin binding and insulin-like growth factor I binding. An important paralog of this gene is IGFBP5.

UniProtKB/Swiss-Prot Summary for IGFBP3 Gene

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
- IBP3_HUMAN,P17936

Gene Wiki entry for IGFBP3 Gene

Additional gene information for IGFBP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFBP3 Gene

Genomics for IGFBP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data

Request up-to-date GeneHancer data

Promoters and enhancers for IGFBP3 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH07J045918	Promoter/Enhancer	2.2	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	600.7	+0.3	305	7.1	CTCF FOXA1 LARP7 ZNF143 RBFOX2 POLR2A REST RAD21 TRIM22 EZH2	IGFBP3 TTC4P1 IGFBP1 RNU7-76P ENSG00000229628 ENSG00000237471 lnc-TBRG4-6
GH07J046352	Enhancer	0.7	ENCODE	12.2	-430.7	-430654	0.1	BRCA1 CTCF TEAD4 RAD21 TRIM22 SP1 SMARCA5 ZBTB10 ATF3 ZBTB48	IGFBP3 lnc-IGFBP1-6 HSALNG0057781 LOC105375265
GH07J046143	Enhancer	1.3	FANTOM5 Ensembl ENCODE dbSUPER	2.1	-223.7	-223729	4.1	TEAD4 FOXA1 REST PKNOX1 CEBPA EED CEBPB ETS1 SP1 RELB	HSALNG0057769 ZNF619P1 lnc-IGFBP1-12 RNU7-76P ENSG00000237471 TTC4P1 IGFBP3
GH07J045917	Promoter/Enhancer	1.2	Ensembl ENCODE dbSUPER	0.7	+4.4	4448	0.9	CTCF FOXA1 ZNF143 REST RAD21 TRIM22 EZH2 SCRT2 ZNF10 ZNF444	ENSG00000229628 IGFBP3 lnc-TBRG4-6 IGFBP1
GH07J045888	Promoter/Enhancer	2	EPDnew FANTOM5 Ensembl ENCODE dbSUPER	0.3	+32.5	32511	2.3	HNRNPL GATAD2A REST NFKBIZ RBFOX2 RXRB IRF2 SP1 EZH2 PBX2	IGFBP1 HSALNG0057755 SNORA5C SNORA5B CICP20 SNORA5A lnc-TBRG4-6 IGFBP3

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGFBP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFBP3

Top Transcription factor binding sites by QIAGEN in the IGFBP3 gene promoter:

AML1a
TBP

Genomic Locations for IGFBP3 Gene

chr7:45,912,245-45,921,874: (GRCh38/hg38)

Size:: 9,630 bases
Orientation:: Minus strand

chr7:45,951,844-45,961,473: (GRCh37/hg19)

Size:: 9,630 bases
Orientation:: Minus strand

Genomic View for IGFBP3 Gene

Genes around IGFBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

7p12.3 by HGNC
7p12.3 by Entrez Gene
7p12.3 by Ensembl

IGFBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for IGFBP3 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGFBP3 Gene

NC_000007.14

Proteins for IGFBP3 Gene

Protein details for IGFBP3 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

P17936-IBP3_HUMAN

Recommended name:

Insulin-like growth factor-binding protein 3

Protein Accession:

P17936

Secondary Accessions:
- A4D2F5
- D3DVM0
- Q2V509
- Q6P1M6
- Q9UCL4
Protein attributes for IGFBP3 Gene
Size:

291 amino acids

Molecular mass:

31674 Da
Quaternary structure:
Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219.
Alternative splice isoforms for IGFBP3 Gene
UniProtKB/Swiss-Prot:
P17936-1

P17936-2

neXtProt entry for IGFBP3 Gene

Protein Expression for IGFBP3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IGFBP3 Gene

Phosphorylated by FAM20C in the extracellular medium.
- P17936-IBP3_HUMAN
Glycosylation at Asn116, Asn136, Ser148, Ser151, Ser153, Ser155, Ser156, Thr157, Ser161, Ser192, Thr195, Asn199, and Thr277
- NX_P17936 (NX_P17936-1)
Modification sites at PhosphoSitePlus
- P17936
Glycosylation from GlyConnect
- IBP3_HUMAN (1945)

Other Protein References for IGFBP3 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

LifeSpan BioSciences IGFBP3 Antibody (LS-B7473) and IGFBP3 Antibody (LS-B12492)

G Biosciences Immunotag™ Phospho-IGFBP-3 (Ser183) Antibody and Immunotag™ IGFBP-3 Antibody

GeneTex Anti-IGFBP3 antibody [N2C3] and Anti-IGFBP3 antibody [N3C2], Internal

NSJ Bioreagents IGFBP3 Antibody

Creative Diagnostics Anti-IGFBP3 monoclonal antibody, clone 3H7

Creative Biolabs

BioLegend IGFBP-3 Antibody

Human IGFBP-3 Antibody (AF675)

OriGene Antibodies for IGFBP3
- AP01138BT-N
- AP01138BT-S
- AP01138PU-N
- AP01138PU-S
- AP14345PU-N
- AP14347PU-N
- AP20503PU-N
- AP55946PU-N
- AP55946PU-S
- CF807469
- CF807472
- CF807823
- TA303275
- TA323616
- TA325554
- TA325555
- TA328352
- TA350695
- TA807469
- TA807469S
- TA807472
- TA807472S
- TA807823
- TA807823S
Custom Antibody Services

Novus Biologicals Antibodies for IGFBP3

Abcam antibodies for IGFBP3
- IGFBP3

Invitrogen Antibodies for IGFBP3 (AFLGC-IGFBP3)

Biorbyt antibodies for IGFBP3
- orb338990
- orb10884
- orb47965
- orb99420
- orb38296
- orb38294

Boster Bio Antibodies for IGFBP3
- PA1498
- A00435
- A00435-2
- A00435-3
- A00435S183
- A00435S183-1
- PB9710

ProSci Antibodies for IGFBP3
- insulin-like growth factor binding protein 3
Custom Antibody Services

Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP3

Sino Biological Antibodies for IGFBP3

Protein Products

RayBiotech Recombinant Human IGFBP3, transfected HEK293 cell culture supernatant, Recombinant Human IGFBP3, transfected HEK293 cell lysate, and Recombinant Human IGFBP-3

Creative Biomart Recombinant Human Insulin-like Growth Factor Binding Protein 3

Recombinant Human IGFBP-3 Protein, CF (675-B3)

OriGene Purified Proteins for IGFBP3
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Novus Biologicals proteins and lysates for IGFBP3

Sino Biological Recombinant Proteins for IGFBP3
Sino Biological Cell Lysates for IGFBP3

ProSpec Recombinant Proteins for IGFBP3

antibodies-online: Show 54 available IGFBP3 Proteins ranked by validation data
Compare Top IGFBP3 Proteins

Signalway Proteins for IGFBP3
- AP73424
- AP83797

ProSci Proteins for IGFBP3

Abcam proteins for IGFBP3
- IGFBP3

Assay Products

G Biosciences Immunotag™ Human IGFBP-3 (Insulin-like growth factor-binding protein 3) ELISA and Immunotag™ Insulin-like growth factor-binding protein 3 ELISA Kit

RayBiotech Human IGFBP-3 ELISA

Creative Diagnostics IGFBP-3 Mouse / Rat ELISA Kit, IGFBP3 Mouse ELISA Kit, and IGFBP3 Human ELISA Kit

OriGene ELISA Kits for IGFBP3
- EA100258
Custom Assay Services

Human IGFBP-3 Quantikine ELISA Kit (DGB300)

Novus Biologicals ELISA Kits for IGFBP3

Boster Bio ELISA Kits for IGFBP3
- EK0386
- EK0387
- EZ0386

Signalway ELISA kits for IGFBP3
- EK1140
- EK11563
- EK14697

Abcam assays for IGFBP3
- IGFBP3

Sino Biological Assays for IGFBP3

No data available for DME Specific Peptides for IGFBP3 Gene

Domains & Families for IGFBP3 Gene

Gene Families for IGFBP3 Gene

HGNC:

Insulin like growth factor binding proteins

Human Protein Atlas (HPA):

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Protein Domains for IGFBP3 Gene

InterPro:

Blocks:

Insulin-like growth factor-binding protein, IGFBP
Thyroglobulin type-1

ProtoNet:

P17936

Suggested Antigen Peptide Sequences for IGFBP3 Gene

GenScript: Design optimal peptide antigens:

cDNA FLJ35128 fis, clone PLACE6008768, moderately similar to Insulin-like growth factor-binding protein 3 (B3KRZ1_HUMAN)
cDNA FLJ38655 fis, clone HHDPC2009208, highly similar to Insulin-like growth factor-binding protein 3 (B3KTS0_HUMAN)
cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 (B3KWK7_HUMAN)
Insulin-like growth factor-binding protein 3 (IBP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P17936

UniProtKB/Swiss-Prot:

IBP3_HUMAN :

The thyroglobulin type-1 domain mediates interaction with HN.

Domain:

The thyroglobulin type-1 domain mediates interaction with HN.

Function for IGFBP3 Gene

Molecular function for IGFBP3 Gene

UniProtKB/Swiss-Prot Function:

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

IBP3_HUMAN,P17936

UniProtKB/Swiss-Prot Induction:

Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters.

IBP3_HUMAN,P17936

GENATLAS Biochemistry:

insulin-like growth factor binding protein 3,high affinity,expressed by liver and non hepatic tissues,principal serum IGFBP,complexing with IGF1,IGF2 and an acid labile subunit. Mainly regulated by GH. Regulator of cell somatic growth and cellular proliferation,either IGF dependent or IGF independent,parameter of GH activity in acromegalic patients

IGFBP3

Phenotypes From GWAS Catalog for IGFBP3 Gene

Gene Ontology (GO) - Molecular Function for IGFBP3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	IEA,IBA	21873635
GO:0005515	protein binding	IPI	9388210
GO:0005520	insulin-like growth factor binding	IEA,NAS	12599210
GO:0008160	protein tyrosine phosphatase activator activity	IDA	11940579
GO:0019838	growth factor binding	IEA	--

Phenotypes for IGFBP3 Gene

MGI mutant phenotypes for IGFBP3:

inferred from 3 alleles

GenomeRNAi human phenotypes for IGFBP3:

Animal Models for IGFBP3 Gene

MGI Knock Outs for IGFBP3:

Igfbp3 ^{Igfbp3<tm1Jep>}
Igfbp3 ^{Igfbp3<tm1Lex>}
Igfbp3 ^{Igfbp3<tm1b(KOMP)Wtsi>}

Animal Model Products

Taconic Biosciences Mouse Models for IGFBP3
- Igfbp3

CRISPR Products

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OriGene CRISPR knockouts for IGFBP3
- GA102355
- GA202094
- KN209150
- KN209150BN
- KN209150LP
- KN209150RB
- KN409150
- KN508180

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP3

Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP3

miRNA for IGFBP3 Gene

miRTarBase miRNAs that target IGFBP3

miRNA Products

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Inhibitory RNA Products

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Clone Products

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OriGene clones in human,mouse,rat for IGFBP3
- SC215608
- SC215609
- MC203300
- RN204906
- SC119779
- SC301776
OriGene ORF clones in human,mouse,rat for IGFBP3
- MG204018
- MR204018
- MR204018L3
- MR204018L4
- RC209150
- RC209150L1
- RC209150L2
- RC209150L3
- RC209150L4
- RC216898
- RC216898L1
- RC216898L2
- RC216898L3
- RC216898L4
- RG209150
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- RR204906
- RR204906L3
- RR204906L4
- MR204018L3V
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- RC209150L1V
- RC209150L2V
- RC209150L3V
- RC209150L4V
- RC216898L1V
- RC216898L2V
- RC216898L3V
- RC216898L4V
- RR204906L3V
- RR204906L4V
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Sino Biological Human cDNA Clone for IGFBP3

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Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for IGFBP3

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for IGFBP3

Horizon Cell Lines for IGFBP3
- IGFBP3 knockout cell line

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP3 Gene

Localization for IGFBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP3 Gene

Secreted.

P17936-IBP3_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
extracellular	5
nucleus	5
endoplasmic reticulum	4
cytosol	3
plasma membrane	2
cytoskeleton	2
mitochondrion	2
lysosome	2
peroxisome	1
endosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (2)
Nucleoplasm (2)
Vesicles (2)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFBP3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA,TAS	--
GO:0005615	extracellular space	IEA,IDA	17119061
GO:0005634	nucleus	IDA	17434920
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0016942	insulin-like growth factor binding protein complex	IC	10766744

Pathways & Interactions for IGFBP3 Gene

SuperPathways for IGFBP3 Gene

	SuperPathway	Contained pathways
1	Gene Expression	Gene Expression .48	Generic Transcription Pathway .48
2	TP53 Regulates Transcription of Cell Death Genes	TP53 Regulates Transcription of Cell Death Genes .47	TP53 Regulates Transcription of Death Receptors and Ligands .01
3	Glucose / Energy Metabolism	Glucose / Energy Metabolism -
4	Cellular senescence (KEGG)	Cellular senescence -
5	Relaxin signaling pathway	Growth hormone synthesis, secretion and action .35

Pathways by source for IGFBP3 Gene

4 BioSystems pathways for IGFBP3 Gene

7 Reactome pathways for IGFBP3 Gene

1 PharmGKB pathway for IGFBP3 Gene

Celecoxib Pathway, Pharmacodynamics

4 KEGG pathways for IGFBP3 Gene

2 GeneGo (Thomson Reuters) pathways for IGFBP3 Gene

Development IGF-1 receptor signaling
Transcription Receptor-mediated HIF regulation

1 R&D Systems pathway for IGFBP3 Gene

Mesenchymal Stem Cells and Lineage-specific Markers

1 Cell Signaling Technology pathway for IGFBP3 Gene

Glucose / Energy Metabolism

Interacting Proteins for IGFBP3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: P17936-IBP3_HUMAN ENSP00000370473 for IGFBP3 Gene via UniProtKB STRING IID

Symbol	External ID(s)	Details
EGFR	P00533 ⁴ ¹²⁶ ENSP00000275493 ²¹	EBI-715709, EBI-297353 STRING: ENSP00000275493 IID: # exp=1
PRKDC	P78527 ⁴ ¹²⁶ ENSP00000313420 ²¹	EBI-715709, EBI-352053 STRING: ENSP00000313420 IID: # exp=1
ADAM12	ENSP00000357668 ²¹ O43184 ¹²⁶	STRING: ENSP00000357668 IID: # exp=2 # pred=1
ALB	ENSP00000295897 ²¹ P02768 ¹²⁶	STRING: ENSP00000295897 IID: # pred=1
APP	ENSP00000284981 ²¹ P05067 ¹²⁶	STRING: ENSP00000284981 IID: # pred=1

GPS-Prot Interaction Network for IGFBP3

SIGNOR curated interactions for IGFBP3 Gene

Is activated by:

SND1
CSNK2A1

Is inactivated by:

MECP2

Gene Ontology (GO) - Biological Process for IGFBP3 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0001649	osteoblast differentiation	IEA	--
GO:0001933	negative regulation of protein phosphorylation	IDA	17591901
GO:0006468	protein phosphorylation	IDA	17434920
GO:0006915	apoptotic process	IEA	--

Drugs & Compounds for IGFBP3 Gene

(93) Drugs for IGFBP3 Gene - From: DrugBank, PharmGKB, and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Alitretinoin	Approved, Investigational	MalaCards Medline Plus	Pharma	Agonist, Target		17
Mecasermin	Approved, Investigational	MalaCards Medline Plus	Pharma	Target, Carrier, carrier		36
Fluorouracil	Approved	MalaCards Medline Plus	Pharma		RNA processing inhibitor and thymidylate synthase inhibitor	2338
Lonafarnib	Investigational	MalaCards Medline Plus	Pharma	Target	Ftase inhibitor,potent and selective	36

(43) Additional Compounds for IGFBP3 Gene - From: Novoseek

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs

Drug Products

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Browse compounds at ApexBio

Transcripts for IGFBP3 Gene

mRNA/cDNA for IGFBP3 Gene

2 REFSEQ mRNAs :

37 NCBI additional mRNA sequence :

11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000275521 2262 nts (view in UCSC)
ENST00000381083 2631 nts (view in UCSC)
ENST00000381086 2322 nts (view in UCSC)
ENST00000417621 810 nts (view in UCSC)
ENST00000428530 894 nts (view in UCSC)

CRISPR Products

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OriGene CRISPR knockouts for IGFBP3
- GA102355
- GA202094
- KN209150
- KN209150BN
- KN209150LP
- KN209150RB
- KN409150
- KN508180

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP3

Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP3

miRNA Products

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Inhibitory RNA Products

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Clone Products

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OriGene clones in human,mouse,rat for IGFBP3
- SC215608
- SC215609
- MC203300
- RN204906
- SC119779
- SC301776
OriGene ORF clones in human,mouse,rat for IGFBP3
- MG204018
- MR204018
- MR204018L3
- MR204018L4
- RC209150
- RC209150L1
- RC209150L2
- RC209150L3
- RC209150L4
- RC216898
- RC216898L1
- RC216898L2
- RC216898L3
- RC216898L4
- RG209150
- RG216898
- RR204906
- RR204906L3
- RR204906L4
- MR204018L3V
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- RC209150L1V
- RC209150L2V
- RC209150L3V
- RC209150L4V
- RC216898L1V
- RC216898L2V
- RC216898L3V
- RC216898L4V
- RR204906L3V
- RR204906L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

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Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP3 Gene

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	·	5g	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	·	9c	·	9d	·
SP1:									-		-		-		-										-		-						-												-
SP2:					-		-		-		-		-		-		-		-		-				-		-						-												-
SP3:							-		-		-		-		-		-								-		-						-												-
SP4:																									-		-						-												-
SP5:							-		-		-		-		-		-								-		-						-		-		-								-
SP6:							-		-		-		-		-										-		-						-
SP7:							-		-		-		-												-		-						-
SP8:																											-						-												-
SP9:													-		-												-						-
SP10:																									-		-		-				-												-
SP11:			-		-		-		-		-		-		-		-		-		-		-		-		-						-
SP12:											-		-		-										-		-
SP13:																																	-
SP14:																																													-
SP15:																									-		-
SP16:

ExUns:	9e	^	10	^	11a	·	11b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:			-
SP15:
SP16:

Relevant External Links for IGFBP3 Gene

GeneLoc Exon Structure for: IGFBP3

Expression for IGFBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGFBP3 Gene

mRNA expression in normal human tissues for IGFBP3 Gene

mRNA expression by BioGPS for IGFBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Basal Keratinocytes Embryonic Epidermis
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Detroit 551
NULL (Integumentary System)
- MSC-containing human skin substitute (Grafix)
- Vascular endothelial growth factor-induced cells(James D et. al. 2010)
- Vascular endothelial growth factor-induced embryoid bodies (Li Z et. al. 2009)
Bone (Muscoskeletal System)
- Bone marrow-derived mesenchymal stem cells (family)
- Bone marrow-derived mesenchymal stem cells
- HyStem+BMP4-induced E15 cells
Heart (Cardiovascular System)
- Primitive Heart Tube Cells Primitive Heart Tube
- Heart Tube
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- Floor plate-like cells(Fasano CA et. al. 2010)
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
- N2/LSB/S/F8-induced cells(Kriks S et. al. 2011)
Mesenchymal Stem Cells
- Bone marrow-derived mesenchymal stem cells (family)
- Bone marrow-derived mesenchymal stem cells
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
Chorion (Extraembryonic Tissues)
- Chorionic Mesoderm Cells Chorion Bilayer
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
Kidney (Urinary System)
- S-shaped Body
Intestine (Gastrointestinal Tract)
- Duodenum
Eye (Sensory Organs)
- Conjunctival Epithelium
Placenta (Extraembryonic Tissues)
- Syncytiotrophoblast-like cells(Sudheer S et. al. 2012)
Liver (Hepatobiliary System)
- Hepatocyte-like cells(Si-Tayeb K et. al. 2010)
Adipose (Muscoskeletal System)
- HyStem+BMP4-induced E15 cells
Uncategorized
- MSC-containing human skin substitute (Grafix)
Fibroblasts
- Detroit 551
Cartilage (Muscoskeletal System)
- HyStem+BMP4-induced E15 cells
Uterus (Reproductive System)
Prostate (Endocrine System)
Spleen (Hematopoietic System)
Gall Bladder (Hepatobiliary System)
Stomach (Gastrointestinal Tract)
Ovary (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for IGFBP3 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.0).

Protein differential expression in normal tissues from HIPED for IGFBP3 Gene

This gene is overexpressed in Amniocyte (35.3), Testis (12.7), and Serum (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGFBP3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MaxQB, and MOPED for IGFBP3 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for IGFBP3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFBP3

SOURCE GeneReport for Unigene cluster for IGFBP3 Gene:

Hs.450230

mRNA Expression by UniProt/SwissProt for IGFBP3 Gene:

P17936-IBP3_HUMAN

Tissue specificity: Expressed by most tissues. Present in plasma.

Evidence on tissue expression from TISSUES for IGFBP3 Gene

Nervous system(5)
Kidney(5)
Skin(4.9)
Liver(4.8)
Spleen(4.6)
Intestine(4.6)
Bone marrow(4.4)
Pancreas(4.4)
Lung(4.4)
Stomach(4.3)
Heart(3.8)
Eye(3.7)
Blood(3.6)
Muscle(3.5)
Thyroid gland(3.2)
Bone(3)
Lymph node(2.9)
Adrenal gland(2.7)
Gall bladder(2.3)
Urine(2.2)

Primer Products

OriGene qPCR primer pairs for IGFBP3
- HP226141
- MP206589
OriGene qPCR primer pairs and template standards for IGFBP3

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for IGFBP3

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP3 Gene

Orthologs for IGFBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP3 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
Chimpanzee (Pan troglodytes)	Mammalia	IGFBP3 ³⁰ ³¹	99.44 (n)	OneToOne	463396 XM_003318419.2 XP_003318467.1 7:44530474-44539356
Cow (Bos Taurus)	Mammalia	IGFBP3 ³⁰ ³¹	83.62 (n)	OneToOne	282261 NM_174556.1 NP_776981.1 4:76705105-76712709
Rat (Rattus norvegicus)	Mammalia	Igfbp3 ³⁰	83.56 (n)		24484 NM_012588.2 NP_036720.2
Mouse (Mus musculus)	Mammalia	Igfbp3 ³⁰ ¹⁷ ³¹	83.1 (n)	OneToOne	16009 NM_008343.2 NP_032369.2 7206086 11:7206086-7213923
Dog (Canis familiaris)	Mammalia	IGFBP3 ³⁰ ³¹	82.61 (n)	OneToOne	100855619 XM_003639557.2 XP_003639605.1 16:1021225-1026392
Platypus (Ornithorhynchus anatinus)	Mammalia	IGFBP3 ³¹	72 (a)	OneToOne	4:12164836-12179157
Oppossum (Monodelphis domestica)	Mammalia	IGFBP3 ³¹	71 (a)	OneToOne	6:273394526-273406799
Chicken (Gallus gallus)	Aves	IGFBP3 ³⁰ ³¹	74.19 (n)	OneToOne	420790 NM_001101034.1 NP_001094504.1 2:55011807-55031149
Lizard (Anolis carolinensis)	Reptilia	IGFBP3 ³¹	62 (a)	OneToOne	6:53876086-53907146
Zebrafish (Danio rerio)	Actinopterygii	igfbp3 ³⁰ ³¹	61.94 (n)	OneToOne	403079 NM_205751.2 NP_991314.2 20:7037979-7090577
Zebrafish (Danio rerio)	Actinopterygii	Dr.12583 ³⁰			AJ299410.1
Sea Squirt (Ciona savignyi)	Ascidiacea	-- ³¹	26 (a)	OneToMany	reftig_55:436617-438288

Species where no ortholog for IGFBP3 was found in the sources mined by GeneCards:

A. gosspyii yeast (Eremothecium gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
Alpha proteobacteria (Wolbachia pipientis)
Amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
Baker's yeast (Saccharomyces cerevisiae)
Barley (Hordeum vulgare)
Beta proteobacteria (Neisseria meningitidis)
Bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
Common water flea (Daphnia pulex)
Corn (Zea mays)
E. coli (Escherichia coli)
Filamentous fungi (Aspergillus nidulans)
Firmicute Bacteria (Streptococcus pneumoniae)
Fission Yeast (Schizosaccharomyces pombe)
Fruit Fly (Drosophila melanogaster)
Green Algae (Chlamydomonas reinhardtii)
Honey Bee (Apis mellifera)
K. Lactis Yeast (Kluyveromyces lactis)
Loblloly Pine (Pinus taeda)
Malaria Parasite (Plasmodium falciparum)
Medicago Trunc (Medicago Truncatula)
Moss (Physcomitrella patens)
Orangutan (Pongo pygmaeus)
Pig (Sus scrofa)
Rainbow Trout (Oncorhynchus mykiss)
Rice (Oryza sativa)
Rice Blast Fungus (Magnaporthe grisea)
Schistosome Parasite (Schistosoma mansoni)
Sea Anemone (Nematostella vectensis)
Sea Vase (Ciona intestinalis)
Sea Urchin (Strongylocentrotus purpuratus)
Sorghum (Sorghum bicolor)
Soybean (Glycine max)
Stem Rust Fungus (Puccinia graminis)
Sugarcane (Saccharum officinarum)
Thale Cress (Arabidopsis thaliana)
Tomato (Lycopersicon esculentum)
Toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
Tropical Clawed Frog (Silurana tropicalis)
Wheat (Triticum aestivum)
Worm (Caenorhabditis elegans)

Evolution for IGFBP3 Gene

ENSEMBL:: Gene Tree for IGFBP3 (if available)
TreeFam:: Gene Tree for IGFBP3 (if available)
Aminode:: Evolutionary constrained regions (ECRs) for IGFBP3: view image

Paralogs for IGFBP3 Gene

(3) SIMAP similar genes for IGFBP3 Gene using alignment to 5 proteins:

IBP3_HUMAN
B3KWK7_HUMAN
C9JMX4_HUMAN
H0Y485_HUMAN
H0Y5K2_HUMAN

Variants for IGFBP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFBP3 Gene

SNP ID	Clinical significance and condition	Chr 07 pos	Variation	Type
716144	Benign: not provided	45,916,598(-)	C/T	MISSENSE_VARIANT
736283	Benign: not provided	45,917,261(-)	G/A	SYNONYMOUS_VARIANT
792074	Benign: not provided	45,917,447(-)	C/T	INTRON_VARIANT
rs538312081	A colorectal cancer sample		p.Arg252Cys
VAR_036279	A colorectal cancer sample		p.Thr7Met

Additional dbSNP identifiers (rs#s) for IGFBP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGFBP3 Gene

Variant ID	Type	Subtype	PubMed ID
nsv1145131	CNV	deletion	24896259
nsv950212	CNV	deletion	24416366

Variation tolerance for IGFBP3 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 8.44; 85.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP3 Gene

Human Gene Mutation Database (HGMD): IGFBP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for: IGFBP3

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for IGFBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP3 Gene

Disorders for IGFBP3 Gene

(81) MalaCards diseases for IGFBP3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder	Aliases	PubMed IDs
insulin-like growth factor i	insulin-like growth factor i, resistance to	15476454
acid-labile subunit deficiency	aclsd	1700965
laron syndrome	growth hormone insensitivity syndrome	17350302
acromegaly	somatotroph adenoma	7586626
marasmus	nutritional atrophy	15087254

- elite association - COSMIC cancer census association via MalaCards

Search IGFBP3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IGFBP3

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology
: Open Targets Platform

Search disorders for IGFBP3 gene in PubMed and other databases

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP3 Gene

Publications for IGFBP3 Gene

Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. (PMID: 1695633) Cubbage ML … Powell DR (The Journal of biological chemistry 1990) ² ³ ⁴ ²³
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density. (PMID: 20302654) Biong M … Kristensen VN (BMC medical genomics 2010) ³ ²³ ⁴¹
Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma. (PMID: 19551141) Ricketts C … Maher ER (PloS one 2009) ³ ²³ ⁴¹
IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. (PMID: 19240240) D'Aloisio AA … Baird DD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) ³ ²³ ⁴¹
Genetic and epigenetic variability in the gene for IGFBP-3 (IGFBP3): correlation with serum IGFBP-3 levels and growth in short children born small for gestational age. (PMID: 18929499) van der Kaay DC … Deal CL (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2009) ³ ²³ ⁴¹