The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of sever... See more...

Aliases for IGFBP2 Gene

Aliases for IGFBP2 Gene

  • Insulin Like Growth Factor Binding Protein 2 2 3 5
  • Insulin-Like Growth Factor Binding Protein 2, 36kDa 2 3
  • Insulin-Like Growth Factor-Binding Protein 2 3 4
  • IGF-Binding Protein 2 3 4
  • IBP2 3 4
  • Insulin-Like Growth Factor Binding Protein 2 (36kD) 2
  • Insulin-Like Growth Factor Binding Protein 2 2
  • IGF-BP53 3
  • IGFBP-2 4
  • IGFBP2 5
  • IBP-2 4
  • BP2 4

External Ids for IGFBP2 Gene

Previous HGNC Symbols for IGFBP2 Gene

  • IBP2

Previous GeneCards Identifiers for IGFBP2 Gene

  • GC02P215595
  • GC02P216219
  • GC02P217462
  • GC02P217700
  • GC02P217323
  • GC02P217206
  • GC02P217497
  • GC02P209352

Summaries for IGFBP2 Gene

Entrez Gene Summary for IGFBP2 Gene

  • The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

GeneCards Summary for IGFBP2 Gene

IGFBP2 (Insulin Like Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with IGFBP2 include Malignant Ovarian Cyst and Insulin-Like Growth Factor I. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP4.

UniProtKB/Swiss-Prot Summary for IGFBP2 Gene

  • Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Gene Wiki entry for IGFBP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFBP2 Gene

Genomics for IGFBP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGFBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J216632 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 255.8 +2.6 2584 6.7 ZNF600 JUND CEBPA ZIC2 POLR2A ETS1 ZNF341 SIN3A ZNF217 KLF9 IGFBP2 XRCC5 SMARCAL1 lnc-IGFBP2-2 IGFBP5
GH02J216631 Enhancer 0.4 Ensembl dbSUPER 250.7 -1.2 -1159 0.7 ZSCAN4 IGFBP2 IGFBP5 ENSG00000236886 piR-42491-137 RPL37A
GH02J216618 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 28.6 -12.3 -12327 3.8 MYC CEBPA ATF3 YY1 FOXA2 SMAD4 TAL1 RARA FOXP1 BCL6 piR-42491-137 IGFBP2 XRCC5 SMARCAL1 ENSG00000236886 IGFBP5 RPL37A
GH02J216533 Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 24.6 -97.2 -97198 4.1 ZNF600 SSRP1 ZMYM3 KLF9 CEBPA ZIC2 MXD4 KLF11 FEZF1 ZNF341 NONHSAG030480.2 IGFBP2 LOC101928180 RPL37A
GH02J216545 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 18.4 -81.2 -81228 14 IKZF1 CEBPA KLF11 HOMEZ FOXA2 KDM6A MAFF SMAD4 SAP130 ETV4 IGFBP2 LOC101928180 NONHSAG030480.2 LOC105373871 lnc-IGFBP5-3 RPL37A LINC01280
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGFBP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFBP2

Top Transcription factor binding sites by QIAGEN in the IGFBP2 gene promoter:
  • CREB
  • deltaCREB
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3
  • STAT5A

Genomic Locations for IGFBP2 Gene

Latest Assembly
chr2:216,632,828-216,664,436
(GRCh38/hg38)
Size:
31,609 bases
Orientation:
Plus strand

Previous Assembly
chr2:217,497,551-217,529,159
(GRCh37/hg19 by Entrez Gene)
Size:
31,609 bases
Orientation:
Plus strand

chr2:217,497,551-217,529,159
(GRCh37/hg19 by Ensembl)
Size:
31,609 bases
Orientation:
Plus strand

Genomic View for IGFBP2 Gene

Genes around IGFBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP2 Gene

Proteins for IGFBP2 Gene

  • Protein details for IGFBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18065-IBP2_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 2
    Protein Accession:
    P18065
    Secondary Accessions:
    • Q14619
    • Q9UCL3

    Protein attributes for IGFBP2 Gene

    Size:
    325 amino acids
    Molecular mass:
    34814 Da
    Quaternary structure:
    • Binds IGF2 more than IGF1.

    Three dimensional structures from OCA and Proteopedia for IGFBP2 Gene

neXtProt entry for IGFBP2 Gene

Post-translational modifications for IGFBP2 Gene

Other Protein References for IGFBP2 Gene

Antibodies for research

  • Abcam antibodies for IGFBP2

No data available for DME Specific Peptides for IGFBP2 Gene

Domains & Families for IGFBP2 Gene

Gene Families for IGFBP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IGFBP2 Gene

InterPro:
Blocks:
  • Insulin-like growth factor-binding protein, IGFBP
  • Thyroglobulin type-1

Suggested Antigen Peptide Sequences for IGFBP2 Gene

GenScript: Design optimal peptide antigens:
  • Insulin-like growth factor-binding protein 2 (IBP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P18065

UniProtKB/Swiss-Prot:

IBP2_HUMAN :
  • The C-terminus is required for IGF-binding and growth inhibition.
Domain:
  • The C-terminus is required for IGF-binding and growth inhibition.
genes like me logo Genes that share domains with IGFBP2: view

Function for IGFBP2 Gene

Molecular function for IGFBP2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GENATLAS Biochemistry:
insulin-like growth factor binding protein 2 ,high affinity,regulator of somatic growth and cellular proliferation,major IGFBP of the spinal fluid expressed by multiple neural tissues,highly expressed in infancy and older age adult,deregulated in pancreatic beta cell tumorigenesis

Phenotypes From GWAS Catalog for IGFBP2 Gene

Gene Ontology (GO) - Molecular Function for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 24431302
GO:0005515 protein binding IPI 19095771
GO:0005520 insulin-like growth factor binding IEA --
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IEA,IDA 19081843
genes like me logo Genes that share ontologies with IGFBP2: view
genes like me logo Genes that share phenotypes with IGFBP2: view

Animal Models for IGFBP2 Gene

MGI Knock Outs for IGFBP2:

miRNA for IGFBP2 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP2 Gene

Localization for IGFBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space ISS,IDA 15694994
GO:0016324 apical plasma membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with IGFBP2: view

Pathways & Interactions for IGFBP2 Gene

genes like me logo Genes that share pathways with IGFBP2: view

Pathways by source for IGFBP2 Gene

1 GeneGo (Thomson Reuters) pathway for IGFBP2 Gene
  • Development IGF-1 receptor signaling
1 Cell Signaling Technology pathway for IGFBP2 Gene

SIGNOR curated interactions for IGFBP2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007565 female pregnancy IEA --
GO:0007568 aging IEA --
GO:0007584 response to nutrient IEA --
GO:0009612 response to mechanical stimulus IEA --
genes like me logo Genes that share ontologies with IGFBP2: view

Drugs & Compounds for IGFBP2 Gene

(39) Drugs for IGFBP2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mecasermin Approved, Investigational Pharma Carrier 36

(26) Additional Compounds for IGFBP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP2: view

Transcripts for IGFBP2 Gene

mRNA/cDNA for IGFBP2 Gene

4 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP2

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for IGFBP2 Gene

GeneLoc Exon Structure for
IGFBP2

Expression for IGFBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGFBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP2 Gene

This gene is overexpressed in Artery - Aorta (x8.9), Artery - Coronary (x4.3), and Liver (x4.3).

Protein differential expression in normal tissues from HIPED for IGFBP2 Gene

This gene is overexpressed in Amniocyte (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGFBP2 Gene



Protein tissue co-expression partners for IGFBP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFBP2

SOURCE GeneReport for Unigene cluster for IGFBP2 Gene:

Hs.438102

Evidence on tissue expression from TISSUES for IGFBP2 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Eye(4.5)
  • Pancreas(3.3)
  • Blood(3.2)
  • Muscle(3.2)
  • Stomach(3.2)
  • Heart(3.1)
  • Kidney(2.9)
  • Spleen(2.8)
  • Intestine(2.6)
  • Lung(2.6)
  • Skin(2.5)
  • Adrenal gland(2.4)
  • Thyroid gland(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with IGFBP2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP2 Gene

Orthologs for IGFBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IGFBP2 29 30
  • 97.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IGFBP2 29 30
  • 93.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IGFBP2 29 30
  • 90.86 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Igfbp2 29 16 30
  • 87.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Igfbp2 29
  • 86.79 (n)
Oppossum
(Monodelphis domestica)
Mammalia IGFBP2 30
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 43 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves IGFBP2 29 30
  • 77.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IGFBP2 30
  • 77 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia igfbp2 29
  • 69.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20883 29
Zebrafish
(Danio rerio)
Actinopterygii igfbp2a 29 30
  • 60.08 (n)
OneToMany
igfbp2b 30
  • 49 (a)
OneToMany
igfbp2 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9110 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 28 (a)
OneToMany
Species where no ortholog for IGFBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IGFBP2 Gene

ENSEMBL:
Gene Tree for IGFBP2 (if available)
TreeFam:
Gene Tree for IGFBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGFBP2: view image
Alliance of Genome Resources:
Additional Orthologs for IGFBP2

Paralogs for IGFBP2 Gene

Paralogs for IGFBP2 Gene

(3) SIMAP similar genes for IGFBP2 Gene using alignment to 4 proteins:

  • IBP2_HUMAN
  • C9JMY1_HUMAN
  • C9JW52_HUMAN
  • H7C1H0_HUMAN
genes like me logo Genes that share paralogs with IGFBP2: view

Variants for IGFBP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFBP2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs9341096 -- p.Ala137Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IGFBP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IGFBP2 Gene

Variant ID Type Subtype PubMed ID
esv2673456 CNV deletion 23128226
esv2721463 CNV deletion 23290073
nsv460098 CNV loss 19166990
nsv584454 CNV loss 21841781
nsv584455 CNV loss 21841781

Variation tolerance for IGFBP2 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP2
Leiden Open Variation Database (LOVD)
IGFBP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP2 Gene

Disorders for IGFBP2 Gene

MalaCards: The human disease database

(43) MalaCards diseases for IGFBP2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
malignant ovarian cyst
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
ovarian cyst
  • ovarian cysts
laron syndrome
  • growth hormone insensitivity syndrome
anorexia nervosa
  • anorexia nervosa, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFBP2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IGFBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP2 Gene

Publications for IGFBP2 Gene

  1. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PMID: 19843326) Neuhausen SL … Gillen DL (Breast cancer research : BCR 2009) 3 22 40
  2. Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. (PMID: 18210156) Garner CP … Neuhausen SL (Human genetics 2008) 3 22 40
  3. Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. (PMID: 19081843) Zhou J … Duan C (PloS one 2008) 3 4 22
  4. Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2). (PMID: 17020769) Kuang Z … Norton RS (Journal of molecular biology 2006) 3 4 22
  5. Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (PMID: 1697583) Zapf J … Froesch ER (The Journal of biological chemistry 1990) 2 3 4

Products for IGFBP2 Gene

Sources for IGFBP2 Gene