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The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of sever... See more...
Aliases for IGFBP2 Gene
Aliases for IGFBP2 Gene
External Ids for IGFBP2 Gene
- HGNC: 5471
- NCBI Entrez Gene: 3485
- Ensembl: ENSG00000115457
- OMIM®: 146731
- UniProtKB/Swiss-Prot: P18065
Previous HGNC Symbols for IGFBP2 Gene
- IBP2
Previous GeneCards Identifiers for IGFBP2 Gene
- GC02P215595
- GC02P216219
- GC02P217462
- GC02P217700
- GC02P217323
- GC02P217206
- GC02P217497
- GC02P209352
Summaries for IGFBP2 Gene
-
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
GeneCards Summary for IGFBP2 Gene
IGFBP2 (Insulin Like Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with IGFBP2 include Malignant Ovarian Cyst and Insulin-Like Growth Factor I. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP4.
UniProtKB/Swiss-Prot Summary for IGFBP2 Gene
-
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Additional gene information for IGFBP2 Gene
- HGNC (5471)
- NCBI Entrez Gene (3485)
- Ensembl (ENSG00000115457)
- OMIM® (146731)
- UniProtKB/Swiss-Prot (P18065)
- Open Targets Platform(ENSG00000115457)
- Monarch Initiative
- Search for IGFBP2 at DataMed
- Search for IGFBP2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFBP2 Gene
Genomics for IGFBP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IGFBP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IGFBP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFBP2
- Top Transcription factor binding sites by QIAGEN in the IGFBP2 gene promoter:
-
- CREB
- deltaCREB
- POU2F1
- POU2F1a
- PPAR-gamma1
- PPAR-gamma2
- STAT3
- STAT5A
Genomic Locations for IGFBP2 Gene
Latest Assembly
- chr2:216,632,828-216,664,436
- (GRCh38/hg38)
- Size:
- 31,609 bases
- Orientation:
- Plus strand
Previous Assembly
- chr2:217,497,551-217,529,159
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 31,609 bases
- Orientation:
- Plus strand
- chr2:217,497,551-217,529,159
- (GRCh37/hg19 by Ensembl)
- Size:
- 31,609 bases
- Orientation:
- Plus strand
Genomic View for IGFBP2 Gene
Genes around IGFBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q35 by HGNC
- 2q35 by Entrez Gene
- 2q35 by Ensembl
IGFBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFBP2 Gene
Proteins for IGFBP2 Gene
-
Protein details for IGFBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18065-IBP2_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein 2
- Protein Accession:
- P18065
- Q14619
- Q9UCL3
Protein attributes for IGFBP2 Gene
- Size:
- 325 amino acids
- Molecular mass:
- 34814 Da
- Quaternary structure:
-
- Binds IGF2 more than IGF1.
Protein Expression for IGFBP2 Gene
Post-translational modifications for IGFBP2 Gene
- O-glycosylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for IGFBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences IGFBP2 / IGF-BP53 Antibody (LS-B9078) and IGFBP2 / IGF-BP53 Antibody (LS-B11951)
- G Biosciences Immunotag™ IGFBP2 Antibody
- NSJ Bioreagents IGFBP2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for IGFBP2
- Novus Biologicals Antibodies for IGFBP2
-
Abcam antibodies for IGFBP2
- Invitrogen Antibodies for IGFBP2 (AFLGC-IGFBP2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP2
- Sino Biological Antibodies for IGFBP2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBP2
- Origene Custom Protein Services for IGFBP2
- Sino Biological Recombinant Proteins for IGFBP2
- Sino Biological Cell Lysates for IGFBP2
-
ProSci Proteins for IGFBP2
-
Abcam proteins for IGFBP2
Assay products for research
- RayBiotech Human IGFBP-2 ELISA
- Novus Biologicals ELISA Kits for IGFBP2
- antibodies-online: Show 117 available IGFBP2 Elisa Kits ranked by validation data
- Compare Top IGFBP2 Elisa Kits
-
Quality Products:
- ABIN624998
- ABIN1115523
- ABIN414869
- ABIN816448
- ABIN1889294
- ABIN3032934
- ABIN1570530
- ABIN5524642
- ABIN2708248
- ABIN6720226
- ABIN1115543
- ABIN625401
- ABIN1889295
- ABIN365357
- ABIN4993101
- ABIN1570531
- ABIN5524643
- ABIN2708526
- ABIN6720032
- ABIN5596296
- ABIN1115544
- ABIN416319
- ABIN1570533
- ABIN5524645
- ABIN365594
- ABIN5670902
- ABIN627199
- ABIN5594653
- ABIN5655428
- ABIN4970192
- ABIN413972
- ABIN1570529
- ABIN456864
- ABIN5594651
- ABIN993096
- ABIN5655423
- ABIN2535068
- ABIN4970193
- ABIN6228915
- ABIN1138180
-
Abcam assays for IGFBP2
No data available for DME Specific Peptides for IGFBP2 Gene
Domains & Families for IGFBP2 Gene
Gene Families for IGFBP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for IGFBP2 Gene
- InterPro:
- Blocks:
-
- Insulin-like growth factor-binding protein, IGFBP
- Thyroglobulin type-1
- ProtoNet:
Suggested Antigen Peptide Sequences for IGFBP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Insulin-like growth factor-binding protein 2 (IBP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P18065UniProtKB/Swiss-Prot:
IBP2_HUMAN :- The C-terminus is required for IGF-binding and growth inhibition.
- Domain:
-
- The C-terminus is required for IGF-binding and growth inhibition.
Function for IGFBP2 Gene
Molecular function for IGFBP2 Gene
- UniProtKB/Swiss-Prot Function:
- Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
- GENATLAS Biochemistry:
- insulin-like growth factor binding protein 2 ,high affinity,regulator of somatic growth and cellular proliferation,major IGFBP of the spinal fluid expressed by multiple neural tissues,highly expressed in infancy and older age adult,deregulated in pancreatic beta cell tumorigenesis
Phenotypes From GWAS Catalog for IGFBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | TAS | 24431302 |
| GO:0005515 | protein binding | IPI | 19095771 |
| GO:0005520 | insulin-like growth factor binding | IEA | -- |
| GO:0019838 | growth factor binding | IEA | -- |
| GO:0031994 | insulin-like growth factor I binding | IEA,IDA | 19081843 |
Phenotypes for IGFBP2 Gene
- MGI mutant phenotypes for IGFBP2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IGFBP2:
-
- Increased gamma-H2AX phosphorylation
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- shRNA abundance <= 25%
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased number of mitotic cells
- Increased shRNA abundance
- Increased G1 DNA content
- Decreased viability of wild-type and TP53 knockout cells
Animal Models for IGFBP2 Gene
- MGI Knock Outs for IGFBP2:
-
- Igfbp2 Igfbp2<tm1Jep>
Animal Models for research
-
Taconic Biosciences Mouse Models for IGFBP2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IGFBP2 - Starting at $85 >
- * IGFBP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IGFBP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP2
miRNA for IGFBP2 Gene
- miRTarBase miRNAs that target IGFBP2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP2
- Browse OriGene Inhibitory RNA Products For IGFBP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP2
Clone products for research
- Applied Biological Materials (abm): Clones for IGFBP2 - Starting at $45 >
- * IGFBP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IGFBP2
- Addgene plasmids for IGFBP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP2
Cell Lines for research
-
Horizon Cell Lines for IGFBP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP2 Gene
Localization for IGFBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFBP2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005615 | extracellular space | ISS,IDA | 15694994 |
| GO:0016324 | apical plasma membrane | IEA | -- |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
Pathways & Interactions for IGFBP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glucose / Energy Metabolism | ||
| 2 | Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
| 3 | Metabolism of proteins | ||
| 4 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||
| 5 | Development IGF-1 receptor signaling |
Development IGF-1 receptor signaling
.48
|
|
Pathways by source for IGFBP2 Gene
2 BioSystems pathways for IGFBP2 Gene
2 Reactome pathways for IGFBP2 Gene
1 GeneGo (Thomson Reuters) pathway for IGFBP2 Gene
- Development IGF-1 receptor signaling
1 R&D Systems pathway for IGFBP2 Gene
1 Cell Signaling Technology pathway for IGFBP2 Gene
Interacting Proteins for IGFBP2 Gene
Selected Interacting proteins:
P18065-IBP2_HUMAN
ENSP00000233809
for IGFBP2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IGFBP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007565 | female pregnancy | IEA | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0007584 | response to nutrient | IEA | -- |
| GO:0009612 | response to mechanical stimulus | IEA | -- |
Drugs & Compounds for IGFBP2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Mecasermin | Approved, Investigational | Pharma | Carrier | 36 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
Transcripts for IGFBP2 Gene
mRNA/cDNA for IGFBP2 Gene
- 4 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000233809 1414 nts (view in UCSC)
- ENST00000434997 477 nts (view in UCSC)
- ENST00000436812 751 nts (view in UCSC)
- ENST00000456764 846 nts (view in UCSC)
- ENST00000490362 4414 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IGFBP2 - Starting at $85 >
- * IGFBP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IGFBP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP2
- Browse OriGene Inhibitory RNA Products For IGFBP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP2
Clone products for research
- Applied Biological Materials (abm): Clones for IGFBP2 - Starting at $45 >
- * IGFBP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IGFBP2
- Addgene plasmids for IGFBP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: |
Relevant External Links for IGFBP2 Gene
- GeneLoc Exon Structure for
- IGFBP2
Expression for IGFBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Trachea
- Dental Placode Cells Dental Placode
- Mature Choroid Plexus Cells Choroid Plexus
- Bone (Muscoskeletal System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
- Trabecular meshwork-derived mesenchymal stem cells
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Cerebellum
- Cartilage (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Intermediate Mesoderm (Gastrulation Derivatives)
- Kidney (Urinary System)
- NULL (Integumentary System)
- Uncategorized
- Mesenchymal Stem Cells
- Adipose (Muscoskeletal System)
-
Prostate (Endocrine System)
-
Heart (Cardiovascular System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for IGFBP2 Gene
This gene is overexpressed in Artery - Aorta (x8.9), Artery - Coronary (x4.3), and Liver (x4.3).
This gene is overexpressed in Amniocyte (55.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGFBP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFBP2
SOURCE GeneReport for Unigene cluster for IGFBP2 Gene:
Hs.438102Evidence on tissue expression from TISSUES for IGFBP2 Gene
- Nervous system(4.9)
- Liver(4.7)
- Eye(4.5)
- Pancreas(3.3)
- Blood(3.2)
- Muscle(3.2)
- Stomach(3.2)
- Heart(3.1)
- Kidney(2.9)
- Spleen(2.8)
- Intestine(2.6)
- Lung(2.6)
- Skin(2.5)
- Adrenal gland(2.4)
- Thyroid gland(2.3)
- Bone marrow(2.2)
Primer products for research
-
OriGene qPCR primer pairs for IGFBP2
-
OriGene qPCR primer pairs and template standards for IGFBP2
Gene Expression Assays for research
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP2 Gene
Orthologs for IGFBP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IGFBP2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IGFBP2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IGFBP2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Igfbp2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Igfbp2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | IGFBP2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | IGFBP2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IGFBP2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | igfbp2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.20883 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | igfbp2a 30 31 |
|
OneToMany | |
| igfbp2b 31 |
|
OneToMany | |||
| igfbp2 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9110 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for IGFBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IGFBP2 Gene
- ENSEMBL:
- Gene Tree for IGFBP2 (if available)
- TreeFam:
- Gene Tree for IGFBP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IGFBP2: view image
Paralogs for IGFBP2 Gene
Variants for IGFBP2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFBP2 Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs9341096 | - |
p.Ala137Asp |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2673456 | CNV | deletion | 23128226 |
| esv2721463 | CNV | deletion | 23290073 |
| nsv460098 | CNV | loss | 19166990 |
| nsv584454 | CNV | loss | 21841781 |
| nsv584455 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.60;
12.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGFBP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IGFBP2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP2 Gene
Disorders for IGFBP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| malignant ovarian cyst |
|
|
| insulin-like growth factor i |
|
|
| ovarian cyst |
|
|
| laron syndrome |
|
|
| anorexia nervosa |
|
|
Search IGFBP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IGFBP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP2 Gene
Publications for IGFBP2 Gene
- Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PMID: 19843326) Neuhausen SL … Gillen DL (Breast cancer research : BCR 2009) 3 23 41
- Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. (PMID: 19081843) Zhou J … Duan C (PloS one 2008) 3 4 23
- Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent. (PMID: 18210156) Garner CP … Neuhausen SL (Human genetics 2008) 3 23 41
- Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2). (PMID: 17020769) Kuang Z … Norton RS (Journal of molecular biology 2006) 3 4 23
- Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (PMID: 1697583) Zapf J … Froesch ER (The Journal of biological chemistry 1990) 2 3 4
ExternalLinks
Products for IGFBP2 Gene
- View all 18 R&D Systems IGFBP2 (IGFBP-2) Products
- View all R&D Systems IGFBP2 (IGFBP-2) Proteins and Enzymes
- View all 9 R&D Systems IGFBP2 (IGFBP-2) Primary Antibodies
- View all 3 R&D Systems IGFBP2 (IGFBP-2) ELISAs
- View all R&D Systems IGFBP2 (IGFBP-2) Simple Plex Assays
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- Learn more about R&D Systems custom IGFBP2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for IGFBP2
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBP2
- Origene Custom Protein Services for IGFBP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP2
- Browse OriGene Inhibitory RNA Products For IGFBP2
- OriGene qPCR primer pairs for IGFBP2
- OriGene qPCR primer pairs and template standards for IGFBP2
- OriGene CRISPR knockouts for IGFBP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IGFBP2
- Sino Biological Human cDNA Clone for IGFBP2
- Sino Biological Recombinant Proteins for IGFBP2
- Sino Biological Cell Lysates for IGFBP2
- Sino Biological Antibodies for IGFBP2
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IGFBP2
- Novus Biologicals proteins and lysates for IGFBP2
- Novus Biologicals ELISA Kits for IGFBP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IGFBP2
- Abcam proteins for IGFBP2
- Abcam assays for IGFBP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for IGFBP2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IGFBP2 (AFLGC-IGFBP2)
- VectorBuilder Custom and pre-made DNA vectors for IGFBP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IGFBP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IGFBP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IGFBP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IGFBP2
- Addgene plasmids for IGFBP2
- antibodies-online: Show 39 available IGFBP2 Antibodies ranked by validation data
- Compare Top IGFBP2 Antibodies
- antibodies-online: Show 117 available IGFBP2 Elisa Kits ranked by validation data
- Compare Top IGFBP2 Elisa Kits
- Quality Products:
- ABIN624998
- ABIN1115523
- ABIN414869
- ABIN816448
- ABIN1889294
- ABIN3032934
- ABIN1570530
- ABIN5524642
- ABIN2708248
- ABIN6720226
- ABIN1115543
- ABIN625401
- ABIN1889295
- ABIN365357
- ABIN4993101
- ABIN1570531
- ABIN5524643
- ABIN2708526
- ABIN6720032
- ABIN5596296
- ABIN1115544
- ABIN416319
- ABIN1570533
- ABIN5524645
- ABIN365594
- ABIN5670902
- ABIN627199
- ABIN5594653
- ABIN5655428
- ABIN4970192
- ABIN413972
- ABIN1570529
- ABIN456864
- ABIN5594651
- ABIN993096
- ABIN5655423
- ABIN2535068
- ABIN4970193
- ABIN6228915
- ABIN1138180
- antibodies-online: Show 35 available IGFBP2 Proteins ranked by validation data
- Compare Top IGFBP2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP2
- Search Santa Cruz Biotechnology (SCBT) for IGFBP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP2
- Custom Antibody ServicesProSci Antibodies for IGFBP2
- ProSci Proteins for IGFBP2
- Horizon Cell Lines for IGFBP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFBP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFBP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IGFBP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP2
Sources for IGFBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB