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The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
IGFBP2 (Insulin Like Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with IGFBP2 include Malignant Ovarian Cyst and Insulin-Like Growth Factor I. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP4.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 24431302 |
GO:0005515 | protein binding | IPI | 19095771 |
GO:0005520 | insulin-like growth factor binding | IEA | -- |
GO:0019838 | growth factor binding | IEA | -- |
GO:0031994 | insulin-like growth factor I binding | IEA,IDA | 19081843 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | ISS,IDA | 15694994 |
GO:0016324 | apical plasma membrane | IEA | -- |
GO:0031410 | cytoplasmic vesicle | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glucose / Energy Metabolism | ||
2 | Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
3 | Metabolism of proteins | ||
4 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||
5 | Development IGF-1 receptor signaling |
Development IGF-1 receptor signaling
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007565 | female pregnancy | IEA | -- |
GO:0007568 | aging | IEA | -- |
GO:0007584 | response to nutrient | IEA | -- |
GO:0009612 | response to mechanical stimulus | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Mecasermin | Approved, Investigational | Pharma | Carrier | 36 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||
SP2: | - | - | - | ||||||||||||||||
SP3: | - | ||||||||||||||||||
SP4: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IGFBP2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IGFBP2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IGFBP2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Igfbp2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Igfbp2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | IGFBP2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | IGFBP2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IGFBP2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | igfbp2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.20883 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | igfbp2a 30 31 |
|
OneToMany | |
igfbp2b 31 |
|
OneToMany | |||
igfbp2 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9110 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs9341096 | - |
p.Ala137Asp |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2673456 | CNV | deletion | 23128226 |
esv2721463 | CNV | deletion | 23290073 |
nsv460098 | CNV | loss | 19166990 |
nsv584454 | CNV | loss | 21841781 |
nsv584455 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
malignant ovarian cyst |
|
|
insulin-like growth factor i |
|
|
ovarian cyst |
|
|
laron syndrome |
|
|
anorexia nervosa |
|
|