Aliases for IGFBP2 Gene
Aliases for IGFBP2 Gene
External Ids for IGFBP2 Gene
- HGNC: 5471
- Entrez Gene: 3485
- Ensembl: ENSG00000115457
- OMIM: 146731
- UniProtKB: P18065
Previous HGNC Symbols for IGFBP2 Gene
- IBP2
Previous GeneCards Identifiers for IGFBP2 Gene
- GC02P215595
- GC02P216219
- GC02P217462
- GC02P217700
- GC02P217323
- GC02P217206
- GC02P217497
- GC02P209352
Summaries for IGFBP2 Gene
-
The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
GeneCards Summary for IGFBP2 Gene
IGFBP2 (Insulin Like Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with IGFBP2 include Malignant Ovarian Cyst and Insulin-Like Growth Factor I. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP4.
UniProtKB/Swiss-Prot for IGFBP2 Gene
-
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Additional gene information for IGFBP2 Gene
- Monarch Initiative
- Search for IGFBP2 at DataMed
- Search for IGFBP2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFBP2 Gene
Genomics for IGFBP2 Gene
GeneHancer (GH) Regulatory Elements for IGFBP2 Gene
Promoters and enhancers for IGFBP2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02I216633 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE dbSUPER | 555.9 | +3.0 | 2950 | 5.9 | SIN3A RAD21 RFX5 ETS1 ZNF335 GLIS2 SCRT2 FOS RCOR1 EGR2 | IGFBP2 ENSG00000236886 | |
| GH02I216632 | Enhancer | 0.6 | ENCODE dbSUPER | 550.8 | -0.3 | -325 | 0.2 | SCRT2 CTBP2 FOS | IGFBP2 PSMB3P2 | |
| GH02I216618 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 28.6 | -12.3 | -12342 | 3.3 | HDGF FOXA2 ZNF2 YY1 TCF12 ZNF766 RXRA NFIL3 ATF4 SMARCA4 | IGFBP2 XRCC5 SMARCAL1 ENSG00000236886 IGFBP5 PSMB3P2 | |
| GH02I216533 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 24.6 | -97.2 | -97198 | 4.1 | FEZF1 ZNF48 ZNF207 FOS ATF7 RXRA KAT8 NFIL3 SSRP1 ZNF184 | LOC101928180 IGFBP2 XRCC5 SMARCAL1 RPL37A LOC105373871 | |
| GH02I216690 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 10.3 | +61.0 | 61003 | 7.5 | PKNOX1 FEZF1 GLI4 ZNF2 GLIS2 ZNF143 KLF7 ATF7 ZNF263 SP3 | ENSG00000236886 IGFBP5 IGFBP2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around IGFBP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IGFBP2 gene promoter:
Regulatory Element Products
Genomic Locations for IGFBP2 Gene
Genomic Locations for IGFBP2 Gene
- chr2:216,632,828-216,664,436
- (GRCh38/hg38)
- Size:
- 31,609 bases
- Orientation:
- Plus strand
- chr2:217,497,551-217,529,159
- (GRCh37/hg19)
Genomic View for IGFBP2 Gene
Genes around IGFBP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q35 by Ensembl
- 2q35 by Entrez Gene
- 2q35 by HGNC
IGFBP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFBP2 Gene
Proteins for IGFBP2 Gene
-
Protein details for IGFBP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18065-IBP2_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein 2
- Protein Accession:
- P18065
- Q14619
- Q9UCL3
Protein attributes for IGFBP2 Gene
- Size:
- 325 amino acids
- Molecular mass:
- 34814 Da
- Quaternary structure:
-
- Binds IGF2 more than IGF1.
Protein Expression for IGFBP2 Gene
Post-translational modifications for IGFBP2 Gene
- O-glycosylated.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for IGFBP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IGFBP2 (IGFBP-2)
-
Custom Antibody ServicesOriGene Antibodies for IGFBP2
- Novus Biologicals Antibodies for IGFBP2
-
Abcam antibodies for IGFBP2
-
Cloud-Clone Corp. Antibodies for IGFBP2
- Invitrogen Antibodies for IGFBP2
- GeneTex IGFBP2 antibody for IGFBP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP2
- Sino Biological Antibodies for IGFBP2
Protein Products
- R&D Systems Proteins and Enzymes for IGFBP2 (IGFBP-2)
-
OriGene Purified Proteins for IGFBP2
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBP2
- Origene Custom Protein Services for IGFBP2
- Sino Biological Recombinant Proteins for IGFBP2
- Sino Biological Cell Lysates for IGFBP2
-
Cloud-Clone Corp. Proteins for IGFBP2
- GeneTex Proteins for IGFBP2
-
ProSci Proteins for IGFBP2
-
Abcam proteins for IGFBP2
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for IGFBP2
- R&D Systems Proteome Profiler Antibody Arrays, Luminex Assays, ELISAs, and other biochemical assays for IGFBP2 (IGFBP-2)
-
Cloud-Clone Corp. Assay Kits for IGFBP2
- antibodies-online: Search results for 89 available IGFBP2 Elisa Kits ranked by validation data
- Compare Top IGFBP2 Elisa Kits
-
Recommended
- 1 Cat (Feline) ELISA Kit
- 7 Chicken ELISA Kits
- 8 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 2 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 23 Human ELISA Kits
- 2 Monkey ELISA Kits
- 16 Mouse (Murine) ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
-
Abcam assays for IGFBP2
No data available for DME Specific Peptides for IGFBP2 Gene
Domains & Families for IGFBP2 Gene
Gene Families for IGFBP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for IGFBP2 Gene
Suggested Antigen Peptide Sequences for IGFBP2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P18065UniProtKB/Swiss-Prot:
IBP2_HUMAN :- The C-terminus is required for IGF-binding and growth inhibition.
- Domain:
-
- The C-terminus is required for IGF-binding and growth inhibition.
Function for IGFBP2 Gene
Molecular function for IGFBP2 Gene
- GENATLAS Biochemistry:
- insulin-like growth factor binding protein 2 ,high affinity,regulator of somatic growth and cellular proliferation,major IGFBP of the spinal fluid expressed by multiple neural tissues,highly expressed in infancy and older age adult,deregulated in pancreatic beta cell tumorigenesis
- UniProtKB/Swiss-Prot Function:
- Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Phenotypes From GWAS Catalog for IGFBP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | TAS | 24431302 |
| GO:0005515 | protein binding | IPI | 19095771 |
| GO:0005520 | insulin-like growth factor binding | IEA | -- |
| GO:0019838 | growth factor binding | IEA | -- |
| GO:0031994 | insulin-like growth factor I binding | IDA,IEA | 19081843 |
Phenotypes for IGFBP2 Gene
- MGI mutant phenotypes for IGFBP2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IGFBP2:
Animal Models for IGFBP2 Gene
- MGI Knock Outs for IGFBP2:
-
- Igfbp2 tm1Jep
Animal Model Products
-
Taconic Biosciences Mouse Models for IGFBP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGFBP2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IGFBP2 gene
- Search ViGene Biosciences for IGFBP2
CRISPR Products
-
OriGene CRISPR knockouts for IGFBP2
- genomics-online: gRNA clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
- Applied Biological Materials CRISPR for IGFBP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP2
- GenScript: Design CRISPR guide RNA sequences for IGFBP2
miRNA for IGFBP2 Gene
- miRTarBase miRNAs that target IGFBP2
miRNA Products
- Search ViGene Biosciences for IGFBP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IGFBP2
- Browse OriGene Inhibitory RNA Products For IGFBP2
- genomics-online: shRNA clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IGFBP2 gene
Clone Products
- Sino Biological Human cDNA Clone for IGFBP2
- VectorBuilder custom plasmid, inducible vectors for IGFBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGFBP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IGFBP2
- Applied Biological Materials Clones for IGFBP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IGFBP2
-
ViGene Biosciences adenoviral particle packaged cDNA for IGFBP2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IGFBP2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IGFBP2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP2 Gene
Localization for IGFBP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFBP2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| nucleus | 2 |
| cytoskeleton | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
| GO:0005615 | extracellular space | ISS,IDA | 15694994 |
| GO:0016324 | apical plasma membrane | IEA | -- |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
| GO:0070062 | extracellular exosome | IDA,HDA | 23376485 |
Pathways & Interactions for IGFBP2 Gene
Pathways by source for IGFBP2 Gene
2 BioSystems pathways for IGFBP2 Gene
2 Reactome pathways for IGFBP2 Gene
1 GeneGo (Thomson Reuters) pathway for IGFBP2 Gene
1 R&D Systems pathway for IGFBP2 Gene
1 Cell Signaling Technology pathway for IGFBP2 Gene
Interacting Proteins for IGFBP2 Gene
Selected Interacting proteins:
P18065-IBP2_HUMAN
ENSP00000233809
for IGFBP2 Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007565 | female pregnancy | IEA | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0007584 | response to nutrient | IEA | -- |
No data available for SIGNOR curated interactions for IGFBP2 Gene
Transcripts for IGFBP2 Gene
mRNA/cDNA for IGFBP2 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (412) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IGFBP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IGFBP2
- genomics-online: gRNA clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
- Applied Biological Materials CRISPR for IGFBP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP2
- GenScript: Design CRISPR guide RNA sequences for IGFBP2
miRNA Products
- Search ViGene Biosciences for IGFBP2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IGFBP2
- Browse OriGene Inhibitory RNA Products For IGFBP2
- genomics-online: shRNA clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IGFBP2 gene
Clone Products
- Sino Biological Human cDNA Clone for IGFBP2
- VectorBuilder custom plasmid, inducible vectors for IGFBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGFBP2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IGFBP2
- Applied Biological Materials Clones for IGFBP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||
| SP3: | - | ||||||||||||||||||
| SP4: |
Expression for IGFBP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Trachea
- Dental Placode Cells Dental Placode
- Mature Choroid Plexus Cells Choroid Plexus
- Bone (Muscoskeletal System)
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
- Trabecular meshwork-derived mesenchymal stem cells
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Cerebellum
- Cartilage (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Intermediate Mesoderm (Gastrulation Derivatives)
- Kidney (Urinary System)
- NULL (Integumentary System)
- Uncategorized
- Mesenchymal Stem Cells
- Adipose (Muscoskeletal System)
-
Prostate (Endocrine System)
-
Heart (Cardiovascular System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for IGFBP2 Gene
This gene is overexpressed in Artery - Aorta (x8.9), Artery - Coronary (x4.3), and Liver (x4.3).
This gene is overexpressed in Amniocyte (55.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IGFBP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of IGFBP2 Gene:
IGFBP2SOURCE GeneReport for Unigene cluster for IGFBP2 Gene:
Hs.438102Evidence on tissue expression from TISSUES for IGFBP2 Gene
- Nervous system(4.9)
- Liver(4.7)
- Eye(4.4)
- Blood(3.1)
- Muscle(3)
- Kidney(2.8)
- Pancreas(2.8)
- Stomach(2.8)
- Heart(2.7)
- Lung(2.6)
- Spleen(2.4)
- Intestine(2.3)
- Adrenal gland(2.1)
- Thyroid gland(2.1)
- Skin(2)
Primer Products
-
OriGene qPCR primer pairs for IGFBP2
-
OriGene qPCR primer pairs and template standards for IGFBP2
- genomics-online: primer clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP2 Gene
Orthologs for IGFBP2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IGFBP2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | IGFBP2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | IGFBP2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Igfbp2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Igfbp2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IGFBP2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | IGFBP2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | IGFBP2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | igfbp2 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.20883 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | igfbp2a 33 34 |
|
||
| igfbp2b 34 |
|
OneToMany | |||
| igfbp2 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9110 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for IGFBP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IGFBP2 Gene
(3) SIMAP similar genes for IGFBP2 Gene using alignment to 4 proteins:
Variants for IGFBP2 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000009766 | -- | 216,646,520(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000011307 | -- | 216,650,288(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000028824 | -- | 216,634,242(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000032078 | -- | 216,639,657(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000076699 | -- | 216,647,687(+) | T/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2673456 | CNV | deletion | 23128226 |
| esv2721463 | CNV | deletion | 23290073 |
| nsv460098 | CNV | loss | 19166990 |
| nsv584454 | CNV | loss | 21841781 |
| nsv584455 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.60;
12.94% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGFBP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IGFBP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFBP2 Gene
Disorders for IGFBP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| malignant ovarian cyst |
|
|
| insulin-like growth factor i |
|
|
| pallister-killian syndrome |
|
|
| glioblastoma multiforme |
|
|
| complete androgen insensitivity syndrome |
|
|
Search IGFBP2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IGFBP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP2 Gene
Publications for IGFBP2 Gene
- Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. (PMID: 19081843) Zhou J … Duan C (PloS one 2008) 3 4 22 58
- Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2). (PMID: 17020769) Kuang Z … Norton RS (Journal of molecular biology 2006) 3 4 22 58
- Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia. (PMID: 1697583) Zapf J … Froesch ER (The Journal of biological chemistry 1990) 2 3 4 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
- Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
Products for IGFBP2 Gene
- R&D Systems Antibodies for IGFBP2 (IGFBP-2)
- R&D Systems Proteins and Enzymes for IGFBP2 (IGFBP-2)
- R&D Systems ELISAs, Luminex Assays, Proteome Profiler Antibody Arrays, and other biochemical assays for IGFBP2 (IGFBP-2)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IGFBP2
- Custom Assay ServicesOriGene ELISA Kits for IGFBP2
- OriGene Purified Proteins for IGFBP2
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFBP2
- Origene Custom Protein Services for IGFBP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFBP2
- Browse OriGene Inhibitory RNA Products For IGFBP2
- OriGene qPCR primer pairs and template standards for IGFBP2
- OriGene qPCR primer pairs for IGFBP2
- OriGene CRISPR knockouts for IGFBP2
- OriGene ORF clones in human for IGFBP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IGFBP2
- GenScript: Next-day shipping of latest version cDNA ORF clones for IGFBP2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for IGFBP2
- GenScript Custom Assay Services for IGFBP2
- GenScript Custom overexpressing Cell Line Services for IGFBP2
- GenScript: Design CRISPR guide RNA sequences for IGFBP2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IGFBP2
- Sino Biological Human cDNA Clone for IGFBP2
- Sino Biological Cell Lysates for IGFBP2
- Sino Biological Recombinant Proteins for IGFBP2
- Sino Biological Antibodies for IGFBP2
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for IGFBP2
- Novus Biologicals lysates and proteins for IGFBP2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IGFBP2
- Abcam proteins for IGFBP2
- Abcam assays for IGFBP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for IGFBP2
- Cloud-Clone Corp. Proteins for IGFBP2
- Cloud-Clone Corp. Assay Kits for IGFBP2
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for IGFBP2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for IGFBP2
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGFBP2
- VectorBuilder custom plasmid, inducible vectors for IGFBP2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IGFBP2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IGFBP2
- antibodies-online: Search results for 147 available IGFBP2 Antibodies ranked by validation data
- Compare Top IGFBP2 Antibodies
- antibodies-online: Search results for 89 available IGFBP2 Elisa Kits ranked by validation data
- Compare Top IGFBP2 Elisa Kits
- Recommended
- 1 Cat (Feline) ELISA Kit
- 7 Chicken ELISA Kits
- 8 Cow (Bovine) ELISA Kits
- 2 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 2 Guinea Pig ELISA Kits
- 1 Horse (Equine) ELISA Kit
- 23 Human ELISA Kits
- 2 Monkey ELISA Kits
- 16 Mouse (Murine) ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 2 Rabbit ELISA Kits
- 13 Rat (Rattus) ELISA Kits
- 1 Rhesus Monkey ELISA Kit
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for available IGFBP2 related products ranked by validation data
- GeneTex IGFBP2 antibody for IGFBP2
- GeneTex Proteins for IGFBP2
- ViGene Biosciences adenoviral particle packaged cDNA for IGFBP2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IGFBP2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for IGFBP2 gene
- Search ViGene Biosciences for IGFBP2
- Santa Cruz Biotechnology (SCBT) Antibodies for IGFBP2
- Search Santa Cruz Biotechnology (SCBT) for IGFBP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IGFBP2
- Horizon Cell Lines for IGFBP2
- genomics-online: cdna clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
- orf clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
- genomics-online: gRNA clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
- genomics-online: primer clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
- genomics-online: shRNA clones - Search results for 119 available IGFBP2 gene related products
- Overview of 119 available IGFBP2 gene related products
Sources for IGFBP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems