This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cel... See more...

Aliases for IGFBP1 Gene

Aliases for IGFBP1 Gene

  • Insulin Like Growth Factor Binding Protein 1 2 3 5
  • IGF-Binding Protein 1 2 3 4
  • Placental Protein 12 2 3 4
  • PP12 2 3 4
  • Alpha-Pregnancy-Associated Endometrial Globulin 2 3
  • Insulin-Like Growth Factor-Binding Protein 1 3 4
  • Growth Hormone Independent-Binding Protein 2 3
  • Amniotic Fluid Binding Protein 2 3
  • Binding Protein-28 2 3
  • Binding Protein-26 2 3
  • Binding Protein-25 2 3
  • IGF-BP25 2 3
  • HIGFBP-1 2 3
  • IGFBP-1 3 4
  • IBP-1 3 4
  • AFBP 2 3
  • IBP1 3 4
  • Insulin-Like Growth Factor Binding Protein 1 2
  • IGFBP1 5

External Ids for IGFBP1 Gene

Previous HGNC Symbols for IGFBP1 Gene

  • IBP1

Previous GeneCards Identifiers for IGFBP1 Gene

  • GC07P045574
  • GC07P045668
  • GC07P045701
  • GC07P045894
  • GC07P045816
  • GC07P045927
  • GC07P046043
  • GC07P046067
  • GC07P046348
  • GC07P046383
  • GC07P046335
  • GC07P046473
  • GC07P046097
  • GC07P046128
  • GC07P046158
  • GC07P046194
  • GC07P046223
  • GC07P046253
  • GC07P046284
  • GC07P046321
  • GC07P046552

Summaries for IGFBP1 Gene

Entrez Gene Summary for IGFBP1 Gene

  • This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]

GeneCards Summary for IGFBP1 Gene

IGFBP1 (Insulin Like Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with IGFBP1 include Ovarian Disease and Hyperinsulinism. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding and insulin-like growth factor II binding. An important paralog of this gene is IGFBP2.

UniProtKB/Swiss-Prot Summary for IGFBP1 Gene

  • IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Gene Wiki entry for IGFBP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFBP1 Gene

Genomics for IGFBP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGFBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGFBP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFBP1

Top Transcription factor binding sites by QIAGEN in the IGFBP1 gene promoter:
  • c-Fos
  • C/EBPalpha
  • p53
  • PPAR-alpha
  • TBP

Genomic Locations for IGFBP1 Gene

Latest Assembly
chr7:45,888,360-45,893,660
(GRCh38/hg38)
Size:
5,301 bases
Orientation:
Plus strand

Previous Assembly
chr7:45,928,087-45,933,259
(GRCh37/hg19 by Entrez Gene)
Size:
5,173 bases
Orientation:
Plus strand

chr7:45,927,956-45,933,267
(GRCh37/hg19 by Ensembl)
Size:
5,312 bases
Orientation:
Plus strand

Genomic View for IGFBP1 Gene

Genes around IGFBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFBP1 Gene

Proteins for IGFBP1 Gene

  • Protein details for IGFBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08833-IBP1_HUMAN
    Recommended name:
    Insulin-like growth factor-binding protein 1
    Protein Accession:
    P08833
    Secondary Accessions:
    • A4D2F4
    • D3DVL9
    • Q8IYP5

    Protein attributes for IGFBP1 Gene

    Size:
    259 amino acids
    Molecular mass:
    27904 Da
    Quaternary structure:
    • Binds equally well IGF1 and IGF2.
    SequenceCaution:
    • Sequence=AAA52540.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGFBP1 Gene

neXtProt entry for IGFBP1 Gene

Post-translational modifications for IGFBP1 Gene

  • Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGFBP1 Gene

Antibodies for research

  • Abcam antibodies for IGFBP1

Protein products for research

  • Abcam proteins for IGFBP1

No data available for DME Specific Peptides for IGFBP1 Gene

Domains & Families for IGFBP1 Gene

Gene Families for IGFBP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IGFBP1 Gene

InterPro:
Blocks:
  • Insulin-like growth factor-binding protein, IGFBP
  • Thyroglobulin type-1
ProtoNet:

Suggested Antigen Peptide Sequences for IGFBP1 Gene

GenScript: Design optimal peptide antigens:
  • Insulin-like growth factor binding protein 1 (C1K3N3_HUMAN)
  • Placental protein 12 (IBP1_HUMAN)
  • Insulin-like growth factor binding protein 1 (Q6PEY6_HUMAN)
genes like me logo Genes that share domains with IGFBP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGFBP1 Gene

Function for IGFBP1 Gene

Molecular function for IGFBP1 Gene

UniProtKB/Swiss-Prot Function:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
GENATLAS Biochemistry:
insulin-like growth factor binding protein 1,high affinity,expressed in liver, decidua,kidney and in amniotic fluid,regulator of somatic growth and cellular proliferation,regulated by insulin and corticoids,duplicated in an atypical Silver Russel syndrome

Phenotypes From GWAS Catalog for IGFBP1 Gene

Gene Ontology (GO) - Molecular Function for IGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding TAS 24431302
GO:0005515 protein binding IPI 16924115
GO:0005520 insulin-like growth factor binding IEA,TAS 2454104
GO:0019838 growth factor binding IEA --
GO:0031994 insulin-like growth factor I binding IBA,IDA 21550830
genes like me logo Genes that share ontologies with IGFBP1: view
genes like me logo Genes that share phenotypes with IGFBP1: view

Animal Models for IGFBP1 Gene

MGI Knock Outs for IGFBP1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGFBP1 Gene

Localization for IGFBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFBP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFBP1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
nucleus 2
cytosol 2
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with IGFBP1: view

Pathways & Interactions for IGFBP1 Gene

genes like me logo Genes that share pathways with IGFBP1: view

SIGNOR curated interactions for IGFBP1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2454104
GO:0007568 aging IEA --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0030307 positive regulation of cell growth IEA --
GO:0036499 PERK-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with IGFBP1: view

Drugs & Compounds for IGFBP1 Gene

(73) Drugs for IGFBP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mecasermin Approved, Investigational Pharma Carrier 36

(31) Additional Compounds for IGFBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IGFBP1: view

Transcripts for IGFBP1 Gene

mRNA/cDNA for IGFBP1 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFBP1

Alternative Splicing Database (ASD) splice patterns (SP) for IGFBP1 Gene

No ASD Table

Relevant External Links for IGFBP1 Gene

GeneLoc Exon Structure for
IGFBP1

Expression for IGFBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGFBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFBP1 Gene

This gene is overexpressed in Liver (x50.0).

Protein differential expression in normal tissues from HIPED for IGFBP1 Gene

This gene is overexpressed in Fetal gut (46.3) and Placenta (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFBP1 Gene



Protein tissue co-expression partners for IGFBP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFBP1

SOURCE GeneReport for Unigene cluster for IGFBP1 Gene:

Hs.642938

Evidence on tissue expression from TISSUES for IGFBP1 Gene

  • Liver(4.8)
  • Skin(4.4)
  • Blood(2.5)
  • Heart(2.4)
  • Nervous system(2.4)
  • Kidney(2.3)
  • Pancreas(2.3)
  • Muscle(2.3)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with IGFBP1: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFBP1 Gene

Orthologs for IGFBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGFBP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IGFBP1 30 31
  • 99.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IGFBP1 30 31
  • 76.45 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Igfbp1 30 17 31
  • 75.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Igfbp1 30
  • 75.25 (n)
Dog
(Canis familiaris)
Mammalia IGFBP1 30 31
  • 72.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IGFBP1 31
  • 58 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IGFBP1 31
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IGFBP1 30 31
  • 61.86 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IGFBP1 31
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia igfbp1 30
  • 56.91 (n)
Zebrafish
(Danio rerio)
Actinopterygii igfbp1b 30 31
  • 56.44 (n)
OneToMany
igfbp1a 31
  • 35 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 27 (a)
OneToMany
Species where no ortholog for IGFBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IGFBP1 Gene

ENSEMBL:
Gene Tree for IGFBP1 (if available)
TreeFam:
Gene Tree for IGFBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGFBP1: view image

Paralogs for IGFBP1 Gene

Paralogs for IGFBP1 Gene

(2) SIMAP similar genes for IGFBP1 Gene using alignment to 5 proteins:

  • IBP1_HUMAN
  • C1K3N3_HUMAN
  • C9J6H2_HUMAN
  • C9JXF9_HUMAN
  • Q6PEY6_HUMAN
genes like me logo Genes that share paralogs with IGFBP1: view

Variants for IGFBP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFBP1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs1065782 - p.Val183Ile
rs41258845 - p.His114Asp
rs4619 - p.Ile253Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IGFBP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for IGFBP1 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFBP1 Gene

Human Gene Mutation Database (HGMD)
IGFBP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFBP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IGFBP1 Gene

Disorders for IGFBP1 Gene

MalaCards: The human disease database

(51) MalaCards diseases for IGFBP1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ovarian disease
  • ovarian dysfunction
hyperinsulinism
  • hyperinsulinemia
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
hyperandrogenism
  • hyperandrogenization syndrome
mild pre-eclampsia
  • mild toxemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGFBP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IGFBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGFBP1 Gene

Publications for IGFBP1 Gene

  1. Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms. (PMID: 19765076) Dolcini L … Galliano M (The FEBS journal 2009) 3 4 23
  2. Insulin-like growth factor-binding protein-1: serum levels, promoter polymorphism, and associations with components of the metabolic syndrome in short subjects born small for gestational age. (PMID: 19158202) van der Kaay D … Hokken-Koelega A (The Journal of clinical endocrinology and metabolism 2009) 3 23 41
  3. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PMID: 19843326) Neuhausen SL … Gillen DL (Breast cancer research : BCR 2009) 3 23 41
  4. IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3). (PMID: 18596909) Patel AV … Breast and Prostate Cancer Cohort Consortium (PloS one 2008) 3 23 41
  5. Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population. (PMID: 17566087) Cheng I … Le Marchand L (The Journal of clinical endocrinology and metabolism 2007) 3 23 41

Products for IGFBP1 Gene

Sources for IGFBP1 Gene