Aliases for IGFALS Gene
- Insulin Like Growth Factor Binding Protein Acid Labile Subunit 2 3 5
- ALS 2 3 4
- Insulin-Like Growth Factor-Binding Protein Complex Acid Labile Subunit 3 4
- Insulin-Like Growth Factor Binding Protein Complex Acid Labile Chain 3
- Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit 2
- IGFALS 5
- ACLSD 3
External Ids for IGFALS Gene
Previous GeneCards Identifiers for IGFALS Gene
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for IGFALS Gene
IGFALS (Insulin Like Growth Factor Binding Protein Acid Labile Subunit) is a Protein Coding gene. Diseases associated with IGFALS include Acid-Labile Subunit Deficiency and Laron Syndrome. Among its related pathways are Relaxin signaling pathway and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is TLR8.
UniProtKB/Swiss-Prot Summary for IGFALS Gene
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.