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The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow pube... See more...
Aliases for IGFALS Gene
Aliases for IGFALS Gene
- Insulin Like Growth Factor Binding Protein Acid Labile Subunit 2 3 5
- ALS 2 3 4
- Insulin-Like Growth Factor-Binding Protein Complex Acid Labile Subunit 3 4
- Insulin-Like Growth Factor Binding Protein Complex Acid Labile Chain 3
- Insulin-Like Growth Factor Binding Protein, Acid Labile Subunit 2
- IGFALS 5
- ACLSD 3
External Ids for IGFALS Gene
- HGNC: 5468
- Entrez Gene: 3483
- Ensembl: ENSG00000099769
- OMIM: 601489
- UniProtKB: P35858
Previous GeneCards Identifiers for IGFALS Gene
- GC16M001857
- GC16M001780
- GC16M001840
Summaries for IGFALS Gene
-
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for IGFALS Gene
IGFALS (Insulin Like Growth Factor Binding Protein Acid Labile Subunit) is a Protein Coding gene. Diseases associated with IGFALS include Acid-Labile Subunit Deficiency and Laron Syndrome. Among its related pathways are Relaxin signaling pathway and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include insulin-like growth factor binding. An important paralog of this gene is TLR8.
UniProtKB/Swiss-Prot Summary for IGFALS Gene
-
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
Additional gene information for IGFALS Gene
- HGNC(5468)
- Entrez Gene(3483)
- Ensembl(ENSG00000099769)
- OMIM(601489)
- UniProtKB(P35858)
- Open Targets Platform(ENSG00000099769)
- Monarch Initiative
- Search for IGFALS at DataMed
- Search for IGFALS at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGFALS Gene
Genomics for IGFALS Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IGFALS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IGFALS on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGFALS
- Top Transcription factor binding sites by QIAGEN in the IGFALS gene promoter:
-
- CP2
- Pax-5
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- STAT5B
- YY1
Genomic Locations for IGFALS Gene
Genomic Locations for IGFALS Gene
- chr16:1,790,413-1,794,971
- (GRCh38/hg38)
- Size:
- 4,559 bases
- Orientation:
- Minus strand
- chr16:1,840,414-1,844,972
- (GRCh37/hg19)
- Size:
- 4,559 bases
- Orientation:
- Minus strand
Genomic View for IGFALS Gene
Genes around IGFALS on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by HGNC
- 16p13.3 by Entrez Gene
- 16p13.3 by Ensembl
IGFALS Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGFALS Gene
Proteins for IGFALS Gene
-
Protein details for IGFALS Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35858-ALS_HUMAN
- Recommended name:
- Insulin-like growth factor-binding protein complex acid labile subunit
- Protein Accession:
- P35858
- B4DZY8
- E9PGU3
Protein attributes for IGFALS Gene
- Size:
- 605 amino acids
- Molecular mass:
- 66035 Da
- Quaternary structure:
-
- Forms a ternary complex of about 140 to 150 kDa with IGF-I or IGF-II and IGFBP-3.
Protein Expression for IGFALS Gene
Post-translational modifications for IGFALS Gene
Other Protein References for IGFALS Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ IGFALS Antibody
- GeneTex Anti-ALS antibody and Anti-ALS antibody [C1C3-2]
- BioLegend IGFALS (ALS) Antibody
- Novus Biologicals Antibodies for IGFALS
-
Abcam antibodies for IGFALS
- Invitrogen Antibodies for IGFALS (AFLGC-IGFALS)
-
Boster Bio Antibodies for IGFALS
-
Santa Cruz Biotechnology (SCBT) Antibodies for IGFALS
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFALS
- Origene Custom Protein Services for IGFALS
- antibodies-online: Show 6 available IGFALS Proteins ranked by validation data
- Compare Top IGFALS Proteins
-
Quality Products:
-
Abcam proteins for IGFALS
Assay Products
- BioLegend Human IGFALS ELISA MAX(TM) Deluxe
- Novus Biologicals ELISA Kits for IGFALS
- antibodies-online: Show 21 available IGFALS Elisa Kits ranked by validation data
- Compare Top IGFALS Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for IGFALS
No data available for DME Specific Peptides for IGFALS Gene
Domains & Families for IGFALS Gene
Gene Families for IGFALS Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IGFALS Gene
- InterPro:
- Blocks:
-
- Cysteine-rich flanking region, N-terminal
- Leucine-rich repeat signature
- Cysteine-rich flanking region, C-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for IGFALS Gene
- GenScript: Design optimal peptide antigens:
-
- Insulin-like growth factor-binding protein complex acid labile subunit (ALS_HUMAN)
- Insulin-like growth factor binding protein, acid labile subunit (Q8TAY0_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGFALS Gene
Function for IGFALS Gene
Molecular function for IGFALS Gene
- UniProtKB/Swiss-Prot Function:
- Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
Phenotypes From GWAS Catalog for IGFALS Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
| GO:0005520 | insulin-like growth factor binding | IBA | 21873635 |
Phenotypes for IGFALS Gene
- MGI mutant phenotypes for IGFALS:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IGFALS:
Animal Models for IGFALS Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IGFALS - Select products 50% OFF >
- * IGFALS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IGFALS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFALS
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFALS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFALS
- Browse OriGene Inhibitory RNA Products For IGFALS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFALS
Clone Products
- Applied Biological Materials (abm): Clones for IGFALS - Select products 50% OFF >
- * IGFALS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IGFALS
- Addgene plasmids for IGFALS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFALS
Cell Line Products
-
Horizon Cell Lines for IGFALS
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for IGFALS Gene
Localization for IGFALS Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGFALS Gene
- Secreted, extracellular space.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS,IBA | 21873635 |
| GO:0031012 | extracellular matrix | IBA | 21873635 |
| GO:0042567 | insulin-like growth factor ternary complex | IBA,IDA | 9497324 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGFALS Gene
Pathways & Interactions for IGFALS Gene
Pathways by source for IGFALS Gene
2 Reactome pathways for IGFALS Gene
1 KEGG pathway for IGFALS Gene
Interacting Proteins for IGFALS Gene
GPS-Prot Interaction Network for IGFALS
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007155 | cell adhesion | IEA | -- |
| GO:0007165 | signal transduction | TAS | 1384485 |
| GO:0044267 | cellular protein metabolic process | TAS | -- |
No data available for SIGNOR curated interactions for IGFALS Gene
Drugs & Compounds for IGFALS Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Copper | Approved, Investigational | Pharma | Target | 249 | ||
| Mecasermin | Approved, Investigational | Pharma | Carrier | 36 | ||
| Zinc | Approved, Investigational | Pharma | Target | 1594 | ||
| zinc acetate | Approved, Investigational | Pharma | Target | 0 | ||
| Zinc chloride | Approved, Investigational | Pharma | Target, inducer | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for IGFALS Gene
mRNA/cDNA for IGFALS Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000215539 2058 nts (view in UCSC)
- ENST00000415638 2136 nts (view in UCSC)
- ENST00000568221 730 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IGFALS - Select products 50% OFF >
- * IGFALS CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IGFALS
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFALS
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGFALS
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGFALS
- Browse OriGene Inhibitory RNA Products For IGFALS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFALS
Clone Products
- Applied Biological Materials (abm): Clones for IGFALS - Select products 50% OFF >
- * IGFALS as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for IGFALS
- Addgene plasmids for IGFALS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFALS
Relevant External Links for IGFALS Gene
- GeneLoc Exon Structure for
- IGFALS
Expression for IGFALS Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Visceral White Adipocytes Visceral White Adipose
- Body Subcutaneous White Adipose
- Visceral White Adipose
- Inner Cell Mass (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for IGFALS Gene
This gene is overexpressed in Liver (x38.2).
This gene is overexpressed in Serum (33.9), Plasma (11.2), and Synovial fluid (10.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGFALS Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGFALS
SOURCE GeneReport for Unigene cluster for IGFALS Gene:
Hs.839mRNA Expression by UniProt/SwissProt for IGFALS Gene:
P35858-ALS_HUMAN
Tissue specificity:
Plasma.
Evidence on tissue expression from TISSUES for IGFALS Gene
- Liver(4.6)
- Bone marrow(4.2)
- Blood(2.3)
- Nervous system(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFALS Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- endocrine
- nervous
- reproductive
- urinary
Regions:
Head and neck:
- brain
- eye
- head
Abdomen:
- kidney
- pancreas
Pelvis:
- fallopian tube
- ovary
- penis
- prostate
- testicle
- uterus
- vagina
- vas deferens
- vulva
General:
- blood vessel
- peripheral nerve
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for IGFALS
-
OriGene qPCR primer pairs and template standards for IGFALS
Gene Expression Assay Products
Orthologs for IGFALS Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IGFALS 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IGFALS 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IGFALS 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Igfals 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Igfals 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | IGFALS 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IGFALS 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IGFALS 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IGFALS 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | igfals 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-66h3.1 30 |
|
||
| IGFALS 31 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007059 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Toll-7 32 |
|
|
|
| CG7896 32 |
|
|
|||
| 18w 32 |
|
|
|||
| BG:DS03192.2 32 |
|
|
|||
| CG8561 32 |
|
|
|||
| trn 32 |
|
|
|||
| CG5195 32 |
|
|
|||
| CG6749 32 |
|
|
|||
| Tollo 32 |
|
|
|||
| CG9562 32 |
|
|
|||
| haf 31 |
|
OneToMany |
- Species where no ortholog for IGFALS was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IGFALS Gene
- ENSEMBL:
- Gene Tree for IGFALS (if available)
- TreeFam:
- Gene Tree for IGFALS (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IGFALS: view image
Paralogs for IGFALS Gene
Paralogs for IGFALS Gene
(1) SIMAP similar genes for IGFALS Gene using alignment to 3 proteins:
- ALS_HUMAN
- H3BSX8_HUMAN
- Q8TAY0_HUMAN
Pseudogenes.org Pseudogenes for IGFALS Gene
Variants for IGFALS Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGFALS Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711955 | Benign: not provided | 1,790,957(-) | C/A | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 714690 | Benign: not provided | 1,792,405(-) | C/CG | FRAMESHIFT_VARIANT,INTRON_VARIANT | |
| 716575 | Likely Benign: not provided | 1,792,067(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT | |
| 718756 | Conflicting Interpretations: Acid-labile subunit deficiency; not provided | 1,790,982(-) | C/T | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 723901 | Likely Benign: not provided | 1,790,849(-) | C/T | NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4856n54 | CNV | loss | 21841781 |
| esv2422427 | CNV | duplication | 17116639 |
| nsv1042986 | CNV | loss | 25217958 |
| nsv1051692 | CNV | loss | 25217958 |
| nsv1160328 | CNV | deletion | 26073780 |
| nsv457336 | CNV | loss | 19166990 |
| nsv471069 | CNV | loss | 18288195 |
| nsv482185 | CNV | gain | 20164927 |
| nsv517196 | CNV | gain+loss | 19592680 |
| nsv518641 | CNV | loss | 19592680 |
| nsv571170 | CNV | loss | 21841781 |
| nsv571171 | CNV | gain+loss | 21841781 |
| nsv571172 | CNV | loss | 21841781 |
| nsv827500 | CNV | gain | 20364138 |
| nsv952900 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.56;
64.99% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGFALS Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFALS Gene
Disorders for IGFALS Gene
(4) MalaCards diseases for IGFALS Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acid-labile subunit deficiency |
|
|
| laron syndrome |
|
|
| body dysmorphic disorder |
|
|
| amyotrophic lateral sclerosis 1 |
|
|
Search IGFALS in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ALS_HUMAN- Acid-labile subunit deficiency (ACLSD) [MIM:615961]: A disorder characterized by severely reduced serum IGF-I and IGFBP-3 concentrations and mild growth retardation. Pubertal delay in boys and insulin insensitivity are common findings. {ECO:0000269 PubMed:14762184, ECO:0000269 PubMed:16507628, ECO:0000269 PubMed:17726072, ECO:0000269 PubMed:18303074, ECO:0000269 PubMed:19129715, ECO:0000269 PubMed:20389102, ECO:0000269 PubMed:21396577, ECO:0000269 PubMed:23488611}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for IGFALS
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for IGFALS Gene
Publications for IGFALS Gene
- Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density. (PMID: 20302654) Biong M … Kristensen VN (BMC medical genomics 2010) 3 23 41
- Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins. (PMID: 19129715) Fofanova-Gambetti OV … Rosenfeld RG (Hormone research 2009) 3 4 23
- Primary acid-labile subunit deficiency due to recessive IGFALS mutations results in postnatal growth deficit associated with low circulating insulin growth factor (IGF)-I, IGF binding protein-3 levels, and hyperinsulinemia. (PMID: 18303074) Heath KE … Campos-Barros A (The Journal of clinical endocrinology and metabolism 2008) 3 4 23
- Risk of testicular germ cell tumors and polymorphisms in the insulin-like growth factor genes. (PMID: 18349294) Chia VM … McGlynn KA (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 23 41
- Phenotypic effects of null and haploinsufficiency of acid-labile subunit in a family with two novel IGFALS gene mutations. (PMID: 17726072) Domené HM … Jasper HG (The Journal of clinical endocrinology and metabolism 2007) 3 4 23
ExternalLinks
Products for IGFALS Gene
- View all 5 R&D Systems IGFALS (IGFALS/ALS) Products
- View all R&D Systems IGFALS (IGFALS/ALS) Proteins and Enzymes
- View all 3 R&D Systems IGFALS (IGFALS/ALS) Primary Antibodies
- View all R&D Systems IGFALS (IGFALS/ALS) cDNA Clones
- Learn more about R&D Systems custom IGFALS antibody, protein, and immunoassay development services
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for IGFALS
- Origene Custom Protein Services for IGFALS
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- Browse OriGene Inhibitory RNA Products For IGFALS
- OriGene qPCR primer pairs for IGFALS
- OriGene qPCR primer pairs and template standards for IGFALS
- OriGene CRISPR knockouts for IGFALS
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for IGFALS
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for IGFALS
- Novus Biologicals proteins and lysates for IGFALS
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- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IGFALS
- Abcam proteins for IGFALS
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for IGFALS (AFLGC-IGFALS)
- VectorBuilder Custom and pre-made DNA vectors for IGFALS (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IGFALS (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IGFALS (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IGFALS CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IGFALS
- Addgene plasmids for IGFALS
- antibodies-online: Show 10 available IGFALS Antibodies ranked by validation data
- Compare Top IGFALS Antibodies
- antibodies-online: Show 21 available IGFALS Elisa Kits ranked by validation data
- Compare Top IGFALS Elisa Kits
- Quality Products:
- antibodies-online: Show 6 available IGFALS Proteins ranked by validation data
- Compare Top IGFALS Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for IGFALS
- Search Santa Cruz Biotechnology (SCBT) for IGFALS siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IGFALS
- Horizon Cell Lines for IGFALS
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGFALS
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGFALS
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IGFALS
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGFALS
- Boster Bio Antibodies for IGFALS
- Browse Boster Bio ELISA Kits
- Signalway ELISA kits for IGFALS
Sources for IGFALS Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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