Aliases for IGF2R Gene
- Insulin Like Growth Factor 2 Receptor 2 3 5
- MPRI 2 3 4
- Cation-Independent Mannose-6-Phosphate Receptor 3 4
- Insulin-Like Growth Factor II Receptor 3 4
- Insulin-Like Growth Factor 2 Receptor 2 4
- 300 KDa Mannose 6-Phosphate Receptor 3 4
- CI Man-6-P Receptor 3 4
- M6P/IGF2 Receptor 3 4
- IGF-II Receptor 3 4
- M6P/IGF2R 3 4
- CI-M6PR 2 3
External Ids for IGF2R Gene
Previous GeneCards Identifiers for IGF2R Gene
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
GeneCards Summary for IGF2R Gene
IGF2R (Insulin Like Growth Factor 2 Receptor) is a Protein Coding gene. Diseases associated with IGF2R include Hepatocellular Carcinoma and Adult Hepatocellular Carcinoma. Among its related pathways are Lysosome and Retrograde transport at the Trans-Golgi-Network. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and enzyme binding.
UniProtKB/Swiss-Prot Summary for IGF2R Gene
Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005).
Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IR homodimers are activated by insulin.