Aliases for IGF2R Gene
Aliases for IGF2R Gene
- Insulin Like Growth Factor 2 Receptor 2 3 5
- Insulin-Like Growth Factor II Receptor 3 4
- Insulin-Like Growth Factor 2 Receptor 2 4
- 300 KDa Mannose 6-Phosphate Receptor 3 4
- CI Man-6-P Receptor 3 4
- M6P/IGF2 Receptor 3 4
- IGF-II Receptor 3 4
- M6P/IGF2R 3 4
- MPR 300 3 4
- MPRI 3 4
- Cation-Independent Mannose-6-Phosphate Receptor 3
External Ids for IGF2R Gene
- HGNC: 5467
- Entrez Gene: 3482
- Ensembl: ENSG00000197081
- OMIM: 147280
- UniProtKB: P11717
Previous GeneCards Identifiers for IGF2R Gene
- GC06P159829
- GC06P160263
- GC06P160299
- GC06P160360
- GC06P160310
- GC06P160390
- GC06P157860
Summaries for IGF2R Gene
-
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
GeneCards Summary for IGF2R Gene
IGF2R (Insulin Like Growth Factor 2 Receptor) is a Protein Coding gene. Diseases associated with IGF2R include Hepatocellular Carcinoma and Mucolipidosis Ii Alpha/Beta. Among its related pathways are mTOR Pathway and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and enzyme binding.
UniProtKB/Swiss-Prot for IGF2R Gene
-
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
-
Insulin receptors (IRs) and insulin-like growth factor receptors (IGFRs) are formed from two subunits, each of which is comprised of an extracellular alpha-subunit and a transmembrane beta-subunit with intracellular tyrosine kinase activity. IR homodimers are activated by insulin.
Additional gene information for IGF2R Gene
- Monarch Initiative
- Search for IGF2R at DataMed
- Search for IGF2R at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2R Gene
Genomics for IGF2R Gene
GeneHancer (GH) Regulatory Elements for IGF2R Gene
Promoters and enhancers for IGF2R Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IGF2R on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IGF2R gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- c-Fos
- SRY
- Sox5
- ER-alpha
Regulatory Element Products
Genomic Locations for IGF2R Gene
Genomic Locations for IGF2R Gene
- chr6:159,969,099-160,113,507
- (GRCh38/hg38)
- Size:
- 144,409 bases
- Orientation:
- Plus strand
- chr6:160,390,131-160,534,539
- (GRCh37/hg19)
- Size:
- 144,409 bases
- Orientation:
- Plus strand
Genomic View for IGF2R Gene
Genes around IGF2R on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q25.3 by Entrez Gene
- 6q25.3 by HGNC
- 6q25.3 by Ensembl
IGF2R Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGF2R Gene
Proteins for IGF2R Gene
-
Protein details for IGF2R Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11717-MPRI_HUMAN
- Recommended name:
- Cation-independent mannose-6-phosphate receptor
- Protein Accession:
- P11717
- Q7Z7G9
- Q96PT5
Protein attributes for IGF2R Gene
- Size:
- 2491 amino acids
- Molecular mass:
- 274375 Da
- Quaternary structure:
-
- Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.
Protein Expression for IGF2R Gene
Post-translational modifications for IGF2R Gene
Other Protein References for IGF2R Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IGF2R (IGF-II R)
-
Custom Antibody ServicesOriGene Antibodies for IGF2R
- Novus Biologicals Antibodies for IGF2R
-
Abcam antibodies for IGF2R
- Invitrogen Antibodies for IGF2R (AFLGC-IGF2R)
- GeneTex IGF2R Antibody for IGF2R
-
Custom Antibody ServicesProSci Antibodies for IGF2R
-
Santa Cruz Biotechnology (SCBT) Antibodies for IGF2R
- Sino Biological Antibodies for IGF2R
Protein Products
- R&D Systems Proteins and Enzymes for IGF2R (IGF-II R)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for IGF2R
- Origene Custom Protein Services for IGF2R
- Novus Biologicals proteins for IGF2R
- Search GeneTex for Proteins for IGF2R
-
Abcam proteins for IGF2R
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for IGF2R
- R&D Systems ELISAs and other biochemical assays for IGF2R (IGF-II R)
-
Boster Bio ELISA Kits for IGF2R
-
Abcam assays for IGF2R
No data available for DME Specific Peptides for IGF2R Gene
Domains & Families for IGF2R Gene
Gene Families for IGF2R Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IGF2R Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IGF2R Gene
Graphical View of Domain Structure for InterPro Entry
P11717UniProtKB/Swiss-Prot:
MPRI_HUMAN :- Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.
- Belongs to the MRL1/IGF2R family.
- Domain:
-
- Contains 15 repeating units of approximately 147 AA harboring four disulfide bonds each. The most highly conserved region within the repeat consists of a stretch of 13 AA that contains cysteines at both ends.
- Family:
-
- Belongs to the MRL1/IGF2R family.
Function for IGF2R Gene
Molecular function for IGF2R Gene
- UniProtKB/Swiss-Prot Function:
- Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.
- GENATLAS Biochemistry:
- insulin-like growth factor 2,300kDa,non mitogenic receptor interacting with retinoic acid,targetting IGF2 to the lysosomes for degradation,imprinted in a proportion of normal individuals,involved in suppression of breast,tumor and promyelocytic leukemia (see TSG6C) and gastric carcinomas,mutated in endometrial atypical hyperplasia and other cancers (alteration of ligand binding)
Phenotypes From GWAS Catalog for IGF2R Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001965 | G-protein alpha-subunit binding | IEA | -- |
| GO:0001972 | retinoic acid binding | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0005010 | insulin-like growth factor-activated receptor activity | TAS | 10799489 |
| GO:0005515 | protein binding | IDA,IPI | 10900005 |
Phenotypes for IGF2R Gene
- MGI mutant phenotypes for IGF2R:
-
inferred from 8 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- liver/biliary system phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- renal/urinary system phenotype
- hematopoietic system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for IGF2R:
Animal Models for IGF2R Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IGF2R
-
CRISPR Products
-
OriGene CRISPR knockouts for IGF2R
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGF2R
- genomics-online: gRNA clones - Search results for 66 available IGF2R gene related products
- Overview of 66 available IGF2R gene related products
- Applied Biological Materials CRISPR for IGF2R
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGF2R
- GenScript: Design CRISPR guide RNA sequences for IGF2R
miRNA for IGF2R Gene
- miRTarBase miRNAs that target IGF2R
-
- hsa-mir-16-5p (MIRT001451)
- hsa-mir-657 (MIRT016136)
- hsa-mir-155-5p (MIRT020747)
- hsa-mir-9-5p (MIRT021356)
- hsa-mir-26b-5p (MIRT029460)
- hsa-mir-1271-5p (MIRT036067)
- hsa-mir-423-3p (MIRT042556)
- hsa-mir-128-3p (MIRT045878)
- hsa-mir-211-5p (MIRT054454)
- hsa-mir-545-5p (MIRT316722)
- hsa-mir-412-3p (MIRT440461)
- hsa-mir-377-3p (MIRT440462)
- hsa-mir-218-5p (MIRT440463)
- hsa-mir-96-3p (MIRT457092)
- hsa-mir-2681-3p (MIRT457093)
- hsa-mir-548m (MIRT457094)
- hsa-mir-8485 (MIRT607437)
- hsa-mir-7977 (MIRT672614)
- hsa-mir-4284 (MIRT672616)
- hsa-mir-24-3p (MIRT672617)
- hsa-mir-564 (MIRT672618)
- hsa-mir-6860 (MIRT672619)
- hsa-mir-612 (MIRT672620)
- hsa-mir-5189-5p (MIRT672621)
- hsa-mir-3187-5p (MIRT672622)
- hsa-mir-1285-3p (MIRT672623)
- hsa-mir-383-3p (MIRT672624)
- hsa-mir-342-3p (MIRT672625)
- hsa-mir-6777-3p (MIRT672626)
- hsa-mir-6089 (MIRT679245)
- hsa-mir-561-5p (MIRT713895)
- hsa-mir-6715b-3p (MIRT713896)
- hsa-mir-4742-3p (MIRT713897)
- hsa-mir-6715a-3p (MIRT713898)
- hsa-mir-1178-5p (MIRT713899)
- hsa-mir-649 (MIRT713900)
- hsa-mir-106a-3p (MIRT713901)
- hsa-mir-1296-5p (MIRT713902)
- hsa-mir-6877-5p (MIRT713903)
- hsa-mir-4480 (MIRT713904)
- hsa-mir-5008-5p (MIRT713905)
- hsa-mir-3146 (MIRT713906)
- hsa-mir-454-3p (MIRT713907)
- hsa-mir-4295 (MIRT713908)
- hsa-mir-3666 (MIRT713909)
- hsa-mir-301b-3p (MIRT713910)
- hsa-mir-301a-3p (MIRT713911)
- hsa-mir-130b-3p (MIRT713912)
- hsa-mir-130a-3p (MIRT713913)
- hsa-mir-4512 (MIRT713914)
- hsa-mir-6895-5p (MIRT713915)
- hsa-mir-519c-3p (MIRT713916)
- hsa-mir-519b-3p (MIRT713917)
- hsa-mir-519a-3p (MIRT713918)
- hsa-mir-1247-3p (MIRT736383)
- hsa-mir-1827 (MIRT738111)
- hsa-mir-1910-3p (MIRT738412)
- hsa-mir-3612 (MIRT741575)
- hsa-mir-4537 (MIRT746089)
- hsa-mir-455-3p (MIRT746183)
- hsa-mir-4756-3p (MIRT748386)
- hsa-mir-5186 (MIRT749830)
- hsa-mir-5694 (MIRT751245)
- hsa-mir-6499-3p (MIRT752798)
- hsa-mir-650 (MIRT753023)
- hsa-mir-6511a-5p (MIRT753137)
- hsa-mir-6516-5p (MIRT753343)
- hsa-mir-4252 (MIRT768002)
- hsa-mir-4719 (MIRT786518)
- hsa-mir-551b-5p (MIRT787617)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGF2R
- Browse OriGene Inhibitory RNA Products For IGF2R
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGF2R
- genomics-online: shRNA clones - Search results for 66 available IGF2R gene related products
- Overview of 66 available IGF2R gene related products
Clone Products
-
OriGene ORF clones in human for IGF2R
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGF2R
- Applied Biological Materials Clones for IGF2R
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IGF2R
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IGF2R Gene
Localization for IGF2R Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGF2R Gene
- Lysosome membrane; Single-pass type I membrane protein. Note=Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| nucleus | 4 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Golgi apparatus (4)
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005641 | nuclear envelope lumen | IEA | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA | -- |
Pathways & Interactions for IGF2R Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
.74
|
.66
.65
.61
.60
|
| 2 | Apoptosis Pathway |
.39
|
|
| 3 | Clathrin derived vesicle budding | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | MAPK Signaling: Mitogen Stimulation Pathway | ||
Pathways by source for IGF2R Gene
12 Reactome pathways for IGF2R Gene
2 KEGG pathways for IGF2R Gene
3 R&D Systems pathways for IGF2R Gene
5 Tocris pathways for IGF2R Gene
23 Qiagen pathways for IGF2R Gene
2 Cell Signaling Technology pathways for IGF2R Gene
Interacting Proteins for IGF2R Gene
Selected Interacting proteins:
P11717-MPRI_HUMAN
ENSP00000349437
for IGF2R Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for IGF2R
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001889 | liver development | IEA | -- |
| GO:0006898 | receptor-mediated endocytosis | TAS | 10799489 |
| GO:0007041 | lysosomal transport | IEA | -- |
| GO:0007165 | signal transduction | TAS | 7753549 |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
Drugs & Compounds for IGF2R Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cerliponase alfa | Approved, Investigational | Pharma | Target, ligand | 0 | ||
| Mecasermin | Approved, Investigational | Pharma | Target | 0 | ||
| alpha-D-mannose 6-phosphate | Experimental | Pharma | Target | 0 | ||
| mannose | Investigational | Pharma | 0 | |||
| Mannose 6-phosphate | Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| GSK 1838705 |
|
1116235-97-2 |
|
|
||
| Insulin (human) recombinant |
|
11061-68-0 |
|
|
||
| Picropodophyllotoxin |
|
477-47-4 |
|
|
(5) Tocris Compounds for IGF2R Gene
| Compound | Action | Cas Number |
|---|---|---|
| Demethylasterriquinone B1 | Selective insulin RTK activator | 78860-34-1 |
| GSK 1838705 | Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK) | 1116235-97-2 |
| Insulin (human) recombinant | Endogenous peptide agonist | 11061-68-0 |
| Picropodophyllotoxin | Selective IGF1R inhibitor | 477-47-4 |
| PQ 401 | IGF1R inhibitor | 196868-63-0 |
Drug Products
Transcripts for IGF2R Gene
mRNA/cDNA for IGF2R Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (411) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000356956 14044 bps (uc003qta.4)
- ENST00000464636 570 bps (uc063sqj.1)
- ENST00000487607 359 bps (uc063sqk.1)
- ENST00000475834 758 bps (uc063sql.1)
- ENST00000475584 597 bps (uc063sqm.1)
Unigene Clusters for IGF2R Gene
CRISPR Products
-
OriGene CRISPR knockouts for IGF2R
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGF2R
- genomics-online: gRNA clones - Search results for 66 available IGF2R gene related products
- Overview of 66 available IGF2R gene related products
- Applied Biological Materials CRISPR for IGF2R
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGF2R
- GenScript: Design CRISPR guide RNA sequences for IGF2R
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGF2R
- Browse OriGene Inhibitory RNA Products For IGF2R
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGF2R
- genomics-online: shRNA clones - Search results for 66 available IGF2R gene related products
- Overview of 66 available IGF2R gene related products
Clone Products
-
OriGene ORF clones in human for IGF2R
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGF2R
- Applied Biological Materials Clones for IGF2R
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IGF2R Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Zygote (Early Embryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Inner Cell Mass (Early Embryo)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Trophoblast (Extraembryonic Tissues)
- Zygote Zygote
- Morula Cells Morula
- 8-Cell Embryo Morula
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for IGF2R Gene
This gene is overexpressed in Whole Blood (x4.9) and Muscle - Skeletal (x4.6).
This gene is overexpressed in Serum (23.2), Peripheral blood mononuclear cells (7.8), and Amniocyte (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGF2R Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IGF2R Gene:
IGF2RSOURCE GeneReport for Unigene cluster for IGF2R Gene:
Hs.487062Evidence on tissue expression from TISSUES for IGF2R Gene
- Liver(4.8)
- Blood(4.6)
- Nervous system(3.6)
- Lung(3.3)
- Kidney(3.2)
- Intestine(3.1)
- Heart(2.9)
- Muscle(2.9)
- Adrenal gland(2.6)
- Pancreas(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IGF2R Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
- urinary
Regions:
Head and neck:
- brain
- head
- mouth
- salivary gland
Thorax:
- breast
- esophagus
Abdomen:
- kidney
- liver
- spleen
Pelvis:
- testicle
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood vessel
- coagulation system
- skin
Primer Products
-
OriGene qPCR primer pairs for IGF2R
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for IGF2R Gene
Orthologs for IGF2R Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IGF2R 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CI-MPR/IGF2R 34 |
|
OneToOne | |
| IGF2R 33 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Igf2r 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Igf2r 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | IGF2R 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| M6P/IGF2R 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | IGF2R 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IGF2R 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | igf2r 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2029 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | igf2r 34 33 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5040 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Lerp 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MRL1 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for IGF2R was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IGF2R Gene
- ENSEMBL:
- Gene Tree for IGF2R (if available)
- TreeFam:
- Gene Tree for IGF2R (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IGF2R: view image
Paralogs for IGF2R Gene
No data available for Paralogs for IGF2R Gene
Variants for IGF2R Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs121434587 | pathogenic, Hepatocellular carcinoma | 160,069,961(+) | G/T | coding_sequence_variant, missense_variant | |
| rs121434588 | pathogenic, Hepatocellular carcinoma | 160,070,006(+) | G/A | coding_sequence_variant, missense_variant | |
| rs193920850 | uncertain-significance, Malignant tumor of prostate | 160,062,621(+) | T/C | splice_donor_variant | |
| rs8191933 | benign, not specified | 160,096,440(+) | C/T | coding_sequence_variant, synonymous_variant | |
| rs1000044342 | -- | 160,105,222(+) | G/A | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1844e212 | CNV | loss | 25503493 |
| esv1004150 | CNV | deletion | 20482838 |
| esv1551954 | CNV | insertion | 17803354 |
| esv1707140 | CNV | deletion | 17803354 |
| esv23071 | CNV | loss | 19812545 |
| esv2664271 | CNV | deletion | 23128226 |
| esv2733038 | CNV | deletion | 23290073 |
| esv2733039 | CNV | deletion | 23290073 |
| esv2733041 | CNV | deletion | 23290073 |
| esv2733042 | CNV | deletion | 23290073 |
| esv2733043 | CNV | deletion | 23290073 |
| esv2733044 | CNV | deletion | 23290073 |
| esv2733045 | CNV | deletion | 23290073 |
| esv2759484 | CNV | gain+loss | 17122850 |
| esv28288 | CNV | loss | 19812545 |
| esv35098 | CNV | gain | 17911159 |
| esv3611425 | CNV | gain | 21293372 |
| esv3611426 | CNV | loss | 21293372 |
| nsv1074029 | CNV | deletion | 25765185 |
| nsv1074441 | CNV | deletion | 25765185 |
| nsv1126082 | CNV | deletion | 24896259 |
| nsv1140374 | OTHER | inversion | 24896259 |
| nsv472314 | CNV | novel sequence insertion | 20440878 |
| nsv5564 | CNV | insertion | 18451855 |
| nsv604996 | CNV | loss | 21841781 |
| nsv818463 | CNV | gain | 17921354 |
Residual Variation Intolerance Score:
5.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.16;
92.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGF2R Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF2R Gene
Disorders for IGF2R Gene
(7) MalaCards diseases for IGF2R Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatocellular carcinoma |
|
|
| mucolipidosis ii alpha/beta |
|
|
| inclusion-cell disease |
|
|
| glycogen storage disease ii |
|
|
| cerebral palsy, ataxic, autosomal recessive |
|
|
Search IGF2R in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IGF2R
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IGF2R Gene
Publications for IGF2R Gene
- IGF2R missense single-nucleotide polymorphisms and breast cancer risk: the multiethnic cohort study. (PMID: 19435860) Cheng I … Haiman CA (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 44 58
- The 3' UTR IGF2R-A2/B2 variant is associated with increased tumor growth and advanced stages in non-small cell lung cancer. (PMID: 18037232) Kotsinas A … Gorgoulis VG (Cancer letters 2008) 3 22 44 58
- Structure and functional analysis of the IGF-II/IGF2R interaction. (PMID: 18046459) Brown J … Jones EY (The EMBO journal 2008) 3 4 22 58
- Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height. (PMID: 16172012) Petry CJ … Alspac Study Team (Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 2005) 3 22 44 58
- Lack of association of birth size with polymorphisms of two imprinted genes, IGF2R and GRB10. (PMID: 15506681) Kukuvitis A … Polychronakos C (Journal of pediatric endocrinology & metabolism : JPEM 2004) 3 22 44 58
Products for IGF2R Gene
- R&D Systems Antibodies for IGF2R (IGF-II R)
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- antibodies-online: Search results for 142 available IGF2R Antibodies ranked by validation data
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- antibodies-online: Search results for 10 available IGF2R Proteins ranked by validation data
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- GeneTex IGF2R Antibody for IGF2R
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- Horizon Cell Lines for IGF2R
- genomics-online: cdna clones - Search results for 66 available IGF2R gene related products
- Overview of 66 available IGF2R gene related products
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- Overview of 66 available IGF2R gene related products
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Sources for IGF2R Gene
- (1) GeneCards
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- (73) Reactome
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