This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [prov... See more...

Aliases for IGF2BP2 Gene

Aliases for IGF2BP2 Gene

  • Insulin Like Growth Factor 2 MRNA Binding Protein 2 2 3 5
  • Insulin-Like Growth Factor 2 MRNA-Binding Protein 2 3 4
  • IGF-II MRNA-Binding Protein 2 3 4
  • IGF2 MRNA-Binding Protein 2 3 4
  • VICKZ Family Member 2 3 4
  • VICKZ2 3 4
  • IMP-2 3 4
  • IMP2 3 4
  • Insulin-Like Growth Factor 2 MRNA Binding Protein 2 2
  • Hepatocellular Carcinoma Autoantigen P62 4
  • IGF II MRNA Binding Protein 2 2

External Ids for IGF2BP2 Gene

Previous GeneCards Identifiers for IGF2BP2 Gene

  • GC03M186845
  • GC03M185361
  • GC03M182771

Summaries for IGF2BP2 Gene

Entrez Gene Summary for IGF2BP2 Gene

  • This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

GeneCards Summary for IGF2BP2 Gene

IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) is a Protein Coding gene. Diseases associated with IGF2BP2 include Diabetes Mellitus, Noninsulin-Dependent and Rare Diabetes Mellitus Type 2. Among its related pathways are Gene Expression and MAPK-Erk Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is IGF2BP1.

UniProtKB/Swiss-Prot Summary for IGF2BP2 Gene

  • RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Gene Wiki entry for IGF2BP2 Gene

Additional gene information for IGF2BP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGF2BP2 Gene

Genomics for IGF2BP2 Gene

GeneHancer (GH) Regulatory Elements for IGF2BP2 Gene

Promoters and enhancers for IGF2BP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGF2BP2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGF2BP2

Top Transcription factor binding sites by QIAGEN in the IGF2BP2 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for IGF2BP2 Gene

Genomic Locations for IGF2BP2 Gene
chr3:185,643,131-185,825,056
(GRCh38/hg38)
Size:
181,926 bases
Orientation:
Minus strand
chr3:185,361,527-185,542,844
(GRCh37/hg19)
Size:
181,318 bases
Orientation:
Minus strand

Genomic View for IGF2BP2 Gene

Genes around IGF2BP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGF2BP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGF2BP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2BP2 Gene

Proteins for IGF2BP2 Gene

  • Protein details for IGF2BP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M1-IF2B2_HUMAN
    Recommended name:
    Insulin-like growth factor 2 mRNA-binding protein 2
    Protein Accession:
    Q9Y6M1
    Secondary Accessions:
    • A0A4Z0
    • B3FTN2
    • B3FTN3
    • B3FTN4

    Protein attributes for IGF2BP2 Gene

    Size:
    599 amino acids
    Molecular mass:
    66121 Da
    Quaternary structure:
    • Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner. Interacts with HNRPD and IGF2BP1. Interacts with ELAVL1, DHX9 and HNRNPU.
    Miscellaneous:
    • Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
    • [Isoform 6]: Generated by alternative initiation at Met-69.
    SequenceCaution:
    • Sequence=AAH21290.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGF2BP2 Gene

    Alternative splice isoforms for IGF2BP2 Gene

neXtProt entry for IGF2BP2 Gene

Post-translational modifications for IGF2BP2 Gene

  • Ubiquitination at Lys278 and Lys462
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IGF2BP2 Gene

Domains & Families for IGF2BP2 Gene

Gene Families for IGF2BP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for IGF2BP2 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • KH, type 1
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGF2BP2 Gene

GenScript: Design optimal peptide antigens:
  • Truncated insulin-like 2 growth factor 2-binding protein 2 (B3FTN5_HUMAN)
  • VICKZ family member 2 (IF2B2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6M1

UniProtKB/Swiss-Prot:

IF2B2_HUMAN :
  • Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.
  • Belongs to the RRM IMP/VICKZ family.
Domain:
  • Domain KH3 and KH4 are the major RNA-binding modules, although KH1 and KH2 may also contribute. The contribution to RNA-binding of individual KH domains may be target-specific. KH1 and KH2, and possibly KH3 and KH4, promote the formation of higher ordered protein-RNA complexes, which may be essential for IGF2BP1 cytoplasmic retention. KH domains are required for RNA-dependent homo- and heterooligomerization and for localization to stress granules.
Family:
  • Belongs to the RRM IMP/VICKZ family.
genes like me logo Genes that share domains with IGF2BP2: view

Function for IGF2BP2 Gene

Molecular function for IGF2BP2 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Phenotypes From GWAS Catalog for IGF2BP2 Gene

Gene Ontology (GO) - Molecular Function for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003729 mRNA binding IEA --
GO:0003730 mRNA 3'-UTR binding IDA 20080952
GO:0005515 protein binding IPI 12674497
GO:0045182 translation regulator activity ISS 9891060
genes like me logo Genes that share ontologies with IGF2BP2: view
genes like me logo Genes that share phenotypes with IGF2BP2: view

Human Phenotype Ontology for IGF2BP2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IGF2BP2 Gene

MGI Knock Outs for IGF2BP2:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IGF2BP2 Gene

Localization for IGF2BP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGF2BP2 Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGF2BP2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 15618018
GO:0005737 cytoplasm IEA,IDA 15618018
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IDA 15618018
genes like me logo Genes that share ontologies with IGF2BP2: view

Pathways & Interactions for IGF2BP2 Gene

genes like me logo Genes that share pathways with IGF2BP2: view

Pathways by source for IGF2BP2 Gene

1 Cell Signaling Technology pathway for IGF2BP2 Gene

Gene Ontology (GO) - Biological Process for IGF2BP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0009653 anatomical structure morphogenesis TAS 9891060
GO:0017148 negative regulation of translation ISS 9891060
GO:0042035 regulation of cytokine biosynthetic process IC 9891060
GO:0043488 regulation of mRNA stability TAS --
genes like me logo Genes that share ontologies with IGF2BP2: view

No data available for SIGNOR curated interactions for IGF2BP2 Gene

Drugs & Compounds for IGF2BP2 Gene

(1) Drugs for IGF2BP2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Repaglinide Approved, Investigational Pharma Kir6 (KATP) channel blocker 57
genes like me logo Genes that share compounds with IGF2BP2: view

Transcripts for IGF2BP2 Gene

mRNA/cDNA for IGF2BP2 Gene

7 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2BP2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9:

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for IGF2BP2 Gene

GeneLoc Exon Structure for
IGF2BP2

Expression for IGF2BP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGF2BP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IGF2BP2 Gene

This gene is overexpressed in Liver (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGF2BP2 Gene



Protein tissue co-expression partners for IGF2BP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGF2BP2

SOURCE GeneReport for Unigene cluster for IGF2BP2 Gene:

Hs.35354

mRNA Expression by UniProt/SwissProt for IGF2BP2 Gene:

Q9Y6M1-IF2B2_HUMAN
Tissue specificity: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.

Evidence on tissue expression from TISSUES for IGF2BP2 Gene

  • Pancreas(4.5)
genes like me logo Genes that share expression patterns with IGF2BP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGF2BP2 Gene

Orthologs for IGF2BP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGF2BP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGF2BP2 31 30
  • 99.89 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IGF2BP2 31 30
  • 95.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IGF2BP2 31 30
  • 95.04 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Igf2bp2 17 31 30
  • 90.99 (n)
rat
(Rattus norvegicus)
Mammalia Igf2bp2 30
  • 90.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IGF2BP2 31
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGF2BP2 31
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGF2BP2 31 30
  • 79.91 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGF2BP2 31
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii igf2bp2a 31 30
  • 72.8 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Imp 31
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zbp-1 31
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToMany
Species where no ortholog for IGF2BP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for IGF2BP2 Gene

ENSEMBL:
Gene Tree for IGF2BP2 (if available)
TreeFam:
Gene Tree for IGF2BP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGF2BP2: view image

Paralogs for IGF2BP2 Gene

(6) SIMAP similar genes for IGF2BP2 Gene using alignment to 3 proteins:

  • IF2B2_HUMAN
  • B3FTN5_HUMAN
  • F8W930_HUMAN

Pseudogenes.org Pseudogenes for IGF2BP2 Gene

genes like me logo Genes that share paralogs with IGF2BP2: view

Variants for IGF2BP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGF2BP2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
745118 Likely Benign: not provided 185,652,112(-) T/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs4402960 Risk Factor: Diabetes mellitus type 2 185,793,899(-) G/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for IGF2BP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGF2BP2 Gene

Variant ID Type Subtype PubMed ID
dgv962e214 CNV loss 21293372
esv2670919 CNV deletion 23128226
esv2726326 CNV deletion 23290073
esv2726327 CNV deletion 23290073
esv3563023 CNV deletion 23714750
esv3598974 CNV gain 21293372
esv990977 CNV deletion 20482838
nsv1130802 CNV deletion 24896259
nsv1136788 CNV deletion 24896259
nsv1152905 CNV deletion 26484159
nsv963388 CNV duplication 23825009
nsv963389 CNV duplication 23825009
nsv965242 CNV duplication 23825009

Variation tolerance for IGF2BP2 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGF2BP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGF2BP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGF2BP2 Gene

Disorders for IGF2BP2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for IGF2BP2 Gene - From: OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • niddm
rare diabetes mellitus type 2
  • rare insulin-independent diabetes mellitus
testicular cancer
  • childhood neoplasm of the testis
diabetes mellitus
  • diabetes
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGF2BP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IGF2BP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGF2BP2 Gene

Publications for IGF2BP2 Gene

  1. IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population. (PMID: 20523342) Huang Q … Liu ZQ (Acta pharmacologica Sinica 2010) 3 23 41 54
  2. Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. (PMID: 17928989) Horikoshi M … Kadowaki T (Diabetologia 2007) 3 23 41 54
  3. A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. (PMID: 9891060) Nielsen J … Nielsen FC (Molecular and cellular biology 1999) 2 3 4 54
  4. A novel cytoplasmic protein with RNA-binding motifs is an autoantigen in human hepatocellular carcinoma. (PMID: 10190901) Zhang JY … Tan EM (The Journal of experimental medicine 1999) 2 3 4 54
  5. Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains. (PMID: 23640942) Wächter K … Hüttelmaier S (Biological chemistry 2013) 3 4 54

Products for IGF2BP2 Gene

Sources for IGF2BP2 Gene