This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative s... See more...

Aliases for IGF2-AS Gene

Subcategory (RNA class) for IGF2-AS Gene

lncRNA

Number of RNA Genes sources:

2 / 17

Aliases for IGF2-AS Gene

  • IGF2 Antisense RNA 2 3 5
  • IGF2-AS1 2 3 4
  • Insulin-Like Growth Factor 2 Antisense 1 (Non-Protein Coding) 2 3
  • IGF2 Antisense RNA 1 (Non-Protein Coding) 2 3
  • IGF2-AS 2 5
  • IGF2AS 3 4
  • PEG8 2 3
  • Putative Insulin-Like Growth Factor 2 Antisense Gene Protein 1 4
  • Putative Insulin-Like Growth Factor 2 Antisense Gene Protein 4
  • Insulin-Like Growth Factor II, Antisense 3
  • Insulin-Like Growth Factor 2, Antisense 2
  • IGF2 Antisense RNA (Non-Protein Coding) 2
  • IGF2 Antisense Gene Protein 1 4
  • PEG8/IGF2AS, Imprinting 3
  • IGF2 Antisense RNA 1 4
  • PEG8/IGF2AS Protein 4
  • NONHSAG007412.2 91
  • HSALNG0082197 164

External Ids for IGF2-AS Gene

Previous HGNC Symbols for IGF2-AS Gene

  • IGF2AS

Previous GeneCards Identifiers for IGF2-AS Gene

  • GC11P002163
  • GC11P002167
  • GC11P002171

Summaries for IGF2-AS Gene

Entrez Gene Summary for IGF2-AS Gene

  • This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for IGF2-AS Gene

IGF2-AS (IGF2 Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with IGF2-AS include Diabetes Mellitus, Type I and Wilms Tumor 1. Among its related pathways are NF-KappaB Family Pathway and GPCR Pathway.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGF2-AS Gene

Genomics for IGF2-AS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGF2-AS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002131 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.6 1605 21.1 HNRNPL GATAD2A CTCF PRDM10 TFE3 SOX13 PRDM1 RELA ZIC2 ZSCAN4 IGF2 IGF2-AS RF00483 INS-IGF2 TSSC4 CD81 ENSG00000199550 LSP1 FAM99B LINC02708
GH11J002095 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 11.5 -43.7 -43692 3.6 HNRNPL GATAD2A TEAD4 KDM1A RCOR2 RBFOX2 RXRB IRF2 SP1 EZH2 HSALNG0082189 MIR483 IGF2-AS IGF2 HSALNG0082191 MRPL23
GH11J002108 Enhancer 1 Ensembl ENCODE CraniofacialAtlas 12.6 -31.1 -31100 1.6 HNRNPL GATAD2A RBFOX2 RXRB RNF2 MBD1 TFDP1 SAP130 GABPB1 ZGPAT MIR483 IGF2-AS IGF2 TNNT3 TH piR-42694-026 HSALNG0082191 MRPL23
GH11J002089 Enhancer 0.7 Ensembl ENCODE 17.9 -50.8 -50807 0.6 KLF9 HDGF KLF8 KLF10 XRCC5 SP1 SP3 KLF1 ESRRA IGF2-AS MIR483 IGF2 HSALNG0082189 HSALNG0082184 MRPL23
GH11J002175 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +35.6 35599 1.4 MNT CREB1 MAX MAFK PAX8 KDM1A TH IGF2 IGF2-AS MIR483 ASCL2 KRTAP5-6 HSALNG0082199
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGF2-AS on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGF2-AS Gene

Genomic Locations for IGF2-AS Gene
chr11:2,140,501-2,148,666
(GRCh38/hg38)
Size:
8,166 bases
Orientation:
Plus strand
chr11:2,161,731-2,169,896
(GRCh37/hg19)
Size:
8,166 bases
Orientation:
Plus strand

Genomic View for IGF2-AS Gene

Genes around IGF2-AS on UCSC Golden Path with GeneCards custom track
IGF2-AS in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
IGF2-AS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGF2-AS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2-AS Gene

Proteins for IGF2-AS Gene

  • Protein details for IGF2-AS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U949-IG2AS_HUMAN
    Recommended name:
    Putative insulin-like growth factor 2 antisense gene protein
    Protein Accession:
    Q6U949
    Secondary Accessions:
    • A5PKV8
    • A6NNQ2
    • Q7Z712
    • Q9P2W0

    Protein attributes for IGF2-AS Gene

    Size:
    168 amino acids
    Molecular mass:
    18035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90470.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for IGF2-AS Gene

Post-translational modifications for IGF2-AS Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGF2-AS Gene

Domains & Families for IGF2-AS Gene

Gene Families for IGF2-AS Gene

Protein Domains for IGF2-AS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for IGF2-AS Gene

GenScript: Design optimal peptide antigens:
  • PEG8/IGF2AS protein (IG2AS_HUMAN)
genes like me logo Genes that share domains with IGF2-AS: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGF2-AS Gene

Function for IGF2-AS Gene

Phenotypes From GWAS Catalog for IGF2-AS Gene

genes like me logo Genes that share phenotypes with IGF2-AS: view

Animal Model Products

CRISPR Products

miRNA for IGF2-AS Gene

miRTarBase miRNAs that target IGF2-AS

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGF2-AS

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGF2-AS Gene

Localization for IGF2-AS Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGF2-AS gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IGF2-AS Gene

Pathways & Interactions for IGF2-AS Gene

PathCards logo

SuperPathways for IGF2-AS Gene

SuperPathway Contained pathways
1 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
2 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
3 ERK Signaling
.61
.61
.58
.51
.49
4 Nanog in Mammalian ESC Pluripotency
.62
.62
.59
.48
5 CREB Pathway
.68
.68
.63
.50
genes like me logo Genes that share pathways with IGF2-AS: view

Pathways by source for IGF2-AS Gene

53 Qiagen pathways for IGF2-AS Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKC through GPCR
  • Akt Signaling

Gene Ontology (GO) - Biological Process for IGF2-AS Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for IGF2-AS Gene

Drugs & Compounds for IGF2-AS Gene

No Compound Related Data Available

Transcripts for IGF2-AS Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for IGF2-AS Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000A76E5D_9606 lncRNA 2068 2

HGNC: 14062,

RefSeq: NR_028043,

URS00007815C3_9606 lncRNA 2063 1

Ensembl: ENST00000381361 (view in UCSC) ,

URS0000A7761B_9606 lncRNA 1957 1

RefSeq: NR_133657,

URS00000C9A69_9606 lncRNA 1867 1

Ensembl: ENST00000381363 (view in UCSC) ,

URS000194B7E2_9606 lncRNA 1641 1

Ensembl: ENST00000445504 (view in UCSC) ,

IGF2-AS in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for IGF2-AS Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGF2-AS

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2-AS Gene

No ASD Table

Relevant External Links for IGF2-AS Gene

GeneLoc Exon Structure for
IGF2-AS

Expression for IGF2-AS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGF2-AS Gene

mRNA differential expression in normal tissues according to GTEx for IGF2-AS Gene

This gene is overexpressed in Liver (x16.6).

Protein differential expression in normal tissues from HIPED for IGF2-AS Gene

This gene is overexpressed in Plasma (51.5) and Liver, secretome (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGF2-AS Gene



Protein tissue co-expression partners for IGF2-AS Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGF2-AS

SOURCE GeneReport for Unigene cluster for IGF2-AS Gene:

Hs.716962
genes like me logo Genes that share expression patterns with IGF2-AS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGF2-AS Gene

Orthologs for IGF2-AS Gene

Evolution for IGF2-AS Gene

ENSEMBL:
Gene Tree for IGF2-AS (if available)
TreeFam:
Gene Tree for IGF2-AS (if available)

No data available for Orthologs for IGF2-AS Gene

Paralogs for IGF2-AS Gene

No data available for Paralogs for IGF2-AS Gene

Variants for IGF2-AS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGF2-AS Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1003483 - p.Phe125Val
rs1003484 - p.Thr150Ala
rs17883142 - p.Pro112Thr
rs17883406 - p.Ser106Ile

Additional dbSNP identifiers (rs#s) for IGF2-AS Gene

Structural Variations from Database of Genomic Variants (DGV) for IGF2-AS Gene

Variant ID Type Subtype PubMed ID
esv2673506 CNV deletion 23128226
nsv467645 CNV gain 19166990
nsv553047 CNV gain 21841781
nsv553068 CNV loss 21841781
nsv553069 CNV loss 21841781
nsv825707 CNV gain 20364138
nsv951284 CNV deletion 24416366

Additional Variant Information for IGF2-AS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGF2-AS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for IGF2-AS Gene

Disorders for IGF2-AS Gene

MalaCards: The human disease database

(12) MalaCards diseases for IGF2-AS Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
diabetes mellitus, type i
  • diabetes mellitus, insulin-dependent; iddm
wilms tumor 1
  • wt1
prostate disease
  • prostate diseases
beckwith-wiedemann syndrome
  • bws
coronary heart disease 1
  • coronary heart disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with IGF2-AS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGF2-AS Gene

Publications for IGF2-AS Gene

  1. Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors. (PMID: 10731720) Okutsu T … Ishino F (Journal of biochemistry 2000) 2 3 4 23
  2. Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. (PMID: 12702581) Vu TH … Hoffman AR (Cancer research 2003) 3 4 23
  3. IGF2-AS affects the prognosis and metastasis of gastric adenocarcinoma via acting as a ceRNA of miR-503 to regulate SHOX2. (PMID: 31183590) Huang J … Zhang B (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2020) 3
  4. Long Non-Coding RNA IGF2AS in Serum may be a Biomarker for Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma. (PMID: 31850718) Qi J … Li C (Clinical laboratory 2019) 3
  5. Long noncoding RNA IGF2AS regulates high-glucose induced apoptosis in human retinal pigment epithelial cells. (PMID: 31317640) Yu X … Liu Q (IUBMB life 2019) 3

Products for IGF2-AS Gene

Sources for IGF2-AS Gene