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Aliases for IGF2-AS Gene

Subcategory (RNA class) for IGF2-AS Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for IGF2-AS Gene

  • IGF2 Antisense RNA 2 3 5
  • Insulin-Like Growth Factor 2 Antisense 1 (Non-Protein Coding) 2 3
  • IGF2 Antisense RNA 1 (Non-Protein Coding) 2 3
  • IGF2-AS1 3 4
  • IGF2AS 3 4
  • Putative Insulin-Like Growth Factor 2 Antisense Gene Protein 1 4
  • Insulin-Like Growth Factor II, Antisense 3
  • Insulin-Like Growth Factor 2, Antisense 2
  • IGF2 Antisense RNA (Non-Protein Coding) 2
  • IGF2 Antisense Gene Protein 1 4
  • PEG8/IGF2AS, Imprinting 3
  • IGF2 Antisense RNA 1 4
  • PEG8/IGF2AS Protein 4
  • PEG8 3

External Ids for IGF2-AS Gene

Previous HGNC Symbols for IGF2-AS Gene

  • IGF2AS

Previous GeneCards Identifiers for IGF2-AS Gene

  • GC11P002163
  • GC11P002167
  • GC11P002171

Summaries for IGF2-AS Gene

Entrez Gene Summary for IGF2-AS Gene

  • This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for IGF2-AS Gene

IGF2-AS (IGF2 Antisense RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with IGF2-AS include Diabetes Mellitus, Insulin-Dependent and Prostate Disease. Among its related pathways are ERK Signaling and Akt Signaling.

Additional gene information for IGF2-AS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGF2-AS Gene

Genomics for IGF2-AS Gene

GeneHancer (GH) Regulatory Elements for IGF2-AS Gene

Promoters and enhancers for IGF2-AS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002095 Enhancer 1.1 Ensembl ENCODE 11.5 -43.7 -43683 3.6 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 RXRA SP5 MIER2 PPARG MIR483 IGF2-AS IGF2 GC11P002077 ENSG00000240801
GH11J002108 Enhancer 0.9 Ensembl ENCODE 12.5 -31.0 -31046 1.5 ELF3 AHR TFAP4 SAP130 MAX RAD21 RBPJ TEAD3 IKZF5 GATAD2A MIR483 IGF2-AS IGF2 TNNT3 TH ENSG00000240801 GC11P002077
GH11J002178 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 11.3 +38.6 38600 0.5 PKNOX1 ZSCAN4 FOS IGF2 TH IGF2-AS MIR483 ENSG00000236710 ASCL2 SYT8 MIR4686 GC11M002206
GH11J002099 Enhancer 0.8 Ensembl ENCODE 11.9 -40.4 -40365 1.6 CTCF ATF1 ZIC2 ATF2 RFX5 GABPA ZNF335 GLIS1 VEZF1 GABPB1 ENSG00000240801 MIR483 IGF2-AS IGF2 GC11P002077
GH11J002076 Enhancer 0.8 Ensembl ENCODE 11.3 -63.0 -62974 1.8 JUN REST DPF2 ZNF384 FOXA1 SP1 CTBP1 JUND PRDM6 GATA3 GC11P002077 MIR483 IGF2-AS IGF2 SYT8 TNNI2 GC11M002043
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGF2-AS on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGF2-AS Gene

Genomic Locations for IGF2-AS Gene
chr11:2,140,501-2,148,666
(GRCh38/hg38)
Size:
8,166 bases
Orientation:
Plus strand
chr11:2,161,731-2,169,896
(GRCh37/hg19)
Size:
8,166 bases
Orientation:
Plus strand

Genomic View for IGF2-AS Gene

Genes around IGF2-AS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGF2-AS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGF2-AS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGF2-AS Gene

Proteins for IGF2-AS Gene

  • Protein details for IGF2-AS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U949-IG2AS_HUMAN
    Recommended name:
    Putative insulin-like growth factor 2 antisense gene protein
    Protein Accession:
    Q6U949
    Secondary Accessions:
    • A5PKV8
    • A6NNQ2
    • Q7Z712
    • Q9P2W0

    Protein attributes for IGF2-AS Gene

    Size:
    168 amino acids
    Molecular mass:
    18035 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90470.1; Type=Frameshift; Positions=162; Evidence={ECO:0000305};

neXtProt entry for IGF2-AS Gene

Post-translational modifications for IGF2-AS Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGF2-AS Gene

Domains & Families for IGF2-AS Gene

Gene Families for IGF2-AS Gene

Protein Domains for IGF2-AS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for IGF2-AS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGF2-AS: view

No data available for UniProtKB/Swiss-Prot for IGF2-AS Gene

Function for IGF2-AS Gene

Phenotypes From GWAS Catalog for IGF2-AS Gene

genes like me logo Genes that share phenotypes with IGF2-AS: view

Animal Model Products

CRISPR Products

miRNA for IGF2-AS Gene

miRTarBase miRNAs that target IGF2-AS

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGF2-AS

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGF2-AS Gene

Localization for IGF2-AS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IGF2-AS Gene

Pathways & Interactions for IGF2-AS Gene

genes like me logo Genes that share pathways with IGF2-AS: view

Interacting Proteins for IGF2-AS Gene

Gene Ontology (GO) - Biological Process for IGF2-AS Gene

None

No data available for SIGNOR curated interactions for IGF2-AS Gene

Drugs & Compounds for IGF2-AS Gene

No Compound Related Data Available

Transcripts for IGF2-AS Gene

mRNA/cDNA for IGF2-AS Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(5) RNA Central transcripts :

Unigene Clusters for IGF2-AS Gene

IGF2 antisense RNA:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGF2-AS

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGF2-AS Gene

No ASD Table

Relevant External Links for IGF2-AS Gene

GeneLoc Exon Structure for
IGF2-AS
ECgene alternative splicing isoforms for
IGF2-AS

Expression for IGF2-AS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGF2-AS Gene

mRNA differential expression in normal tissues according to GTEx for IGF2-AS Gene

This gene is overexpressed in Liver (x16.6).

Protein differential expression in normal tissues from HIPED for IGF2-AS Gene

This gene is overexpressed in Plasma (51.5) and Liver, secretome (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGF2-AS Gene



Protein tissue co-expression partners for IGF2-AS Gene

SOURCE GeneReport for Unigene cluster for IGF2-AS Gene:

Hs.716962
genes like me logo Genes that share expression patterns with IGF2-AS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGF2-AS Gene

Orthologs for IGF2-AS Gene

Evolution for IGF2-AS Gene

ENSEMBL:
Gene Tree for IGF2-AS (if available)
TreeFam:
Gene Tree for IGF2-AS (if available)

No data available for Orthologs for IGF2-AS Gene

Paralogs for IGF2-AS Gene

No data available for Paralogs for IGF2-AS Gene

Variants for IGF2-AS Gene

Sequence variations from dbSNP and Humsavar for IGF2-AS Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs758689893 uncertain-significance, not specified 2,140,215(+) C/T upstream_transcript_variant
rs1000312512 -- 2,144,347(+) G/A/T intron_variant
rs1000693997 -- 2,145,571(+) C/T intron_variant
rs1000798667 -- 2,138,616(+) C/G upstream_transcript_variant
rs1001024405 -- 2,148,499(+) C/A non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IGF2-AS Gene

Variant ID Type Subtype PubMed ID
esv2673506 CNV deletion 23128226
nsv467645 CNV gain 19166990
nsv553047 CNV gain 21841781
nsv553068 CNV loss 21841781
nsv553069 CNV loss 21841781
nsv825707 CNV gain 20364138
nsv951284 CNV deletion 24416366

Additional Variant Information for IGF2-AS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGF2-AS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for IGF2-AS Gene

Disorders for IGF2-AS Gene

MalaCards: The human disease database

(8) MalaCards diseases for IGF2-AS Gene - From: LncRNADisease and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGF2-AS

genes like me logo Genes that share disorders with IGF2-AS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGF2-AS Gene

Publications for IGF2-AS Gene

  1. Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors. (PMID: 10731720) Okutsu T … Ishino F (Journal of biochemistry 2000) 2 3 4 22 58
  2. Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor. (PMID: 12702581) Vu TH … Hoffman AR (Cancer research 2003) 3 4 22 58
  3. Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. (PMID: 24824313) Cao Y … Ma J (Journal of the National Cancer Institute 2014) 3 58
  4. Methylation alterations at imprinted genes detected among long-term shiftworkers. (PMID: 23193016) Jacobs DI … Zhu Y (Environmental and molecular mutagenesis 2013) 3 58
  5. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V … Todd JA (PLoS genetics 2011) 3 58

Products for IGF2-AS Gene

Sources for IGF2-AS Gene

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