Aliases for IGF2 Gene
External Ids for IGF2 Gene
Previous HGNC Symbols for IGF2 Gene
Previous GeneCards Identifiers for IGF2 Gene
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for IGF2 Gene
IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Silver-Russell Syndrome 3 and Silver-Russell Syndrome 1. Among its related pathways are Proteoglycans in cancer and Nanog in Mammalian ESC Pluripotency. Gene Ontology (GO) annotations related to this gene include growth factor activity and insulin receptor binding. An important paralog of this gene is IGF1.
UniProtKB/Swiss-Prot Summary for IGF2 Gene
The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.