Aliases for IGDCC4 Gene

Aliases for IGDCC4 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 4 2 3 4 5
  • Likely Ortholog Of Mouse Neighbor Of Punc E11 2 3
  • Neighbor Of Punc E11 3 4
  • DDM36 3 4
  • NOPE 3 4
  • Immunoglobulin Superfamily, DCC Subclass, Member 4 2
  • Protein DDM36 4
  • KIAA1628 4
  • HDDM36 4

External Ids for IGDCC4 Gene

Previous GeneCards Identifiers for IGDCC4 Gene

  • GC15M063461
  • GC15M065673
  • GC15M042497

Summaries for IGDCC4 Gene

GeneCards Summary for IGDCC4 Gene

IGDCC4 (Immunoglobulin Superfamily DCC Subclass Member 4) is a Protein Coding gene. Diseases associated with IGDCC4 include Anosognosia and Psychosexual Disorder. An important paralog of this gene is DCC.

Additional gene information for IGDCC4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGDCC4 Gene

Genomics for IGDCC4 Gene

GeneHancer (GH) Regulatory Elements for IGDCC4 Gene

Promoters and enhancers for IGDCC4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGDCC4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGDCC4

Top Transcription factor binding sites by QIAGEN in the IGDCC4 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA
  • NF-YC
  • Pax-5

Genomic Locations for IGDCC4 Gene

Genomic Locations for IGDCC4 Gene
chr15:65,381,480-65,423,072
(GRCh38/hg38)
Size:
41,593 bases
Orientation:
Minus strand
chr15:65,673,802-65,715,410
(GRCh37/hg19)
Size:
41,609 bases
Orientation:
Minus strand

Genomic View for IGDCC4 Gene

Genes around IGDCC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC4 Gene

Proteins for IGDCC4 Gene

  • Protein details for IGDCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDY8-IGDC4_HUMAN
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 4
    Protein Accession:
    Q8TDY8
    Secondary Accessions:
    • Q9HCE4

    Protein attributes for IGDCC4 Gene

    Size:
    1250 amino acids
    Molecular mass:
    134210 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGDCC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGDCC4 Gene

Post-translational modifications for IGDCC4 Gene

  • Glycosylation at Asn90, Asn102, Asn157, Asn483, Asn252, Asn582, Asn761, Asn782, and Asn794
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • IGDC4_HUMAN (1944)

Other Protein References for IGDCC4 Gene

No data available for DME Specific Peptides for IGDCC4 Gene

Domains & Families for IGDCC4 Gene

Gene Families for IGDCC4 Gene

Protein Domains for IGDCC4 Gene

Blocks:
  • Immunoglobulin C-2 type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGDCC4 Gene

GenScript: Design optimal peptide antigens:
  • Protein DDM36 (IGDC4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDY8

UniProtKB/Swiss-Prot:

IGDC4_HUMAN :
  • Belongs to the immunoglobulin superfamily. DCC family.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC4: view

Function for IGDCC4 Gene

Phenotypes From GWAS Catalog for IGDCC4 Gene

genes like me logo Genes that share phenotypes with IGDCC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGDCC4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGDCC4 Gene

Localization for IGDCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGDCC4 gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGDCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGDCC4: view

Pathways & Interactions for IGDCC4 Gene

PathCards logo

SuperPathways for IGDCC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGDCC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGDCC4 Gene

Drugs & Compounds for IGDCC4 Gene

No Compound Related Data Available

Transcripts for IGDCC4 Gene

mRNA/cDNA for IGDCC4 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC4 Gene

No ASD Table

Relevant External Links for IGDCC4 Gene

GeneLoc Exon Structure for
IGDCC4

Expression for IGDCC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGDCC4 Gene

mRNA differential expression in normal tissues according to GTEx for IGDCC4 Gene

This gene is overexpressed in Ovary (x4.3).

Protein differential expression in normal tissues from HIPED for IGDCC4 Gene

This gene is overexpressed in Plasma (26.7), Fetal ovary (21.4), and Fetal testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGDCC4 Gene



Protein tissue co-expression partners for IGDCC4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGDCC4

SOURCE GeneReport for Unigene cluster for IGDCC4 Gene:

Hs.458607

Evidence on tissue expression from TISSUES for IGDCC4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with IGDCC4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGDCC4 Gene

Orthologs for IGDCC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGDCC4 31 30
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IGDCC4 31 30
  • 89.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IGDCC4 31 30
  • 88.67 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igdcc4 30
  • 85.18 (n)
mouse
(Mus musculus)
Mammalia Igdcc4 17 31 30
  • 85 (n)
oppossum
(Monodelphis domestica)
Mammalia IGDCC4 31
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGDCC4 31
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGDCC4 31 30
  • 68.32 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGDCC4 31
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc4 30
  • 57.43 (n)
zebrafish
(Danio rerio)
Actinopterygii igdcc4 31 30
  • 59.29 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cont 31
  • 13 (a)
OneToMany
Species where no ortholog for IGDCC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC4 Gene

ENSEMBL:
Gene Tree for IGDCC4 (if available)
TreeFam:
Gene Tree for IGDCC4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGDCC4: view image

Paralogs for IGDCC4 Gene

(1) SIMAP similar genes for IGDCC4 Gene using alignment to 1 proteins:

  • IGDC4_HUMAN
genes like me logo Genes that share paralogs with IGDCC4: view

Variants for IGDCC4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGDCC4 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
712622 Benign: not provided 65,385,121(-) C/G INTRON_VARIANT
rs33918653 -. - p.Thr1102Alap.Cys1125Tyr
rs12442757 - p.Asn301Ser
rs1469778 - p.Ser803Cys
rs34355056 - p.Ala52Pro

Additional dbSNP identifiers (rs#s) for IGDCC4 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGDCC4 Gene

Variant ID Type Subtype PubMed ID
esv21441 CNV loss 19812545
nsv1036360 CNV gain 25217958
nsv515939 CNV loss 19592680
nsv951976 CNV deletion 24416366

Variation tolerance for IGDCC4 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.09; 96.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGDCC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGDCC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC4 Gene

Disorders for IGDCC4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGDCC4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anosognosia
psychosexual disorder
  • psychosexual disorders
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGDCC4

genes like me logo Genes that share disorders with IGDCC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGDCC4 Gene

Publications for IGDCC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 54
  2. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. (PMID: 30232004) Abraham CG … Espinosa JM (Cell reports 2018) 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma. (PMID: 20658536) Marquardt JU … Nierhoff D (International journal of cancer 2011) 3 54
  5. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 54

Products for IGDCC4 Gene

Sources for IGDCC4 Gene