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Aliases for IGDCC4 Gene

Aliases for IGDCC4 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 4 2 3 5
  • Likely Ortholog Of Mouse Neighbor Of Punc E11 2 3
  • Neighbor Of Punc E11 3 4
  • DDM36 3 4
  • NOPE 3 4
  • Immunoglobulin Superfamily, DCC Subclass, Member 4 2
  • Protein DDM36 4
  • KIAA1628 4
  • HDDM36 4

External Ids for IGDCC4 Gene

Previous GeneCards Identifiers for IGDCC4 Gene

  • GC15M063461
  • GC15M065673
  • GC15M042497

Summaries for IGDCC4 Gene

GeneCards Summary for IGDCC4 Gene

IGDCC4 (Immunoglobulin Superfamily DCC Subclass Member 4) is a Protein Coding gene. An important paralog of this gene is PRTG.

Additional gene information for IGDCC4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGDCC4 Gene

Genomics for IGDCC4 Gene

GeneHancer (GH) Regulatory Elements for IGDCC4 Gene

Promoters and enhancers for IGDCC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I065419 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.4 +1.6 1587 4.2 HDGF SIN3A ZNF2 ZBTB7B SP3 REST ZNF592 SMARCA4 ZSCAN16 GLIS1 IGDCC4 DIS3L ZNF609 INTS14 ENSG00000260773 PARP16 IGDCC3 ENSG00000264937 PDCD7 DENND4A
GH15I065400 Enhancer 1.3 Ensembl ENCODE dbSUPER 22.3 +20.4 20430 4.9 SIN3A ZNF2 IRF4 GLIS2 ZNF213 ARID2 ZNF143 RXRA NCOA1 REST IGDCC4 IGDCC3 RNU6-19P HACD3 GC15P069487 GC15P069486
GH15I065376 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 +45.1 45113 2.5 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 GLIS2 KLF13 SP3 IGDCC3 INTS14 PDCD7 ZNF609 IGDCC4 ENSG00000260773 PARP16 RNU5B-1 SLC24A1 ENSG00000259635
GH15I065408 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.4 +9.4 9441 11 HDGF PKNOX1 FOXA2 SIN3A FEZF1 ZNF2 ETS1 ZNF121 GLIS2 ATF7 INTS14 ZNF609 ENSG00000260773 SLC24A1 PARP16 PDCD7 ENSG00000264937 IGDCC3 IGDCC4 DPP8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGDCC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGDCC4 gene promoter:

Genomic Locations for IGDCC4 Gene

Genomic Locations for IGDCC4 Gene
41,609 bases
Minus strand

Genomic View for IGDCC4 Gene

Genes around IGDCC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC4 Gene

Proteins for IGDCC4 Gene

  • Protein details for IGDCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 4
    Protein Accession:
    Secondary Accessions:
    • Q9HCE4

    Protein attributes for IGDCC4 Gene

    1250 amino acids
    Molecular mass:
    134210 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGDCC4 Gene


neXtProt entry for IGDCC4 Gene

Post-translational modifications for IGDCC4 Gene

  • Glycosylation at posLast=9090, posLast=102102, posLast=157157, posLast=252252, and isoforms=2582
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC4 Gene

No data available for DME Specific Peptides for IGDCC4 Gene

Domains & Families for IGDCC4 Gene

Suggested Antigen Peptide Sequences for IGDCC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. DCC family.
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC4: view

Function for IGDCC4 Gene

Phenotypes for IGDCC4 Gene

genes like me logo Genes that share phenotypes with IGDCC4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGDCC4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGDCC4 Gene

Localization for IGDCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGDCC4 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGDCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGDCC4: view

Pathways & Interactions for IGDCC4 Gene

SuperPathways for IGDCC4 Gene

No Data Available

Interacting Proteins for IGDCC4 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: Q8TDY8-IGDC4_HUMAN ENSP00000319623 for IGDCC4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for IGDCC4 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGDCC4 Gene

Drugs & Compounds for IGDCC4 Gene

No Compound Related Data Available

Transcripts for IGDCC4 Gene

Unigene Clusters for IGDCC4 Gene

Immunoglobulin superfamily, DCC subclass, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC4 Gene

No ASD Table

Relevant External Links for IGDCC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGDCC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGDCC4 Gene

mRNA differential expression in normal tissues according to GTEx for IGDCC4 Gene

This gene is overexpressed in Ovary (x4.3).

Protein differential expression in normal tissues from HIPED for IGDCC4 Gene

This gene is overexpressed in Plasma (26.7), Fetal ovary (21.4), and Fetal testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGDCC4 Gene

Protein tissue co-expression partners for IGDCC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGDCC4 Gene:


SOURCE GeneReport for Unigene cluster for IGDCC4 Gene:


Evidence on tissue expression from TISSUES for IGDCC4 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with IGDCC4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGDCC4 Gene

Orthologs for IGDCC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGDCC4 33 34
  • 99.36 (n)
(Canis familiaris)
Mammalia IGDCC4 33 34
  • 89.44 (n)
(Bos Taurus)
Mammalia IGDCC4 34 33
  • 88.67 (n)
(Rattus norvegicus)
Mammalia Igdcc4 33
  • 85.18 (n)
(Mus musculus)
Mammalia Igdcc4 16 34 33
  • 85 (n)
(Monodelphis domestica)
Mammalia IGDCC4 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia IGDCC4 34
  • 63 (a)
(Gallus gallus)
Aves IGDCC4 34 33
  • 68.32 (n)
(Anolis carolinensis)
Reptilia IGDCC4 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc4 33
  • 57.43 (n)
(Danio rerio)
Actinopterygii igdcc4 34 33
  • 59.29 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cont 34
  • 13 (a)
Species where no ortholog for IGDCC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC4 Gene

Gene Tree for IGDCC4 (if available)
Gene Tree for IGDCC4 (if available)

Paralogs for IGDCC4 Gene

Paralogs for IGDCC4 Gene

(1) SIMAP similar genes for IGDCC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGDCC4: view

Variants for IGDCC4 Gene

Sequence variations from dbSNP and Humsavar for IGDCC4 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000065496 -- 65,386,091(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000074587 -- 65,416,105(-) C/T intron_variant
rs1000130719 -- 65,388,237(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000214909 -- 65,383,092(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000257743 -- 65,421,922(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGDCC4 Gene

Variant ID Type Subtype PubMed ID
esv21441 CNV loss 19812545
nsv1036360 CNV gain 25217958
nsv515939 CNV loss 19592680
nsv951976 CNV deletion 24416366

Variation tolerance for IGDCC4 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.09; 96.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGDCC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC4 Gene

Disorders for IGDCC4 Gene

Additional Disease Information for IGDCC4

No disorders were found for IGDCC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGDCC4 Gene

Publications for IGDCC4 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma. (PMID: 20658536) Marquardt JU … Nierhoff D (International journal of cancer 2011) 3 58
  4. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for IGDCC4 Gene

Sources for IGDCC4 Gene

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