Aliases for IGDCC3 Gene

Aliases for IGDCC3 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 3 2 3 4 5
  • Putative Neuronal Cell Adhesion Molecule 2 3 4
  • PUNC 3 4
  • HsT18880 3

External Ids for IGDCC3 Gene

Previous HGNC Symbols for IGDCC3 Gene

  • PUNC

Previous GeneCards Identifiers for IGDCC3 Gene

  • GC15M063406
  • GC15M065619
  • GC15M042443

Summaries for IGDCC3 Gene

GeneCards Summary for IGDCC3 Gene

IGDCC3 (Immunoglobulin Superfamily DCC Subclass Member 3) is a Protein Coding gene. Diseases associated with IGDCC3 include Epiphyseal Dysplasia, Multiple, 4 and Osteogenesis Imperfecta, Type Xi. An important paralog of this gene is PRTG.

Additional gene information for IGDCC3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGDCC3 Gene

Genomics for IGDCC3 Gene

GeneHancer (GH) Regulatory Elements for IGDCC3 Gene

Promoters and enhancers for IGDCC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGDCC3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGDCC3

Top Transcription factor binding sites by QIAGEN in the IGDCC3 gene promoter:
  • AP-4
  • AREB6
  • NRSF form 1
  • NRSF form 2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • STAT1
  • STAT3

Genomic Locations for IGDCC3 Gene

Genomic Locations for IGDCC3 Gene
chr15:65,327,127-65,378,040
(GRCh38/hg38)
Size:
50,914 bases
Orientation:
Minus strand
chr15:65,619,465-65,670,378
(GRCh37/hg19)
Size:
50,914 bases
Orientation:
Minus strand

Genomic View for IGDCC3 Gene

Genes around IGDCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC3 Gene

Proteins for IGDCC3 Gene

  • Protein details for IGDCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVU1-IGDC3_HUMAN
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 3
    Protein Accession:
    Q8IVU1
    Secondary Accessions:
    • O95215

    Protein attributes for IGDCC3 Gene

    Size:
    814 amino acids
    Molecular mass:
    86724 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGDCC3 Gene

Post-translational modifications for IGDCC3 Gene

  • Glycosylation at Asn93, Asn246, Asn381, Asn382, Asn580, Asn604, and Asn634
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC3 Gene

No data available for DME Specific Peptides for IGDCC3 Gene

Domains & Families for IGDCC3 Gene

Gene Families for IGDCC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IGDCC3 Gene

Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin subtype
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGDCC3 Gene

GenScript: Design optimal peptide antigens:
  • Putative neuronal cell adhesion molecule (IGDC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IVU1

UniProtKB/Swiss-Prot:

IGDC3_HUMAN :
  • Belongs to the immunoglobulin superfamily. DCC family.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC3: view

Function for IGDCC3 Gene

Phenotypes From GWAS Catalog for IGDCC3 Gene

genes like me logo Genes that share phenotypes with IGDCC3: view

Animal Models for IGDCC3 Gene

MGI Knock Outs for IGDCC3:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGDCC3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGDCC3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGDCC3 Gene

Localization for IGDCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGDCC3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

Pathways & Interactions for IGDCC3 Gene

PathCards logo

SuperPathways for IGDCC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050885 neuromuscular process controlling balance IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

No data available for Pathways by source and SIGNOR curated interactions for IGDCC3 Gene

Drugs & Compounds for IGDCC3 Gene

No Compound Related Data Available

Transcripts for IGDCC3 Gene

mRNA/cDNA for IGDCC3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGDCC3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for IGDCC3 Gene

GeneLoc Exon Structure for
IGDCC3

Expression for IGDCC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGDCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGDCC3 Gene

This gene is overexpressed in Brain - Cerebellum (x7.1), Brain - Cerebellar Hemisphere (x6.3), and Testis (x4.8).

Protein differential expression in normal tissues from HIPED for IGDCC3 Gene

This gene is overexpressed in Liver, secretome (54.2) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGDCC3 Gene



Protein tissue co-expression partners for IGDCC3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGDCC3

SOURCE GeneReport for Unigene cluster for IGDCC3 Gene:

Hs.128292

Evidence on tissue expression from TISSUES for IGDCC3 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with IGDCC3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGDCC3 Gene

Orthologs for IGDCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGDCC3 31 30
  • 99.47 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IGDCC3 31 30
  • 89.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IGDCC3 31 30
  • 89.05 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Igdcc3 17 31 30
  • 87.07 (n)
rat
(Rattus norvegicus)
Mammalia Igdcc3 30
  • 86.37 (n)
oppossum
(Monodelphis domestica)
Mammalia IGDCC3 31
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGDCC3 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGDCC3 31 30
  • 70.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGDCC3 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc3 30
  • 63.85 (n)
zebrafish
(Danio rerio)
Actinopterygii igdcc3 31 30
  • 64.05 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cont 31
  • 11 (a)
OneToMany
Species where no ortholog for IGDCC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC3 Gene

ENSEMBL:
Gene Tree for IGDCC3 (if available)
TreeFam:
Gene Tree for IGDCC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGDCC3: view image

Paralogs for IGDCC3 Gene

(13) SIMAP similar genes for IGDCC3 Gene using alignment to 3 proteins:

  • IGDC3_HUMAN
  • H0YKK1_HUMAN
  • H0YNQ1_HUMAN

Pseudogenes.org Pseudogenes for IGDCC3 Gene

genes like me logo Genes that share paralogs with IGDCC3: view

Variants for IGDCC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGDCC3 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
714658 Benign: not provided 65,330,578(-) G/A SYNONYMOUS_VARIANT
776915 Benign: not provided 65,333,345(-) C/T SYNONYMOUS_VARIANT
784324 Benign: not provided 65,375,352(-) C/T MISSENSE_VARIANT
787431 Benign: not provided 65,334,872(-) G/A INTRON_VARIANT
rs12907128 - p.Val751Leu

Additional dbSNP identifiers (rs#s) for IGDCC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGDCC3 Gene

Variant ID Type Subtype PubMed ID
esv28479 CNV gain 19812545
esv3636755 CNV loss 21293372
nsv1036360 CNV gain 25217958
nsv457182 CNV loss 19166990
nsv457183 CNV loss 19166990
nsv569705 CNV loss 21841781
nsv569706 CNV loss 21841781
nsv569707 CNV loss 21841781
nsv951975 CNV deletion 24416366

Variation tolerance for IGDCC3 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGDCC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGDCC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC3 Gene

Disorders for IGDCC3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for IGDCC3 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGDCC3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IGDCC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGDCC3 Gene

Publications for IGDCC3 Gene

  1. Genomic structure and chromosomal localization of the mouse gene Punc. (PMID: 9922388) Salbaum JM (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 4 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3 54
  5. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 54

Products for IGDCC3 Gene

Sources for IGDCC3 Gene