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Aliases for IGDCC3 Gene

Aliases for IGDCC3 Gene

  • Immunoglobulin Superfamily DCC Subclass Member 3 2 3 5
  • Putative Neuronal Cell Adhesion Molecule 2 3 4
  • PUNC 3 4
  • HsT18880 3

External Ids for IGDCC3 Gene

Previous HGNC Symbols for IGDCC3 Gene

  • PUNC

Previous GeneCards Identifiers for IGDCC3 Gene

  • GC15M063406
  • GC15M065619
  • GC15M042443

Summaries for IGDCC3 Gene

GeneCards Summary for IGDCC3 Gene

IGDCC3 (Immunoglobulin Superfamily DCC Subclass Member 3) is a Protein Coding gene. An important paralog of this gene is IGDCC4.

Additional gene information for IGDCC3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGDCC3 Gene

Genomics for IGDCC3 Gene

GeneHancer (GH) Regulatory Elements for IGDCC3 Gene

Promoters and enhancers for IGDCC3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I065376 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 81 2.5 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 GLIS2 KLF13 SP3 IGDCC3 INTS14 PDCD7 ZNF609 IGDCC4 ENSG00000260773 PARP16 RNU5B-1 SLC24A1 ENSG00000259635
GH15I065303 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 16.7 +73.6 73569 2.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GC15M065305 GC15P068442 RNU5B-1 PARP16 ZNF609 TRIP4 INTS14 PDCD7 SLC24A1 ENSG00000264937
GH15I065419 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -43.4 -43445 4.2 HDGF SIN3A ZNF2 ZBTB7B SP3 REST ZNF592 SMARCA4 ZSCAN16 GLIS1 IGDCC4 DIS3L ZNF609 INTS14 ENSG00000260773 PARP16 IGDCC3 ENSG00000264937 PDCD7 DENND4A
GH15I065400 Enhancer 1.3 Ensembl ENCODE dbSUPER 12 -24.6 -24602 4.9 SIN3A ZNF2 IRF4 GLIS2 ZNF213 ARID2 ZNF143 RXRA NCOA1 REST IGDCC4 IGDCC3 RNU6-19P HACD3 GC15P069487 GC15P069486
GH15I065322 Enhancer 0.7 ENCODE 21.9 +54.8 54776 1.1 CTCF SAP130 NFIB SIN3A ZIC2 ZNF121 ZFHX2 CTBP1 GLIS2 ZNF316 IGDCC3 GC15M065329 GC15M065328 GC15M065309 GC15M065320
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGDCC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGDCC3 gene promoter:

Genomic Locations for IGDCC3 Gene

Genomic Locations for IGDCC3 Gene
50,914 bases
Minus strand

Genomic View for IGDCC3 Gene

Genes around IGDCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGDCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGDCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGDCC3 Gene

Proteins for IGDCC3 Gene

  • Protein details for IGDCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily DCC subclass member 3
    Protein Accession:
    Secondary Accessions:
    • O95215

    Protein attributes for IGDCC3 Gene

    814 amino acids
    Molecular mass:
    86724 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGDCC3 Gene

Post-translational modifications for IGDCC3 Gene

  • Glycosylation at posLast=9393, posLast=246246, isoforms=381, posLast=382382, posLast=580580, posLast=604604, and isoforms=634
  • Modification sites at PhosphoSitePlus

Other Protein References for IGDCC3 Gene

No data available for DME Specific Peptides for IGDCC3 Gene

Domains & Families for IGDCC3 Gene

Gene Families for IGDCC3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for IGDCC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. DCC family.
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with IGDCC3: view

Function for IGDCC3 Gene

Phenotypes From GWAS Catalog for IGDCC3 Gene

genes like me logo Genes that share phenotypes with IGDCC3: view

Animal Models for IGDCC3 Gene

MGI Knock Outs for IGDCC3:

Animal Model Products

  • Taconic Biosciences Mouse Models for IGDCC3

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGDCC3 Gene

Localization for IGDCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGDCC3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGDCC3 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGDCC3 Gene

Pathways & Interactions for IGDCC3 Gene

SuperPathways for IGDCC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGDCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050885 neuromuscular process controlling balance IEA --
genes like me logo Genes that share ontologies with IGDCC3: view

No data available for Pathways by source and SIGNOR curated interactions for IGDCC3 Gene

Drugs & Compounds for IGDCC3 Gene

No Compound Related Data Available

Transcripts for IGDCC3 Gene

Unigene Clusters for IGDCC3 Gene

Immunoglobulin superfamily, DCC subclass, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGDCC3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - -
SP2: - -

Relevant External Links for IGDCC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGDCC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGDCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGDCC3 Gene

This gene is overexpressed in Brain - Cerebellum (x7.1), Brain - Cerebellar Hemisphere (x6.3), and Testis (x4.8).

Protein differential expression in normal tissues from HIPED for IGDCC3 Gene

This gene is overexpressed in Liver, secretome (54.2) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGDCC3 Gene

Protein tissue co-expression partners for IGDCC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGDCC3 Gene:


SOURCE GeneReport for Unigene cluster for IGDCC3 Gene:


Evidence on tissue expression from TISSUES for IGDCC3 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with IGDCC3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGDCC3 Gene

Orthologs for IGDCC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGDCC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGDCC3 33 34
  • 99.47 (n)
(Bos Taurus)
Mammalia IGDCC3 33 34
  • 89.15 (n)
(Canis familiaris)
Mammalia IGDCC3 33 34
  • 89.05 (n)
(Mus musculus)
Mammalia Igdcc3 33 16 34
  • 87.07 (n)
(Rattus norvegicus)
Mammalia Igdcc3 33
  • 86.37 (n)
(Monodelphis domestica)
Mammalia IGDCC3 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia IGDCC3 34
  • 76 (a)
(Gallus gallus)
Aves IGDCC3 33 34
  • 70.71 (n)
(Anolis carolinensis)
Reptilia IGDCC3 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igdcc3 33
  • 63.85 (n)
(Danio rerio)
Actinopterygii igdcc3 33 34
  • 64.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cont 34
  • 11 (a)
Species where no ortholog for IGDCC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGDCC3 Gene

Gene Tree for IGDCC3 (if available)
Gene Tree for IGDCC3 (if available)

Paralogs for IGDCC3 Gene

Paralogs for IGDCC3 Gene

(13) SIMAP similar genes for IGDCC3 Gene using alignment to 3 proteins: Pseudogenes for IGDCC3 Gene

genes like me logo Genes that share paralogs with IGDCC3: view

Variants for IGDCC3 Gene

Sequence variations from dbSNP and Humsavar for IGDCC3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000014601 -- 65,350,185(-) G/A intron_variant
rs1000039593 -- 65,340,481(-) C/G intron_variant
rs1000063700 -- 65,364,298(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000095218 -- 65,334,548(-) C/T intron_variant
rs1000204136 -- 65,377,909(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IGDCC3 Gene

Variant ID Type Subtype PubMed ID
esv28479 CNV gain 19812545
esv3636755 CNV loss 21293372
nsv1036360 CNV gain 25217958
nsv457182 CNV loss 19166990
nsv457183 CNV loss 19166990
nsv569705 CNV loss 21841781
nsv569706 CNV loss 21841781
nsv569707 CNV loss 21841781
nsv951975 CNV deletion 24416366

Variation tolerance for IGDCC3 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGDCC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGDCC3 Gene

Disorders for IGDCC3 Gene

Additional Disease Information for IGDCC3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IGDCC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGDCC3 Gene

Publications for IGDCC3 Gene

  1. Genomic structure and chromosomal localization of the mouse gene Punc. (PMID: 9922388) Salbaum JM (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58

Products for IGDCC3 Gene

Sources for IGDCC3 Gene

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