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The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]
IGBP1 (Immunoglobulin Binding Protein 1) is a Protein Coding gene. Diseases associated with IGBP1 include Corpus Callosum, Agenesis Of, With Mental Retardation, Ocular Coloboma, And Micrognathia and Opitz-Gbbb Syndrome. Among its related pathways are Macroautophagy and Autophagy - animal. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and protein phosphatase 2A binding. An important paralog of this gene is IGBP1P2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 9647778 |
GO:0019888 | protein phosphatase regulator activity | IDA | 9647778 |
GO:0051721 | protein phosphatase 2A binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | NAS | 9647778 |
GO:0005829 | cytosol | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Autophagy - animal | ||
2 | Macroautophagy | ||
3 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Translation Regulation of EIF4F activity
.44
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 17438131 |
GO:0007165 | signal transduction | NAS | 9647778 |
GO:0009966 | regulation of signal transduction | IEA | -- |
GO:0032873 | negative regulation of stress-activated MAPK cascade | IMP | 17438131 |
GO:0034612 | response to tumor necrosis factor | IMP | 17438131 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IGBP1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IGBP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IGBP1 30 31 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Igbp1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Igbp1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | IGBP1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IGBP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IGBP1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IGBP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | igbp1 30 |
|
||
Str.1809 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | igbp1 30 31 |
|
OneToOne | |
Dr.17830 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10166 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Tap42 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008797 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | ppfr-4 30 31 |
|
OneToOne | |
Y71H2B.3 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TAP42 31 33 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11551789 | Benign: not provided | 70,146,747(+) |
G/A NM_001551.3(IGBP1):c.597G>A (p.Arg199=) |
SYNONYMOUS_VARIANT,INTRON | |
rs139922265 | Likely Benign: not provided | 70,150,275(+) |
G/A NM_001551.3(IGBP1):c.824G>A (p.Arg275Gln) |
MISSENSE | |
rs1412238750 | Uncertain Significance: not specified | 70,148,797(+) |
C/T NM_001551.3(IGBP1):c.715C>T (p.Pro239Ser) |
MISSENSE_VARIANT,INTRON | |
rs143163513 | Benign/Likely Benign: not specified; not provided | 70,134,651(+) |
G/A NM_001551.3(IGBP1):c.317G>A (p.Arg106Gln) |
MISSENSE | |
rs146978115 | Benign: not provided | 70,134,046(+) |
C/T NM_001551.3(IGBP1):c.99C>T (p.Ala33=) |
SYNONYMOUS |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1584074 | OTHER | inversion | 17803354 |
Disorder | Aliases | PubMed IDs |
---|---|---|
corpus callosum, agenesis of, with mental retardation, ocular coloboma, and micrognathia |
|
|
opitz-gbbb syndrome |
|
|
barbiturate abuse |
|
|
autosomal dominant alport syndrome |
|
|
progressive multifocal leukoencephalopathy |
|
|