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Aliases for IFT88 Gene

Aliases for IFT88 Gene

  • Intraflagellar Transport 88 2 3 5
  • Recessive Polycystic Kidney Disease Protein Tg737 Homolog 3 4
  • Tetratricopeptide Repeat Protein 10 3 4
  • Tetratricopeptide Repeat Domain 10 2 3
  • TPR Repeat Protein 10 3 4
  • Polaris Homolog 2 3
  • TTC10 3 4
  • TG737 3 4
  • Probe HTg737 (Polycystic Kidney Disease, Autosomal Recessive) 3
  • Intraflagellar Transport 88 Homolog (Chlamydomonas) 2
  • Intraflagellar Transport Protein 88 Homolog 3
  • Intraflagellar Transport 88 Homolog 3
  • Testicular Tissue Protein Li 93 3
  • D13S1056E 3
  • HTg737 3
  • DAF19 3

External Ids for IFT88 Gene

Previous HGNC Symbols for IFT88 Gene

  • TTC10

Previous GeneCards Identifiers for IFT88 Gene

  • GC13P020039
  • GC13P021141
  • GC13P001944

Summaries for IFT88 Gene

Entrez Gene Summary for IFT88 Gene

  • This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2017]

GeneCards Summary for IFT88 Gene

IFT88 (Intraflagellar Transport 88) is a Protein Coding gene. Diseases associated with IFT88 include Polycystic Kidney Disease and Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. Gene Ontology (GO) annotations related to this gene include kinesin binding.

UniProtKB/Swiss-Prot for IFT88 Gene

  • Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.

Gene Wiki entry for IFT88 Gene

Additional gene information for IFT88 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFT88 Gene

Genomics for IFT88 Gene

GeneHancer (GH) Regulatory Elements for IFT88 Gene

Promoters and enhancers for IFT88 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J020565 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 671.7 +0.8 846 2.9 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS IFT88 LOC105370103 PIR57097 SLC35E1P1 ZMYM2 XPO4 ZMYM5 CRYL1 IL17D
GH13J020702 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 30.5 +137.0 136956 2.8 PKNOX1 RB1 ARID4B SIN3A BMI1 ZNF48 RFX5 ZNF335 ZNF121 ELK1 GC13M020702 IL17D ENSG00000278291 IFT88 EEF1AKMT1 CRYL1
GH13J020901 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.4 +336.0 335965 2.4 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 ELK1 ZNF143 ATF7 SP3 XPO4 EEF1AKMT1 IFT88 LATS2 GC13P020892
GH13J020552 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 21.9 -12.6 -12618 2.2 ELF3 FOXA2 MLX ARID4B RAD21 RARA YY1 ZSCAN5C THAP11 MIXL1 IFT88 CRYL1 SLC35E1P1 EEF1AKMT1 IL17D LOC105370103
GH13J020556 Enhancer 1.1 ENCODE dbSUPER 21.9 -7.3 -7283 4.6 FOXA2 DMAP1 ETS1 YY1 RXRA MIER2 REST PPARG KAT8 NFIL3 IFT88 SLC35E1P1 IL17D LOC105370103 CRYL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFT88 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFT88 gene promoter:
  • C/EBPalpha
  • Pax-2b
  • Pax-2a
  • Pax-2
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • Hand1
  • E47

Genomic Locations for IFT88 Gene

Genomic Locations for IFT88 Gene
124,992 bases
Plus strand
124,992 bases
Plus strand

Genomic View for IFT88 Gene

Genes around IFT88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFT88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFT88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFT88 Gene

Proteins for IFT88 Gene

  • Protein details for IFT88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intraflagellar transport protein 88 homolog
    Protein Accession:
    Secondary Accessions:
    • A2A491
    • B4DUS2
    • Q5SZJ6
    • Q8N719

    Protein attributes for IFT88 Gene

    833 amino acids
    Molecular mass:
    94270 Da
    Quaternary structure:
    • Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT20, IFT22, HSPB11, IFT27, IFT46, IFT52, TRAF3IP1, IFT57, IFT74, IFT80, IFT81, IFT88 AND IFT172. Interacts with C2CD3.

    Alternative splice isoforms for IFT88 Gene


neXtProt entry for IFT88 Gene

Post-translational modifications for IFT88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IFT88 Gene

Domains & Families for IFT88 Gene

Protein Domains for IFT88 Gene

Suggested Antigen Peptide Sequences for IFT88 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IFT88: view

No data available for UniProtKB/Swiss-Prot for IFT88 Gene

Function for IFT88 Gene

Molecular function for IFT88 Gene

UniProtKB/Swiss-Prot Function:
Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.

Phenotypes From GWAS Catalog for IFT88 Gene

Gene Ontology (GO) - Molecular Function for IFT88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25564561
genes like me logo Genes that share ontologies with IFT88: view
genes like me logo Genes that share phenotypes with IFT88: view

Animal Models for IFT88 Gene

MGI Knock Outs for IFT88:

Animal Model Products

miRNA for IFT88 Gene

miRTarBase miRNAs that target IFT88

Clone Products

  • Addgene plasmids for IFT88

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFT88 Gene

Localization for IFT88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFT88 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFT88 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for IFT88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005814 centriole ISS --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium TAS --
GO:0030992 intraciliary transport particle B ISS --
genes like me logo Genes that share ontologies with IFT88: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFT88 Gene

Pathways & Interactions for IFT88 Gene

genes like me logo Genes that share pathways with IFT88: view

Gene Ontology (GO) - Biological Process for IFT88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030030 cell projection organization IEA --
GO:0035735 intraciliary transport involved in cilium assembly TAS --
GO:0060271 cilium assembly ISS --
GO:1902017 regulation of cilium assembly ISS --
GO:2000785 regulation of autophagosome assembly ISS --
genes like me logo Genes that share ontologies with IFT88: view

No data available for SIGNOR curated interactions for IFT88 Gene

Drugs & Compounds for IFT88 Gene

No Compound Related Data Available

Transcripts for IFT88 Gene

Unigene Clusters for IFT88 Gene

Intraflagellar transport 88 homolog (Chlamydomonas):
Representative Sequences:

Clone Products

  • Addgene plasmids for IFT88

Alternative Splicing Database (ASD) splice patterns (SP) for IFT88 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
SP1: -
SP2: -
SP4: - -
SP7: -

Relevant External Links for IFT88 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFT88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFT88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFT88 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for IFT88 Gene

This gene is overexpressed in Nasal epithelium (44.6) and Testis (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFT88 Gene

Protein tissue co-expression partners for IFT88 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFT88 Gene:


SOURCE GeneReport for Unigene cluster for IFT88 Gene:


mRNA Expression by UniProt/SwissProt for IFT88 Gene:

Tissue specificity: Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for IFT88 Gene

  • Liver(4.3)
  • Kidney(2.4)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with IFT88: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IFT88 Gene

Orthologs for IFT88 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFT88 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFT88 34 33
  • 99.6 (n)
(Canis familiaris)
Mammalia IFT88 34 33
  • 91.95 (n)
(Mus musculus)
Mammalia Ift88 16 34 33
  • 87.14 (n)
(Bos Taurus)
Mammalia IFT88 34 33
  • 87.14 (n)
(Monodelphis domestica)
Mammalia IFT88 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia IFT88 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Ift88 33
  • 84.55 (n)
(Gallus gallus)
Aves IFT88 34 33
  • 78.31 (n)
(Anolis carolinensis)
Reptilia IFT88 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ift88 33
  • 74.03 (n)
Str.14228 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13378 33
(Danio rerio)
Actinopterygii ift88 34 33
  • 70.93 (n)
wufb37b11 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006324 33
  • 47.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta nompB 34 33
  • 46.66 (n)
(Caenorhabditis elegans)
Secernentea osm-5 34 33
  • 53.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
Species where no ortholog for IFT88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFT88 Gene

Gene Tree for IFT88 (if available)
Gene Tree for IFT88 (if available)
Evolutionary constrained regions (ECRs) for IFT88: view image

Paralogs for IFT88 Gene

(1) SIMAP similar genes for IFT88 Gene using alignment to 4 proteins:

  • E7EW86_HUMAN
  • F5H6C2_HUMAN
genes like me logo Genes that share paralogs with IFT88: view

No data available for Paralogs for IFT88 Gene

Variants for IFT88 Gene

Sequence variations from dbSNP and Humsavar for IFT88 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs373832683 uncertain-significance, Jeune thoracic dystrophy 20,663,516(+) G/A/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs1329519 benign, not specified 20,631,001(+) A/T genic_downstream_transcript_variant, intron_variant
rs2442455 benign, not specified 20,615,802(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs9509307 benign, not specified 20,631,053(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000027933 -- 20,657,762(+) AAAATAAATAAA/ genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IFT88 Gene

Variant ID Type Subtype PubMed ID
esv2759925 CNV loss 17122850
esv33630 CNV gain 17666407
esv3631433 CNV loss 21293372
esv3631435 CNV loss 21293372
nsv1078303 OTHER inversion 25765185
nsv1134286 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv826580 CNV gain 20364138
nsv832558 CNV loss 17160897
nsv983554 CNV duplication 23825009

Variation tolerance for IFT88 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.59; 82.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFT88 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFT88 Gene

Disorders for IFT88 Gene

MalaCards: The human disease database

(9) MalaCards diseases for IFT88 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IFT88 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFT88

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFT88: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFT88 Gene

Publications for IFT88 Gene

  1. Characterization of the human homologue of the mouse Tg737 candidate polycystic kidney disease gene. (PMID: 7633404) Schrick JJ … Woychik RP (Human molecular genetics 1995) 2 3 4 22 58
  2. RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly. (PMID: 28428259) Nishijima Y … Nakayama K (Molecular biology of the cell 2017) 3 4 58
  3. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. (PMID: 28625565) Kanie T … Jackson PK (Developmental cell 2017) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. (PMID: 20713499) Huang J … Smoller JW (The American journal of psychiatry 2010) 3 44 58

Products for IFT88 Gene

Sources for IFT88 Gene

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