Aliases for IFT81 Gene
External Ids for IFT81 Gene
Previous HGNC Symbols for IFT81 Gene
Previous GeneCards Identifiers for IFT81 Gene
The protein encoded by this gene, together with IFT74, forms a tubulin-binding module of intraflagellar transport complex B. This module is involved in transport of tubulin within the cilium, and the encoded protein is required for ciliogenesis. Mutations in this gene are a cause of short-rib polydactyly syndromes. [provided by RefSeq, Dec 2016]
GeneCards Summary for IFT81 Gene
IFT81 (Intraflagellar Transport 81) is a Protein Coding gene. Diseases associated with IFT81 include Short-Rib Thoracic Dysplasia 19 With Or Without Polydactyly and Short Rib-Polydactyly Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. Gene Ontology (GO) annotations related to this gene include tubulin binding.
UniProtKB/Swiss-Prot Summary for IFT81 Gene
Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:27666822, PubMed:23990561). Required for proper regulation of SHH signaling (PubMed:27666822).