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Aliases for IFNW1 Gene

Aliases for IFNW1 Gene

  • Interferon Omega 1 2 3 5
  • IFN-Omega 1, Interferon Omega-1 2
  • Interferon Alpha-II-1 4

External Ids for IFNW1 Gene

Previous GeneCards Identifiers for IFNW1 Gene

  • GC09M021468
  • GC09M021341
  • GC09M021130

Summaries for IFNW1 Gene

Entrez Gene Summary for IFNW1 Gene

  • The protein encoded by this gene is an interferon and possesses antiviral activity. The encoded protein binds to the interferon alpha/beta receptor but not to the interferon gamma receptor. This intronless gene has several pseudogenes spread throughout the genome. [provided by RefSeq, Nov 2015]

GeneCards Summary for IFNW1 Gene

IFNW1 (Interferon Omega 1) is a Protein Coding gene. Among its related pathways are Toll-like receptor signaling pathway and Jak-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA2.

Gene Wiki entry for IFNW1 Gene

Additional gene information for IFNW1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNW1 Gene

Genomics for IFNW1 Gene

GeneHancer (GH) Regulatory Elements for IFNW1 Gene

Promoters and enhancers for IFNW1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I021573 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -441.8 -441770 20.1 PKNOX1 SIN3A FEZF1 GTF3C2 ZNF121 FOS RUNX3 DEK REST TSHZ1 FOCAD MIR31 IFNW1 IFNA1 IFNA6 MIR31HG ENSG00000227443
GH09I021016 Enhancer 0.3 FANTOM5 19.6 +125.4 125351 0 IFNW1 IFNA1 IFNA6 IFNA5 HACD4 LOC105375989 SNORA30B
GH09I020784 Enhancer 0.2 FANTOM5 16.4 +357.3 357313 0.1 IFNW1 MIR491 FOCAD GC09P020787
GH09I021153 Enhancer 0.9 Ensembl ENCODE 0.4 -11.9 -11856 0.8 CTCF PKNOX1 ZNF654 JUNB EBF1 BATF RAD21 ATF2 BCL11A ZBTB48 ENSG00000199635 GC09M021161 IFNW1
GH09I021144 Enhancer 0.3 Ensembl 0.8 -2.8 -2756 0.6 SPI1 IFNW1 GC09M021161 ENSG00000199635
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFNW1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNW1 gene promoter:

Genomic Locations for IFNW1 Gene

Genomic Locations for IFNW1 Gene
1,932 bases
Minus strand

Genomic View for IFNW1 Gene

Genes around IFNW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNW1 Gene

Proteins for IFNW1 Gene

  • Protein details for IFNW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon omega-1
    Protein Accession:
    Secondary Accessions:
    • Q13168
    • Q5U802
    • Q5VWD0
    • Q7M4P5

    Protein attributes for IFNW1 Gene

    195 amino acids
    Molecular mass:
    22319 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFNW1 Gene

neXtProt entry for IFNW1 Gene

Post-translational modifications for IFNW1 Gene

Other Protein References for IFNW1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNW1 Gene

Domains & Families for IFNW1 Gene

Gene Families for IFNW1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNW1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNW1: view

Function for IFNW1 Gene

Molecular function for IFNW1 Gene

GENATLAS Biochemistry:
interferon type I,omega 1,leukocyte

Gene Ontology (GO) - Molecular Function for IFNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding TAS 1647209
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNW1: view
genes like me logo Genes that share phenotypes with IFNW1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNW1 Gene

Localization for IFNW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNW1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNW1 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for IFNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNW1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNW1 Gene

Pathways & Interactions for IFNW1 Gene

genes like me logo Genes that share pathways with IFNW1: view

SIGNOR curated interactions for IFNW1 Gene


Gene Ontology (GO) - Biological Process for IFNW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNW1: view

Drugs & Compounds for IFNW1 Gene

No Compound Related Data Available

Transcripts for IFNW1 Gene

mRNA/cDNA for IFNW1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNW1 Gene

Interferon, omega 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNW1 Gene

No ASD Table

Relevant External Links for IFNW1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNW1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNW1 Gene

mRNA differential expression in normal tissues according to GTEx for IFNW1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.3) and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for IFNW1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IFNW1 Gene

Protein tissue co-expression partners for IFNW1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNW1 Gene:


SOURCE GeneReport for Unigene cluster for IFNW1 Gene:


Evidence on tissue expression from TISSUES for IFNW1 Gene

  • Blood(4.1)
  • Liver(4)
genes like me logo Genes that share expression patterns with IFNW1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNW1 Gene

Orthologs for IFNW1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNW1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNW1 33 34
  • 99.32 (n)
(Bos Taurus)
Mammalia LOC100336885 33
  • 79.21 (n)
-- 34
  • 66 (a)
-- 34
  • 66 (a)
-- 34
  • 66 (a)
-- 34
  • 65 (a)
-- 34
  • 65 (a)
-- 34
  • 65 (a)
-- 34
  • 65 (a)
-- 34
  • 65 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
-- 34
  • 64 (a)
  • 64 (a)
-- 34
  • 63 (a)
-- 34
  • 63 (a)
-- 34
  • 63 (a)
IFNW1 34
  • 63 (a)
  • 59 (a)
-- 34
  • 55 (a)
Species where no ortholog for IFNW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNW1 Gene

Gene Tree for IFNW1 (if available)
Gene Tree for IFNW1 (if available)

Paralogs for IFNW1 Gene

(19) SIMAP similar genes for IFNW1 Gene using alignment to 1 proteins: Pseudogenes for IFNW1 Gene

genes like me logo Genes that share paralogs with IFNW1: view

Variants for IFNW1 Gene

Sequence variations from dbSNP and Humsavar for IFNW1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000709534 -- 21,140,326(-) A/C downstream_transcript_variant
rs1000946930 -- 21,140,775(-) T/A 3_prime_UTR_variant
rs1001294648 -- 21,140,174(-) G/C downstream_transcript_variant
rs1001387544 -- 21,140,388(-) G/T downstream_transcript_variant
rs1001810467 -- 21,140,665(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNW1 Gene

Variant ID Type Subtype PubMed ID
nsv972299 CNV duplication 23825009
nsv613752 CNV loss 21841781
esv2764150 CNV gain+loss 21179565

Variation tolerance for IFNW1 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.75; 46.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNW1 Gene

Disorders for IFNW1 Gene

Additional Disease Information for IFNW1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFNW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNW1 Gene

Publications for IFNW1 Gene

  1. Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes. (PMID: 16504056) Morris GA … Todd JA (BMC genetics 2006) 3 22 44 58
  2. Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein. (PMID: 1647209) Adolf GR … Zöphel A (Biochimica et biophysica acta 1991) 3 4 22 58
  3. Purification and characterization of natural human interferon omega 1. Two alternative cleavage sites for the signal peptidase. (PMID: 1693148) Adolf GR … Cantell K (The Journal of biological chemistry 1990) 3 4 22 58
  4. Structural linkage between ligand discrimination and receptor activation by type I interferons. (PMID: 21854986) Thomas C … Garcia KC (Cell 2011) 3 4 58
  5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58

Products for IFNW1 Gene

Sources for IFNW1 Gene

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