This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines h... See more...

Aliases for IFNL2 Gene

Aliases for IFNL2 Gene

  • Interferon Lambda 2 2 3 5
  • Interleukin 28A (Interferon, Lambda 2) 2 3
  • Interferon Lambda-2 3 4
  • Cytokine Zcyto20 3 4
  • Interleukin-28A 3 4
  • IFN-Lambda-2 3 4
  • IL-28A 3 4
  • IL28A 3 4
  • Interleukin 28A 2
  • ZCYTO20 4

External Ids for IFNL2 Gene

Previous HGNC Symbols for IFNL2 Gene

  • IL28A

Previous GeneCards Identifiers for IFNL2 Gene

  • GC19P039760

Summaries for IFNL2 Gene

Entrez Gene Summary for IFNL2 Gene

  • This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]

GeneCards Summary for IFNL2 Gene

IFNL2 (Interferon Lambda 2) is a Protein Coding gene. Among its related pathways are Type III Interferon Signaling Pathways and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and cytokine activity. An important paralog of this gene is IFNL3.

UniProtKB/Swiss-Prot Summary for IFNL2 Gene

  • Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Additional gene information for IFNL2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNL2 Gene

Genomics for IFNL2 Gene

GeneHancer (GH) Regulatory Elements for IFNL2 Gene

Promoters and enhancers for IFNL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039264 Enhancer 0.9 FANTOM5 Ensembl ENCODE 500.7 -1.1 -1074 1.6 USF1 EZH2 SP2 CTCF REST SUZ12 ZNF658 RAD21 RXRA RNF2 IFNL2 IFNL4P1 ZNF546 ZFP36
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNL2

Genomic Locations for IFNL2 Gene

Genomic Locations for IFNL2 Gene
chr19:39,265,883-39,270,092
(GRCh38/hg38)
Size:
4,210 bases
Orientation:
Plus strand
chr19:39,759,154-39,760,732
(GRCh37/hg19)
Size:
1,579 bases
Orientation:
Plus strand

Genomic View for IFNL2 Gene

Genes around IFNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNL2 Gene

Proteins for IFNL2 Gene

  • Protein details for IFNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZJ0-IFNL2_HUMAN
    Recommended name:
    Interferon lambda-2
    Protein Accession:
    Q8IZJ0
    Secondary Accessions:
    • Q45KQ8
    • Q6VN55
    • Q8IWL7

    Protein attributes for IFNL2 Gene

    Size:
    200 amino acids
    Molecular mass:
    22288 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAR24510.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for IFNL2 Gene

Post-translational modifications for IFNL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNL2 Gene

Domains & Families for IFNL2 Gene

Gene Families for IFNL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNL2 Gene

GenScript: Design optimal peptide antigens:
  • Interferon lambda-2 (IL28A_HUMAN)
  • Interleukin 28A (Interferon, lambda 2) (Q45KQ8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZJ0

UniProtKB/Swiss-Prot:

IFNL2_HUMAN :
  • Belongs to the lambda interferon family.
Family:
  • Belongs to the lambda interferon family.
genes like me logo Genes that share domains with IFNL2: view

Function for IFNL2 Gene

Molecular function for IFNL2 Gene

UniProtKB/Swiss-Prot Function:
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
UniProtKB/Swiss-Prot Induction:
By viral infections or double-stranded RNA.

Phenotypes From GWAS Catalog for IFNL2 Gene

Gene Ontology (GO) - Molecular Function for IFNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA 21873635
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with IFNL2: view
genes like me logo Genes that share phenotypes with IFNL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IFNL2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNL2 Gene

Localization for IFNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNL2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
endosome 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IFNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNL2 Gene

Pathways & Interactions for IFNL2 Gene

genes like me logo Genes that share pathways with IFNL2: view

Pathways by source for IFNL2 Gene

2 Sino Biological pathways for IFNL2 Gene
1 BioSystems pathway for IFNL2 Gene
1 Qiagen pathway for IFNL2 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis

SIGNOR curated interactions for IFNL2 Gene

Activates:

Gene Ontology (GO) - Biological Process for IFNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002385 mucosal immune response ISS --
GO:0007259 JAK-STAT cascade IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0045087 innate immune response IBA 21873635
GO:0050778 positive regulation of immune response IEA --
genes like me logo Genes that share ontologies with IFNL2: view

Drugs & Compounds for IFNL2 Gene

(2) Additional Compounds for IFNL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNL2: view

Transcripts for IFNL2 Gene

mRNA/cDNA for IFNL2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNL2

Alternative Splicing Database (ASD) splice patterns (SP) for IFNL2 Gene

No ASD Table

Relevant External Links for IFNL2 Gene

GeneLoc Exon Structure for
IFNL2

Expression for IFNL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNL2 Gene

mRNA differential expression in normal tissues according to GTEx for IFNL2 Gene

This gene is overexpressed in Testis (x18.7), Pancreas (x12.4), Skin - Not Sun Exposed (Suprapubic) (x7.5), and Skin - Sun Exposed (Lower leg) (x5.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFNL2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNL2

SOURCE GeneReport for Unigene cluster for IFNL2 Gene:

Hs.567792

Evidence on tissue expression from TISSUES for IFNL2 Gene

  • Blood(4.3)
  • Lung(2)
genes like me logo Genes that share expression patterns with IFNL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNL2 Gene

Orthologs for IFNL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNL2 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifnl2 31
  • 64 (a)
ManyToMany
Ifnl3 31
  • 61 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFNL 31 31
  • 33 (a)
ManyToMany
Species where no ortholog for IFNL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNL2 Gene

ENSEMBL:
Gene Tree for IFNL2 (if available)
TreeFam:
Gene Tree for IFNL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNL2: view image

Paralogs for IFNL2 Gene

Paralogs for IFNL2 Gene

(2) SIMAP similar genes for IFNL2 Gene using alignment to 1 proteins:

  • IFNL2_HUMAN
genes like me logo Genes that share paralogs with IFNL2: view

Variants for IFNL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNL2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769454 Benign: not provided 39,269,795(+) T/C MISSENSE_VARIANT
777474 Benign: not provided 39,269,186(+) A/G MISSENSE_VARIANT
780556 Benign: not provided 39,268,684(+) T/C SYNONYMOUS_VARIANT
780557 Benign: not provided 39,268,695(+) C/T MISSENSE_VARIANT
782646 Benign: not provided 39,269,998(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for IFNL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFNL2 Gene

Variant ID Type Subtype PubMed ID
nsv833830 CNV loss 17160897
nsv978814 CNV duplication 23825009

Variation tolerance for IFNL2 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.91; 79.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNL2 Gene

Disorders for IFNL2 Gene

Additional Disease Information for IFNL2

No disorders were found for IFNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNL2 Gene

Publications for IFNL2 Gene

  1. Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells. (PMID: 16539846) Li MC … He SH (Acta pharmacologica Sinica 2006) 3 4 23 54
  2. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. (PMID: 12483210) Kotenko SV … Donnelly RP (Nature immunology 2003) 3 4 23 54
  3. IL-28, IL-29 and their class II cytokine receptor IL-28R. (PMID: 12469119) Sheppard P … Klucher KM (Nature immunology 2003) 3 4 23 54
  4. Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma. (PMID: 16618774) Lasfar A … Kotenko SV (Cancer research 2006) 3 23 54
  5. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. (PMID: 16051921) Brand S … Dambacher J (American journal of physiology. Gastrointestinal and liver physiology 2005) 3 23 54

Products for IFNL2 Gene

  • Boster Bio Antibodies for IFNL2
  • Boster Bio ELISA Kits for IFNL2

Sources for IFNL2 Gene