Aliases for IFNK Gene
External Ids for IFNK Gene
Previous GeneCards Identifiers for IFNK Gene
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]
GeneCards Summary for IFNK Gene
IFNK (Interferon Kappa) is a Protein Coding gene. Diseases associated with IFNK include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and JAK-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNW1.
UniProtKB/Swiss-Prot Summary for IFNK Gene
May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.