External Ids for IFNG Gene
Previous GeneCards Identifiers for IFNG Gene
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
GeneCards Summary for IFNG Gene
IFNG (Interferon Gamma) is a Protein Coding gene. Diseases associated with IFNG include Hepatitis C Virus and Tuberous Sclerosis 2. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Development and heterogeneity of the ILC family. Gene Ontology (GO) annotations related to this gene include cytokine activity and interferon-gamma receptor binding.
UniProtKB/Swiss-Prot Summary for IFNG Gene
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.