Aliases for IFNE Gene

Aliases for IFNE Gene

  • Interferon Epsilon 2 3 4 5
  • IFN-Epsilon 3 4
  • IFNE1 3 4
  • Interferon Epsilon 1 3
  • Interferon Epsilon-1 4
  • Interferon Tau-1 3
  • PRO655 3
  • IFN-E 3
  • IFNT1 3
  • INFE1 3

External Ids for IFNE Gene

Previous GeneCards Identifiers for IFNE Gene

  • GC09M021470
  • GC09M021444

Summaries for IFNE Gene

GeneCards Summary for IFNE Gene

IFNE (Interferon Epsilon) is a Protein Coding gene. Diseases associated with IFNE include Hirata Disease and Genital Herpes. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and JAK-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNB1.

UniProtKB/Swiss-Prot Summary for IFNE Gene

  • Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).

Additional gene information for IFNE Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNE Gene

Genomics for IFNE Gene

GeneHancer (GH) Regulatory Elements for IFNE Gene

Promoters and enhancers for IFNE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021481 Enhancer 0.6 Ensembl ENCODE 500.7 +0.5 512 2 SPI1 IKZF1 IKZF2 PRDM1 RELB IFNE RF00017-7471 MIR31HG
GH09J021547 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.6 -72.7 -72671 14.6 TCF12 FOS ZNF10 ZIC2 POLR2A ZBTB26 EP300 HDAC2 ZNF341 ZBTB17 MIR31 IFNE piR-37026-597 MIR31HG MIR31HG-002
GH09J021542 Enhancer 0.8 Ensembl ENCODE dbSUPER 4.9 -61.1 -61051 1.5 TEAD4 POLR2A MAFK GATA2 MAFF NANOG MIR31 IFNE piR-37026-597 MIR31HG MIR31HG-002
GH09J021503 Enhancer 0.7 Ensembl ENCODE 4.6 -24.2 -24187 5.8 POLR2A CEBPB JUN SPI1 RCOR1 MAFK STAT3 FOS EP300 JUND IFNWP2 IFNA8 IFNA12P IFNA20P IFNE TUBB8P1 RF00017-7472 piR-48950-210 MIR31HG MIR31HG-002
GH09J021543 Enhancer 0.4 Ensembl dbSUPER 4.4 -59.8 -59788 0.2 POLR2A MIR31 IFNE piR-37026-597 MIR31HG MIR31HG-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNE on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNE

Top Transcription factor binding sites by QIAGEN in the IFNE gene promoter:
  • Cart-1
  • Evi-1
  • HEN1
  • HNF-3beta
  • ITF-2
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Sox9
  • Tal-1beta

Genomic Locations for IFNE Gene

Genomic Locations for IFNE Gene
chr9:21,480,839-21,482,313
(GRCh38/hg38)
Size:
1,475 bases
Orientation:
Minus strand
chr9:21,480,838-21,482,312
(GRCh37/hg19)
Size:
1,475 bases
Orientation:
Minus strand

Genomic View for IFNE Gene

Genes around IFNE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNE Gene

Proteins for IFNE Gene

  • Protein details for IFNE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WN2-IFNE_HUMAN
    Recommended name:
    Interferon epsilon
    Protein Accession:
    Q86WN2

    Protein attributes for IFNE Gene

    Size:
    208 amino acids
    Molecular mass:
    24414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNE Gene

Post-translational modifications for IFNE Gene

  • Glycosylation at Asn95 and Asn104
  • Modification sites at PhosphoSitePlus

Other Protein References for IFNE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNE Gene

Domains & Families for IFNE Gene

Gene Families for IFNE Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNE Gene

Blocks:
  • Interferon alpha, beta and delta family
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNE Gene

GenScript: Design optimal peptide antigens:
  • Interferon epsilon-1 (IFNE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WN2

UniProtKB/Swiss-Prot:

IFNE_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNE: view

Function for IFNE Gene

Molecular function for IFNE Gene

UniProtKB/Swiss-Prot Function:
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity).
UniProtKB/Swiss-Prot Induction:
By estrogens.

Phenotypes From GWAS Catalog for IFNE Gene

Gene Ontology (GO) - Molecular Function for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IFNE: view
genes like me logo Genes that share phenotypes with IFNE: view

Animal Models for IFNE Gene

MGI Knock Outs for IFNE:
  • Ifne Ifne<tm1.2Pjh>

Animal Model Products

  • Taconic Biosciences Mouse Models for IFNE

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNE

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNE Gene

Localization for IFNE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNE Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNE gene
Compartment Confidence
extracellular 4
nucleus 2
cytosol 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNE Gene

Pathways & Interactions for IFNE Gene

genes like me logo Genes that share pathways with IFNE: view

Pathways by source for IFNE Gene

Gene Ontology (GO) - Biological Process for IFNE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNE: view

No data available for SIGNOR curated interactions for IFNE Gene

Drugs & Compounds for IFNE Gene

No Compound Related Data Available

Transcripts for IFNE Gene

mRNA/cDNA for IFNE Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNE

Alternative Splicing Database (ASD) splice patterns (SP) for IFNE Gene

No ASD Table

Relevant External Links for IFNE Gene

GeneLoc Exon Structure for
IFNE

Expression for IFNE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNE Gene

mRNA differential expression in normal tissues according to GTEx for IFNE Gene

This gene is overexpressed in Esophagus - Mucosa (x6.0) and Bladder (x5.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNE

SOURCE GeneReport for Unigene cluster for IFNE Gene:

Hs.682604

mRNA Expression by UniProt/SwissProt for IFNE Gene:

Q86WN2-IFNE_HUMAN
Tissue specificity: Endometrium-specific.

Evidence on tissue expression from TISSUES for IFNE Gene

  • Lung(3.7)
  • Bone(3.6)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with IFNE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNE Gene

Orthologs for IFNE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFNE 31 30
  • 99.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IFNE 31 30
  • 83.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IFNE 31
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifne 30
  • 72.63 (n)
mouse
(Mus musculus)
Mammalia Ifne 17 31 30
  • 71.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IFN4 31
  • 38 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 37 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC101750245 30
  • 53.18 (n)
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
Species where no ortholog for IFNE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNE Gene

ENSEMBL:
Gene Tree for IFNE (if available)
TreeFam:
Gene Tree for IFNE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNE: view image

Paralogs for IFNE Gene

(18) SIMAP similar genes for IFNE Gene using alignment to 1 proteins:

  • IFNE_HUMAN

Pseudogenes.org Pseudogenes for IFNE Gene

genes like me logo Genes that share paralogs with IFNE: view

Variants for IFNE Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNE Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1125488 - p.Gln46His

Additional dbSNP identifiers (rs#s) for IFNE Gene

Structural Variations from Database of Genomic Variants (DGV) for IFNE Gene

Variant ID Type Subtype PubMed ID
dgv7475n100 CNV loss 25217958
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
esv3619963 CNV loss 21293372
esv3619964 CNV loss 21293372
nsv466297 CNV gain 19166990
nsv525510 CNV gain 19592680
nsv613758 CNV gain 21841781
nsv613759 CNV loss 21841781

Variation tolerance for IFNE Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.74; 57.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNE Gene

Human Gene Mutation Database (HGMD)
IFNE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNE Gene

Disorders for IFNE Gene

MalaCards: The human disease database

(2) MalaCards diseases for IFNE Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hirata disease
  • insulin autoimmune syndrome
genital herpes
  • genital herpes simplex
- elite association - COSMIC cancer census association via MalaCards
Search IFNE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNE

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFNE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNE Gene

Publications for IFNE Gene

  1. Purification of recombinant human interferon-epsilon and oligonucleotide microarray analysis of interferon-epsilon-regulated genes. (PMID: 17287131) Peng FW … Hou YD (Protein expression and purification 2007) 2 3 23 54
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 41 54
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 41 54
  4. Bivariate genetic association of KIAA1797 with heart rate in American Indians: the Strong Heart Family Study. (PMID: 20601674) Melton PE … Almasy L (Human molecular genetics 2010) 3 41 54
  5. Characterization of the type I interferon locus and identification of novel genes. (PMID: 15233997) Hardy MP … Hertzog PJ (Genomics 2004) 3 4 54

Products for IFNE Gene

  • Signalway ELISA kits for IFNE
  • Signalway Proteins for IFNE

Sources for IFNE Gene