This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor ... See more...

Aliases for IFNB1 Gene

Aliases for IFNB1 Gene

  • Interferon Beta 1 2 3 5
  • IFB 2 3 4
  • Interferon, Beta 1, Fibroblast 2 3
  • Fibroblast Interferon 3 4
  • Interferon Beta 3 4
  • IFN-Beta 3 4
  • IFNB 3 4
  • IFF 2 3
  • Interferon-Beta 3
  • IFNB1 5

External Ids for IFNB1 Gene

Previous HGNC Symbols for IFNB1 Gene

  • IFNB

Previous GeneCards Identifiers for IFNB1 Gene

  • GC09M021404
  • GC09M021278
  • GC09M021067
  • GC09M021040

Summaries for IFNB1 Gene

Entrez Gene Summary for IFNB1 Gene

  • This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]

GeneCards Summary for IFNB1 Gene

IFNB1 (Interferon Beta 1) is a Protein Coding gene. Diseases associated with IFNB1 include Secondary Progressive Multiple Sclerosis and Primary Progressive Multiple Sclerosis. Among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA2.

UniProtKB/Swiss-Prot Summary for IFNB1 Gene

Gene Wiki entry for IFNB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNB1 Gene

Genomics for IFNB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021077 Promoter/Enhancer 0.8 EPDnew Ensembl 600.7 -0.5 -459 1.6 CTCF SCRT2 SCRT1 ELF1 ZNF143 RAD21 SPI1 IFNB1 HACD4 piR-61240-295 IFNW1
GH09J021094 Enhancer 0.9 FANTOM5 ENCODE 0.4 -18.1 -18055 3.1 IKZF2 SCRT2 CEBPB ARID3A DPF2 ZNF217 MAX EP300 IKZF1 GATA3 HACD4 FOCAD piR-61240-295 IFNWP4 IFNB1 IFNW1
GH09J021069 Enhancer 0.6 ENCODE 0.4 +7.8 7785 1.3 CTCF PRDM1 SP1 JUND JUN MAFF FOS MAFK EP300 FOSL2 HACD4 IFNB1 IFNNP1 lnc-IFNB1-1
GH09J021061 Enhancer 0.7 Ensembl ENCODE 0.4 +16.8 16841 1 IKZF2 RELB RUNX3 SPI1 MYC MAX IKZF1 IFNNP1 lnc-IFNB1-1 HACD4 IFNB1
GH09J021081 Enhancer 0.3 ENCODE 0.7 -4.3 -4255 0.2 RUNX3 IFNB1 piR-61240-295 IFNW1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNB1

Top Transcription factor binding sites by QIAGEN in the IFNB1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Evi-1
  • IRF-7A
  • MRF-2
  • POU2F1
  • POU2F1a
  • STAT1

Genomic Locations for IFNB1 Gene

Genomic Locations for IFNB1 Gene
chr9:21,077,104-21,077,942
(GRCh38/hg38)
Size:
839 bases
Orientation:
Minus strand
chr9:21,077,104-21,077,943
(GRCh37/hg19)
Size:
840 bases
Orientation:
Minus strand

Genomic View for IFNB1 Gene

Genes around IFNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNB1 Gene

Proteins for IFNB1 Gene

  • Protein details for IFNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01574-IFNB_HUMAN
    Recommended name:
    Interferon beta
    Protein Accession:
    P01574
    Secondary Accessions:
    • Q5VWC9

    Protein attributes for IFNB1 Gene

    Size:
    187 amino acids
    Molecular mass:
    22294 Da
    Quaternary structure:
    • Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.

    Three dimensional structures from OCA and Proteopedia for IFNB1 Gene

neXtProt entry for IFNB1 Gene

Post-translational modifications for IFNB1 Gene

  • Glycosylation at Asn101
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • IFNB_HUMAN (291)

Other Protein References for IFNB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IFNB1

Protein Products

No data available for DME Specific Peptides for IFNB1 Gene

Domains & Families for IFNB1 Gene

Gene Families for IFNB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for IFNB1 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family
ProtoNet:

Suggested Antigen Peptide Sequences for IFNB1 Gene

GenScript: Design optimal peptide antigens:
  • Interferon beta (B5BUQ5_HUMAN)
  • Fibroblast interferon (IFNB_HUMAN)
  • Interferon, beta 1, fibroblast (Q5VWC9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01574

UniProtKB/Swiss-Prot:

IFNB_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNB1: view

Function for IFNB1 Gene

Molecular function for IFNB1 Gene

UniProtKB/Swiss-Prot Function:
Has antiviral, antibacterial and anticancer activities.
GENATLAS Biochemistry:
interferon type I,beta 1,fibroblast,22.3kDa

Phenotypes From GWAS Catalog for IFNB1 Gene

Gene Ontology (GO) - Molecular Function for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 19008854
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding NAS 2414376
GO:0008811 chloramphenicol O-acetyltransferase activity IMP 19176627
genes like me logo Genes that share ontologies with IFNB1: view
genes like me logo Genes that share phenotypes with IFNB1: view

Animal Models for IFNB1 Gene

MGI Knock Outs for IFNB1:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNB1 Gene

Localization for IFNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNB1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
endosome 3
cytosol 3
lysosome 3
cytoskeleton 2
peroxisome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNB1 Gene

Pathways & Interactions for IFNB1 Gene

genes like me logo Genes that share pathways with IFNB1: view

Pathways by source for IFNB1 Gene

3 GeneGo (Thomson Reuters) pathways for IFNB1 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR signaling pathways
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNB1 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway
1 GeneTex pathway for IFNB1 Gene

SIGNOR curated interactions for IFNB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002312 B cell activation involved in immune response IMP 12932356
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with IFNB1: view

Drugs & Compounds for IFNB1 Gene

(77) Drugs for IFNB1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-D-Glucose Experimental Pharma Target 0
mannose Investigational Pharma 0

(58) Additional Compounds for IFNB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNB1: view

Transcripts for IFNB1 Gene

mRNA/cDNA for IFNB1 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNB1

Alternative Splicing Database (ASD) splice patterns (SP) for IFNB1 Gene

No ASD Table

Relevant External Links for IFNB1 Gene

GeneLoc Exon Structure for
IFNB1

Expression for IFNB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNB1

SOURCE GeneReport for Unigene cluster for IFNB1 Gene:

Hs.93177

Evidence on tissue expression from TISSUES for IFNB1 Gene

  • Eye(4.4)
  • Nervous system(4.3)
  • Liver(4.3)
  • Spleen(3.5)
  • Blood(3.5)
  • Lymph node(3.5)
  • Intestine(3.5)
  • Lung(3.4)
  • Pancreas(3.3)
  • Skin(3.2)
  • Kidney(3.2)
  • Bone marrow(3.1)
  • Heart(3)
  • Muscle(2.8)
  • Stomach(2.5)
  • Bone(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with IFNB1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNB1 Gene

Orthologs for IFNB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNB1 30 31
  • 98.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IFNB1 30 31
  • 75.27 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ifnb1 30
  • 67.75 (n)
Mouse
(Mus musculus)
Mammalia Ifnb1 30 17 31
  • 67.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IFNB2 31
  • 60 (a)
OneToMany
IL6 31
  • 59 (a)
OneToMany
IFNB3 31
  • 56 (a)
OneToMany
IFNB1 31
  • 56 (a)
OneToMany
-- 31
  • 55 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia IFN1 31
  • 42 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IFN5 31
  • 38 (a)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 29 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 28 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
Species where no ortholog for IFNB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNB1 Gene

ENSEMBL:
Gene Tree for IFNB1 (if available)
TreeFam:
Gene Tree for IFNB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNB1: view image

Paralogs for IFNB1 Gene

(18) SIMAP similar genes for IFNB1 Gene using alignment to 3 proteins:

  • IFNB_HUMAN
  • B5BUQ5_HUMAN
  • Q5VWC9_HUMAN
genes like me logo Genes that share paralogs with IFNB1: view

Variants for IFNB1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNB1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
717236 Benign: not provided 21,077,642(-) G/A SYNONYMOUS_VARIANT
718451 Benign: not provided 21,077,372(-) T/C MISSENSE_VARIANT
780797 Benign: not provided 21,077,690(-) G/T MISSENSE_VARIANT
788591 Benign: not provided 21,077,638(-) A/G SYNONYMOUS_VARIANT
VAR_036330 A breast cancer sample p.Trp164Cys

Additional dbSNP identifiers (rs#s) for IFNB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFNB1 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv1017312 CNV gain 25217958
nsv1161847 CNV deletion 26073780
nsv466294 CNV loss 19166990
nsv613752 CNV loss 21841781
nsv613753 CNV loss 21841781

Variation tolerance for IFNB1 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNB1 Gene

Human Gene Mutation Database (HGMD)
IFNB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNB1 Gene

Disorders for IFNB1 Gene

MalaCards: The human disease database

(105) MalaCards diseases for IFNB1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
secondary progressive multiple sclerosis
  • secondary-progressive ms
primary progressive multiple sclerosis
  • ppms
relapsing-remitting multiple sclerosis
  • relapsing-remitting ms
newcastle disease
  • newcastle's disease
demyelinating disease
  • demyelinating disorder
- elite association - COSMIC cancer census association via MalaCards
Search IFNB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IFNB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNB1 Gene

Publications for IFNB1 Gene

  1. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential. (PMID: 20127681) Oshiumi H … Seya T (European journal of immunology 2010) 3 23
  2. Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells. (PMID: 20154210) Buss C … Eitel J (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 23
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 41

Products for IFNB1 Gene

  • Addgene plasmids for IFNB1

Sources for IFNB1 Gene