Aliases for IFNB1 Gene
Aliases for IFNB1 Gene
External Ids for IFNB1 Gene
- HGNC: 5434
- Entrez Gene: 3456
- Ensembl: ENSG00000171855
- OMIM: 147640
- UniProtKB: P01574
Previous HGNC Symbols for IFNB1 Gene
- IFNB
Previous GeneCards Identifiers for IFNB1 Gene
- GC09M021404
- GC09M021278
- GC09M021067
- GC09M021040
Summaries for IFNB1 Gene
-
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
GeneCards Summary for IFNB1 Gene
IFNB1 (Interferon Beta 1) is a Protein Coding gene. Diseases associated with IFNB1 include Primary Progressive Multiple Sclerosis and Newcastle Disease. Among its related pathways are Toll-like Receptor Signaling Pathway and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.
UniProtKB/Swiss-Prot for IFNB1 Gene
-
Has antiviral, antibacterial and anticancer activities.
Additional gene information for IFNB1 Gene
- Monarch Initiative
- Search for IFNB1 at DataMed
- Search for IFNB1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNB1 Gene
Genomics for IFNB1 Gene
GeneHancer (GH) Regulatory Elements for IFNB1 Gene
Promoters and enhancers for IFNB1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J021077 | Promoter | 0.7 | EPDnew | 650.7 | 0.0 | 0 | 0.1 | SCRT1 SCRT2 | IFNB1 IFNNP1 | |
| GH09J021094 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 0.4 | -18.0 | -18034 | 3.1 | MAX BATF GATA3 SCRT2 ATF7 IKZF2 CREM SMARCE1 CEBPB DPF2 | HACD4 FOCAD IFNWP4 IFNB1 | |
| GH09J021081 | Enhancer | 0.5 | Ensembl ENCODE | 0.7 | -4.1 | -4073 | 0.5 | RUNX3 | IFNB1 IFNWP4 | |
| GH09J021069 | Enhancer | 0.8 | Ensembl ENCODE | 0.4 | +7.8 | 7806 | 1.3 | CTCF JUN BACH1 EP300 JUND MAFF FOS FOSL2 MAFK PRDM1 | HACD4 IFNB1 IFNNP1 | |
| GH09J021061 | Enhancer | 0.5 | ENCODE | 0.4 | +16.6 | 16603 | 0.2 | IKZF1 MAX IKZF2 MYC RUNX3 SPI1 | HACD4 IFNNP1 IFNB1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IFNB1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IFNB1 gene promoter:
-
- STAT1
- AP-1
- c-Jun
- ATF-2
- Evi-1
- IRF-7A
- POU2F1a
- POU2F1
- MRF-2
Regulatory Element Products
Genomic Locations for IFNB1 Gene
Genomic Locations for IFNB1 Gene
- chr9:21,077,105-21,077,963
- (GRCh38/hg38)
- Size:
- 859 bases
- Orientation:
- Minus strand
- chr9:21,077,104-21,077,943
- (GRCh37/hg19)
- Size:
- 840 bases
- Orientation:
- Minus strand
Genomic View for IFNB1 Gene
Genes around IFNB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p21.3 by Entrez Gene
- 9p21.3 by HGNC
- 9p21.3 by Ensembl
IFNB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IFNB1 Gene
Proteins for IFNB1 Gene
-
Protein details for IFNB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01574-IFNB_HUMAN
- Recommended name:
- Interferon beta
- Protein Accession:
- P01574
- Q5VWC9
Protein attributes for IFNB1 Gene
- Size:
- 187 amino acids
- Molecular mass:
- 22294 Da
- Quaternary structure:
-
- Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.
Post-translational modifications for IFNB1 Gene
Other Protein References for IFNB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IFNB1 (IFN-beta)
-
Custom Antibody ServicesOriGene Antibodies for IFNB1
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-
Abcam antibodies for IFNB1
- Invitrogen Antibodies for IFNB1
- antibodies-online: Search results for 375 available IFNB1 Antibodies ranked by validation data
- Compare Top IFNB1 Antibodies
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Recommended
- 26 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 MA Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 17 WB Antibodies (anti-rat)
- 243 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 3 Func Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- GeneTex IFNB1 Antibody for IFNB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IFNB1
- Sino Biological Antibodies for IFNB1
Protein Products
- R&D Systems Proteins and Enzymes for IFNB1 (IFN-beta)
-
OriGene Purified Proteins for IFNB1
- Search Origene for MassSpec and Protein Over-expression Lysates for IFNB1
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- Sino Biological Recombinant Proteins for IFNB1
- Sino Biological Cell Lysates for IFNB1
- ProSpec Recombinant Proteins for IFNB1
- GeneTex Proteins for IFNB1
-
ProSci Proteins for IFNB1
-
Abcam proteins for IFNB1
Assay Products
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for IFNB1 (IFN-beta)
- antibodies-online: Search results for 102 available IFNB1 Elisa Kits ranked by validation data
- Compare Top IFNB1 Elisa Kits
-
Recommended
- 10 Chicken ELISA Kits
- 6 Cow (Bovine) ELISA Kits
- 5 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 2 Guinea Pig ELISA Kits
- 5 Horse (Equine) ELISA Kits
- 18 Human ELISA Kits
- 1 Mammalian ELISA Kit
- 9 Monkey ELISA Kits
- 16 Mouse (Murine) ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 4 Rabbit ELISA Kits
- 12 Rat (Rattus) ELISA Kits
- 2 Rhesus Monkey ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
No data available for DME Specific Peptides for IFNB1 Gene
Domains & Families for IFNB1 Gene
Gene Families for IFNB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted secreted proteins
Protein Domains for IFNB1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IFNB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P01574- Family:
-
- Belongs to the alpha/beta interferon family.
Function for IFNB1 Gene
Molecular function for IFNB1 Gene
- UniProtKB/Swiss-Prot Function:
- Has antiviral, antibacterial and anticancer activities.
- GENATLAS Biochemistry:
- interferon type I,beta 1,fibroblast,22.3kDa
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IDA | 19008854 |
| GO:0005126 | cytokine receptor binding | IEA | -- |
| GO:0005132 | type I interferon receptor binding | NAS | 2414376 |
| GO:0008811 | chloramphenicol O-acetyltransferase activity | IMP | 19176627 |
Phenotypes for IFNB1 Gene
- MGI mutant phenotypes for IFNB1:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for IFNB1:
-
- Decreased viability ratio
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- Decreased NF-kappaB reporter expression
- Decreased IL-8 secretion
- Increased viability
Animal Models for IFNB1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IFNB1
-
CRISPR Products
-
OriGene CRISPR knockouts for IFNB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNB1
- genomics-online: gRNA clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
- Applied Biological Materials CRISPR for IFNB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNB1
- GenScript: Design CRISPR guide RNA sequences for IFNB1
miRNA for IFNB1 Gene
- miRTarBase miRNAs that target IFNB1
-
- hsa-let-7b-5p (MIRT004614)
- hsa-mir-26a-5p (MIRT004615)
- hsa-mir-145-5p (MIRT004616)
- hsa-mir-34a-5p (MIRT004617)
- hsa-mir-607 (MIRT644947)
- hsa-mir-6080 (MIRT644948)
- hsa-mir-4698 (MIRT644949)
- hsa-mir-8063 (MIRT644950)
- hsa-mir-513c-3p (MIRT644951)
- hsa-mir-513a-3p (MIRT644952)
- hsa-mir-3606-3p (MIRT644953)
- hsa-mir-4282 (MIRT644954)
- hsa-mir-548c-3p (MIRT644955)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNB1
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNB1
- genomics-online: shRNA clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IFNB1
- VectorBuilder custom plasmid, inducible vectors for IFNB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IFNB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IFNB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNB1
- Applied Biological Materials Clones for IFNB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IFNB1
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNB1 Gene
Localization for IFNB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IFNB1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| endosome | 2 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNB1 Gene
Pathways & Interactions for IFNB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
| 2 | Toll-like Receptor Signaling Pathway | ||
| 3 | Immune response IFN alpha/beta signaling pathway |
.30
|
|
| 4 | Influenza A |
.33
.33
|
|
| 5 | Cellular Senescence (REACTOME) | ||
Pathways by source for IFNB1 Gene
1 GeneTex pathway for IFNB1 Gene
10 BioSystems pathways for IFNB1 Gene
14 Reactome pathways for IFNB1 Gene
19 KEGG pathways for IFNB1 Gene
3 GeneGo (Thomson Reuters) pathways for IFNB1 Gene
5 R&D Systems pathways for IFNB1 Gene
4 Qiagen pathways for IFNB1 Gene
Interacting Proteins for IFNB1 Gene
GPS-Prot Interaction Network for IFNB1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IBA | -- |
| GO:0002286 | T cell activation involved in immune response | IBA | -- |
| GO:0002312 | B cell activation involved in immune response | IMP | 12932356 |
| GO:0002323 | natural killer cell activation involved in immune response | IBA | -- |
| GO:0006952 | defense response | IEA | -- |
Transcripts for IFNB1 Gene
mRNA/cDNA for IFNB1 Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (9) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000380232 859 bps (uc003zok.4)
Unigene Clusters for IFNB1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IFNB1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNB1
- genomics-online: gRNA clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
- Applied Biological Materials CRISPR for IFNB1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNB1
- GenScript: Design CRISPR guide RNA sequences for IFNB1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNB1
- Browse OriGene Inhibitory RNA Products For IFNB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNB1
- genomics-online: shRNA clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IFNB1
- VectorBuilder custom plasmid, inducible vectors for IFNB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IFNB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IFNB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNB1
- Applied Biological Materials Clones for IFNB1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IFNB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Multinucleated Osteoclasts Bone Marrow
-
Pancreas (Endocrine System)
NURSA nuclear receptor signaling pathways regulating expression of IFNB1 Gene:
IFNB1SOURCE GeneReport for Unigene cluster for IFNB1 Gene:
Hs.93177Evidence on tissue expression from TISSUES for IFNB1 Gene
- Eye(4.2)
- Nervous system(4.1)
- Liver(4)
- Blood(3.1)
- Lung(3)
- Spleen(3)
- Lymph node(2.9)
- Intestine(2.8)
- Pancreas(2.6)
- Skin(2.5)
- Kidney(2.4)
- Bone marrow(2.2)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for IFNB1
-
OriGene qPCR primer pairs for IFNB1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNB1 Gene
Orthologs for IFNB1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IFNB1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IFNB1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ifnb1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ifnb1 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | IFNB2 34 |
|
OneToMany | |
| IL6 34 |
|
OneToMany | |||
| IFNB3 34 |
|
OneToMany | |||
| IFNB1 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | IFN1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IFN5 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for IFNB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for IFNB1 Gene
- ENSEMBL:
- Gene Tree for IFNB1 (if available)
- TreeFam:
- Gene Tree for IFNB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IFNB1: view image
Paralogs for IFNB1 Gene
Variants for IFNB1 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036330 | A breast cancer sample | p.Trp164Cys | |||
| rs1000648622 | -- | 21,078,434(-) | G/C | upstream_transcript_variant | |
| rs1002257328 | -- | 21,078,969(-) | A/G | upstream_transcript_variant | |
| rs1002988939 | -- | 21,077,005(-) | T/C | downstream_transcript_variant | |
| rs1003210947 | -- | 21,078,526(-) | A/G | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2764150 | CNV | gain+loss | 21179565 |
| nsv1017312 | CNV | gain | 25217958 |
| nsv1161847 | CNV | deletion | 26073780 |
| nsv466294 | CNV | loss | 19166990 |
| nsv613752 | CNV | loss | 21841781 |
| nsv613753 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.07;
21.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IFNB1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNB1 Gene
Disorders for IFNB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| primary progressive multiple sclerosis |
|
|
| newcastle disease |
|
|
| relapsing-remitting multiple sclerosis |
|
|
| secondary progressive multiple sclerosis |
|
|
| oral erosive lichen |
|
|
Search IFNB1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IFNB1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IFNB1 Gene
Publications for IFNB1 Gene
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
- Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 44 58
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
Products for IFNB1 Gene
- R&D Systems Antibodies for IFNB1 (IFN-beta)
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- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for IFNB1 (IFN-beta)
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- Custom Antibody ServicesOriGene Antibodies for IFNB1
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- OriGene qPCR primer pairs and template standards for IFNB1
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- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IFNB1
- Novus Biologicals lysates and proteins for IFNB1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for IFNB1
- Abcam proteins for IFNB1
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- Browse Primary Antibodies
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for IFNB1
- Cyagen custom Knockout/knockin (KOKI) mouse models for IFNB1
- VectorBuilder custom plasmid, inducible vectors for IFNB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IFNB1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IFNB1
- antibodies-online: Search results for 375 available IFNB1 Antibodies ranked by validation data
- Compare Top IFNB1 Antibodies
- Recommended
- 26 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 MA Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 17 WB Antibodies (anti-rat)
- 243 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 3 Func Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- antibodies-online: Search results for 102 available IFNB1 Elisa Kits ranked by validation data
- Compare Top IFNB1 Elisa Kits
- Recommended
- 10 Chicken ELISA Kits
- 6 Cow (Bovine) ELISA Kits
- 5 Dog (Canine) ELISA Kits
- 1 Goat ELISA Kit
- 2 Guinea Pig ELISA Kits
- 5 Horse (Equine) ELISA Kits
- 18 Human ELISA Kits
- 1 Mammalian ELISA Kit
- 9 Monkey ELISA Kits
- 16 Mouse (Murine) ELISA Kits
- 10 Pig (Porcine) ELISA Kits
- 4 Rabbit ELISA Kits
- 12 Rat (Rattus) ELISA Kits
- 2 Rhesus Monkey ELISA Kits
- 1 Sheep (Ovine) ELISA Kit
- 2 Wild boar (Sus scrofa) ELISA Kits
- antibodies-online: Search results for 67 available IFNB1 Proteins ranked by validation data
- Compare Top IFNB1 Proteins
- GeneTex IFNB1 Antibody for IFNB1
- GeneTex Proteins for IFNB1
- Santa Cruz Biotechnology (SCBT) Antibodies for IFNB1
- Search Santa Cruz Biotechnology (SCBT) for IFNB1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IFNB1
- Custom Antibody ServicesProSci Antibodies for IFNB1
- ProSci Proteins for IFNB1
- Horizon Cell Lines for IFNB1
- genomics-online: cdna clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
- orf clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
- genomics-online: gRNA clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
- genomics-online: primer clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
- genomics-online: shRNA clones - Search results for 147 available IFNB1 gene related products
- Overview of 147 available IFNB1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNB1
- GeneCopoeia miRNA 3'UTR Target clone products for IFNB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNB1
Sources for IFNB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt