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This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor ... See more...
Aliases for IFNB1 Gene
Aliases for IFNB1 Gene
External Ids for IFNB1 Gene
- HGNC: 5434
- NCBI Entrez Gene: 3456
- Ensembl: ENSG00000171855
- OMIM®: 147640
- UniProtKB/Swiss-Prot: P01574
Previous HGNC Symbols for IFNB1 Gene
- IFNB
Previous GeneCards Identifiers for IFNB1 Gene
- GC09M021404
- GC09M021278
- GC09M021067
- GC09M021040
Summaries for IFNB1 Gene
-
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
GeneCards Summary for IFNB1 Gene
IFNB1 (Interferon Beta 1) is a Protein Coding gene. Diseases associated with IFNB1 include Primary Progressive Multiple Sclerosis and Relapsing-Remitting Multiple Sclerosis. Among its related pathways are JAK-STAT signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA2.
UniProtKB/Swiss-Prot Summary for IFNB1 Gene
-
Has antiviral, antibacterial and anticancer activities.
Additional gene information for IFNB1 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNB1 Gene
Genomics for IFNB1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IFNB1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH09J021077 | Promoter/Enhancer | 0.8 | EPDnew Ensembl | 250.7 | -0.5 | -459 | 1.6 | ELF1 CTCF SCRT1 SPI1 ZNF143 RAD21 SCRT2 | IFNB1 HACD4 piR-61240-295 IFNW1 | |
| GH09J021094 | Enhancer | 0.9 | FANTOM5 ENCODE | 0.4 | -18.1 | -18055 | 3.1 | CEBPB MAX ZNF217 EP300 MYC SMARCE1 BATF IKZF1 DPF2 ATF2 | HACD4 FOCAD piR-61240-295 IFNWP4 IFNB1 IFNW1 | |
| GH09J021061 | Enhancer | 0.7 | Ensembl ENCODE | 0.4 | +16.8 | 16841 | 1 | SPI1 MYC MAX IKZF1 IKZF2 RUNX3 RELB | IFNNP1 lnc-IFNB1-1 HACD4 IFNB1 | |
| GH09J021069 | Enhancer | 0.5 | ENCODE | 0.4 | +7.8 | 7785 | 1.3 | JUND CTCF EP300 MAFF MAFK NFE2L2 FOS BACH1 PRDM1 | HACD4 IFNB1 IFNNP1 lnc-IFNB1-1 | |
| GH09J021081 | Enhancer | 0.3 | ENCODE | 0.7 | -4.3 | -4255 | 0.2 | RUNX3 | IFNB1 piR-61240-295 IFNW1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IFNB1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNB1
- Top Transcription factor binding sites by QIAGEN in the IFNB1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- Evi-1
- IRF-7A
- MRF-2
- POU2F1
- POU2F1a
- STAT1
Genomic Locations for IFNB1 Gene
Latest Assembly
- chr9:21,077,104-21,077,942
- (GRCh38/hg38)
- Size:
- 839 bases
- Orientation:
- Minus strand
Previous Assembly
- chr9:21,077,103-21,077,941
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 839 bases
- Orientation:
- Minus strand
Genomic View for IFNB1 Gene
Genes around IFNB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p21.3 by HGNC
- 9p21.3 by Entrez Gene
- 9p21.3 by Ensembl
IFNB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IFNB1 Gene
Proteins for IFNB1 Gene
-
Protein details for IFNB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01574-IFNB_HUMAN
- Recommended name:
- Interferon beta
- Protein Accession:
- P01574
- Q5VWC9
Protein attributes for IFNB1 Gene
- Size:
- 187 amino acids
- Molecular mass:
- 22294 Da
- Quaternary structure:
-
- Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.
Post-translational modifications for IFNB1 Gene
Other Protein References for IFNB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences IFN Beta / Interferon Beta Antibody (LS-B1361) and IFN Beta / Interferon Beta Antibody (LS-B11441)
- G Biosciences Immunotag™ IFNB1 Antibody
- NSJ Bioreagents Interferon beta Antibody
- BioLegend IFN-beta Antibody
-
Custom Antibody ServicesOriGene Antibodies for IFNB1
- Novus Biologicals Antibodies for IFNB1
-
Abcam antibodies for IFNB1
- Invitrogen Antibodies for IFNB1 (AFLGC-Ifnb1)
- antibodies-online: Show 100 available IFNB1 Antibodies ranked by validation data
- Compare Top IFNB1 Antibodies
-
Recommended
- 197 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 28 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 MA Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Biorbyt antibodies for IFNB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IFNB1
- Sino Biological Antibodies for IFNB1
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for IFNB1
- Origene Custom Protein Services for IFNB1
- Sino Biological Recombinant Proteins for IFNB1
- Sino Biological Cell Lysates for IFNB1
- ProSpec Recombinant Proteins for IFNB1
-
ProSci Proteins for IFNB1
-
Abcam proteins for IFNB1
Assay products for research
- Novus Biologicals ELISA Kits for IFNB1
- antibodies-online: Show 121 available IFNB1 Elisa Kits ranked by validation data
- Compare Top IFNB1 Elisa Kits
-
Quality Products:
- ABIN414734
- ABIN1115567
- ABIN365229
- ABIN1028931
- ABIN5522331
- ABIN5526832
- ABIN5668911
- ABIN5593106
- ABIN770880
- ABIN455488
- ABIN1115569
- ABIN415550
- ABIN366343
- ABIN1570483
- ABIN5522333
- ABIN5526833
- ABIN5669986
- ABIN5593107
- ABIN775143
- ABIN773329
- ABIN1115568
- ABIN416262
- ABIN365376
- ABIN1570485
- ABIN5522335
- ABIN5670648
- ABIN578695
- ABIN5593108
- ABIN771985
- ABIN5655583
- ABIN414096
- ABIN4947729
- ABIN1028930
- ABIN364795
- ABIN5522330
- ABIN1563354
- ABIN5655575
- ABIN5655576
- ABIN2535206
- ABIN2948634
No data available for DME Specific Peptides for IFNB1 Gene
Domains & Families for IFNB1 Gene
Gene Families for IFNB1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted secreted proteins
Protein Domains for IFNB1 Gene
- InterPro:
- Blocks:
-
- Interferon alpha, beta and delta family
Suggested Antigen Peptide Sequences for IFNB1 Gene
- GenScript: Design optimal peptide antigens:
-
- Interferon beta (B5BUQ5_HUMAN)
- Fibroblast interferon (IFNB_HUMAN)
- Interferon, beta 1, fibroblast (Q5VWC9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P01574- Family:
-
- Belongs to the alpha/beta interferon family.
Function for IFNB1 Gene
Molecular function for IFNB1 Gene
- UniProtKB/Swiss-Prot Function:
- Has antiviral, antibacterial and anticancer activities.
- GENATLAS Biochemistry:
- interferon type I,beta 1,fibroblast,22.3kDa
Phenotypes From GWAS Catalog for IFNB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IDA | 19008854 |
| GO:0005126 | cytokine receptor binding | IEA | -- |
| GO:0005132 | type I interferon receptor binding | NAS | 2414376 |
| GO:0005515 | protein binding | IPI | 32296183 |
| GO:0008811 | chloramphenicol O-acetyltransferase activity | IMP | 19176627 |
Phenotypes for IFNB1 Gene
- MGI mutant phenotypes for IFNB1:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for IFNB1:
-
- Strongly decreased CFP-tsO45G cell surface transport
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability ratio
- Decreased viability after Maraba virus infection
- Inconclusive
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased IL-8 secretion
Animal Models for IFNB1 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IFNB1 - Starting at $85 >
- * IFNB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNB1
miRNA for IFNB1 Gene
- miRTarBase miRNAs that target IFNB1
-
- hsa-let-7b-5p (MIRT004614)
- hsa-miR-26a-5p (MIRT004615)
- hsa-miR-145-5p (MIRT004616)
- hsa-miR-34a-5p (MIRT004617)
- hsa-miR-607 (MIRT644947)
- hsa-miR-6080 (MIRT644948)
- hsa-miR-4698 (MIRT644949)
- hsa-miR-8063 (MIRT644950)
- hsa-miR-513c-3p (MIRT644951)
- hsa-miR-513a-3p (MIRT644952)
- hsa-miR-3606-3p (MIRT644953)
- hsa-miR-4282 (MIRT644954)
- hsa-miR-548c-3p (MIRT644955)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNB1
- Browse OriGene Inhibitory RNA Products For IFNB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNB1
Clone products for research
- Applied Biological Materials (abm): Clones for IFNB1 - Starting at $45 >
- * IFNB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IFNB1
- Addgene plasmids for IFNB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNB1
Cell Lines for research
-
Horizon Cell Lines for IFNB1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNB1 Gene
Localization for IFNB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IFNB1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 3 |
| mitochondrion | 3 |
| nucleus | 3 |
| endoplasmic reticulum | 3 |
| endosome | 3 |
| cytosol | 3 |
| lysosome | 3 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNB1 Gene
Pathways & Interactions for IFNB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-like Receptor Signaling Pathway |
.37
|
.34
.31
|
| 2 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
| 3 | Immune response IFN alpha/beta signaling pathway |
Immune response IFN alpha/beta signaling pathway
.74
|
Cytokine Network
.30
|
| 4 | Measles |
.35
|
.33
|
| 5 | Human cytomegalovirus infection | ||
Pathways by source for IFNB1 Gene
10 BioSystems pathways for IFNB1 Gene
14 Reactome pathways for IFNB1 Gene
27 KEGG pathways for IFNB1 Gene
3 GeneGo (Thomson Reuters) pathways for IFNB1 Gene
- Immune response IFN alpha/beta signaling pathway
- Immune response TLR signaling pathways
- Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 R&D Systems pathways for IFNB1 Gene
4 Qiagen pathways for IFNB1 Gene
- all-trans-Retinoic Acid Mediated Apoptosis
- Cytokine Network
- Interferon Pathway
- JAK-STAT Pathway
1 GeneTex pathway for IFNB1 Gene
Interacting Proteins for IFNB1 Gene
Selected Interacting proteins:
P01574-IFNB_HUMAN
ENSP00000369581
for IFNB1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IFNB1
SIGNOR curated interactions for IFNB1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IBA | 21873635 |
| GO:0002286 | T cell activation involved in immune response | IBA | 21873635 |
| GO:0002312 | B cell activation involved in immune response | IMP | 12932356 |
| GO:0002323 | natural killer cell activation involved in immune response | IBA | 21873635 |
| GO:0006952 | defense response | IEA | -- |
Transcripts for IFNB1 Gene
mRNA/cDNA for IFNB1 Gene
- 1 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000380232 839 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IFNB1 - Starting at $85 >
- * IFNB1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNB1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNB1
- Browse OriGene Inhibitory RNA Products For IFNB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNB1
Clone products for research
- Applied Biological Materials (abm): Clones for IFNB1 - Starting at $45 >
- * IFNB1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IFNB1
- Addgene plasmids for IFNB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNB1
Relevant External Links for IFNB1 Gene
- GeneLoc Exon Structure for
- IFNB1
Expression for IFNB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Multinucleated Osteoclasts Bone Marrow
-
Pancreas (Endocrine System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNB1
SOURCE GeneReport for Unigene cluster for IFNB1 Gene:
Hs.93177Evidence on tissue expression from TISSUES for IFNB1 Gene
- Eye(4.3)
- Nervous system(4.2)
- Liver(4.2)
- Intestine(3.3)
- Spleen(3.2)
- Lung(3.2)
- Lymph node(3.2)
- Blood(3.2)
- Pancreas(3.1)
- Skin(2.9)
- Kidney(2.9)
- Bone marrow(2.8)
- Heart(2.7)
- Muscle(2.5)
- Stomach(2.4)
- Thyroid gland(2.2)
- Bone(2.1)
Primer products for research
-
OriGene qPCR primer pairs for IFNB1
-
OriGene qPCR primer pairs and template standards for IFNB1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNB1 Gene
Orthologs for IFNB1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IFNB1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IFNB1 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ifnb1 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ifnb1 29 16 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IFNB2 30 |
|
OneToMany | |
| IL6 30 |
|
OneToMany | |||
| IFNB3 30 |
|
OneToMany | |||
| IFNB1 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | IFN1 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IFN5 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany |
- Species where no ortholog for IFNB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IFNB1 Gene
- ENSEMBL:
- Gene Tree for IFNB1 (if available)
- TreeFam:
- Gene Tree for IFNB1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IFNB1: view image
- Alliance of Genome Resources:
- Additional Orthologs for IFNB1
Paralogs for IFNB1 Gene
Paralogs for IFNB1 Gene
(18) SIMAP similar genes for IFNB1 Gene using alignment to 3 proteins:
- IFNB_HUMAN
- B5BUQ5_HUMAN
- Q5VWC9_HUMAN
Variants for IFNB1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNB1 Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs141894933 | Benign: not provided | 21,077,372(-) |
T/C NM_002176.4(IFNB1):c.498A>G (p.Ile166Met) |
MISSENSE | |
| rs144322634 | Benign: not provided | 21,077,638(-) |
A/G NM_002176.4(IFNB1):c.232T>C (p.Leu78=) |
SYNONYMOUS | |
| rs2229231 | Benign: not provided | 21,077,642(-) |
G/A NM_002176.4(IFNB1):c.228C>T (p.Ala76=) |
SYNONYMOUS | |
| rs34130181 | Benign: not provided | 21,077,690(-) |
G/T NM_002176.4(IFNB1):c.180C>A (p.Asp60Glu) |
MISSENSE | |
| VAR_036330 | A breast cancer sample |
p.Trp164Cys |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2764150 | CNV | gain+loss | 21179565 |
| nsv1017312 | CNV | gain | 25217958 |
| nsv1161847 | CNV | deletion | 26073780 |
| nsv466294 | CNV | loss | 19166990 |
| nsv613752 | CNV | loss | 21841781 |
| nsv613753 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.07;
21.85% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IFNB1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNB1 Gene
Disorders for IFNB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| primary progressive multiple sclerosis |
|
|
| relapsing-remitting multiple sclerosis |
|
|
| secondary progressive multiple sclerosis |
|
|
| newcastle disease |
|
|
| demyelinating disease |
|
|
Search IFNB1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IFNB1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IFNB1 Gene
Publications for IFNB1 Gene
- DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential. (PMID: 20127681) Oshiumi H … Seya T (European journal of immunology 2010) 3 22
- Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells. (PMID: 20154210) Buss C … Eitel J (Journal of immunology (Baltimore, Md. : 1950) 2010) 3 22
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 40
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
- Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 40
ExternalLinks
Products for IFNB1 Gene
- View all 38 R&D Systems IFNB1 (IFN-beta) Products
- View all 2 R&D Systems IFNB1 (IFN-beta) Proteins and Enzymes
- View all 24 R&D Systems IFNB1 (IFN-beta) Primary Antibodies
- View all 6 R&D Systems IFNB1 (IFN-beta) ELISAs
- View all R&D Systems IFNB1 (IFN-beta) Simple Plex Assays
- View all 5 R&D Systems IFNB1 (IFN-beta) Luminex Assays
- Learn more about R&D Systems custom IFNB1 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for IFNB1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for IFNB1
- Origene Custom Protein Services for IFNB1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNB1
- Browse OriGene Inhibitory RNA Products For IFNB1
- OriGene qPCR primer pairs for IFNB1
- OriGene qPCR primer pairs and template standards for IFNB1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IFNB1
- Sino Biological Human cDNA Clone for IFNB1
- Sino Biological Recombinant Proteins for IFNB1
- Sino Biological Cell Lysates for IFNB1
- Sino Biological Antibodies for IFNB1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IFNB1
- Novus Biologicals proteins and lysates for IFNB1
- Novus Biologicals ELISA Kits for IFNB1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IFNB1
- Abcam proteins for IFNB1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for IFNB1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for IFNB1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IFNB1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IFNB1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IFNB1
- Addgene plasmids for IFNB1
- antibodies-online: Show 100 available IFNB1 Antibodies ranked by validation data
- Compare Top IFNB1 Antibodies
- Recommended
- 197 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 5 FACS Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 Neut Antibody (anti-human)
- 28 WB Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 2 MA Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 121 available IFNB1 Elisa Kits ranked by validation data
- Compare Top IFNB1 Elisa Kits
- Quality Products:
- ABIN414734
- ABIN1115567
- ABIN365229
- ABIN1028931
- ABIN5522331
- ABIN5526832
- ABIN5668911
- ABIN5593106
- ABIN770880
- ABIN455488
- ABIN1115569
- ABIN415550
- ABIN366343
- ABIN1570483
- ABIN5522333
- ABIN5526833
- ABIN5669986
- ABIN5593107
- ABIN775143
- ABIN773329
- ABIN1115568
- ABIN416262
- ABIN365376
- ABIN1570485
- ABIN5522335
- ABIN5670648
- ABIN578695
- ABIN5593108
- ABIN771985
- ABIN5655583
- ABIN414096
- ABIN4947729
- ABIN1028930
- ABIN364795
- ABIN5522330
- ABIN1563354
- ABIN5655575
- ABIN5655576
- ABIN2535206
- ABIN2948634
- antibodies-online: Show 61 available IFNB1 Proteins ranked by validation data
- Compare Top IFNB1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for IFNB1
- Search Santa Cruz Biotechnology (SCBT) for IFNB1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IFNB1
- Custom Antibody ServicesProSci Antibodies for IFNB1
- ProSci Proteins for IFNB1
- Horizon Cell Lines for IFNB1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNB1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNB1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IFNB1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNB1
- Biorbyt antibodies for IFNB1
Sources for IFNB1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources