IFNB1 Gene (Protein Coding)

Interferon Beta 1

GC09M021077
GIFtS:
42
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor ... See more...

Aliases for IFNB1 Gene

Aliases for IFNB1 Gene

  • Interferon Beta 1 2 3 5
  • Interferon, Beta 1, Fibroblast 2 3
  • Fibroblast Interferon 3 4
  • Interferon Beta 3 4
  • IFN-Beta 3 4
  • IFNB 3 4
  • IFB 3 4
  • Interferon-Beta 3
  • IFF 3

External Ids for IFNB1 Gene

Previous HGNC Symbols for IFNB1 Gene

  • IFNB

Previous GeneCards Identifiers for IFNB1 Gene

  • GC09M021404
  • GC09M021278
  • GC09M021067
  • GC09M021040

Summaries for IFNB1 Gene

Entrez Gene Summary for IFNB1 Gene

  • This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]

GeneCards Summary for IFNB1 Gene

IFNB1 (Interferon Beta 1) is a Protein Coding gene. Diseases associated with IFNB1 include Primary Progressive Multiple Sclerosis and Newcastle Disease. Among its related pathways are Cellular Senescence (REACTOME) and Osteoclast Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA2.

UniProtKB/Swiss-Prot Summary for IFNB1 Gene

Gene Wiki entry for IFNB1 Gene

Additional gene information for IFNB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNB1 Gene

Genomics for IFNB1 Gene

GeneHancer (GH) Regulatory Elements for IFNB1 Gene

Promoters and enhancers for IFNB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J021077 Promoter/Enhancer 0.8 EPDnew Ensembl 750.6 -0.5 -457 1.6 ELF1 SCRT2 SCRT1 ZNF143 CTCF IFNB1 HACD4 piR-61240-295
GH09J021069 Enhancer 0.6 ENCODE 0.4 +7.8 7787 1.3 MAFK PRDM1 CTCF JUN JUND SP1 EP300 FOS FOSL2 NFE2L2 HACD4 IFNB1 IFNNP1 lnc-IFNB1-1
GH09J021061 Enhancer 0.6 Ensembl ENCODE 0.4 +16.8 16843 1 MYC MAX IKZF1 IKZF2 RUNX3 IFNNP1 lnc-IFNB1-1 HACD4 IFNB1
GH09J021075 Enhancer 0.3 Ensembl 0.6 +2.4 2443 0.6 CTCF HACD4 IFNB1 IFNNP1 lnc-IFNB1-1
GH09J021081 Enhancer 0.3 ENCODE 0.6 -4.3 -4253 0.2 RUNX3 IFNB1 piR-61240-295
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNB1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Evi-1
  • IRF-7A
  • MRF-2
  • POU2F1
  • POU2F1a
  • STAT1

Genomic Locations for IFNB1 Gene

Genomic Locations for IFNB1 Gene
chr9:21,077,104-21,077,944
(GRCh38/hg38)
Size:
841 bases
Orientation:
Minus strand
chr9:21,077,104-21,077,943
(GRCh37/hg19)
Size:
840 bases
Orientation:
Minus strand

Genomic View for IFNB1 Gene

Genes around IFNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IFNB1 Gene

Proteins for IFNB1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IFNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01574-IFNB_HUMAN
    Recommended name:
    Interferon beta
    Protein Accession:
    P01574
    Secondary Accessions:
    • Q5VWC9

    Protein attributes for IFNB1 Gene

    Size:
    187 amino acids
    Molecular mass:
    22294 Da
    Quaternary structure:
    • Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.

    Three dimensional structures from OCA and Proteopedia for IFNB1 Gene

neXtProt entry for IFNB1 Gene

Post-translational modifications for IFNB1 Gene

  • Glycosylation at Asn101
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • IFNB_HUMAN (291)

Other Protein References for IFNB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for IFNB1
  • Santa Cruz Biotechnology (SCBT) Antibodies for IFNB1

No data available for DME Specific Peptides for IFNB1 Gene

Domains & Families for IFNB1 Gene

Gene Families for IFNB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for IFNB1 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFNB1 Gene

GenScript: Design optimal peptide antigens:
  • Interferon beta (B5BUQ5_HUMAN)
  • Fibroblast interferon (IFNB_HUMAN)
  • Interferon, beta 1, fibroblast (Q5VWC9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01574

UniProtKB/Swiss-Prot:

IFNB_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNB1: view

Function for IFNB1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for IFNB1 Gene

UniProtKB/Swiss-Prot Function:
Has antiviral, antibacterial and anticancer activities.
GENATLAS Biochemistry:
interferon type I,beta 1,fibroblast,22.3kDa

Phenotypes From GWAS Catalog for IFNB1 Gene

Gene Ontology (GO) - Molecular Function for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IDA 19008854
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding NAS 2414376
GO:0008811 chloramphenicol O-acetyltransferase activity IMP 19176627
genes like me logo Genes that share ontologies with IFNB1: view
genes like me logo Genes that share phenotypes with IFNB1: view

Animal Models for IFNB1 Gene

MGI Knock Outs for IFNB1:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for IFNB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFNB1 Gene

Localization for IFNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNB1 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
mitochondrion 2
endosome 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNB1 Gene

Pathways & Interactions for IFNB1 Gene

genes like me logo Genes that share pathways with IFNB1: view

SIGNOR curated interactions for IFNB1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IFNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002312 B cell activation involved in immune response IMP 12932356
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with IFNB1: view

Drugs & Compounds for IFNB1 Gene

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  1. Drug

(76) Drugs for IFNB1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Beta-D-Glucose Experimental Pharma Target 0
mannose Investigational Pharma 0

(59) Additional Compounds for IFNB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNB1: view

Transcripts for IFNB1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IFNB1 Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for IFNB1

Alternative Splicing Database (ASD) splice patterns (SP) for IFNB1 Gene

No ASD Table

Relevant External Links for IFNB1 Gene

GeneLoc Exon Structure for
IFNB1
ECgene alternative splicing isoforms for
IFNB1

Expression for IFNB1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNB1 Gene

mRNA expression in normal human tissues for IFNB1 Gene
mRNA expression by GTEx for IFNB1 GenemRNA expression by BioGPS for IFNB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IFNB1 Gene:

IFNB1

SOURCE GeneReport for Unigene cluster for IFNB1 Gene:

Hs.93177

Evidence on tissue expression from TISSUES for IFNB1 Gene

  • Eye(4.2)
  • Nervous system(4.1)
  • Liver(4)
  • Blood(3.1)
  • Lung(3)
  • Spleen(3)
  • Lymph node(2.9)
  • Intestine(2.8)
  • Pancreas(2.6)
  • Skin(2.5)
  • Kidney(2.4)
  • Bone marrow(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with IFNB1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNB1 Gene

Orthologs for IFNB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFNB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IFNB1 33 32
  • 98.75 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia IFNB1 33 32
  • 75.27 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ifnb1 32
  • 67.75 (n)
mouse
(Mus musculus)
 Mammalia Ifnb1 17 33 32
  • 67.4 (n)
cow
(Bos Taurus)
 Mammalia IFNB2 33
  • 60 (a)
 OneToMany
IL6 33
  • 59 (a)
 OneToMany
IFNB3 33
  • 56 (a)
 OneToMany
IFNB1 33
  • 56 (a)
 OneToMany
-- 33
  • 55 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia IFN1 33
  • 42 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IFN5 33
  • 38 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves -- 33
  • 29 (a)
 ManyToMany
-- 33
  • 27 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 28 (a)
 ManyToMany
-- 33
  • 27 (a)
 ManyToMany
-- 33
  • 26 (a)
 ManyToMany
-- 33
  • 26 (a)
 ManyToMany
-- 33
  • 25 (a)
 ManyToMany
-- 33
  • 23 (a)
 ManyToMany
Species where no ortholog for IFNB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNB1 Gene

ENSEMBL:
Gene Tree for IFNB1 (if available)
TreeFam:
Gene Tree for IFNB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNB1: view image

Paralogs for IFNB1 Gene

Paralogs for IFNB1 Gene

(18) SIMAP similar genes for IFNB1 Gene using alignment to 3 proteins:

  • IFNB_HUMAN
  • B5BUQ5_HUMAN
  • Q5VWC9_HUMAN
genes like me logo Genes that share paralogs with IFNB1: view

Variants for IFNB1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for IFNB1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
VAR_036330 A breast cancer sample p.Trp164Cys
rs1000648622 -- 21,078,434(-) G/C upstream_transcript_variant
rs1002257328 -- 21,078,969(-) A/G upstream_transcript_variant
rs1002988939 -- 21,077,005(-) T/C downstream_transcript_variant
rs1003210947 -- 21,078,526(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNB1 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv1017312 CNV gain 25217958
nsv1161847 CNV deletion 26073780
nsv466294 CNV loss 19166990
nsv613752 CNV loss 21841781
nsv613753 CNV loss 21841781

Variation tolerance for IFNB1 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.07; 21.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNB1 Gene

Human Gene Mutation Database (HGMD)
IFNB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNB1 Gene

Disorders for IFNB1 Gene

MalaCards: The human disease database

(51) MalaCards diseases for IFNB1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IFNB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFNB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNB1 Gene

Publications for IFNB1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 43 56
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 43 56
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 43 56
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 43 56

ExternalLinks

View latest publications for IFNB1 gene in Mastermind

Products for IFNB1 Gene

  • Addgene plasmids for IFNB1

Sources for IFNB1 Gene