Aliases for IFNAR2 Gene
External Ids for IFNAR2 Gene
Previous HGNC Symbols for IFNAR2 Gene
Previous GeneCards Identifiers for IFNAR2 Gene
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for IFNAR2 Gene
IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) is a Protein Coding gene. Diseases associated with IFNAR2 include Immunodeficiency 45 and Measles. Among its related pathways are Toll-like Receptor Signaling Pathway and Osteoclast differentiation. Gene Ontology (GO) annotations related to this gene include protein kinase binding and type I interferon binding. An important paralog of this gene is ENSG00000249624.
UniProtKB/Swiss-Prot Summary for IFNAR2 Gene
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).