The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for thi... See more...
Aliases for IFNAR2 Gene
Aliases for IFNAR2 Gene
External Ids for IFNAR2 Gene
- HGNC: 5433
- Entrez Gene: 3455
- Ensembl: ENSG00000159110
- OMIM: 602376
- UniProtKB: P48551
Previous HGNC Symbols for IFNAR2 Gene
- IFNABR
Previous GeneCards Identifiers for IFNAR2 Gene
- GC21P031179
- GC21P033522
- GC21P033524
- GC21P034602
- GC21P020067
Summaries for IFNAR2 Gene
-
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for IFNAR2 Gene
IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) is a Protein Coding gene. Diseases associated with IFNAR2 include Immunodeficiency 45 and Measles. Among its related pathways are Allograft rejection and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include protein kinase binding and type I interferon binding. An important paralog of this gene is ENSG00000249624.
UniProtKB/Swiss-Prot Summary for IFNAR2 Gene
-
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
Additional gene information for IFNAR2 Gene
- Monarch Initiative
- Search for IFNAR2 at DataMed
- Search for IFNAR2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNAR2 Gene
Genomics for IFNAR2 Gene
GeneHancer (GH) Regulatory Elements for IFNAR2 Gene
Promoters and enhancers for IFNAR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IFNAR2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IFNAR2 gene promoter:
-
- STAT1
- STAT5A
Genomic Locations for IFNAR2 Gene
Genomic Locations for IFNAR2 Gene
- chr21:33,229,895-33,265,675
- (GRCh38/hg38)
- Size:
- 35,781 bases
- Orientation:
- Plus strand
- chr21:34,602,206-34,637,980
- (GRCh37/hg19)
- Size:
- 35,775 bases
- Orientation:
- Plus strand
Genomic View for IFNAR2 Gene
Genes around IFNAR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.11 by HGNC
- 21q22.11 by Entrez Gene
- 21q22.11 by Ensembl
IFNAR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IFNAR2 Gene
Proteins for IFNAR2 Gene
-
Protein details for IFNAR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48551-INAR2_HUMAN
- Recommended name:
- Interferon alpha/beta receptor 2
- Protein Accession:
- P48551
- A8KAJ4
- D3DSE8
- D3DSE9
- Q15467
- Q6FHD7
Protein attributes for IFNAR2 Gene
- Size:
- 515 amino acids
- Molecular mass:
- 57759 Da
- Quaternary structure:
-
- Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Isoform 1 interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453). Interacts with JAK1 (PubMed:8181059, PubMed:7759950).
Three dimensional structures from OCA and Proteopedia for IFNAR2 Gene
Protein Expression for IFNAR2 Gene
Post-translational modifications for IFNAR2 Gene
- Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
- Glycosylated.
-
Glycosylation at Asn58, Asn87, Asn116, Asn188, and Asn192
- NX_P48551 (NX_P48551-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- INAR2_HUMAN (2051)
Other Protein References for IFNAR2 Gene
Antibody Products
-
Miltenyi Biotec
- Recombinant Anti IFNAR2 Antibody (130-099-552)
- Recombinant Anti IFNAR2 Antibody (130-099-567)
- Recombinant Anti IFNAR2 Antibody (130-099-555)
- Recombinant Anti IFNAR2 Antibody (130-099-554)
- Recombinant Anti IFNAR2 Antibody (130-099-560)
- Recombinant Anti IFNAR2 Antibody (130-099-558)
- Recombinant Anti IFNAR2 Antibody (130-105-248)
- Recombinant Anti IFNAR2 Antibody (130-099-556)
- Recombinant Anti IFNAR2 Antibody (130-105-290)
- Recombinant Anti IFNAR2 Antibody (130-099-570)
- G Biosciences Immunotag™ INAR2 Antibody and Immunotag™ IFNAR2 Antibody
-
Custom Antibody ServicesOriGene Antibodies for IFNAR2
- Novus Biologicals Antibodies for IFNAR2
-
Abcam antibodies for IFNAR2
- Invitrogen Antibodies for IFNAR2 (AFLGC-IFNAR2)
-
Biorbyt antibodies for IFNAR2
-
Boster Bio Antibodies for IFNAR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for IFNAR2
- Sino Biological Antibodies for IFNAR2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for IFNAR2
- Origene Custom Protein Services for IFNAR2
- Novus Biologicals lysates for IFNAR2
- Sino Biological Recombinant Proteins for IFNAR2
- Sino Biological Cell Lysates for IFNAR2
-
Abcam proteins for IFNAR2
Assay Products
- RayBiotech Human IFN alpha/beta R2 ELISA
- Aviva Systems Biology IFNAR2 ELISA Kit (Human) : 96 Wells (OKEH00769) and IFNAR2 ELISA Kit (Human) (OKCD08611)
No data available for DME Specific Peptides for IFNAR2 Gene
Domains & Families for IFNAR2 Gene
Gene Families for IFNAR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IFNAR2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IFNAR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Type I interferon receptor 2 (INAR2_HUMAN)
- Interferon (Alpha, beta and omega) receptor 2 (Q9BUA0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P48551- Family:
-
- Belongs to the type II cytokine receptor family.
Function for IFNAR2 Gene
Molecular function for IFNAR2 Gene
- UniProtKB/Swiss-Prot Function:
- Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
- GENATLAS Biochemistry:
- interferon alpha/beta (type I) receptor,beta subunit,identified by monoclonal antibody IFNAR beta 1,cytokin receptor family II,member
Phenotypes From GWAS Catalog for IFNAR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IBA | 21873635 |
| GO:0004905 | type I interferon receptor activity | IDA,TAS | 7665574 |
| GO:0005515 | protein binding | IPI,IEA | 7665574 |
| GO:0019901 | protein kinase binding | IPI | 7759950 |
Phenotypes for IFNAR2 Gene
- MGI mutant phenotypes for IFNAR2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IFNAR2:
Animal Models for IFNAR2 Gene
- MGI Knock Outs for IFNAR2:
-
- Ifnar2 Ifnar2<tm1Pjh>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IFNAR2 - Select products 50% OFF >
- * IFNAR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * IFNAR2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for IFNAR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNAR2
- genomics-online: gRNA clones - Search for available IFNAR2 gRNA products
- Overview of 128 available IFNAR2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNAR2
miRNA for IFNAR2 Gene
- miRTarBase miRNAs that target IFNAR2
-
- hsa-mir-106b-5p (MIRT020448)
- hsa-mir-484 (MIRT042241)
- hsa-mir-18a-5p (MIRT085092)
- hsa-mir-218-5p (MIRT085093)
- hsa-mir-18b-5p (MIRT085097)
- hsa-mir-519c-3p (MIRT085098)
- hsa-mir-519b-3p (MIRT085099)
- hsa-mir-519a-3p (MIRT085100)
- hsa-mir-651-3p (MIRT085102)
- hsa-mir-4735-3p (MIRT085108)
- hsa-mir-3591-5p (MIRT085109)
- hsa-mir-5589-3p (MIRT085110)
- hsa-mir-6730-5p (MIRT085112)
- hsa-mir-17-5p (MIRT155230)
- hsa-mir-20a-5p (MIRT155231)
- hsa-mir-30a-5p (MIRT155233)
- hsa-mir-93-5p (MIRT155234)
- hsa-mir-30c-5p (MIRT155236)
- hsa-mir-30d-5p (MIRT155237)
- hsa-mir-30b-5p (MIRT155243)
- hsa-mir-30e-5p (MIRT155251)
- hsa-mir-20b-5p (MIRT155254)
- hsa-mir-519d-3p (MIRT155259)
- hsa-mir-516b-3p (MIRT155261)
- hsa-mir-516a-3p (MIRT155263)
- hsa-mir-636 (MIRT155271)
- hsa-mir-651-5p (MIRT155272)
- hsa-mir-1258 (MIRT155277)
- hsa-mir-2115-5p (MIRT155281)
- hsa-mir-3678-3p (MIRT155293)
- hsa-mir-3714 (MIRT155296)
- hsa-mir-7162-5p (MIRT155330)
- hsa-mir-1273h-3p (MIRT155331)
- hsa-mir-142-3p (MIRT511401)
- hsa-mir-4280 (MIRT511402)
- hsa-mir-520e (MIRT511403)
- hsa-mir-520d-3p (MIRT511404)
- hsa-mir-520c-3p (MIRT511405)
- hsa-mir-520b (MIRT511406)
- hsa-mir-520a-3p (MIRT511407)
- hsa-mir-373-3p (MIRT511408)
- hsa-mir-372-3p (MIRT511409)
- hsa-mir-302e (MIRT511410)
- hsa-mir-302d-3p (MIRT511411)
- hsa-mir-302c-3p (MIRT511412)
- hsa-mir-302b-3p (MIRT511413)
- hsa-mir-302a-3p (MIRT511414)
- hsa-mir-6510-3p (MIRT539932)
- hsa-mir-1228-5p (MIRT539933)
- hsa-mir-6888-3p (MIRT539934)
- hsa-mir-6729-5p (MIRT539935)
- hsa-mir-4649-5p (MIRT539936)
- hsa-mir-1273a (MIRT539937)
- hsa-mir-4522 (MIRT539938)
- hsa-mir-6774-5p (MIRT539939)
- hsa-mir-635 (MIRT539940)
- hsa-mir-3120-5p (MIRT539941)
- hsa-mir-4538 (MIRT539942)
- hsa-mir-4453 (MIRT539943)
- hsa-mir-3664-5p (MIRT539944)
- hsa-mir-506-3p (MIRT547848)
- hsa-mir-124-3p (MIRT547849)
- hsa-mir-2467-3p (MIRT547850)
- hsa-mir-4771 (MIRT547851)
- hsa-mir-3166 (MIRT547852)
- hsa-mir-1265 (MIRT547853)
- hsa-mir-2392 (MIRT547854)
- hsa-mir-3910 (MIRT547855)
- hsa-mir-655-5p (MIRT662165)
- hsa-mir-603 (MIRT662166)
- hsa-mir-8485 (MIRT662167)
- hsa-mir-7150 (MIRT670124)
- hsa-mir-4737 (MIRT670125)
- hsa-mir-7977 (MIRT670126)
- hsa-mir-566 (MIRT670127)
- hsa-mir-4736 (MIRT670128)
- hsa-mir-4763-3p (MIRT670129)
- hsa-mir-1207-5p (MIRT670130)
- hsa-mir-6720-3p (MIRT670131)
- hsa-mir-381-5p (MIRT670132)
- hsa-mir-5690 (MIRT670133)
- hsa-mir-665 (MIRT702783)
- hsa-mir-4722-5p (MIRT702784)
- hsa-mir-6133 (MIRT702785)
- hsa-mir-6130 (MIRT702786)
- hsa-mir-6129 (MIRT702787)
- hsa-mir-6127 (MIRT702788)
- hsa-mir-4510 (MIRT702789)
- hsa-mir-4419a (MIRT702790)
- hsa-mir-1827 (MIRT702791)
- hsa-mir-4649-3p (MIRT702792)
- hsa-mir-4756-5p (MIRT702793)
- hsa-mir-4739 (MIRT702794)
- hsa-mir-1321 (MIRT702795)
- hsa-mir-940 (MIRT702796)
- hsa-mir-6893-5p (MIRT702797)
- hsa-mir-6808-5p (MIRT702798)
- hsa-mir-34b-3p (MIRT702799)
- hsa-mir-629-3p (MIRT721326)
- hsa-mir-4279 (MIRT721327)
- hsa-mir-7111-3p (MIRT721328)
- hsa-mir-513a-5p (MIRT721329)
- hsa-mir-122-5p (MIRT721330)
- hsa-mir-504-3p (MIRT721331)
- hsa-mir-342-3p (MIRT721332)
- hsa-mir-4254 (MIRT721333)
- hsa-mir-6769b-3p (MIRT721334)
- hsa-mir-4723-3p (MIRT721335)
- hsa-mir-3183 (MIRT721336)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IFNAR2
- Browse OriGene Inhibitory RNA Products For IFNAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNAR2
- genomics-online: shRNA clones - Search for available IFNAR2 shRNA products
- Overview of 128 available IFNAR2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for IFNAR2 - Select products 50% OFF >
- * IFNAR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * IFNAR2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG208241
- MG225728
- MR208241
- MR208241L3
- MR208241L3V
- MR208241L4
- MR208241L4V
- MR225728
- MR225728L3
- MR225728L3V
- MR225728L4
- MR225728L4V
- RC201212
- RC201212L1
- RC201212L1V
- RC201212L2
- RC201212L2V
- RC201212L3
- RC201212L3V
- RC201212L4
- RC201212L4V
- RC218039
- RC218039L1
- RC218039L1V
- RC218039L2
- RC218039L2V
- RC218039L3
- RC218039L3V
- RC218039L4
- RC218039L4V
- RC219921
- RC219921L1
- RC219921L1V
- RC219921L2
- RC219921L2V
- RC219921L3
- RC219921L3V
- RC219921L4
- RC219921L4V
- RC236829
- RC236830
- RC238664
- RG201212
- RG218039
- RG219921
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IFNAR2
- Addgene plasmids for IFNAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNAR2
Cell Line Products
-
Horizon Cell Lines for IFNAR2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IFNAR2 Gene
Localization for IFNAR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IFNAR2 Gene
- Isoform 1: Cell membrane; Single-pass type I membrane protein.
- Isoform 2: Cell membrane; Single-pass type I membrane protein.
- Isoform 3: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
| GO:0005886 | plasma membrane | IBA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | IDA,TAS | 7759950 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNAR2 Gene
Pathways & Interactions for IFNAR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-like Receptor Signaling Pathway |
.34
|
|
| 2 | Measles |
.35
|
.33
|
| 3 | Immune response IFN alpha/beta signaling pathway | ||
| 4 | PI3K-Akt signaling pathway | ||
| 5 | JAK-STAT signaling pathway (KEGG) | ||
Pathways by source for IFNAR2 Gene
5 BioSystems pathways for IFNAR2 Gene
5 Reactome pathways for IFNAR2 Gene
1 PharmGKB pathway for IFNAR2 Gene
16 KEGG pathways for IFNAR2 Gene
1 GeneGo (Thomson Reuters) pathway for IFNAR2 Gene
2 R&D Systems pathways for IFNAR2 Gene
3 Qiagen pathways for IFNAR2 Gene
- Interferon Pathway
- JAK-STAT Pathway
- THC Differentiation Pathway
1 GeneTex pathway for IFNAR2 Gene
Interacting Proteins for IFNAR2 Gene
Selected Interacting proteins:
P48551-INAR2_HUMAN
ENSP00000343957
for IFNAR2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IFNAR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007166 | cell surface receptor signaling pathway | TAS | 8798579 |
| GO:0007259 | JAK-STAT cascade | TAS | 7588638 |
| GO:0009615 | response to virus | TAS | 7588638 |
| GO:0019221 | cytokine-mediated signaling pathway | IBA | 21873635 |
| GO:0035455 | response to interferon-alpha | IMP | 26424569 |
Drugs & Compounds for IFNAR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Interferon Alfa-2a, Recombinant | Approved, Investigational | Pharma | Target, binder | 0 | ||
| Interferon alfacon-1 | Approved, Investigational | Pharma | Target, binder | 13 | ||
| Interferon alfa-n1 | Approved, Investigational | Pharma | Target, agonist, binder | 0 | ||
| Interferon alfa-n3 | Approved, Investigational | Pharma | Target, agonist, binder | 0 | ||
| Interferon beta-1b | Approved | Pharma | Target, agonist, binder | 90 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for IFNAR2 Gene
mRNA/cDNA for IFNAR2 Gene
- (6) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (186) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000382264 1389 bps (ENST00000382264.7)
- ENST00000404220 4284 bps (ENST00000404220.7)
- ENST00000342136 2899 bps (ENST00000342136.8)
- ENST00000420068 505 bps (ENST00000420068.1)
- ENST00000342101 2606 bps (ENST00000342101.7)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IFNAR2 - Select products 50% OFF >
- * IFNAR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * IFNAR2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for IFNAR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNAR2
- genomics-online: gRNA clones - Search for available IFNAR2 gRNA products
- Overview of 128 available IFNAR2 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNAR2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IFNAR2
- Browse OriGene Inhibitory RNA Products For IFNAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNAR2
- genomics-online: shRNA clones - Search for available IFNAR2 shRNA products
- Overview of 128 available IFNAR2 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for IFNAR2 - Select products 50% OFF >
- * IFNAR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * IFNAR2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
-
- MG208241
- MG225728
- MR208241
- MR208241L3
- MR208241L3V
- MR208241L4
- MR208241L4V
- MR225728
- MR225728L3
- MR225728L3V
- MR225728L4
- MR225728L4V
- RC201212
- RC201212L1
- RC201212L1V
- RC201212L2
- RC201212L2V
- RC201212L3
- RC201212L3V
- RC201212L4
- RC201212L4V
- RC218039
- RC218039L1
- RC218039L1V
- RC218039L2
- RC218039L2V
- RC218039L3
- RC218039L3V
- RC218039L4
- RC218039L4V
- RC219921
- RC219921L1
- RC219921L1V
- RC219921L2
- RC219921L2V
- RC219921L3
- RC219921L3V
- RC219921L4
- RC219921L4V
- RC236829
- RC236830
- RC238664
- RG201212
- RG218039
- RG219921
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IFNAR2
- Addgene plasmids for IFNAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNAR2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Expression for IFNAR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for IFNAR2 Gene
This gene is overexpressed in Whole Blood (x6.5).
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFNAR2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IFNAR2 Gene:
IFNAR2SOURCE GeneReport for Unigene cluster for IFNAR2 Gene:
Hs.708195mRNA Expression by UniProt/SwissProt for IFNAR2 Gene:
P48551-INAR2_HUMAN
Tissue specificity:
Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
Evidence on tissue expression from TISSUES for IFNAR2 Gene
- Blood(4.4)
- Spleen(2.5)
Primer Products
-
OriGene qPCR primer pairs for IFNAR2
-
OriGene qPCR primer pairs and template standards for IFNAR2
- genomics-online: primer clones - Search for available IFNAR2 Primer products
- Overview of 128 available IFNAR2 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNAR2 Gene
Orthologs for IFNAR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IFNAR2 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IFNAR2 32 |
|
||
| -- 33 |
|
OneToMany | |||
| -- 33 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | IFNAR2 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ifnar2 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Ifnar2 17 33 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IFNAR2 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IFNAR2 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IFNAR2 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | IFNAR2 33 |
|
OneToOne |
- Species where no ortholog for IFNAR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for IFNAR2 Gene
- ENSEMBL:
- Gene Tree for IFNAR2 (if available)
- TreeFam:
- Gene Tree for IFNAR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IFNAR2: view image
Paralogs for IFNAR2 Gene
Variants for IFNAR2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IFNAR2 Gene
- INAR2_HUMAN-P48551
- Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2229207 | risk-factor, Hepatitis b virus, susceptibility to, - | 33,241,945(+) | T/C | coding_sequence_variant, missense_variant | |
| rs775739391 | pathogenic, Immunodeficiency 45 | 33,246,807(+) | A/ | coding_sequence_variant, frameshift | |
| rs1131668 | benign, not specified | 33,262,573(+) | G/A/T | coding_sequence_variant, intron_variant, missense_variant | |
| rs1000001509 | -- | 33,247,760(+) | A/G | intron_variant | |
| rs1000251675 | -- | 33,265,172(+) | T/C | 3_prime_UTR_variant, genic_downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7814n54 | CNV | loss | 21841781 |
| esv2723349 | CNV | deletion | 23290073 |
| esv2723351 | CNV | deletion | 23290073 |
| esv990908 | CNV | deletion | 20482838 |
| nsv1136627 | CNV | deletion | 24896259 |
| nsv587367 | CNV | loss | 21841781 |
| nsv587368 | CNV | loss | 21841781 |
| nsv587369 | CNV | loss | 21841781 |
| nsv587370 | CNV | loss | 21841781 |
| nsv587371 | CNV | loss | 21841781 |
| nsv587372 | CNV | loss | 21841781 |
| nsv587373 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.31;
62.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IFNAR2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for IFNAR2 Gene
(9) MalaCards diseases for IFNAR2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 45 |
|
|
| measles |
|
|
| mumps |
|
|
| primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection |
|
|
| hepatitis |
|
|
Search IFNAR2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
INAR2_HUMAN- Immunodeficiency 45 (IMD45) [MIM:616669]: An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. {ECO:0000269 PubMed:26424569}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for IFNAR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for IFNAR2 Gene
Publications for IFNAR2 Gene
- The human interferon alpha/beta receptor: characterization and molecular cloning. (PMID: 8181059) Novick D … Rubinstein M (Cell 1994) 2 3 4 23 56
- IFNAR1 and IFNAR2 polymorphisms in patients with Behçet's disease. (PMID: 19796549) Pay S … Dinc A (Clinical and experimental rheumatology 2009) 3 23 43 56
- IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response. (PMID: 15885318) Leyva L … Matesanz F (Journal of neuroimmunology 2005) 3 23 43 56
- The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding. (PMID: 12842042) Chill JH … Anglister J (Structure (London, England : 1993) 2003) 3 4 23 56
- Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. (PMID: 7588638) Lutfalla G … Mogensen KE (The EMBO journal 1995) 3 4 23 56
ExternalLinks
Products for IFNAR2 Gene
- View all 12 R&D Systems IFNAR2 (IFN-alpha/beta R2) Products
- View all R&D Systems IFNAR2 (IFN-alpha/beta R2) Proteins and Enzymes
- View all 10 R&D Systems IFNAR2 (IFN-alpha/beta R2) Primary Antibodies
- View all R&D Systems IFNAR2 (IFN-alpha/beta R2) cDNA Clones
- Learn more about R&D Systems custom IFNAR2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for IFNAR2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for IFNAR2
- Origene Custom Protein Services for IFNAR2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IFNAR2
- Browse OriGene Inhibitory RNA Products For IFNAR2
- OriGene qPCR primer pairs for IFNAR2
- OriGene qPCR primer pairs and template standards for IFNAR2
- OriGene CRISPR knockouts for IFNAR2
- MG208241
- MG225728
- MR208241
- MR208241L3
- MR208241L3V
- MR208241L4
- MR208241L4V
- MR225728
- MR225728L3
- MR225728L3V
- MR225728L4
- MR225728L4V
- RC201212
- RC201212L1
- RC201212L1V
- RC201212L2
- RC201212L2V
- RC201212L3
- RC201212L3V
- RC201212L4
- RC201212L4V
- RC218039
- RC218039L1
- RC218039L1V
- RC218039L2
- RC218039L2V
- RC218039L3
- RC218039L3V
- RC218039L4
- RC218039L4V
- RC219921
- RC219921L1
- RC219921L1V
- RC219921L2
- RC219921L2V
- RC219921L3
- RC219921L3V
- RC219921L4
- RC219921L4V
- RC236829
- RC236830
- RC238664
- RG201212
- RG218039
- RG219921
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IFNAR2
- Sino Biological Human cDNA Clone for IFNAR2
- Sino Biological Recombinant Proteins for IFNAR2
- Sino Biological Cell Lysates for IFNAR2
- Sino Biological Antibodies for IFNAR2
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for IFNAR2
- Novus Biologicals lysates for IFNAR2
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- Abcam proteins for IFNAR2
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- Invitrogen Antibodies for IFNAR2 (AFLGC-IFNAR2)
- Addgene plasmids for IFNAR2
- antibodies-online: Show 17 available IFNAR2 Antibodies ranked by validation data
- Compare Top IFNAR2 Antibodies
- antibodies-online: Show 17 available IFNAR2 Elisa Kits ranked by validation data
- Compare Top IFNAR2 Elisa Kits
- antibodies-online: Show 21 available IFNAR2 Proteins ranked by validation data
- Compare Top IFNAR2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for IFNAR2
- Search Santa Cruz Biotechnology (SCBT) for IFNAR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IFNAR2
- Horizon Cell Lines for IFNAR2
- genomics-online: cdna clones - Search for available IFNAR2 CDNA products
- Overview of 128 available IFNAR2 gene related products
- orf clones - Search for available IFNAR2 ORF products
- Overview of 128 available IFNAR2 gene related products
- genomics-online: gRNA clones - Search for available IFNAR2 gRNA products
- Overview of 128 available IFNAR2 gene related products
- genomics-online: primer clones - Search for available IFNAR2 Primer products
- Overview of 128 available IFNAR2 gene related products
- genomics-online: shRNA clones - Search for available IFNAR2 shRNA products
- Overview of 128 available IFNAR2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNAR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IFNAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNAR2
- Boster Bio Antibodies for IFNAR2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for IFNAR2
Sources for IFNAR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
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- (112) Disease Ontology
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- (115) MedlinePlus
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- (118) NCBI Bookshelf
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- (135) dbSUPER
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- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
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- (164) Synthego
- (165) Bio Basic
- (166) ENA
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- (168) LncBase
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- (170) LNCipedia
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- (176) snOPY
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