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The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are assoc... See more...
Aliases for IFNAR2 Gene
Aliases for IFNAR2 Gene
- Interferon Alpha And Beta Receptor Subunit 2 2 3 5
- Interferon Alpha/Beta Receptor 2 2 3 4
- Type I Interferon Receptor 2 2 3 4
- Interferon (Alpha, Beta And Omega) Receptor 2 2 3
- IFNalpha/Beta Receptor Subunit 2 2 3
- Interferon Alpha Binding Protein 3 4
- IFN-Alpha/Beta Receptor 2 3 4
- IFN-R-2 3 4
- IFNABR 3 4
External Ids for IFNAR2 Gene
- HGNC: 5433
- NCBI Entrez Gene: 3455
- Ensembl: ENSG00000159110
- OMIM®: 602376
- UniProtKB/Swiss-Prot: P48551
Previous HGNC Symbols for IFNAR2 Gene
- IFNABR
Previous GeneCards Identifiers for IFNAR2 Gene
- GC21P031179
- GC21P033522
- GC21P033524
- GC21P034602
- GC21P020067
Summaries for IFNAR2 Gene
-
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]
GeneCards Summary for IFNAR2 Gene
IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) is a Protein Coding gene. Diseases associated with IFNAR2 include Immunodeficiency 45 and Primary Immunodeficiency With Post-Measles-Mumps-Rubella Vaccine Viral Infection. Among its related pathways are JAK-STAT signaling pathway and Immune response IFN alpha/beta signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and type I interferon binding. An important paralog of this gene is IL20RA.
UniProtKB/Swiss-Prot Summary for IFNAR2 Gene
-
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569, PubMed:32972995). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
Additional gene information for IFNAR2 Gene
- HGNC (5433)
- NCBI Entrez Gene (3455)
- Ensembl (ENSG00000159110)
- OMIM® (602376)
- UniProtKB/Swiss-Prot (P48551)
- Open Targets Platform(ENSG00000159110)
- Monarch Initiative
- Alliance of Genome Resources
- Search for IFNAR2 at DataMed
- Search for IFNAR2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNAR2 Gene
Genomics for IFNAR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IFNAR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IFNAR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNAR2
- Top Transcription factor binding sites by QIAGEN in the IFNAR2 gene promoter:
-
- STAT1
- STAT5A
Genomic Locations for IFNAR2 Gene
Latest Assembly
- chr21:33,229,901-33,265,675
- (GRCh38/hg38)
- Size:
- 35,775 bases
- Orientation:
- Plus strand
Previous Assembly
- chr21:34,602,243-34,637,969
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 35,727 bases
- Orientation:
- Plus strand
Genomic View for IFNAR2 Gene
Genes around IFNAR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.11 by HGNC
- 21q22.11 by Entrez Gene
- 21q22.11 by Ensembl
IFNAR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IFNAR2 Gene
Proteins for IFNAR2 Gene
-
Protein details for IFNAR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P48551-INAR2_HUMAN
- Recommended name:
- Interferon alpha/beta receptor 2
- Protein Accession:
- P48551
- A8KAJ4
- D3DSE8
- D3DSE9
- Q15467
- Q6FHD7
Protein attributes for IFNAR2 Gene
- Size:
- 515 amino acids
- Molecular mass:
- 57759 Da
- Quaternary structure:
-
- Heterodimer with IFNAR1 (PubMed:8181059, PubMed:7665574, PubMed:10049744, PubMed:24075985, PubMed:21854986). Isoform 1 interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453). Interacts with JAK1 (PubMed:8181059, PubMed:7759950).
- Miscellaneous:
-
- [Isoform 3]: Soluble receptor.
Three dimensional structures from OCA and Proteopedia for IFNAR2 Gene
Protein Expression for IFNAR2 Gene
Post-translational modifications for IFNAR2 Gene
- Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
- Glycosylated.
-
Glycosylation at Asn58, Asn87, Asn116, Asn188, and Asn192
- NX_P48551 (NX_P48551-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- INAR2_HUMAN (2051)
Other Protein References for IFNAR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences IFNAR2 Antibody (LS-B3605) and IFNAR2 Antibody (LS-B13369)
- G Biosciences Immunotag™ INAR2 Antibody and Immunotag™ IFNAR2 Antibody
- GeneTex Anti-IFNAR2 antibody
-
Custom Antibody ServicesOriGene Antibodies for IFNAR2
- Novus Biologicals Antibodies for IFNAR2
-
Abcam antibodies for IFNAR2
- Invitrogen Antibodies for IFNAR2 (AFLGC-IFNAR2)
-
Biorbyt antibodies for IFNAR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for IFNAR2
- Sino Biological Antibodies for IFNAR2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for IFNAR2
- Origene Custom Protein Services for IFNAR2
- Novus Biologicals lysates for IFNAR2
- Sino Biological Recombinant Proteins for IFNAR2
- Sino Biological Cell Lysates for IFNAR2
-
Abcam proteins for IFNAR2
No data available for DME Specific Peptides for IFNAR2 Gene
Domains & Families for IFNAR2 Gene
Gene Families for IFNAR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- FDA approved drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IFNAR2 Gene
Suggested Antigen Peptide Sequences for IFNAR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Type I interferon receptor 2 (INAR2_HUMAN)
- Interferon (Alpha, beta and omega) receptor 2 (Q9BUA0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P48551- Family:
-
- Belongs to the type II cytokine receptor family.
Function for IFNAR2 Gene
Molecular function for IFNAR2 Gene
- UniProtKB/Swiss-Prot Function:
- Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569, PubMed:32972995). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
- GENATLAS Biochemistry:
- interferon alpha/beta (type I) receptor,beta subunit,identified by monoclonal antibody IFNAR beta 1,cytokin receptor family II,member
Phenotypes From GWAS Catalog for IFNAR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IBA | 21873635 |
| GO:0004905 | type I interferon receptor activity | TAS,IDA | 7665574 |
| GO:0005515 | protein binding | IEA,IPI | 7665574 |
| GO:0019901 | protein kinase binding | IPI | 7759950 |
| GO:0019962 | type I interferon binding | IPI | -- |
Phenotypes for IFNAR2 Gene
- MGI mutant phenotypes for IFNAR2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IFNAR2:
Animal Models for IFNAR2 Gene
- MGI Knock Outs for IFNAR2:
-
- Ifnar2 Ifnar2<tm1Pjh>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IFNAR2 - Starting at $85 >
- * IFNAR2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IFNAR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNAR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNAR2
miRNA for IFNAR2 Gene
- miRTarBase miRNAs that target IFNAR2
-
- hsa-miR-106b-5p (MIRT020448)
- hsa-miR-484 (MIRT042241)
- hsa-miR-18a-5p (MIRT085092)
- hsa-miR-218-5p (MIRT085093)
- hsa-miR-18b-5p (MIRT085097)
- hsa-miR-519c-3p (MIRT085098)
- hsa-miR-519b-3p (MIRT085099)
- hsa-miR-519a-3p (MIRT085100)
- hsa-miR-651-3p (MIRT085102)
- hsa-miR-4735-3p (MIRT085108)
- hsa-miR-3591-5p (MIRT085109)
- hsa-miR-5589-3p (MIRT085110)
- hsa-miR-6730-5p (MIRT085112)
- hsa-miR-17-5p (MIRT155230)
- hsa-miR-20a-5p (MIRT155231)
- hsa-miR-30a-5p (MIRT155233)
- hsa-miR-93-5p (MIRT155234)
- hsa-miR-30c-5p (MIRT155236)
- hsa-miR-30d-5p (MIRT155237)
- hsa-miR-30b-5p (MIRT155243)
- hsa-miR-30e-5p (MIRT155251)
- hsa-miR-20b-5p (MIRT155254)
- hsa-miR-519d-3p (MIRT155259)
- hsa-miR-516b-3p (MIRT155261)
- hsa-miR-516a-3p (MIRT155263)
- hsa-miR-636 (MIRT155271)
- hsa-miR-651-5p (MIRT155272)
- hsa-miR-1258 (MIRT155277)
- hsa-miR-2115-5p (MIRT155281)
- hsa-miR-3678-3p (MIRT155293)
- hsa-miR-3714 (MIRT155296)
- hsa-miR-7162-5p (MIRT155330)
- hsa-miR-1273h-3p (MIRT155331)
- hsa-miR-142-3p (MIRT511401)
- hsa-miR-4280 (MIRT511402)
- hsa-miR-520e (MIRT511403)
- hsa-miR-520d-3p (MIRT511404)
- hsa-miR-520c-3p (MIRT511405)
- hsa-miR-520b (MIRT511406)
- hsa-miR-520a-3p (MIRT511407)
- hsa-miR-373-3p (MIRT511408)
- hsa-miR-372-3p (MIRT511409)
- hsa-miR-302e (MIRT511410)
- hsa-miR-302d-3p (MIRT511411)
- hsa-miR-302c-3p (MIRT511412)
- hsa-miR-302b-3p (MIRT511413)
- hsa-miR-302a-3p (MIRT511414)
- hsa-miR-6510-3p (MIRT539932)
- hsa-miR-1228-5p (MIRT539933)
- hsa-miR-6888-3p (MIRT539934)
- hsa-miR-6729-5p (MIRT539935)
- hsa-miR-4649-5p (MIRT539936)
- hsa-miR-1273a (MIRT539937)
- hsa-miR-4522 (MIRT539938)
- hsa-miR-6774-5p (MIRT539939)
- hsa-miR-635 (MIRT539940)
- hsa-miR-3120-5p (MIRT539941)
- hsa-miR-4538 (MIRT539942)
- hsa-miR-4453 (MIRT539943)
- hsa-miR-3664-5p (MIRT539944)
- hsa-miR-506-3p (MIRT547848)
- hsa-miR-124-3p (MIRT547849)
- hsa-miR-2467-3p (MIRT547850)
- hsa-miR-4771 (MIRT547851)
- hsa-miR-3166 (MIRT547852)
- hsa-miR-1265 (MIRT547853)
- hsa-miR-2392 (MIRT547854)
- hsa-miR-3910 (MIRT547855)
- hsa-miR-655-5p (MIRT662165)
- hsa-miR-603 (MIRT662166)
- hsa-miR-8485 (MIRT662167)
- hsa-miR-7150 (MIRT670124)
- hsa-miR-4737 (MIRT670125)
- hsa-miR-7977 (MIRT670126)
- hsa-miR-566 (MIRT670127)
- hsa-miR-4736 (MIRT670128)
- hsa-miR-4763-3p (MIRT670129)
- hsa-miR-1207-5p (MIRT670130)
- hsa-miR-6720-3p (MIRT670131)
- hsa-miR-381-5p (MIRT670132)
- hsa-miR-5690 (MIRT670133)
- hsa-miR-665 (MIRT702783)
- hsa-miR-4722-5p (MIRT702784)
- hsa-miR-6133 (MIRT702785)
- hsa-miR-6130 (MIRT702786)
- hsa-miR-6129 (MIRT702787)
- hsa-miR-6127 (MIRT702788)
- hsa-miR-4510 (MIRT702789)
- hsa-miR-4419a (MIRT702790)
- hsa-miR-1827 (MIRT702791)
- hsa-miR-4649-3p (MIRT702792)
- hsa-miR-4756-5p (MIRT702793)
- hsa-miR-4739 (MIRT702794)
- hsa-miR-1321 (MIRT702795)
- hsa-miR-940 (MIRT702796)
- hsa-miR-6893-5p (MIRT702797)
- hsa-miR-6808-5p (MIRT702798)
- hsa-miR-34b-3p (MIRT702799)
- hsa-miR-629-3p (MIRT721326)
- hsa-miR-4279 (MIRT721327)
- hsa-miR-7111-3p (MIRT721328)
- hsa-miR-513a-5p (MIRT721329)
- hsa-miR-122-5p (MIRT721330)
- hsa-miR-504-3p (MIRT721331)
- hsa-miR-342-3p (MIRT721332)
- hsa-miR-4254 (MIRT721333)
- hsa-miR-6769b-3p (MIRT721334)
- hsa-miR-4723-3p (MIRT721335)
- hsa-miR-3183 (MIRT721336)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNAR2
- Browse OriGene Inhibitory RNA Products For IFNAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNAR2
Clone products for research
- Applied Biological Materials (abm): Clones for IFNAR2 - Starting at $45 >
- * IFNAR2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG208241
- MG225728
- MR208241
- MR208241L3
- MR208241L4
- MR225728
- MR225728L3
- MR225728L4
- RC201212
- RC201212L1
- RC201212L2
- RC201212L3
- RC201212L4
- RC218039
- RC218039L1
- RC218039L2
- RC218039L3
- RC218039L4
- RC219921
- RC219921L1
- RC219921L2
- RC219921L3
- RC219921L4
- RC236829
- RC236830
- RC238664
- RG201212
- RG218039
- RG219921
- MR208241L3V
- MR208241L4V
- MR225728L3V
- MR225728L4V
- RC201212L1V
- RC201212L2V
- RC201212L3V
- RC201212L4V
- RC218039L1V
- RC218039L2V
- RC218039L3V
- RC218039L4V
- RC219921L1V
- RC219921L2V
- RC219921L3V
- RC219921L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IFNAR2
- Addgene plasmids for IFNAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNAR2
Cell Lines for research
-
Horizon Cell Lines for IFNAR2
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IFNAR2 Gene
Localization for IFNAR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IFNAR2 Gene
- [Isoform 1]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 2]: Cell membrane. Single-pass type I membrane protein.
- [Isoform 3]: Secreted.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS,IEA | -- |
| GO:0005615 | extracellular space | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IDA | 7759950 |
| GO:0016020 | membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNAR2 Gene
Pathways & Interactions for IFNAR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-like Receptor Signaling Pathway |
.34
|
|
| 2 | Measles |
.35
|
.33
|
| 3 | Immune response IFN alpha/beta signaling pathway |
Immune response IFN alpha/beta signaling pathway
.74
|
|
| 4 | PI3K-Akt signaling pathway | ||
| 5 | JAK-STAT signaling pathway | ||
Pathways by source for IFNAR2 Gene
5 BioSystems pathways for IFNAR2 Gene
5 Reactome pathways for IFNAR2 Gene
1 PharmGKB pathway for IFNAR2 Gene
17 KEGG pathways for IFNAR2 Gene
1 GeneGo (Thomson Reuters) pathway for IFNAR2 Gene
- Immune response IFN alpha/beta signaling pathway
1 R&D Systems pathway for IFNAR2 Gene
3 Qiagen pathways for IFNAR2 Gene
- Interferon Pathway
- JAK-STAT Pathway
- THC Differentiation Pathway
1 GeneTex pathway for IFNAR2 Gene
Interacting Proteins for IFNAR2 Gene
Selected Interacting proteins:
P48551-INAR2_HUMAN
ENSP00000343957
for IFNAR2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IFNAR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007166 | cell surface receptor signaling pathway | TAS | 8798579 |
| GO:0007259 | JAK-STAT cascade | TAS | 7588638 |
| GO:0009615 | response to virus | TAS | 7588638 |
| GO:0019221 | cytokine-mediated signaling pathway | IBA | 21873635 |
| GO:0035455 | response to interferon-alpha | IMP | 26424569 |
Drugs & Compounds for IFNAR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Interferon alfacon-1 | Approved, Investigational | Pharma | Target, binder | 13 | ||
| Interferon alfa-n1 | Approved, Investigational | Pharma | Target, agonist, binder | 0 | ||
| Interferon alfa-n3 | Approved, Investigational | Pharma | Target, agonist, binder | 0 | ||
| Interferon beta-1b | Approved | Pharma | Target, agonist, binder | 100 | ||
| Interferon alfa-2a | Approved, Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
Transcripts for IFNAR2 Gene
mRNA/cDNA for IFNAR2 Gene
- 8 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000342101 2606 nts (view in UCSC)
- ENST00000342136 4074 nts (view in UCSC)
- ENST00000382238 1127 nts (view in UCSC)
- ENST00000382264 1389 nts (view in UCSC)
- ENST00000404220 4284 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IFNAR2 - Starting at $85 >
- * IFNAR2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IFNAR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNAR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNAR2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNAR2
- Browse OriGene Inhibitory RNA Products For IFNAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNAR2
Clone products for research
- Applied Biological Materials (abm): Clones for IFNAR2 - Starting at $45 >
- * IFNAR2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG208241
- MG225728
- MR208241
- MR208241L3
- MR208241L4
- MR225728
- MR225728L3
- MR225728L4
- RC201212
- RC201212L1
- RC201212L2
- RC201212L3
- RC201212L4
- RC218039
- RC218039L1
- RC218039L2
- RC218039L3
- RC218039L4
- RC219921
- RC219921L1
- RC219921L2
- RC219921L3
- RC219921L4
- RC236829
- RC236830
- RC238664
- RG201212
- RG218039
- RG219921
- MR208241L3V
- MR208241L4V
- MR225728L3V
- MR225728L4V
- RC201212L1V
- RC201212L2V
- RC201212L3V
- RC201212L4V
- RC218039L1V
- RC218039L2V
- RC218039L3V
- RC218039L4V
- RC219921L1V
- RC219921L2V
- RC219921L3V
- RC219921L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IFNAR2
- Addgene plasmids for IFNAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNAR2
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - |
Relevant External Links for IFNAR2 Gene
- GeneLoc Exon Structure for
- IFNAR2
Expression for IFNAR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
mRNA differential expression in normal tissues according to GTEx for IFNAR2 Gene
This gene is overexpressed in Whole Blood (x6.5).
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFNAR2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNAR2
SOURCE GeneReport for Unigene cluster for IFNAR2 Gene:
Hs.708195mRNA Expression by UniProt/SwissProt for IFNAR2 Gene:
P48551-INAR2_HUMAN
Tissue specificity:
Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
Evidence on tissue expression from TISSUES for IFNAR2 Gene
- Blood(4.5)
- Spleen(3)
- Lung(2.3)
- Liver(2.3)
- Nervous system(2.2)
- Kidney(2.2)
- Lymph node(2.1)
- Heart(2.1)
- Intestine(2)
Primer products for research
-
OriGene qPCR primer pairs for IFNAR2
-
OriGene qPCR primer pairs and template standards for IFNAR2
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNAR2 Gene
Orthologs for IFNAR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IFNAR2 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | LOC100856468 29 |
|
||
| -- 30 |
|
OneToMany | |||
| -- 30 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | IFNAR2 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ifnar2 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ifnar2 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IFNAR2 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IFNAR2 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IFNAR2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IFNAR2 30 |
|
OneToOne |
- Species where no ortholog for IFNAR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IFNAR2 Gene
- ENSEMBL:
- Gene Tree for IFNAR2 (if available)
- TreeFam:
- Gene Tree for IFNAR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IFNAR2: view image
- Alliance of Genome Resources:
- Additional Orthologs for IFNAR2
Paralogs for IFNAR2 Gene
Variants for IFNAR2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IFNAR2 Gene
- INAR2_HUMAN-P48551
- Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNAR2 Gene
| SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 1002745 | Uncertain Significance: not provided | 33,252,762(+) |
A/G NM_001289125.3(IFNAR2):c.641A>G (p.His214Arg) |
MISSENSE | |
| 1004056 | Uncertain Significance: not provided | 33,263,019(+) |
A/G NM_001289125.3(IFNAR2):c.1067A>G (p.Glu356Gly) |
MISSENSE_VARIANT,THREE_PRIME_UTR | |
| 1005430 | Uncertain Significance: not provided | 33,245,028(+) |
C/T NM_001289125.3(IFNAR2):c.175C>T (p.His59Tyr) |
MISSENSE | |
| 1014936 | Uncertain Significance: not provided | 33,246,889(+) |
C/G NM_001289125.3(IFNAR2):c.393C>G (p.Asp131Glu) |
MISSENSE | |
| 1016589 | Uncertain Significance: not provided | 33,263,037(+) |
C/T NM_001289125.3(IFNAR2):c.1085C>T (p.Pro362Leu) |
MISSENSE_VARIANT,THREE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7814n54 | CNV | loss | 21841781 |
| esv2723349 | CNV | deletion | 23290073 |
| esv2723351 | CNV | deletion | 23290073 |
| esv990908 | CNV | deletion | 20482838 |
| nsv1136627 | CNV | deletion | 24896259 |
| nsv587367 | CNV | loss | 21841781 |
| nsv587368 | CNV | loss | 21841781 |
| nsv587369 | CNV | loss | 21841781 |
| nsv587370 | CNV | loss | 21841781 |
| nsv587371 | CNV | loss | 21841781 |
| nsv587372 | CNV | loss | 21841781 |
| nsv587373 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.31;
62.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IFNAR2 Gene
SNP Genotyping and Copy Number Assays for research
Disorders for IFNAR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 45 |
|
|
| primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection |
|
|
| immunodeficiency 44 |
|
|
| hepatitis b |
|
|
| measles |
|
|
Search IFNAR2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
INAR2_HUMAN- Immunodeficiency 45 (IMD45) [MIM:616669]: An autosomal recessive disorder characterized by increased susceptibility to viral infection due to impaired antiviral immunity, resulting in infection-associated encephalopathy. Affected individuals are at risk for developing fatal encephalitis after routine measles/mumps/rubella (MMR) vaccination. {ECO:0000269 PubMed:26424569}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for IFNAR2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for IFNAR2 Gene
Publications for IFNAR2 Gene
- The human interferon alpha/beta receptor: characterization and molecular cloning. (PMID: 8181059) Novick D … Rubinstein M (Cell 1994) 2 3 4 22
- Human IFNAR2 deficiency: Lessons for antiviral immunity. (PMID: 26424569) Duncan CJ … Hambleton S (Science translational medicine 2015) 3 4 72
- A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α. (PMID: 20065083) Kreil S … German CML Study Group (Haematologica 2010) 3 22 40
- Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 22 40
- IFNAR1 and IFNAR2 polymorphisms in patients with Behçet's disease. (PMID: 19796549) Pay S … Dinc A (Clinical and experimental rheumatology 2009) 3 22 40
ExternalLinks
Products for IFNAR2 Gene
- View all 12 R&D Systems IFNAR2 (IFN-alpha/beta R2) Products
- View all R&D Systems IFNAR2 (IFN-alpha/beta R2) Proteins and Enzymes
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- Learn more about R&D Systems custom IFNAR2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for IFNAR2
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- OriGene qPCR primer pairs for IFNAR2
- OriGene qPCR primer pairs and template standards for IFNAR2
- OriGene CRISPR knockouts for IFNAR2
- MG208241
- MG225728
- MR208241
- MR208241L3
- MR208241L4
- MR225728
- MR225728L3
- MR225728L4
- RC201212
- RC201212L1
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- RC201212L3
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- RC218039
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- RC219921
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- RC219921L3
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- RC236829
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- RG201212
- RG218039
- RG219921
- MR208241L3V
- MR208241L4V
- MR225728L3V
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- RC201212L1V
- RC201212L2V
- RC201212L3V
- RC201212L4V
- RC218039L1V
- RC218039L2V
- RC218039L3V
- RC218039L4V
- RC219921L1V
- RC219921L2V
- RC219921L3V
- RC219921L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IFNAR2
- Sino Biological Human cDNA Clone for IFNAR2
- Sino Biological Recombinant Proteins for IFNAR2
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- Sino Biological Antibodies for IFNAR2
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- Novus Biologicals lysates for IFNAR2
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- VectorBuilder Viral vectors for IFNAR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for IFNAR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for IFNAR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for IFNAR2
- Addgene plasmids for IFNAR2
- antibodies-online: Show 17 available IFNAR2 Antibodies ranked by validation data
- Compare Top IFNAR2 Antibodies
- antibodies-online: Show 17 available IFNAR2 Elisa Kits ranked by validation data
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- antibodies-online: Show 21 available IFNAR2 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for IFNAR2
- Search Santa Cruz Biotechnology (SCBT) for IFNAR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IFNAR2
- Horizon Cell Lines for IFNAR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNAR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNAR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IFNAR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNAR2
- Biorbyt antibodies for IFNAR2
Sources for IFNAR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
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- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
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- (38) GenAtlas
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- (43) Atlas
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- (65) Reactome
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- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
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