Aliases for IFNA8 Gene

Aliases for IFNA8 Gene

  • Interferon Alpha 8 2 3 5
  • Interferon Alpha Type 201 2 3
  • Interferon Alpha-B2 3 4
  • Interferon Alpha-8 3 4
  • Interferon Alpha-B 3 4
  • IFN-Alpha-8 3 4
  • IFN-AlphaB 2 3
  • LeIF B 3 4
  • Interferon Alpha-B'' 2
  • Interferon, Alpha 8 2
  • Interferon Alpha-B' 3
  • IFNA8 5

External Ids for IFNA8 Gene

Previous GeneCards Identifiers for IFNA8 Gene

  • GC09P021736
  • GC09P021610
  • GC09P021399
  • GC09P021372

Summaries for IFNA8 Gene

GeneCards Summary for IFNA8 Gene

IFNA8 (Interferon Alpha 8) is a Protein Coding gene. Diseases associated with IFNA8 include St. Louis Encephalitis and Common Wart. Among its related pathways are JAK-STAT signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA16.

UniProtKB/Swiss-Prot Summary for IFNA8 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA8 Gene

Genomics for IFNA8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021332 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 11.1 -75.1 -75116 4.8 ZNF207 ZNF600 POLR2A YY1 MXD4 SIN3A ETS1 ZNF341 KLF7 KMT2B HSALNG0070353-002 KLHL9 lnc-KLHL9-1 IFNA13 IFNA5 IFNA12P IFNA8 IFNWP2 HSALNG0070358 HSALNG0070353-001
GH09J021503 Enhancer 0.7 Ensembl ENCODE 10 +97.4 97383 5.8 CEBPB EP300 STAT3 POLR2A SPI1 MAFK ZNF660 IFNWP2 IFNA8 IFNA12P IFNA20P IFNE TUBB8P1 RF00017-6895 piR-48950-210 MIR31HG MIR31HG-002
GH09J021318 Enhancer 0.5 Ensembl 12.2 -90.7 -90716 1.2 ZNF654 YY1 TRIM22 CTCF RAD21 SMC3 ZNF660 PRDM1 IFNA12P IFNA8 IFNWP2 IFNA13 IFNA20P HSALNG0070355 IFNA5 KLHL9 HSALNG0070353-001 LOC107987053
GH09J021252 Enhancer 0.5 ENCODE 11.7 -155.9 -155884 0.6 ZNF654 CTCF SIN3A RAD21 SMC3 POLR2A PKNOX1 RUNX3 PRDM1 IFNA12P IFNA8 IFNWP2 IFNA13 IFNA20P piR-43105-652 HSALNG0070353-001 IFNA14 IFNA5
GH09J021450 Enhancer 0.5 Ensembl ENCODE 11.5 +42.5 42465 1.4 CEBPB NFE2L2 IFNWP2 IFNA8 IFNA12P IFNA13 IFNA5 IFNWP19 HSALNG0070363-002 IFNA1 IFNE MIR31HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA8

Top Transcription factor binding sites by QIAGEN in the IFNA8 gene promoter:
  • Brachyury
  • C/EBPalpha
  • Egr-2
  • Egr-3
  • Egr-4
  • LCR-F1

Genomic Locations for IFNA8 Gene

Latest Assembly
chr9:21,409,117-21,410,185
(GRCh38/hg38)
Size:
1,069 bases
Orientation:
Plus strand

Previous Assembly
chr9:21,409,116-21,410,184
(GRCh37/hg19 by Entrez Gene)
Size:
1,069 bases
Orientation:
Plus strand

chr9:21,409,146-21,410,184
(GRCh37/hg19 by Ensembl)
Size:
1,039 bases
Orientation:
Plus strand

Genomic View for IFNA8 Gene

Genes around IFNA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA8 Gene

Proteins for IFNA8 Gene

  • Protein details for IFNA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32881-IFNA8_HUMAN
    Recommended name:
    Interferon alpha-8
    Protein Accession:
    P32881
    Secondary Accessions:
    • P01565
    • P09236
    • Q5VWV7
    • Q5VYQ3

    Protein attributes for IFNA8 Gene

    Size:
    189 amino acids
    Molecular mass:
    21989 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IFNA8 Gene

neXtProt entry for IFNA8 Gene

Post-translational modifications for IFNA8 Gene

No Post-translational modifications

Other Protein References for IFNA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for IFNA8
  • Santa Cruz Biotechnology (SCBT) Antibodies for IFNA8

No data available for DME Specific Peptides for IFNA8 Gene

Domains & Families for IFNA8 Gene

Gene Families for IFNA8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA8 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family

Suggested Antigen Peptide Sequences for IFNA8 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-B2 (IFNA8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32881

UniProtKB/Swiss-Prot:

IFNA8_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA8: view

Function for IFNA8 Gene

Molecular function for IFNA8 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 8,leukocyte

Phenotypes From GWAS Catalog for IFNA8 Gene

Gene Ontology (GO) - Molecular Function for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with IFNA8: view
genes like me logo Genes that share phenotypes with IFNA8: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA8 Gene

Localization for IFNA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA8 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA8 Gene

Pathways & Interactions for IFNA8 Gene

genes like me logo Genes that share pathways with IFNA8: view

Pathways by source for IFNA8 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA8 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA8 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway

Gene Ontology (GO) - Biological Process for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA8: view

No data available for SIGNOR curated interactions for IFNA8 Gene

Drugs & Compounds for IFNA8 Gene

No Compound Related Data Available

Transcripts for IFNA8 Gene

mRNA/cDNA for IFNA8 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA8

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA8 Gene

No ASD Table

Relevant External Links for IFNA8 Gene

GeneLoc Exon Structure for
IFNA8

Expression for IFNA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA8 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA8 Gene

This gene is overexpressed in Brain - Cerebellum (x16.1), Brain - Cerebellar Hemisphere (x13.4), and Brain - Frontal Cortex (BA9) (x5.8).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA8

SOURCE GeneReport for Unigene cluster for IFNA8 Gene:

Hs.73890
genes like me logo Genes that share expression patterns with IFNA8: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA8 Gene

Orthologs for IFNA8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA8 29 30
  • 98.94 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ifna6 30
  • 64 (a)
ManyToMany
Ifna13 30
  • 63 (a)
ManyToMany
Ifna5 30
  • 63 (a)
ManyToMany
Ifna12 30
  • 63 (a)
ManyToMany
Ifna1 30
  • 62 (a)
ManyToMany
Gm12597 30
  • 62 (a)
ManyToMany
Ifna9 30
  • 61 (a)
ManyToMany
Ifna2 30
  • 61 (a)
ManyToMany
Ifnab 30
  • 61 (a)
ManyToMany
Ifna7 30
  • 60 (a)
ManyToMany
Gm13280 30
  • 60 (a)
ManyToMany
Ifna14 30
  • 60 (a)
ManyToMany
Ifna11 30
  • 59 (a)
ManyToMany
Ifna4 30
  • 58 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 61 (a)
ManyToMany
-- 30
  • 60 (a)
ManyToMany
-- 30
  • 60 (a)
ManyToMany
-- 30
  • 60 (a)
ManyToMany
-- 30
  • 60 (a)
ManyToMany
IFNAG 30 30
  • 60 (a)
ManyToMany
INFAF 30
  • 59 (a)
ManyToMany
IFNAH 30
  • 59 (a)
ManyToMany
IFNAA 30
  • 59 (a)
ManyToMany
Species where no ortholog for IFNA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA8 Gene

ENSEMBL:
Gene Tree for IFNA8 (if available)
TreeFam:
Gene Tree for IFNA8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA8: view image
Alliance of Genome Resources:
Additional Orthologs for IFNA8

Paralogs for IFNA8 Gene

(18) SIMAP similar genes for IFNA8 Gene using alignment to 1 proteins:

  • IFNA8_HUMAN
genes like me logo Genes that share paralogs with IFNA8: view

Variants for IFNA8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA8 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs3739630 -- p.Glu137Lys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFNA8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFNA8 Gene

Variant ID Type Subtype PubMed ID
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
nsv466297 CNV gain 19166990
nsv613758 CNV gain 21841781
nsv968603 CNV duplication 23825009

Variation tolerance for IFNA8 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA8
Leiden Open Variation Database (LOVD)
IFNA8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA8 Gene

Disorders for IFNA8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IFNA8 Gene - From: COP

Disorder Aliases PubMed IDs
st. louis encephalitis
  • neuroinvasive st. louis encephalitis virus infection
common wart
- elite association - COSMIC cancer census association via MalaCards
Search IFNA8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA8

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IFNA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA8 Gene

Publications for IFNA8 Gene

  1. Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population. (PMID: 8836918) Hussain M … Testa D (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996) 3 4 22
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 40
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 40
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 40
  5. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 40

Products for IFNA8 Gene

Sources for IFNA8 Gene