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Aliases for IFNA8 Gene

Aliases for IFNA8 Gene

  • Interferon Alpha 8 2 3 5
  • Interferon Alpha-B 2 3 4
  • Interferon Alpha Type 201 2 3
  • Interferon Alpha-B2 3 4
  • IFN-Alpha-8 3 4
  • LeIF B 3 4
  • Interferon, Alpha 8 2
  • Interferon Alpha-8 3
  • IFN-AlphaB 3

External Ids for IFNA8 Gene

Previous GeneCards Identifiers for IFNA8 Gene

  • GC09P021736
  • GC09P021610
  • GC09P021399
  • GC09P021372

Summaries for IFNA8 Gene

GeneCards Summary for IFNA8 Gene

IFNA8 (Interferon Alpha 8) is a Protein Coding gene. Diseases associated with IFNA8 include St. Louis Encephalitis. Among its related pathways are Cytokine Signaling in Immune system and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA16.

UniProtKB/Swiss-Prot for IFNA8 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA8 Gene

Additional gene information for IFNA8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA8 Gene

Genomics for IFNA8 Gene

GeneHancer (GH) Regulatory Elements for IFNA8 Gene

Promoters and enhancers for IFNA8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I021334 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11.1 -74.1 -74059 1.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ETS1 GLIS2 ELK1 ZNF207 KLHL9 IFNA13 IFNA5 IFNA12P IFNA8 IFNWP2 IFNA20P
GH09I021252 Enhancer 0.8 Ensembl ENCODE 11.7 -155.9 -155882 0.7 CTCF PKNOX1 ZNF654 FOXA2 SIN3A RAD21 POLR2A ZNF143 SMC3 RUNX3 IFNA12P IFNA8 IFNWP2 IFNA13 IFNA20P IFNA14 IFNA22P
GH09I021503 Enhancer 0.7 Ensembl ENCODE 10 +96.9 96940 4.3 MAFF JUN STAT3 CEBPB RCOR1 ZBTB33 EP300 IFNWP2 IFNA8 IFNA12P IFNA20P IFNE GC09P021512 MIR31HG
GH09I021350 Promoter 0.5 EPDnew 11.6 -58.2 -58171 0.1 IFNA6 IFNA12P IFNA8 IFNWP2 KLHL9
GH09I021228 Promoter 0.5 EPDnew 10.9 -180.9 -180886 0.1 GC09P021226 IFNA17 IFNA12P IFNA8 IFNWP2 IFNA5 IFNA13 IFNA20P IFNWP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFNA8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNA8 gene promoter:

Genomic Locations for IFNA8 Gene

Genomic Locations for IFNA8 Gene
1,039 bases
Plus strand

Genomic View for IFNA8 Gene

Genes around IFNA8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA8 Gene

Proteins for IFNA8 Gene

  • Protein details for IFNA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-8
    Protein Accession:
    Secondary Accessions:
    • P01565
    • P09236
    • Q5VWV7
    • Q5VYQ3

    Protein attributes for IFNA8 Gene

    189 amino acids
    Molecular mass:
    21989 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA8 Gene

Post-translational modifications for IFNA8 Gene

No Post-translational modifications

Other Protein References for IFNA8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA8 Gene

Domains & Families for IFNA8 Gene

Gene Families for IFNA8 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA8: view

Function for IFNA8 Gene

Molecular function for IFNA8 Gene

GENATLAS Biochemistry:
interferon type I,alpha 8,leukocyte
UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Ontology (GO) - Molecular Function for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA --
genes like me logo Genes that share ontologies with IFNA8: view
genes like me logo Genes that share phenotypes with IFNA8: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA8 Gene

Localization for IFNA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA8 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA8 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA8 Gene

Pathways & Interactions for IFNA8 Gene

genes like me logo Genes that share pathways with IFNA8: view

Gene Ontology (GO) - Biological Process for IFNA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA8: view

No data available for SIGNOR curated interactions for IFNA8 Gene

Drugs & Compounds for IFNA8 Gene

No Compound Related Data Available

Transcripts for IFNA8 Gene

mRNA/cDNA for IFNA8 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA8 Gene

No ASD Table

Relevant External Links for IFNA8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA8 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA8 Gene

This gene is overexpressed in Brain - Cerebellum (x16.1), Brain - Cerebellar Hemisphere (x13.4), and Brain - Frontal Cortex (BA9) (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of IFNA8 Gene:


SOURCE GeneReport for Unigene cluster for IFNA8 Gene:

genes like me logo Genes that share expression patterns with IFNA8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA8 Gene

Orthologs for IFNA8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA8 33 34
  • 98.94 (n)
(Mus musculus)
Mammalia Ifna6 34
  • 64 (a)
Ifna12 34
  • 63 (a)
Ifna13 34
  • 63 (a)
Ifna5 34
  • 63 (a)
Gm12597 34
  • 62 (a)
Ifna1 34
  • 62 (a)
Ifna2 34
  • 61 (a)
Ifna9 34
  • 61 (a)
Ifnab 34
  • 61 (a)
Gm13280 34
  • 60 (a)
Ifna14 34
  • 60 (a)
Ifna7 34
  • 60 (a)
Ifna11 34
  • 59 (a)
Ifna4 34
  • 58 (a)
(Bos Taurus)
Mammalia -- 34
  • 61 (a)
-- 34
  • 60 (a)
-- 34
  • 60 (a)
-- 34
  • 60 (a)
-- 34
  • 60 (a)
IFNAG 34 34
  • 60 (a)
  • 59 (a)
  • 59 (a)
  • 59 (a)
Species where no ortholog for IFNA8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA8 Gene

Gene Tree for IFNA8 (if available)
Gene Tree for IFNA8 (if available)

Paralogs for IFNA8 Gene

(18) SIMAP similar genes for IFNA8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA8: view

Variants for IFNA8 Gene

Sequence variations from dbSNP and Humsavar for IFNA8 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000853564 -- 21,407,191(+) C/T upstream_transcript_variant
rs1003444118 -- 21,410,524(+) A/G downstream_transcript_variant
rs1004162725 -- 21,407,264(+) T/A upstream_transcript_variant
rs1004432517 -- 21,407,438(+) C/G upstream_transcript_variant
rs1004989880 -- 21,407,587(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNA8 Gene

Variant ID Type Subtype PubMed ID
nsv968603 CNV duplication 23825009
nsv613758 CNV gain 21841781
nsv466297 CNV gain 19166990
esv2764150 CNV gain+loss 21179565
esv2752289 CNV gain 17911159

Variation tolerance for IFNA8 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA8 Gene

Disorders for IFNA8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
st. louis encephalitis
  • neuroinvasive st. louis encephalitis virus infection
- elite association - COSMIC cancer census association via MalaCards
Search IFNA8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFNA8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA8 Gene

Publications for IFNA8 Gene

  1. Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population. (PMID: 8836918) Hussain M … Testa D (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996) 3 4 22 58
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
  5. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 44 58

Products for IFNA8 Gene

Sources for IFNA8 Gene

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