Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IFNA7 Gene

Aliases for IFNA7 Gene

  • Interferon Alpha 7 2 3 5
  • Interferon Alpha-J1 3 4
  • Interferon Alpha-J 3 4
  • IFN-Alpha-J1 3 4
  • LeIF J 3 4
  • Interferon Alpha-7 3
  • IFN-Alpha 7 3
  • IFN-Alpha-7 4
  • IFN-AlphaJ 3
  • IFNA-J 3

External Ids for IFNA7 Gene

Previous GeneCards Identifiers for IFNA7 Gene

  • GC09M021529
  • GC09M021402
  • GC09M021191
  • GC09M021214
  • GC09M021224
  • GC09M021164
  • GC09M021228
  • GC09M021234
  • GC09M021237
  • GC09M021241
  • GC09M021244
  • GC09M021247
  • GC09M021251
  • GC09M021256
  • GC09M021261
  • GC09M021265
  • GC09M021271
  • GC09M021275
  • GC09M021283
  • GC09M021288
  • GC09M021293

Summaries for IFNA7 Gene

GeneCards Summary for IFNA7 Gene

IFNA7 (Interferon Alpha 7) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway and Kaposi's sarcoma-associated herpesvirus infection. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA4.

UniProtKB/Swiss-Prot for IFNA7 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA7 Gene

Additional gene information for IFNA7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA7 Gene

Genomics for IFNA7 Gene

GeneHancer (GH) Regulatory Elements for IFNA7 Gene

Promoters and enhancers for IFNA7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021195 Enhancer 0.6 Ensembl 0.4 +6.6 6627 0.8 CTCF SRF ZNF654 TRIM22 RAD21 ZNF664 SMC3 ZSCAN29 IFNA13 IFNA20P IFNWP9 IFNA7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNA7 gene promoter:
  • IRF-7A
  • Egr-2
  • Egr-4
  • Egr-3

Genomic Locations for IFNA7 Gene

Genomic Locations for IFNA7 Gene
737 bases
Minus strand
737 bases
Minus strand

Genomic View for IFNA7 Gene

Genes around IFNA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA7 Gene

Proteins for IFNA7 Gene

  • Protein details for IFNA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-7
    Protein Accession:
    Secondary Accessions:
    • Q14607
    • Q5VV14

    Protein attributes for IFNA7 Gene

    189 amino acids
    Molecular mass:
    22107 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA7 Gene

Post-translational modifications for IFNA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA7 Gene

Domains & Families for IFNA7 Gene

Gene Families for IFNA7 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA7: view

Function for IFNA7 Gene

Molecular function for IFNA7 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 7,leukocyte

Gene Ontology (GO) - Molecular Function for IFNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS 2995168
genes like me logo Genes that share ontologies with IFNA7: view
genes like me logo Genes that share phenotypes with IFNA7: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA7 Gene

Localization for IFNA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA7 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA7 Gene

Pathways & Interactions for IFNA7 Gene

genes like me logo Genes that share pathways with IFNA7: view

Gene Ontology (GO) - Biological Process for IFNA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA --
genes like me logo Genes that share ontologies with IFNA7: view

No data available for SIGNOR curated interactions for IFNA7 Gene

Drugs & Compounds for IFNA7 Gene

No Compound Related Data Available

Transcripts for IFNA7 Gene

mRNA/cDNA for IFNA7 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNA7 Gene

Interferon, alpha 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA7 Gene

No ASD Table

Relevant External Links for IFNA7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA7 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA7 Gene:


SOURCE GeneReport for Unigene cluster for IFNA7 Gene:


Evidence on tissue expression from TISSUES for IFNA7 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with IFNA7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA7 Gene

Orthologs for IFNA7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA7 33
  • 98.06 (n)
-- 34
  • 93 (a)
(Bos Taurus)
Mammalia IFNAH 34
  • 62 (a)
IFNAG 34 34
  • 62 (a)
-- 34
  • 62 (a)
-- 34
  • 61 (a)
-- 34
  • 61 (a)
-- 34
  • 61 (a)
  • 60 (a)
  • 60 (a)
-- 34
  • 60 (a)
(Mus musculus)
Mammalia Gm12597 34
  • 62 (a)
Ifna1 34
  • 61 (a)
Ifna13 34
  • 61 (a)
Ifna5 34
  • 61 (a)
Ifna12 34
  • 61 (a)
Ifna6 34
  • 61 (a)
Gm13280 34
  • 60 (a)
Ifnab 34
  • 59 (a)
Ifna9 34
  • 59 (a)
Ifna7 34
  • 59 (a)
Ifna14 34
  • 58 (a)
Ifna2 34
  • 58 (a)
Ifna11 34
  • 57 (a)
Ifna4 34
  • 55 (a)
Species where no ortholog for IFNA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA7 Gene

Gene Tree for IFNA7 (if available)
Gene Tree for IFNA7 (if available)
Evolutionary constrained regions (ECRs) for IFNA7: view image

Paralogs for IFNA7 Gene

(18) SIMAP similar genes for IFNA7 Gene using alignment to 1 proteins:

  • IFNA7_HUMAN Pseudogenes for IFNA7 Gene

genes like me logo Genes that share paralogs with IFNA7: view

Variants for IFNA7 Gene

Sequence variations from dbSNP and Humsavar for IFNA7 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1002264155 -- 21,202,419(-) G/A upstream_transcript_variant
rs1002880550 -- 21,203,591(-) C/T upstream_transcript_variant
rs1002931388 -- 21,203,861(-) G/C upstream_transcript_variant
rs1003211379 -- 21,202,958(-) T/C upstream_transcript_variant
rs1003266730 -- 21,203,093(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNA7 Gene

Variant ID Type Subtype PubMed ID
dgv1253e201 CNV deletion 23290073
dgv7474n100 CNV loss 25217958
esv2738274 CNV deletion 23290073
esv2738277 CNV deletion 23290073
esv2764150 CNV gain+loss 21179565
esv3573167 CNV loss 25503493
esv3619952 CNV loss 21293372
esv3619953 CNV gain 21293372
esv3619954 CNV loss 21293372
esv6326 CNV loss 19470904
nsv1021574 CNV gain 25217958
nsv1033177 CNV gain 25217958
nsv1035128 CNV gain 25217958
nsv1118060 CNV deletion 24896259
nsv516132 CNV loss 19592680
nsv613755 CNV loss 21841781
nsv613756 CNV loss 21841781
nsv8425 CNV gain+loss 18304495
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA7 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA7 Gene

Disorders for IFNA7 Gene

Additional Disease Information for IFNA7

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IFNA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA7 Gene

Publications for IFNA7 Gene

  1. Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. (PMID: 8910771) Hussain M … Liao MJ (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996) 3 4 22 58
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PMID: 9425112) Nyman TA … Kalkkinen N (The Biochemical journal 1998) 3 4 58
  5. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade OI … Diaz MO (Genomics 1992) 2 3 58

Products for IFNA7 Gene

Sources for IFNA7 Gene

Loading form....