Aliases for IFNA6 Gene

Aliases for IFNA6 Gene

  • Interferon Alpha 6 2 3 5
  • Interferon Alpha-54 3 4
  • Interferon Alpha-6 3 4
  • Interferon Alpha-K 3 4
  • IFN-Alpha-6 3 4
  • IFN-AlphaK 2 3
  • LeIF K 3 4
  • Interferon, Alpha 6 2
  • IFNA6 5

External Ids for IFNA6 Gene

Previous GeneCards Identifiers for IFNA6 Gene

  • GC09M021677
  • GC09M021551
  • GC09M021340

Summaries for IFNA6 Gene

GeneCards Summary for IFNA6 Gene

IFNA6 (Interferon Alpha 6) is a Protein Coding gene. Diseases associated with IFNA6 include Louping Ill. Among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA5.

UniProtKB/Swiss-Prot Summary for IFNA6 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA6 Gene

Additional gene information for IFNA6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA6 Gene

Genomics for IFNA6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021350 Promoter 0.3 EPDnew 600.7 +0.4 402 0.1 IFNA6 IFNA12P IFNA8 IFNWP2 HSALNG0070353 KLHL9
GH09J021016 Enhancer 0.9 FANTOM5 Ensembl ENCODE 9.1 +334.6 334577 4 TEAD4 CEBPB FOS MAFK USF2 SPI1 HACD4 IFNW1 IFNA1 IFNA6 FOCAD IFNA5 LOC105375989 lnc-IFNB1-2 piR-40176-033
GH09J021744 Enhancer 0.7 FANTOM5 Ensembl ENCODE 7.1 -393.8 -393823 1.2 CEBPB MAX EP300 MTAP IFNA1 IFNA6 IFNA5 HSALNG0070382 LOC107987026 ENSG00000264545 IFNE
GH09J021653 Enhancer 0.4 FANTOM5 11 -302.2 -302159 0.3 MAFF MAFK HSALNG0070376 IFNA1 IFNA6 KLHL9 KHSRPP1 ENSG00000264545 MTAP IFNE
GH09J021573 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -232.5 -232537 20.1 PRDM10 ZNF629 CTCF FOXA1 PRDM1 ZIC2 ZSCAN4 PATZ1 REST ZNF501 FOCAD MIR31 IFNW1 IFNA1 IFNA6 MIR31HG MIR31HG-002 MN309174-656 IFNE ENSG00000264545
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA6

Top Transcription factor binding sites by QIAGEN in the IFNA6 gene promoter:
  • Egr-2
  • Egr-3
  • Egr-4
  • HEN1
  • IRF-7A
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for IFNA6 Gene

Genomic Locations for IFNA6 Gene
chr9:21,349,835-21,351,378
(GRCh38/hg38)
Size:
1,544 bases
Orientation:
Minus strand
chr9:21,349,834-21,351,377
(GRCh37/hg19)
Size:
1,544 bases
Orientation:
Minus strand

Genomic View for IFNA6 Gene

Genes around IFNA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA6 Gene

Proteins for IFNA6 Gene

  • Protein details for IFNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05013-IFNA6_HUMAN
    Recommended name:
    Interferon alpha-6
    Protein Accession:
    P05013
    Secondary Accessions:
    • Q5VYQ1

    Protein attributes for IFNA6 Gene

    Size:
    189 amino acids
    Molecular mass:
    22141 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA6 Gene

Post-translational modifications for IFNA6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA6 Gene

Domains & Families for IFNA6 Gene

Gene Families for IFNA6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA6 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family
ProtoNet:

Suggested Antigen Peptide Sequences for IFNA6 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-K (IFNA6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05013

UniProtKB/Swiss-Prot:

IFNA6_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA6: view

Function for IFNA6 Gene

Molecular function for IFNA6 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 6,leukocyte

Phenotypes From GWAS Catalog for IFNA6 Gene

Gene Ontology (GO) - Molecular Function for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IFNA6: view
genes like me logo Genes that share phenotypes with IFNA6: view

Animal Model Products

CRISPR Products

miRNA for IFNA6 Gene

miRTarBase miRNAs that target IFNA6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA6 Gene

Localization for IFNA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA6 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IBA 21873635
genes like me logo Genes that share ontologies with IFNA6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA6 Gene

Pathways & Interactions for IFNA6 Gene

genes like me logo Genes that share pathways with IFNA6: view

Pathways by source for IFNA6 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA6 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA6 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway

Gene Ontology (GO) - Biological Process for IFNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA6: view

No data available for SIGNOR curated interactions for IFNA6 Gene

Drugs & Compounds for IFNA6 Gene

No Compound Related Data Available

Transcripts for IFNA6 Gene

mRNA/cDNA for IFNA6 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA6

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA6 Gene

No ASD Table

Relevant External Links for IFNA6 Gene

GeneLoc Exon Structure for
IFNA6

Expression for IFNA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA6 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA6 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x6.2), Brain - Hippocampus (x4.5), and Brain - Amygdala (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA6

SOURCE GeneReport for Unigene cluster for IFNA6 Gene:

Hs.533470

Evidence on tissue expression from TISSUES for IFNA6 Gene

  • Spleen(4.3)
  • Nervous system(4.2)
  • Kidney(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with IFNA6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA6 Gene

Orthologs for IFNA6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA6 30 31
  • 99.12 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IFNAG 31 31
  • 65 (a)
ManyToMany
-- 31
  • 65 (a)
ManyToMany
-- 31
  • 64 (a)
ManyToMany
-- 31
  • 64 (a)
ManyToMany
IFNAA 31
  • 63 (a)
ManyToMany
-- 31
  • 63 (a)
ManyToMany
-- 31
  • 63 (a)
ManyToMany
INFAF 31
  • 62 (a)
ManyToMany
IFNAH 31
  • 62 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Ifna13 31
  • 61 (a)
ManyToMany
Gm12597 31
  • 61 (a)
ManyToMany
Ifna6 31
  • 61 (a)
ManyToMany
Ifna5 31
  • 60 (a)
ManyToMany
Ifna12 31
  • 60 (a)
ManyToMany
Gm13280 31
  • 60 (a)
ManyToMany
Ifna1 31
  • 59 (a)
ManyToMany
Ifna9 31
  • 59 (a)
ManyToMany
Ifna14 31
  • 58 (a)
ManyToMany
Ifna7 31
  • 58 (a)
ManyToMany
Ifnab 31
  • 57 (a)
ManyToMany
Ifna2 31
  • 57 (a)
ManyToMany
Ifna11 31
  • 56 (a)
ManyToMany
Ifna4 31
  • 55 (a)
ManyToMany
Species where no ortholog for IFNA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA6 Gene

ENSEMBL:
Gene Tree for IFNA6 (if available)
TreeFam:
Gene Tree for IFNA6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA6: view image

Paralogs for IFNA6 Gene

(18) SIMAP similar genes for IFNA6 Gene using alignment to 1 proteins:

  • IFNA6_HUMAN
genes like me logo Genes that share paralogs with IFNA6: view

Variants for IFNA6 Gene

Additional dbSNP identifiers (rs#s) for IFNA6 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFNA6 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv968602 CNV duplication 23825009

Variation tolerance for IFNA6 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 10.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA6 Gene

Disorders for IFNA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
louping ill
- elite association - COSMIC cancer census association via MalaCards
Search IFNA6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IFNA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA6 Gene

Publications for IFNA6 Gene

  1. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 41
  4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 41
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 41

Products for IFNA6 Gene

Sources for IFNA6 Gene