Aliases for IFNA5 Gene

Aliases for IFNA5 Gene

  • Interferon Alpha 5 2 3 5
  • Interferon Alpha-61 3 4
  • Interferon Alpha-5 3 4
  • Interferon Alpha-G 3 4
  • IFN-Alpha-5 3 4
  • IFN-AlphaG 2 3
  • LeIF G 3 4
  • Interferon, Alpha 5 2
  • INFA5 3
  • IFNA5 5
  • INA5 3

External Ids for IFNA5 Gene

Previous GeneCards Identifiers for IFNA5 Gene

  • GC09M021632
  • GC09M021505
  • GC09M021294

Summaries for IFNA5 Gene

GeneCards Summary for IFNA5 Gene

IFNA5 (Interferon Alpha 5) is a Protein Coding gene. Diseases associated with IFNA5 include Hemangioma Of Lung and Myiasis. Among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA21.

UniProtKB/Swiss-Prot Summary for IFNA5 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA5 Gene

Additional gene information for IFNA5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA5 Gene

Genomics for IFNA5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021305 Promoter 0.3 EPDnew 600.7 0.0 -28 0.1 IFNA5 HSALNG0070355 KLHL9 LOC107987053
GH09J021332 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 11.2 -28.7 -28688 4.8 HNRNPL POLR2A BACH1 LARP7 ZNF143 ZSCAN4 RBFOX2 PATZ1 SMAD5 BRD4 HSALNG0070353 KLHL9 lnc-KLHL9-1 IFNA13 IFNA5 IFNA12P IFNA8 IFNWP2 IFNA20P lnc-IFNA8-3
GH09J021402 Promoter 0.8 Ensembl 11.1 -97.4 -97388 1 TEAD4 IKZF2 EZH2 CTCF ZBTB26 ZBTB17 YY1 IKZF1 ZNF335 EBF1 IFNA12P lnc-IFNA8-1 IFNA13 IFNA5 IFNA11P lnc-IFNA2-2 IFNA8 IFNA2
GH09J021450 Enhancer 0.6 Ensembl ENCODE 11 -146.3 -146269 1.4 CEBPB ESR1 NFE2L2 IFNWP2 IFNA8 IFNA12P IFNA13 IFNA5 IFNWP19 MIR31HG-001 IFNA1 IFNE MIR31HG
GH09J021239 Promoter/Enhancer 0.5 EPDnew Ensembl 11.3 +65.2 65212 1 IFNA14 IFNA5 IFNA13 piR-39858-645
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA5

Top Transcription factor binding sites by QIAGEN in the IFNA5 gene promoter:
  • AML1a
  • C/EBPalpha
  • SRY

Genomic Locations for IFNA5 Gene

Genomic Locations for IFNA5 Gene
chr9:21,304,326-21,305,313
(GRCh38/hg38)
Size:
988 bases
Orientation:
Minus strand
chr9:21,304,613-21,305,312
(GRCh37/hg19)
Size:
700 bases
Orientation:
Minus strand

Genomic View for IFNA5 Gene

Genes around IFNA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA5 Gene

Proteins for IFNA5 Gene

  • Protein details for IFNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01569-IFNA5_HUMAN
    Recommended name:
    Interferon alpha-5
    Protein Accession:
    P01569
    Secondary Accessions:
    • Q52LX3

    Protein attributes for IFNA5 Gene

    Size:
    189 amino acids
    Molecular mass:
    21942 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA5 Gene

Post-translational modifications for IFNA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA5 Gene

Domains & Families for IFNA5 Gene

Gene Families for IFNA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA5 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family
ProtoNet:

Suggested Antigen Peptide Sequences for IFNA5 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-G (IFNA5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01569

UniProtKB/Swiss-Prot:

IFNA5_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA5: view

Function for IFNA5 Gene

Molecular function for IFNA5 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 5,leukocyte

Phenotypes From GWAS Catalog for IFNA5 Gene

Gene Ontology (GO) - Molecular Function for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IFNA5: view
genes like me logo Genes that share phenotypes with IFNA5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA5 Gene

Localization for IFNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA5 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA5 Gene

Pathways & Interactions for IFNA5 Gene

genes like me logo Genes that share pathways with IFNA5: view

Pathways by source for IFNA5 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA5 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA5 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway
1 GeneTex pathway for IFNA5 Gene

Gene Ontology (GO) - Biological Process for IFNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA5: view

No data available for SIGNOR curated interactions for IFNA5 Gene

Drugs & Compounds for IFNA5 Gene

(1) Drugs for IFNA5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with IFNA5: view

Transcripts for IFNA5 Gene

mRNA/cDNA for IFNA5 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA5

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA5 Gene

No ASD Table

Relevant External Links for IFNA5 Gene

GeneLoc Exon Structure for
IFNA5

Expression for IFNA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA5 Gene

Protein differential expression in normal tissues from HIPED for IFNA5 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFNA5 Gene



Protein tissue co-expression partners for IFNA5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA5

SOURCE GeneReport for Unigene cluster for IFNA5 Gene:

Hs.37113

Evidence on tissue expression from TISSUES for IFNA5 Gene

  • Spleen(4.3)
  • Nervous system(4.3)
  • Kidney(2.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with IFNA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA5 Gene

Orthologs for IFNA5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA5 30 31
  • 98.94 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 64 (a)
ManyToMany
IFNAG 31 31
  • 63 (a)
ManyToMany
-- 31
  • 63 (a)
ManyToMany
-- 31
  • 63 (a)
ManyToMany
INFAF 31
  • 62 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
IFNAH 31
  • 61 (a)
ManyToMany
IFNAA 31
  • 61 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Ifna13 31
  • 62 (a)
ManyToMany
Ifna6 31
  • 61 (a)
ManyToMany
Ifna5 31
  • 60 (a)
ManyToMany
Ifna9 31
  • 60 (a)
ManyToMany
Ifna1 31
  • 60 (a)
ManyToMany
Ifna12 31
  • 60 (a)
ManyToMany
Gm12597 31
  • 59 (a)
ManyToMany
Gm13280 31
  • 59 (a)
ManyToMany
Ifna14 31
  • 58 (a)
ManyToMany
Ifna11 31
  • 58 (a)
ManyToMany
Ifnab 31
  • 58 (a)
ManyToMany
Ifna7 31
  • 57 (a)
ManyToMany
Ifna2 31
  • 57 (a)
ManyToMany
Ifna4 31
  • 56 (a)
ManyToMany
Species where no ortholog for IFNA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA5 Gene

ENSEMBL:
Gene Tree for IFNA5 (if available)
TreeFam:
Gene Tree for IFNA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA5: view image

Paralogs for IFNA5 Gene

(18) SIMAP similar genes for IFNA5 Gene using alignment to 1 proteins:

  • IFNA5_HUMAN
genes like me logo Genes that share paralogs with IFNA5: view

Variants for IFNA5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA5 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
715409 Benign: not provided 21,304,914(-) G/A NONSENSE
776415 Benign: not provided 21,305,060(-) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for IFNA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFNA5 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
esv3619961 CNV loss 21293372
nsv438097 CNV loss 16468122
nsv613757 CNV loss 21841781
nsv968601 CNV duplication 23825009

Variation tolerance for IFNA5 Gene

Residual Variation Intolerance Score: 79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA5 Gene

Disorders for IFNA5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IFNA5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemangioma of lung
  • pulmonary hemangioma
myiasis
  • infestation by fly larvae
- elite association - COSMIC cancer census association via MalaCards
Search IFNA5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IFNA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA5 Gene

Publications for IFNA5 Gene

  1. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 41
  4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 41
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 41

Products for IFNA5 Gene

Sources for IFNA5 Gene