Aliases for IFNA4 Gene
Aliases for IFNA4 Gene
External Ids for IFNA4 Gene
- HGNC: 5425
- Entrez Gene: 3441
- Ensembl: ENSG00000236637
- OMIM: 147564
- UniProtKB: P05014
Previous GeneCards Identifiers for IFNA4 Gene
- GC09M021514
- GC09M021387
- GC09M021176
- GC09M021149
Summaries for IFNA4 Gene
GeneCards Summary for IFNA4 Gene
IFNA4 (Interferon Alpha 4) is a Protein Coding gene. Diseases associated with IFNA4 include Rabies. Among its related pathways are Toll-like Receptor Signaling Pathway and Kaposi's sarcoma-associated herpesvirus infection. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA17.
UniProtKB/Swiss-Prot for IFNA4 Gene
-
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA4 Gene
Genomics for IFNA4 Gene
GeneHancer (GH) Regulatory Elements for IFNA4 Gene
Promoters and enhancers for IFNA4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IFNA4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IFNA4 gene promoter:
-
- IRF-7A
- Olf-1
- Egr-4
- Egr-2
- GR
- GR-alpha
Regulatory Element Products
Genomic Locations for IFNA4 Gene
Genomic Locations for IFNA4 Gene
- chr9:21,186,618-21,187,671
- (GRCh38/hg38)
- Size:
- 1,054 bases
- Orientation:
- Minus strand
- chr9:21,186,617-21,187,598
- (GRCh37/hg19)
- Size:
- 982 bases
- Orientation:
- Minus strand
Genomic View for IFNA4 Gene
Genes around IFNA4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9p21.3 by Entrez Gene
- 9p21.3 by HGNC
- 9p21.3 by Ensembl
IFNA4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IFNA4 Gene
Proteins for IFNA4 Gene
-
Protein details for IFNA4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05014-IFNA4_HUMAN
- Recommended name:
- Interferon alpha-4
- Protein Accession:
- P05014
- P13358
- Q14CS4
- Q5VV15
Protein attributes for IFNA4 Gene
- Size:
- 189 amino acids
- Molecular mass:
- 21808 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for IFNA4 Gene
Other Protein References for IFNA4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for IFNA4
- Invitrogen Antibodies for IFNA4 (AFLGC-IFNA4)
- Search GeneTex for Antibodies for IFNA4
-
Boster Bio Antibodies for IFNA4
-
Santa Cruz Biotechnology (SCBT) Antibodies for IFNA4
- Sino Biological Antibodies for IFNA4
Protein Products
- R&D Systems Proteins and Enzymes for IFNA4 (IFN-alpha 4)
-
OriGene Purified Proteins for IFNA4
- Search Origene for MassSpec and Protein Over-expression Lysates for IFNA4
- Origene Custom Protein Services for IFNA4
- Novus Biologicals lysates for IFNA4
- Sino Biological Recombinant Proteins for IFNA4
- Sino Biological Cell Lysates for IFNA4
- Search GeneTex for Proteins for IFNA4
-
ProSci Proteins for IFNA4
-
Abcam proteins for IFNA4
Assay Products
No data available for DME Specific Peptides for IFNA4 Gene
Domains & Families for IFNA4 Gene
Gene Families for IFNA4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for IFNA4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IFNA4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P05014- Family:
-
- Belongs to the alpha/beta interferon family.
Function for IFNA4 Gene
Molecular function for IFNA4 Gene
- UniProtKB/Swiss-Prot Function:
- Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
- GENATLAS Biochemistry:
- interferon type I,alpha 4,leukocyte
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IBA | -- |
| GO:0005126 | cytokine receptor binding | IEA | -- |
| GO:0005132 | type I interferon receptor binding | TAS | 3891272 |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for IFNA4 Gene
- GenomeRNAi human phenotypes for IFNA4:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IFNA4
-
CRISPR Products
-
OriGene CRISPR knockouts for IFNA4
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- genomics-online: gRNA clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
- Applied Biological Materials CRISPR for IFNA4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNA4
- GenScript: Design CRISPR guide RNA sequences for IFNA4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNA4
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA4
- genomics-online: shRNA clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IFNA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNA4
- Applied Biological Materials Clones for IFNA4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IFNA4 (IFN-alpha 4)
Cell Line Products
-
Horizon Cell Lines for IFNA4
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA4 Gene
Localization for IFNA4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IFNA4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA4 Gene
Pathways & Interactions for IFNA4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
| 2 | Toll-like Receptor Signaling Pathway | ||
| 3 | Immune response IFN alpha/beta signaling pathway |
.30
|
|
| 4 | Influenza A |
.33
.33
|
|
| 5 | Kaposi's sarcoma-associated herpesvirus infection |
.33
|
|
Pathways by source for IFNA4 Gene
2 BioSystems pathways for IFNA4 Gene
10 Reactome pathways for IFNA4 Gene
19 KEGG pathways for IFNA4 Gene
2 GeneGo (Thomson Reuters) pathways for IFNA4 Gene
4 R&D Systems pathways for IFNA4 Gene
4 Qiagen pathways for IFNA4 Gene
Interacting Proteins for IFNA4 Gene
Selected Interacting proteins:
ENSP00000412897
P05014-IFNA4_HUMAN
for IFNA4 Gene via
STRING
IID
UniProtKB
| Symbol | External ID(s) | Details |
|---|---|---|
| IFNA6 | ||
| ALDOA | ||
| ENSG00000285043 | ||
| IFNA10 | ||
| IFNA14 |
GPS-Prot Interaction Network for IFNA4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IBA | -- |
| GO:0002286 | T cell activation involved in immune response | IBA | -- |
| GO:0002323 | natural killer cell activation involved in immune response | IBA | -- |
| GO:0006952 | defense response | IEA | -- |
| GO:0006959 | humoral immune response | IBA | -- |
No data available for SIGNOR curated interactions for IFNA4 Gene
Transcripts for IFNA4 Gene
mRNA/cDNA for IFNA4 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000421715 978 bps (uc003zon.3)
CRISPR Products
-
OriGene CRISPR knockouts for IFNA4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNA4
- genomics-online: gRNA clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
- Applied Biological Materials CRISPR for IFNA4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IFNA4
- GenScript: Design CRISPR guide RNA sequences for IFNA4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IFNA4
- Browse OriGene Inhibitory RNA Products For IFNA4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA4
- genomics-online: shRNA clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
Clone Products
- Sino Biological Human cDNA Clone for IFNA4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IFNA4
- Applied Biological Materials Clones for IFNA4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IFNA4 (IFN-alpha 4)
Expression for IFNA4 Gene
NURSA nuclear receptor signaling pathways regulating expression of IFNA4 Gene:
IFNA4SOURCE GeneReport for Unigene cluster for IFNA4 Gene:
Hs.1510Evidence on tissue expression from TISSUES for IFNA4 Gene
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for IFNA4
-
OriGene qPCR primer pairs and template standards for IFNA4
- genomics-online: primer clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA4 Gene
Orthologs for IFNA4 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IFNA17 33 |
|
||
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Ifna6 34 33 |
|
ManyToMany | |
| Gm12597 34 |
|
ManyToMany | |||
| Ifna13 34 |
|
ManyToMany | |||
| Ifna5 34 |
|
ManyToMany | |||
| Ifna12 34 |
|
ManyToMany | |||
| Ifna1 34 |
|
ManyToMany | |||
| Gm13280 34 |
|
ManyToMany | |||
| Ifna9 34 |
|
ManyToMany | |||
| Ifnab 16 34 |
|
||||
| Ifna11 34 |
|
ManyToMany | |||
| Ifna2 34 |
|
ManyToMany | |||
| Ifna14 34 |
|
ManyToMany | |||
| Ifna4 34 |
|
ManyToMany | |||
| Ifna7 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Ifna2 33 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
ManyToMany | |
| IFNAG 34 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| IFNAH 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| IFNAA 34 |
|
ManyToMany | |||
| INFAF 34 |
|
ManyToMany |
- Species where no ortholog for IFNA4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for IFNA4 Gene
- ENSEMBL:
- Gene Tree for IFNA4 (if available)
- TreeFam:
- Gene Tree for IFNA4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IFNA4: view image
Paralogs for IFNA4 Gene
Paralogs for IFNA4 Gene
(18) SIMAP similar genes for IFNA4 Gene using alignment to 1 proteins:
- IFNA4_HUMAN
Variants for IFNA4 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA4 Gene
- IFNA4_HUMAN-P05014
- Two forms exist; alpha-4a (shown here) and alpha-4b (PubMed:9335434). They seem to be equally abundant (PubMed:9335434).
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000338497 | -- | 21,188,418(-) | C/T | upstream_transcript_variant | |
| rs1001411417 | -- | 21,188,453(-) | A/T | upstream_transcript_variant | |
| rs1003734990 | -- | 21,189,134(-) | T/C | upstream_transcript_variant | |
| rs1003808795 | -- | 21,189,278(-) | G/A/C | upstream_transcript_variant | |
| rs1005424956 | -- | 21,187,947(-) | T/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv7474n100 | CNV | loss | 25217958 |
| esv2738274 | CNV | deletion | 23290073 |
| esv2738275 | CNV | deletion | 23290073 |
| esv2759678 | CNV | loss | 17122850 |
| esv2764150 | CNV | gain+loss | 21179565 |
| esv3573167 | CNV | loss | 25503493 |
| esv3619950 | CNV | loss | 21293372 |
| nsv1033177 | CNV | gain | 25217958 |
| nsv613752 | CNV | loss | 21841781 |
| nsv613755 | CNV | loss | 21841781 |
| nsv968599 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.67;
57.00% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IFNA4 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for IFNA4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rabies |
|
|
Search IFNA4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IFNA4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA4 Gene
Publications for IFNA4 Gene
- Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58
- DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PMID: 9425112) Nyman TA … Kalkkinen N (The Biochemical journal 1998) 3 4 58
- Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population. (PMID: 9335434) Hussain M … Liao MJ (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997) 3 4 58
Products for IFNA4 Gene
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- antibodies-online: Search results for 53 available IFNA4 Antibodies ranked by validation data
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- Recommended
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- Search GeneTex for Antibodies for IFNA4
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- Santa Cruz Biotechnology (SCBT) Antibodies for IFNA4
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- genomics-online: cdna clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
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- genomics-online: gRNA clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
- genomics-online: primer clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
- genomics-online: shRNA clones - Search results for 151 available IFNA4 gene related products
- Overview of 151 available IFNA4 gene related products
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IFNA4
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- Boster Bio Antibodies for IFNA4
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Sources for IFNA4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
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