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IFNA4 (Interferon Alpha 4) is a Protein Coding gene. Diseases associated with IFNA4 include Rabies. Among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA10.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH09J021183 | Enhancer | 0.5 | Ensembl | 0.7 | +4.2 | 4181 | 1 | CTCF RAD21 TRIM22 CEBPA ZNF654 | IFNA20P IFNA4 IFNWP15 IFNA21 | |
GH09J021169 | Enhancer | 0.2 | Ensembl | 0.4 | +18.1 | 18081 | 0.8 | IFNA13 IFNA21 lnc-IFNA4-2 IFNA4 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IBA | 21873635 |
GO:0005126 | cytokine receptor binding | IEA | -- |
GO:0005132 | type I interferon receptor binding | TAS,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Toll-like Receptor Signaling Pathway |
.37
.34
|
|
2 | Immune response IFN alpha/beta signaling pathway |
Immune response IFN alpha/beta signaling pathway
.74
|
Cytokine Network
.30
|
3 | Measles |
.35
|
.33
|
4 | Human cytomegalovirus infection | ||
5 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IBA | 21873635 |
GO:0002286 | T cell activation involved in immune response | IBA | 21873635 |
GO:0002323 | natural killer cell activation involved in immune response | IBA | 21873635 |
GO:0006952 | defense response | IEA | -- |
GO:0006959 | humoral immune response | IBA | 21873635 |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IFNA17 30 |
|
||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Ifna6 30 17 31 |
|
ManyToMany | |
Ifna13 17 31 |
|
ManyToMany | |||
Ifna5 17 31 |
|
ManyToMany | |||
Gm12597 31 |
|
ManyToMany | |||
Ifna1 17 31 |
|
ManyToMany | |||
Ifna12 17 31 |
|
ManyToMany | |||
Ifna9 17 31 |
|
ManyToMany | |||
Gm13280 31 |
|
ManyToMany | |||
Ifna11 17 31 |
|
ManyToMany | |||
Ifna14 17 31 |
|
ManyToMany | |||
Ifna2 17 31 |
|
ManyToMany | |||
Ifnab 17 31 |
|
ManyToMany | |||
Ifna7 17 31 |
|
ManyToMany | |||
Ifna4 31 |
|
ManyToMany | |||
Ifna15 17 |
|
||||
Ifna16 17 |
|
||||
Rat (Rattus norvegicus) |
Mammalia | Ifna2 30 |
|
||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
IFNAG 31 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
IFNAH 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
IFNAA 31 |
|
ManyToMany | |||
INFAF 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
750472 | Likely Benign: not provided | 21,187,391(-) | G/A | SYNONYMOUS_VARIANT | |
783544 | Benign: not provided | 21,187,429(-) | T/C | MISSENSE_VARIANT | |
rs1062571 | - | p.Ala74Thr | |||
rs201964250 | - | p.His49Pro | |||
rs3750480 | - | p.Glu137Val |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv7474n100 | CNV | loss | 25217958 |
esv2738274 | CNV | deletion | 23290073 |
esv2738275 | CNV | deletion | 23290073 |
esv2759678 | CNV | loss | 17122850 |
esv2764150 | CNV | gain+loss | 21179565 |
esv3573167 | CNV | loss | 25503493 |
esv3619950 | CNV | loss | 21293372 |
nsv1033177 | CNV | gain | 25217958 |
nsv613752 | CNV | loss | 21841781 |
nsv613755 | CNV | loss | 21841781 |
nsv968599 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rabies |
|
|