IFNA4 Gene (Protein Coding)

Interferon Alpha 4

GC09M021186
GIFtS:
34
See more...

Aliases for IFNA4 Gene

Aliases for IFNA4 Gene

  • Interferon Alpha 4 2 3 5
  • Interferon Alpha-4B 3 4
  • Interferon Alpha-76 3 4
  • Interferon Alpha-M1 3 4
  • Interferon Alpha-4 3 4
  • IFN-Alpha4a 2 3
  • IFN-Alpha-4 3 4
  • MGC142200 2
  • INFA4 3
  • IFNA4 5

External Ids for IFNA4 Gene

Previous GeneCards Identifiers for IFNA4 Gene

  • GC09M021514
  • GC09M021387
  • GC09M021176
  • GC09M021149

Summaries for IFNA4 Gene

GeneCards Summary for IFNA4 Gene

IFNA4 (Interferon Alpha 4) is a Protein Coding gene. Diseases associated with IFNA4 include Rabies. Among its related pathways are JAK-STAT signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA10.

UniProtKB/Swiss-Prot Summary for IFNA4 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA4 Gene

Additional gene information for IFNA4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA4 Gene

Genomics for IFNA4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for IFNA4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH09J021183 Enhancer 0.5 Ensembl 0.7 +4.2 4181 1 ZNF654 CEBPA CTCF TRIM22 RAD21 IFNA20P IFNA4 IFNWP15 IFNA21
GH09J021169 Enhancer 0.2 Ensembl 0.4 +18.1 18081 0.8 IFNA13 IFNA21 lnc-IFNA4-2 IFNA4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA4

Top Transcription factor binding sites by QIAGEN in the IFNA4 gene promoter:
  • Egr-2
  • Egr-4
  • GR
  • GR-alpha
  • IRF-7A
  • Olf-1

Genomic Locations for IFNA4 Gene

Latest Assembly
chr9:21,186,618-21,187,682
(GRCh38/hg38)
Size:
1,065 bases
Orientation:
Minus strand

Previous Assembly
chr9:21,186,617-21,187,681
(GRCh37/hg19 by Entrez Gene)
Size:
1,065 bases
Orientation:
Minus strand

chr9:21,186,617-21,187,598
(GRCh37/hg19 by Ensembl)
Size:
982 bases
Orientation:
Minus strand

Genomic View for IFNA4 Gene

Genes around IFNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IFNA4 Gene

Proteins for IFNA4 Gene

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  1. Antibodies for research
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  3. Assay products for research

  • Protein details for IFNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05014-IFNA4_HUMAN
    Recommended name:
    Interferon alpha-4
    Protein Accession:
    P05014
    Secondary Accessions:
    • P13358
    • Q14CS4
    • Q5VV15

    Protein attributes for IFNA4 Gene

    Size:
    189 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA4 Gene

Post-translational modifications for IFNA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA4 Gene

Domains & Families for IFNA4 Gene

Gene Families for IFNA4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA4 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family

Suggested Antigen Peptide Sequences for IFNA4 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-M1 (IFNA4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05014

UniProtKB/Swiss-Prot:

IFNA4_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA4: view

Function for IFNA4 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for IFNA4 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 4,leukocyte

Gene Ontology (GO) - Molecular Function for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS,IBA 21873635
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IFNA4: view
genes like me logo Genes that share phenotypes with IFNA4: view

Animal Models for IFNA4 Gene

MGI Knock Outs for IFNA4:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA4 Gene

Localization for IFNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA4 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA4 Gene

Pathways & Interactions for IFNA4 Gene

genes like me logo Genes that share pathways with IFNA4: view

Pathways by source for IFNA4 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA4 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA4 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway

Gene Ontology (GO) - Biological Process for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA4: view

No data available for SIGNOR curated interactions for IFNA4 Gene

Drugs & Compounds for IFNA4 Gene

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No Compound Related Data Available

Transcripts for IFNA4 Gene

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mRNA/cDNA for IFNA4 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA4

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA4 Gene

No ASD Table

Relevant External Links for IFNA4 Gene

GeneLoc Exon Structure for
IFNA4

Expression for IFNA4 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA4 Gene

mRNA expression in normal human tissues for IFNA4 Gene
mRNA expression by GTEx for IFNA4 GenemRNA expression by BioGPS for IFNA4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA4

SOURCE GeneReport for Unigene cluster for IFNA4 Gene:

Hs.1510

Evidence on tissue expression from TISSUES for IFNA4 Gene

  • Nervous system(4.2)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with IFNA4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA4 Gene

Orthologs for IFNA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia IFNA17 29
  • 98.94 (n)
-- 30
  • 97 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Ifna6 29 16 30
  • 76.04 (n)
 ManyToMany
Ifna13 16 30
  • 62 (a)
 ManyToMany
Ifna5 16 30
  • 62 (a)
 ManyToMany
Gm12597 30
  • 62 (a)
 ManyToMany
Ifna1 16 30
  • 61 (a)
 ManyToMany
Ifna12 16 30
  • 61 (a)
 ManyToMany
Ifna9 16 30
  • 60 (a)
 ManyToMany
Gm13280 30
  • 60 (a)
 ManyToMany
Ifna11 16 30
  • 59 (a)
 ManyToMany
Ifna14 16 30
  • 59 (a)
 ManyToMany
Ifna2 16 30
  • 59 (a)
 ManyToMany
Ifnab 16 30
  • 59 (a)
 ManyToMany
Ifna7 16 30
  • 58 (a)
 ManyToMany
Ifna4 30
  • 58 (a)
 ManyToMany
Ifna15 16
Ifna16 16
Rat
(Rattus norvegicus)
 Mammalia Ifna2 29
  • 75.27 (n)
Cow
(Bos Taurus)
 Mammalia -- 30
  • 64 (a)
 ManyToMany
IFNAG 30 30
  • 64 (a)
 ManyToMany
-- 30
  • 63 (a)
 ManyToMany
IFNAH 30
  • 63 (a)
 ManyToMany
-- 30
  • 63 (a)
 ManyToMany
-- 30
  • 63 (a)
 ManyToMany
-- 30
  • 62 (a)
 ManyToMany
IFNAA 30
  • 62 (a)
 ManyToMany
INFAF 30
  • 62 (a)
 ManyToMany
Species where no ortholog for IFNA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA4 Gene

ENSEMBL:
Gene Tree for IFNA4 (if available)
TreeFam:
Gene Tree for IFNA4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA4: view image
Alliance of Genome Resources:
Additional Orthologs for IFNA4

Paralogs for IFNA4 Gene

Paralogs for IFNA4 Gene

(18) SIMAP similar genes for IFNA4 Gene using alignment to 1 proteins:

  • IFNA4_HUMAN
genes like me logo Genes that share paralogs with IFNA4: view

Variants for IFNA4 Gene

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Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA4 Gene

IFNA4_HUMAN-P05014
Two forms exist; alpha-4a (shown here) and alpha-4b (PubMed:9335434). They seem to be equally abundant (PubMed:9335434).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA4 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1008510966 Likely Benign: not provided 21,187,391(-) G/A
NM_021068.3(IFNA4):c.141C>T (p.Ile47=) 		SYNONYMOUS
rs146590081 Benign: not provided 21,187,429(-) T/C
NM_021068.3(IFNA4):c.103A>G (p.Arg35Gly) 		MISSENSE
rs1062571 -- p.Ala74Thr
rs201964250 -- p.His49Pro
rs3750480 -- p.Glu137Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFNA4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFNA4 Gene

Variant ID Type Subtype PubMed ID
dgv7474n100 CNV loss 25217958
esv2738274 CNV deletion 23290073
esv2738275 CNV deletion 23290073
esv2759678 CNV loss 17122850
esv2764150 CNV gain+loss 21179565
esv3573167 CNV loss 25503493
esv3619950 CNV loss 21293372
nsv1033177 CNV gain 25217958
nsv613752 CNV loss 21841781
nsv613755 CNV loss 21841781
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA4 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA4 Gene

Human Gene Mutation Database (HGMD)
IFNA4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA4
Leiden Open Variation Database (LOVD)
IFNA4

SNP Genotyping and Copy Number Assays for research

Disorders for IFNA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
rabies
  • lyssa
- elite association - COSMIC cancer census association via MalaCards
Search IFNA4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IFNA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA4 Gene

Publications for IFNA4 Gene

  1. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 40
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  4. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PMID: 9425112) Nyman TA … Kalkkinen N (The Biochemical journal 1998) 3 4
  5. Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population. (PMID: 9335434) Hussain M … Liao MJ (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997) 3 4

ExternalLinks

View latest publications for IFNA4 gene in Mastermind

Products for IFNA4 Gene

Sources for IFNA4 Gene