Aliases for IFNA4 Gene

Aliases for IFNA4 Gene

  • Interferon Alpha 4 2 3 5
  • Interferon Alpha-4B 3 4
  • Interferon Alpha-76 3 4
  • Interferon Alpha-M1 3 4
  • Interferon Alpha-4 3 4
  • IFN-Alpha-4 3 4
  • IFN-Alpha4a 3
  • INFA4 3

External Ids for IFNA4 Gene

Previous GeneCards Identifiers for IFNA4 Gene

  • GC09M021514
  • GC09M021387
  • GC09M021176
  • GC09M021149

Summaries for IFNA4 Gene

GeneCards Summary for IFNA4 Gene

IFNA4 (Interferon Alpha 4) is a Protein Coding gene. Diseases associated with IFNA4 include Rabies. Among its related pathways are Interferon gamma signaling and NOD-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA17.

UniProtKB/Swiss-Prot Summary for IFNA4 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA4 Gene

Additional gene information for IFNA4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA4 Gene

Genomics for IFNA4 Gene

GeneHancer (GH) Regulatory Elements for IFNA4 Gene

Promoters and enhancers for IFNA4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021183 Enhancer 0.4 Ensembl 0.6 +4.2 4170 1 CTCF RAD21 CEBPA TRIM22 IFNA20P IFNA4 IFNWP15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNA4 gene promoter:
  • Egr-2
  • Egr-4
  • GR
  • GR-alpha
  • IRF-7A
  • Olf-1

Genomic Locations for IFNA4 Gene

Genomic Locations for IFNA4 Gene
1,054 bases
Minus strand
982 bases
Minus strand

Genomic View for IFNA4 Gene

Genes around IFNA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA4 Gene

Proteins for IFNA4 Gene

  • Protein details for IFNA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-4
    Protein Accession:
    Secondary Accessions:
    • P13358
    • Q14CS4
    • Q5VV15

    Protein attributes for IFNA4 Gene

    189 amino acids
    Molecular mass:
    21808 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA4 Gene

Post-translational modifications for IFNA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA4 Gene

Domains & Families for IFNA4 Gene

Gene Families for IFNA4 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNA4 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-M1 (IFNA4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA4: view

Function for IFNA4 Gene

Molecular function for IFNA4 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 4,leukocyte

Gene Ontology (GO) - Molecular Function for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS,IBA 21873635
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IFNA4: view
genes like me logo Genes that share phenotypes with IFNA4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA4 Gene

Localization for IFNA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA4 Gene

Pathways & Interactions for IFNA4 Gene

genes like me logo Genes that share pathways with IFNA4: view

Gene Ontology (GO) - Biological Process for IFNA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA4: view

No data available for SIGNOR curated interactions for IFNA4 Gene

Drugs & Compounds for IFNA4 Gene

No Compound Related Data Available

Transcripts for IFNA4 Gene

mRNA/cDNA for IFNA4 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA4 Gene

No ASD Table

Relevant External Links for IFNA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA4 Gene:


SOURCE GeneReport for Unigene cluster for IFNA4 Gene:


Evidence on tissue expression from TISSUES for IFNA4 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with IFNA4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA4 Gene

Orthologs for IFNA4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA17 32
  • 98.94 (n)
-- 33
  • 97 (a)
(Mus musculus)
Mammalia Ifna6 33 32
  • 76.04 (n)
Gm12597 33
  • 62 (a)
Ifna13 33
  • 62 (a)
Ifna5 33
  • 62 (a)
Ifna12 33
  • 61 (a)
Ifna1 33
  • 61 (a)
Gm13280 33
  • 60 (a)
Ifna9 33
  • 60 (a)
Ifnab 17 33
  • 59 (a)
Ifna11 33
  • 59 (a)
Ifna2 33
  • 59 (a)
Ifna14 33
  • 59 (a)
Ifna4 33
  • 58 (a)
Ifna7 33
  • 58 (a)
(Rattus norvegicus)
Mammalia Ifna2 32
  • 75.27 (n)
(Bos Taurus)
Mammalia -- 33
  • 64 (a)
IFNAG 33 33
  • 64 (a)
-- 33
  • 63 (a)
  • 63 (a)
-- 33
  • 63 (a)
-- 33
  • 63 (a)
-- 33
  • 62 (a)
  • 62 (a)
  • 62 (a)
Species where no ortholog for IFNA4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA4 Gene

Gene Tree for IFNA4 (if available)
Gene Tree for IFNA4 (if available)
Evolutionary constrained regions (ECRs) for IFNA4: view image

Paralogs for IFNA4 Gene

(18) SIMAP similar genes for IFNA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IFNA4: view

Variants for IFNA4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA4 Gene

Two forms exist; alpha-4a (shown here) and alpha-4b (PubMed:9335434). They seem to be equally abundant (PubMed:9335434).

Sequence variations from dbSNP and Humsavar for IFNA4 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000338497 -- 21,188,418(-) C/T upstream_transcript_variant
rs1001411417 -- 21,188,453(-) A/T upstream_transcript_variant
rs1003734990 -- 21,189,134(-) T/C upstream_transcript_variant
rs1003808795 -- 21,189,278(-) G/A/C upstream_transcript_variant
rs1005424956 -- 21,187,947(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNA4 Gene

Variant ID Type Subtype PubMed ID
dgv7474n100 CNV loss 25217958
esv2738274 CNV deletion 23290073
esv2738275 CNV deletion 23290073
esv2759678 CNV loss 17122850
esv2764150 CNV gain+loss 21179565
esv3573167 CNV loss 25503493
esv3619950 CNV loss 21293372
nsv1033177 CNV gain 25217958
nsv613752 CNV loss 21841781
nsv613755 CNV loss 21841781
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA4 Gene

Residual Variation Intolerance Score: 93.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for IFNA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFNA4 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • lyssa
- elite association - COSMIC cancer census association via MalaCards
Search IFNA4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFNA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA4 Gene

Publications for IFNA4 Gene

  1. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 43 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 56
  4. Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (PMID: 9425112) Nyman TA … Kalkkinen N (The Biochemical journal 1998) 3 4 56
  5. Both variant forms of interferon-alpha4 gene (IFNA4a and IFNA4b) are present in the human population. (PMID: 9335434) Hussain M … Liao MJ (Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997) 3 4 56

Products for IFNA4 Gene

Sources for IFNA4 Gene