This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011] See more...

Aliases for IFNA21 Gene

Aliases for IFNA21 Gene

  • Interferon Alpha 21 2 3 5
  • Leukocyte Interferon Protein 2 3
  • Interferon Alpha-21 3 4
  • Interferon Alpha-F 3 4
  • IFN-Alpha-21 3 4
  • IFN-AlphaI 2 3
  • LeIF F 3 4
  • LeIF-F 3
  • IFNA21 5

External Ids for IFNA21 Gene

Previous GeneCards Identifiers for IFNA21 Gene

  • GC09M021493
  • GC09M021366
  • GC09M021155
  • GC09M021128

Summaries for IFNA21 Gene

Entrez Gene Summary for IFNA21 Gene

  • This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]

GeneCards Summary for IFNA21 Gene

IFNA21 (Interferon Alpha 21) is a Protein Coding gene. Diseases associated with IFNA21 include Rubella and Melanoma, Cutaneous Malignant 1. Among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA4.

UniProtKB/Swiss-Prot Summary for IFNA21 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA21 Gene

Additional gene information for IFNA21 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA21 Gene

Genomics for IFNA21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J020821 Enhancer 0.2 FANTOM5 6.3 +344.8 344815 0.3 IFNA5 IFNA21 piR-38051-293 piR-47211-676 FOCAD HACD4
GH09J021160 Enhancer 0.7 Ensembl ENCODE 0.4 +6.3 6259 2.8 IKZF2 EED RUNX3 CBFB BATF JUN SPI1 IKZF1 ETV6 ENSG00000199635 KY994054-057 IFNA20P IFNA21 IFNW1
GH09J021153 Enhancer 0.6 ENCODE 0.4 +12.5 12523 0.1 CTCF RAD21 IKZF2 ZBTB20 RELB ZBTB48 ATF2 IKZF1 JUNB ZNF654 KY994054-057 IFNA21 IFNW1
GH09J021183 Enhancer 0.5 Ensembl 0.4 -16.8 -16841 1 CTCF RAD21 TRIM22 CEBPA ZNF654 IFNA20P IFNA4 IFNWP15 IFNA21
GH09J021144 Enhancer 0.3 Ensembl 0.4 +21.7 21659 1.2 YY1 SPI1 IFNW1 KY994054-057 IFNA21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA21

Top Transcription factor binding sites by QIAGEN in the IFNA21 gene promoter:
  • Egr-3
  • Egr-4
  • GR
  • GR-alpha
  • GR-beta
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RORalpha1
  • S8

Genomic Locations for IFNA21 Gene

Genomic Locations for IFNA21 Gene
chr9:21,165,637-21,166,660
(GRCh38/hg38)
Size:
1,024 bases
Orientation:
Minus strand
chr9:21,165,636-21,166,659
(GRCh37/hg19)
Size:
1,024 bases
Orientation:
Minus strand

Genomic View for IFNA21 Gene

Genes around IFNA21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA21 Gene

Proteins for IFNA21 Gene

  • Protein details for IFNA21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01568-IFN21_HUMAN
    Recommended name:
    Interferon alpha-21
    Protein Accession:
    P01568
    Secondary Accessions:
    • Q14608
    • Q5VWD1
    • Q7M4Q4

    Protein attributes for IFNA21 Gene

    Size:
    189 amino acids
    Molecular mass:
    21741 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36041.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IFNA21 Gene

Post-translational modifications for IFNA21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA21 Gene

Domains & Families for IFNA21 Gene

Gene Families for IFNA21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA21 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family
ProtoNet:

Suggested Antigen Peptide Sequences for IFNA21 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-F (IFN21_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01568

UniProtKB/Swiss-Prot:

IFN21_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA21: view

Function for IFNA21 Gene

Molecular function for IFNA21 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 21,leukocyte

Phenotypes From GWAS Catalog for IFNA21 Gene

Gene Ontology (GO) - Molecular Function for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IFNA21: view
genes like me logo Genes that share phenotypes with IFNA21: view

Animal Model Products

CRISPR Products

miRNA for IFNA21 Gene

miRTarBase miRNAs that target IFNA21

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA21 Gene

Localization for IFNA21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA21 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA21 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
endosome 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA21 Gene

Pathways & Interactions for IFNA21 Gene

genes like me logo Genes that share pathways with IFNA21: view

Pathways by source for IFNA21 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA21 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA21 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway

Gene Ontology (GO) - Biological Process for IFNA21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA21: view

No data available for SIGNOR curated interactions for IFNA21 Gene

Drugs & Compounds for IFNA21 Gene

No Compound Related Data Available

Transcripts for IFNA21 Gene

mRNA/cDNA for IFNA21 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA21

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA21 Gene

No ASD Table

Relevant External Links for IFNA21 Gene

GeneLoc Exon Structure for
IFNA21

Expression for IFNA21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA21 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA21 Gene

This gene is overexpressed in Brain - Cerebellum (x6.0), Brain - Cerebellar Hemisphere (x5.6), and Brain - Frontal Cortex (BA9) (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA21

SOURCE GeneReport for Unigene cluster for IFNA21 Gene:

Hs.113211

Evidence on tissue expression from TISSUES for IFNA21 Gene

  • Blood(4.5)
  • Kidney(2.6)
  • Spleen(2.3)
  • Liver(2.3)
  • Lymph node(2.3)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with IFNA21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA21 Gene

Orthologs for IFNA21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA21 30 31
  • 100 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 62 (a)
ManyToMany
IFNAG 31 31
  • 62 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
IFNAH 31
  • 62 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
INFAF 31
  • 61 (a)
ManyToMany
IFNAA 31
  • 60 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Gm12597 31
  • 61 (a)
ManyToMany
Ifna5 31
  • 61 (a)
ManyToMany
Ifna12 31
  • 61 (a)
ManyToMany
Ifna6 31
  • 61 (a)
ManyToMany
Ifna13 31
  • 60 (a)
ManyToMany
Ifna1 31
  • 60 (a)
ManyToMany
Gm13280 31
  • 59 (a)
ManyToMany
Ifna9 31
  • 59 (a)
ManyToMany
Ifna14 31
  • 58 (a)
ManyToMany
Ifnab 31
  • 58 (a)
ManyToMany
Ifna7 31
  • 57 (a)
ManyToMany
Ifna11 31
  • 57 (a)
ManyToMany
Ifna2 31
  • 57 (a)
ManyToMany
Ifna4 31
  • 56 (a)
ManyToMany
Species where no ortholog for IFNA21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA21 Gene

ENSEMBL:
Gene Tree for IFNA21 (if available)
TreeFam:
Gene Tree for IFNA21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA21: view image

Paralogs for IFNA21 Gene

(18) SIMAP similar genes for IFNA21 Gene using alignment to 1 proteins:

  • IFN21_HUMAN

Pseudogenes.org Pseudogenes for IFNA21 Gene

genes like me logo Genes that share paralogs with IFNA21: view

Variants for IFNA21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA21 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1053885 - p.Leu119Met
rs3750478 - p.Lys179Glu

Additional dbSNP identifiers (rs#s) for IFNA21 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFNA21 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
nsv613752 CNV loss 21841781
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA21 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA21 Gene

Disorders for IFNA21 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IFNA21 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rubella
  • german measles
melanoma, cutaneous malignant 1
  • melanoma, cutaneous malignant, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IFNA21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IFNA21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA21 Gene

Publications for IFNA21 Gene

  1. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 41
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 41
  4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for IFNA21 Gene

Sources for IFNA21 Gene