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Aliases for IFNA2 Gene

Aliases for IFNA2 Gene

  • Interferon Alpha 2 2 3 5
  • Alpha-2a Interferon 2 3
  • Interferon Alpha 2b 2 3
  • Interferon Alpha A 2 3
  • IFN-Alpha-2 3 4
  • LeIF A 3 4
  • IFNA2B 3 4
  • Interferon Alpha 2a 3
  • Interferon Alpha-2 3
  • Interferon Alpha-A 4
  • IFN-AlphaA 3
  • IFNA2A 4
  • IFNA2C 4
  • INFA2 3
  • IFNA 3

External Ids for IFNA2 Gene

Previous GeneCards Identifiers for IFNA2 Gene

  • GC09M021711
  • GC09M021585

Summaries for IFNA2 Gene

Entrez Gene Summary for IFNA2 Gene

  • This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]

GeneCards Summary for IFNA2 Gene

IFNA2 (Interferon Alpha 2) is a Protein Coding gene. Diseases associated with IFNA2 include Hepatitis B and Peyronie Disease. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA6.

UniProtKB/Swiss-Prot for IFNA2 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities.

Gene Wiki entry for IFNA2 Gene

Additional gene information for IFNA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFNA2 Gene

Genomics for IFNA2 Gene

GeneHancer (GH) Regulatory Elements for IFNA2 Gene

Promoters and enhancers for IFNA2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021381 Enhancer 1 Ensembl ENCODE 0.7 +3.4 3431 1.1 PKNOX1 FOXA2 SMAD1 RB1 BMI1 YBX1 BATF KLF5 IRF4 ZNF207 IFNA2 IFNA13
GH09J021396 Promoter/Enhancer 1.3 Ensembl ENCODE 0.4 -10.8 -10809 0.4 RB1 SIN3A BMI1 ZNF2 IRF4 ZNF48 RAD21 ZNF335 ZNF121 ZNF143 ENSG00000261696 IFNA2
GH09J021388 Enhancer 0.2 FANTOM5 0.7 -3.0 -2952 0 IFNA2 ENSG00000261696
GH09J021372 Enhancer 0.2 FANTOM5 0.4 +12.6 12589 0 IFNA13 IFNA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFNA2 gene promoter:
  • Egr-2
  • NF-kappaB1
  • NF-kappaB
  • Egr-4
  • Brachyury
  • Egr-3
  • LCR-F1

Genomic Locations for IFNA2 Gene

Genomic Locations for IFNA2 Gene
1,144 bases
Minus strand
1,143 bases
Minus strand

Genomic View for IFNA2 Gene

Genes around IFNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA2 Gene

Proteins for IFNA2 Gene

  • Protein details for IFNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon alpha-2
    Protein Accession:
    Secondary Accessions:
    • H2DF54
    • H2DF55
    • P01564
    • Q14606
    • Q6DJX8
    • Q96KI6

    Protein attributes for IFNA2 Gene

    188 amino acids
    Molecular mass:
    21550 Da
    Quaternary structure:
    • Interacts with IFNAR2.

    Three dimensional structures from OCA and Proteopedia for IFNA2 Gene

neXtProt entry for IFNA2 Gene

Post-translational modifications for IFNA2 Gene

  • Glycosylation at isoforms=129
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for IFNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for IFNA2

No data available for DME Specific Peptides for IFNA2 Gene

Domains & Families for IFNA2 Gene

Gene Families for IFNA2 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IFNA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha/beta interferon family.
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA2: view

Function for IFNA2 Gene

Molecular function for IFNA2 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities.
GENATLAS Biochemistry:
interferon type I,alpha 2,leukocyte

Gene Ontology (GO) - Molecular Function for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS 6158094
GO:0005515 protein binding IPI 7759950
genes like me logo Genes that share ontologies with IFNA2: view
genes like me logo Genes that share phenotypes with IFNA2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA2 Gene

Localization for IFNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA2 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with IFNA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA2 Gene

Pathways & Interactions for IFNA2 Gene

genes like me logo Genes that share pathways with IFNA2: view

Gene Ontology (GO) - Biological Process for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0002286 T cell activation involved in immune response IBA --
GO:0002323 natural killer cell activation involved in immune response IBA --
GO:0006915 apoptotic process TAS 10477584
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with IFNA2: view

No data available for SIGNOR curated interactions for IFNA2 Gene

Drugs & Compounds for IFNA2 Gene

(93) Drugs for IFNA2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sifalimumab Investigational Pharma Target 0

(45) Additional Compounds for IFNA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNA2: view

Transcripts for IFNA2 Gene

mRNA/cDNA for IFNA2 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFNA2 Gene

Interferon, alpha 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA2 Gene

No ASD Table

Relevant External Links for IFNA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IFNA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFNA2 Gene

This gene is overexpressed in Cardia (47.6), Heart (14.3), and Fetal heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFNA2 Gene

Protein tissue co-expression partners for IFNA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IFNA2 Gene:


SOURCE GeneReport for Unigene cluster for IFNA2 Gene:


Evidence on tissue expression from TISSUES for IFNA2 Gene

  • Blood(2.6)
  • Liver(2.4)
  • Kidney(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with IFNA2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA2 Gene

Orthologs for IFNA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IFNA2 34 33
  • 99.65 (n)
(Mus musculus)
Mammalia Ifna5 34
  • 62 (a)
Ifna12 34
  • 62 (a)
Ifna13 34
  • 61 (a)
Gm13280 34
  • 61 (a)
Ifna1 34
  • 61 (a)
Ifna6 34
  • 61 (a)
Ifna14 34
  • 60 (a)
Gm12597 34
  • 60 (a)
Ifna9 34
  • 60 (a)
Ifna2 34
  • 58 (a)
Ifna11 34
  • 58 (a)
Ifnab 34
  • 58 (a)
Ifna7 34
  • 57 (a)
Ifna4 34
  • 56 (a)
(Bos Taurus)
Mammalia -- 34
  • 62 (a)
-- 34
  • 62 (a)
IFNAG 34 34
  • 62 (a)
  • 61 (a)
-- 34
  • 61 (a)
-- 34
  • 61 (a)
  • 61 (a)
  • 61 (a)
-- 34
  • 61 (a)
Species where no ortholog for IFNA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IFNA2 Gene

Gene Tree for IFNA2 (if available)
Gene Tree for IFNA2 (if available)
Evolutionary constrained regions (ECRs) for IFNA2: view image

Paralogs for IFNA2 Gene

(18) SIMAP similar genes for IFNA2 Gene using alignment to 2 proteins:

  • Q6DJX8_HUMAN Pseudogenes for IFNA2 Gene

genes like me logo Genes that share paralogs with IFNA2: view

Variants for IFNA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA2 Gene

Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c (PubMed:7627809).

Sequence variations from dbSNP and Humsavar for IFNA2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
VAR_036329 A breast cancer sample p.Ser177Leu
rs1000122363 -- 21,386,078(-) C/T upstream_transcript_variant
rs1001075147 -- 21,384,604(-) A/T 3_prime_UTR_variant
rs1002164350 -- 21,384,013(-) G/C downstream_transcript_variant
rs1002427114 -- 21,385,584(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFNA2 Gene

Variant ID Type Subtype PubMed ID
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
nsv982201 CNV duplication 23825009

Variation tolerance for IFNA2 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for IFNA2 Gene

MalaCards: The human disease database

(80) MalaCards diseases for IFNA2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis b
  • chronic hepatitis b
peyronie disease
  • penile curvature
hepatitis d
  • delta hepatitis
peyronie's disease
  • peyronies disease
hepatitis c
  • chronic hepatitis c
- elite association - COSMIC cancer census association via MalaCards
Search IFNA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA2 Gene

Publications for IFNA2 Gene

  1. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. (PMID: 8994971) Radhakrishnan R … Walter MR (Structure (London, England : 1993) 1996) 3 4 22 58
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
  3. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 44 58
  4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 44 58
  5. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 44 58

Products for IFNA2 Gene

Sources for IFNA2 Gene

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