Aliases for IFNA2 Gene
External Ids for IFNA2 Gene
Previous GeneCards Identifiers for IFNA2 Gene
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. [provided by RefSeq, Aug 2020]
GeneCards Summary for IFNA2 Gene
IFNA2 (Interferon Alpha 2) is a Protein Coding gene. Diseases associated with IFNA2 include Hepatitis C and Peyronie's Disease. Among its related pathways are JAK-STAT signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA6.
UniProtKB/Swiss-Prot Summary for IFNA2 Gene
Produced by macrophages, IFN-alpha have antiviral activities.