This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011] See more...

Aliases for IFNA2 Gene

Aliases for IFNA2 Gene

  • Interferon Alpha 2 2 3 5
  • Alpha-2a Interferon 2 3
  • Interferon Alpha 2b 2 3
  • Interferon Alpha A 2 3
  • Interferon Alpha-2 3 4
  • IFN-Alpha-2 3 4
  • IFN-AlphaA 2 3
  • IFNA2B 3 4
  • LeIF A 3 4
  • IFNA 2 3
  • Interferon Alpha 2a 3
  • Interferon Alpha-A 4
  • IFNA2A 4
  • IFNA2C 4
  • IFNA2 5

External Ids for IFNA2 Gene

Previous GeneCards Identifiers for IFNA2 Gene

  • GC09M021711
  • GC09M021585
  • GC09M021374

Summaries for IFNA2 Gene

Entrez Gene Summary for IFNA2 Gene

  • This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]

GeneCards Summary for IFNA2 Gene

IFNA2 (Interferon Alpha 2) is a Protein Coding gene. Diseases associated with IFNA2 include Hepatitis C and Peyronie's Disease. Among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA6.

UniProtKB/Swiss-Prot Summary for IFNA2 Gene

Gene Wiki entry for IFNA2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA2 Gene

Genomics for IFNA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021384 Enhancer 0.6 Ensembl 600.7 -0.1 -103 1.4 IKZF2 POLR2A RELB RUNX3 GATAD2B IKZF1 NR2F1 SPI1 SMARCA5 ZNF146 IFNA2 ENSG00000261696 IFNA8
GH09J021383 Enhancer 0.3 Ensembl 600.7 +1.7 1697 0.2 PRDM1 IFNA2 IFNA13
GH09J021396 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 0.4 -10.7 -10703 1 GATAD2A CTCF ZNF692 ZNF143 RAD21 TRIM22 ZNF341 DPF2 ZNF524 RUNX3 ENSG00000261696 KLHL9 IFNA2 IFNA8
GH09J021381 Enhancer 0.9 ENCODE 0.7 +3.4 3409 1.1 SP1 TEAD4 ZNF629 TFE3 BACH1 FOXA1 STAT3 PRDM1 ZNF143 RELA IFNA2 IFNA13
GH09J021402 Promoter 0.8 Ensembl 0.4 -17.3 -17303 1 TEAD4 IKZF2 EZH2 CTCF ZBTB26 ZBTB17 YY1 IKZF1 ZNF335 EBF1 IFNA12P lnc-IFNA8-1 IFNA13 IFNA5 IFNA11P lnc-IFNA2-2 IFNA8 IFNA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA2

Top Transcription factor binding sites by QIAGEN in the IFNA2 gene promoter:
  • Brachyury
  • Egr-2
  • Egr-3
  • Egr-4
  • LCR-F1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for IFNA2 Gene

Genomic Locations for IFNA2 Gene
chr9:21,384,255-21,385,398
(GRCh38/hg38)
Size:
1,144 bases
Orientation:
Minus strand
chr9:21,384,254-21,385,396
(GRCh37/hg19)
Size:
1,143 bases
Orientation:
Minus strand

Genomic View for IFNA2 Gene

Genes around IFNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA2 Gene

Proteins for IFNA2 Gene

  • Protein details for IFNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01563-IFNA2_HUMAN
    Recommended name:
    Interferon alpha-2
    Protein Accession:
    P01563
    Secondary Accessions:
    • H2DF54
    • H2DF55
    • P01564
    • Q14606
    • Q6DJX8
    • Q96KI6

    Protein attributes for IFNA2 Gene

    Size:
    188 amino acids
    Molecular mass:
    21550 Da
    Quaternary structure:
    • Interacts with IFNAR2.

    Three dimensional structures from OCA and Proteopedia for IFNA2 Gene

neXtProt entry for IFNA2 Gene

Post-translational modifications for IFNA2 Gene

  • Glycosylation at Thr129
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • IFNA2_HUMAN (289)

Other Protein References for IFNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for IFNA2

No data available for DME Specific Peptides for IFNA2 Gene

Domains & Families for IFNA2 Gene

Gene Families for IFNA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA2 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family
ProtoNet:

Suggested Antigen Peptide Sequences for IFNA2 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-A (IFNA2_HUMAN)
  • Interferon, alpha 2 (Q6DJX8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01563

UniProtKB/Swiss-Prot:

IFNA2_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA2: view

Function for IFNA2 Gene

Molecular function for IFNA2 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities.
GENATLAS Biochemistry:
interferon type I,alpha 2,leukocyte

Gene Ontology (GO) - Molecular Function for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS,IBA 21873635
GO:0005515 protein binding IPI 7759950
genes like me logo Genes that share ontologies with IFNA2: view
genes like me logo Genes that share phenotypes with IFNA2: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA2 Gene

Localization for IFNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0062023 colocalizes_with collagen-containing extracellular matrix HDA 28327460
genes like me logo Genes that share ontologies with IFNA2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA2 Gene

Pathways & Interactions for IFNA2 Gene

genes like me logo Genes that share pathways with IFNA2: view

Pathways by source for IFNA2 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA2 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA2 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway
1 GeneTex pathway for IFNA2 Gene

SIGNOR curated interactions for IFNA2 Gene

Activates:

Gene Ontology (GO) - Biological Process for IFNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006915 apoptotic process TAS 10477584
GO:0006952 defense response IEA --
genes like me logo Genes that share ontologies with IFNA2: view

Drugs & Compounds for IFNA2 Gene

(93) Drugs for IFNA2 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sifalimumab Investigational Pharma Target 8

(45) Additional Compounds for IFNA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNA2: view

Transcripts for IFNA2 Gene

mRNA/cDNA for IFNA2 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA2

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA2 Gene

No ASD Table

Relevant External Links for IFNA2 Gene

GeneLoc Exon Structure for
IFNA2

Expression for IFNA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFNA2 Gene

This gene is overexpressed in Cardia (47.6), Heart (14.3), and Fetal heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IFNA2 Gene



Protein tissue co-expression partners for IFNA2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA2

SOURCE GeneReport for Unigene cluster for IFNA2 Gene:

Hs.211575

Evidence on tissue expression from TISSUES for IFNA2 Gene

  • Blood(2.9)
  • Kidney(2.8)
  • Liver(2.6)
  • Lung(2.6)
  • Lymph node(2.5)
  • Spleen(2.5)
  • Intestine(2.3)
  • Skin(2.2)
  • Bone marrow(2.2)
  • Nervous system(2.2)
  • Muscle(2.2)
  • Stomach(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with IFNA2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA2 Gene

Orthologs for IFNA2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA2 30 31
  • 99.65 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ifna5 31
  • 62 (a)
ManyToMany
Ifna12 31
  • 62 (a)
ManyToMany
Ifna13 31
  • 61 (a)
ManyToMany
Gm13280 31
  • 61 (a)
ManyToMany
Ifna1 31
  • 61 (a)
ManyToMany
Ifna6 31
  • 61 (a)
ManyToMany
Ifna14 31
  • 60 (a)
ManyToMany
Gm12597 31
  • 60 (a)
ManyToMany
Ifna9 31
  • 60 (a)
ManyToMany
Ifna2 31
  • 58 (a)
ManyToMany
Ifna11 31
  • 58 (a)
ManyToMany
Ifnab 31
  • 58 (a)
ManyToMany
Ifna7 31
  • 57 (a)
ManyToMany
Ifna4 31
  • 56 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 62 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
IFNAG 31 31
  • 62 (a)
ManyToMany
INFAF 31
  • 61 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
IFNAA 31
  • 61 (a)
ManyToMany
IFNAH 31
  • 61 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
Species where no ortholog for IFNA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA2 Gene

ENSEMBL:
Gene Tree for IFNA2 (if available)
TreeFam:
Gene Tree for IFNA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA2: view image

Paralogs for IFNA2 Gene

(18) SIMAP similar genes for IFNA2 Gene using alignment to 2 proteins:

  • IFNA2_HUMAN
  • Q6DJX8_HUMAN

Pseudogenes.org Pseudogenes for IFNA2 Gene

genes like me logo Genes that share paralogs with IFNA2: view

Variants for IFNA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA2 Gene

IFNA2_HUMAN-P01563
Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c (PubMed:7627809).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA2 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
778411 Benign: not provided 21,384,817(-) C/T MISSENSE_VARIANT
778412 Benign: not provided 21,385,313(-) G/T MISSENSE_VARIANT
781165 Benign: not provided 21,384,793(-) G/A SYNONYMOUS_VARIANT
783545 Benign: not provided 21,385,160(-) T/C MISSENSE_VARIANT
786570 Benign: not provided 21,385,193(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for IFNA2 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFNA2 Gene

Variant ID Type Subtype PubMed ID
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
nsv982201 CNV duplication 23825009

Variation tolerance for IFNA2 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA2 Gene

Human Gene Mutation Database (HGMD)
IFNA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA2

SNP Genotyping and Copy Number Assay Products

Disorders for IFNA2 Gene

MalaCards: The human disease database

(107) MalaCards diseases for IFNA2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatitis c
  • chronic hepatitis c
peyronie's disease
  • peyronie disease
hepatitis b
  • chronic hepatitis b
peyronie disease
hepatitis
  • hepatitis a
- elite association - COSMIC cancer census association via MalaCards
Search IFNA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IFNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA2 Gene

Publications for IFNA2 Gene

  1. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. (PMID: 8994971) Radhakrishnan R … Walter MR (Structure (London, England : 1993) 1996) 3 4 23
  2. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
  4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 41
  5. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 41

Products for IFNA2 Gene

Sources for IFNA2 Gene