Aliases for IFNA16 Gene

Aliases for IFNA16 Gene

  • Interferon Alpha 16 2 3 5
  • Interferon Alpha-16 3 4
  • Interferon Alpha-WA 3 4
  • IFN-Alpha-16 3 4
  • IFN-AlphaO 2 3
  • IFN-Alpha-N-Protein 3
  • IFNA16 5

External Ids for IFNA16 Gene

Previous GeneCards Identifiers for IFNA16 Gene

  • GC09M021543
  • GC09M021417
  • GC09M021206
  • GC09M021179

Summaries for IFNA16 Gene

GeneCards Summary for IFNA16 Gene

IFNA16 (Interferon Alpha 16) is a Protein Coding gene. Among its related pathways are JAK-STAT signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA4.

UniProtKB/Swiss-Prot Summary for IFNA16 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA16 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA16 Gene

Genomics for IFNA16 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA16 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021217 Promoter 0.3 EPDnew 250.7 -0.1 -82 0.1 IFNA16 IFNA13 IFNA17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA16 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA16

Top Transcription factor binding sites by QIAGEN in the IFNA16 gene promoter:
  • C/EBPalpha
  • Egr-2
  • Egr-3
  • Egr-4

Genomic Locations for IFNA16 Gene

Latest Assembly
chr9:21,216,373-21,217,311
(GRCh38/hg38)
Size:
939 bases
Orientation:
Minus strand

Previous Assembly
chr9:21,216,372-21,217,310
(GRCh37/hg19 by Entrez Gene)
Size:
939 bases
Orientation:
Minus strand

chr9:21,216,372-21,217,310
(GRCh37/hg19 by Ensembl)
Size:
939 bases
Orientation:
Minus strand

Genomic View for IFNA16 Gene

Genes around IFNA16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA16 Gene

Proteins for IFNA16 Gene

  • Protein details for IFNA16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05015-IFN16_HUMAN
    Recommended name:
    Interferon alpha-16
    Protein Accession:
    P05015
    Secondary Accessions:
    • Q5VV12

    Protein attributes for IFNA16 Gene

    Size:
    189 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA16 Gene

Post-translational modifications for IFNA16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA16 Gene

Domains & Families for IFNA16 Gene

Gene Families for IFNA16 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA16 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family

Suggested Antigen Peptide Sequences for IFNA16 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-WA (IFN16_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05015

UniProtKB/Swiss-Prot:

IFN16_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA16: view

Function for IFNA16 Gene

Molecular function for IFNA16 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 16,leukocyte

Gene Ontology (GO) - Molecular Function for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS,IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with IFNA16: view
genes like me logo Genes that share phenotypes with IFNA16: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA16

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA16 Gene

Localization for IFNA16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA16 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA16 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA16: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA16 Gene

Pathways & Interactions for IFNA16 Gene

genes like me logo Genes that share pathways with IFNA16: view

Pathways by source for IFNA16 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA16 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA16 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway

Gene Ontology (GO) - Biological Process for IFNA16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA16: view

No data available for SIGNOR curated interactions for IFNA16 Gene

Drugs & Compounds for IFNA16 Gene

No Compound Related Data Available

Transcripts for IFNA16 Gene

mRNA/cDNA for IFNA16 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA16

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA16 Gene

No ASD Table

Relevant External Links for IFNA16 Gene

GeneLoc Exon Structure for
IFNA16

Expression for IFNA16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA16 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA16

SOURCE GeneReport for Unigene cluster for IFNA16 Gene:

Hs.56303
genes like me logo Genes that share expression patterns with IFNA16: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA16 Gene

Orthologs for IFNA16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA16 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA16 29
  • 97 (n)
-- 30
  • 75 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC538620 29
  • 78.66 (n)
-- 30
  • 62 (a)
ManyToMany
IFNAG 30 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
IFNAH 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
INFAF 30
  • 61 (a)
ManyToMany
-- 30
  • 61 (a)
ManyToMany
IFNAA 30
  • 61 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia IFNA7 29
  • 70.05 (n)
Mouse
(Mus musculus)
Mammalia Ifna6 30
  • 61 (a)
ManyToMany
Ifna13 30
  • 61 (a)
ManyToMany
Ifna5 30
  • 61 (a)
ManyToMany
Gm12597 30
  • 61 (a)
ManyToMany
Ifna1 30
  • 60 (a)
ManyToMany
Ifna12 30
  • 60 (a)
ManyToMany
Ifna14 30
  • 59 (a)
ManyToMany
Gm13280 30
  • 59 (a)
ManyToMany
Ifnab 30
  • 59 (a)
ManyToMany
Ifna9 30
  • 58 (a)
ManyToMany
Ifna2 30
  • 58 (a)
ManyToMany
Ifna11 30
  • 57 (a)
ManyToMany
Ifna7 30
  • 57 (a)
ManyToMany
Ifna4 30
  • 56 (a)
ManyToMany
Species where no ortholog for IFNA16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA16 Gene

ENSEMBL:
Gene Tree for IFNA16 (if available)
TreeFam:
Gene Tree for IFNA16 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA16: view image
Alliance of Genome Resources:
Additional Orthologs for IFNA16

Paralogs for IFNA16 Gene

(18) SIMAP similar genes for IFNA16 Gene using alignment to 1 proteins:

  • IFN16_HUMAN
genes like me logo Genes that share paralogs with IFNA16: view

Variants for IFNA16 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA16 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs28368161 Benign: not provided 21,216,935(-) G/A
NM_002173.3(IFNA16):c.371C>T (p.Thr124Ile)
MISSENSE
rs41313958 Benign: not provided 21,217,160(-) T/G
NM_002173.3(IFNA16):c.146A>C (p.His49Pro)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFNA16 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFNA16 Gene

Variant ID Type Subtype PubMed ID
dgv7474n100 CNV loss 25217958
esv2738274 CNV deletion 23290073
esv2738277 CNV deletion 23290073
esv2738279 CNV deletion 23290073
esv2764150 CNV gain+loss 21179565
esv3573167 CNV loss 25503493
esv3619955 CNV loss 21293372
nsv1021574 CNV gain 25217958
nsv1035128 CNV gain 25217958
nsv613756 CNV loss 21841781
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA16 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA16
Leiden Open Variation Database (LOVD)
IFNA16

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA16 Gene

Disorders for IFNA16 Gene

Additional Disease Information for IFNA16

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for IFNA16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA16 Gene

Publications for IFNA16 Gene

  1. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 40
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 40
  3. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade OI … Diaz MO (Genomics 1992) 2 3
  4. Structural relationship of human interferon alpha genes and pseudogenes. (PMID: 4057246) Henco K … Schmid J (Journal of molecular biology 1985) 3 4
  5. Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. (PMID: 6548765) Gren E … Apsalons U (Journal of interferon research 1984) 3 4

Products for IFNA16 Gene

Sources for IFNA16 Gene