Aliases for IFNA14 Gene

Aliases for IFNA14 Gene

  • Interferon Alpha 14 2 3 5
  • Interferon Lambda-2-H 3 4
  • Interferon Alpha-14 3 4
  • Interferon Alpha-H 3 4
  • IFN-Alpha-14 3 4
  • IFN-AlphaH 2 3
  • LEIF2H 2 3
  • LeIF H 3 4
  • Interferon, Alpha 14 2
  • IFNA14 5

External Ids for IFNA14 Gene

Previous GeneCards Identifiers for IFNA14 Gene

  • GC09M021566
  • GC09M021403
  • GC09M021192
  • GC09M021229
  • GC09M021193
  • GC09M021194
  • GC09M021208
  • GC09M021211

Summaries for IFNA14 Gene

GeneCards Summary for IFNA14 Gene

IFNA14 (Interferon Alpha 14) is a Protein Coding gene. Among its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA4.

UniProtKB/Swiss-Prot Summary for IFNA14 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA14 Gene

Additional gene information for IFNA14 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA14 Gene

Genomics for IFNA14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021239 Promoter/Enhancer 0.5 EPDnew Ensembl 600.7 -0.1 -96 1 IFNA14 IFNA5 IFNA13 piR-39858-645
GH09J021235 Enhancer 0.5 ENCODE 0.7 +4.1 4068 0.2 CTCF RAD21 TRIM22 SMC3 ZNF654 ZNF664 HNF4A IFNA14 IFNWP5 IFNA17
GH09J021252 Enhancer 0.6 ENCODE 0.4 -13.2 -13228 0.6 CTCF FOXA1 PRDM1 RAD21 RUNX3 SMC3 ZNF654 SIN3A POLR2A PKNOX1 IFNA12P IFNA8 IFNWP2 IFNA13 IFNA20P piR-43105-652 LOC107987053 IFNA14 IFNA5
GH09J021294 Enhancer 0.9 Ensembl ENCODE 0.2 -55.5 -55496 2.6 TCF12 IKZF2 RCOR1 TRIM22 SCRT2 ARID3A DPF2 RELB RUNX3 GATAD2B IFNA13 IFNA20P MN309174-655 IFNA5 piR-51137-122 LOC107987053 IFNA14
GH09J021228 Promoter 0.3 EPDnew 0.4 +11.7 11744 0.1 IFNA17 IFNA12P IFNA8 IFNWP2 IFNA5 IFNA13 IFNA20P lnc-IFNA17-1 IFNA14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA14

Top Transcription factor binding sites by QIAGEN in the IFNA14 gene promoter:
  • AP-1
  • IRF-1
  • IRF-2
  • NF-E2
  • NF-E2 p45

Genomic Locations for IFNA14 Gene

Genomic Locations for IFNA14 Gene
chr9:21,239,002-21,240,005
(GRCh38/hg38)
Size:
1,004 bases
Orientation:
Minus strand
chr9:21,239,201-21,239,978
(GRCh37/hg19)
Size:
778 bases
Orientation:
Minus strand

Genomic View for IFNA14 Gene

Genes around IFNA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA14 Gene

Proteins for IFNA14 Gene

  • Protein details for IFNA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01570-IFN14_HUMAN
    Recommended name:
    Interferon alpha-14
    Protein Accession:
    P01570
    Secondary Accessions:
    • Q5VZ56
    • Q7M4S1

    Protein attributes for IFNA14 Gene

    Size:
    189 amino acids
    Molecular mass:
    22063 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFNA14 Gene

Post-translational modifications for IFNA14 Gene

  • Glycosylation at Asn95
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • IFN14_HUMAN (288)

Other Protein References for IFNA14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA14 Gene

Domains & Families for IFNA14 Gene

Gene Families for IFNA14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IFNA14 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family
ProtoNet:

Suggested Antigen Peptide Sequences for IFNA14 Gene

GenScript: Design optimal peptide antigens:
  • Interferon lambda-2-H (IFN14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01570

UniProtKB/Swiss-Prot:

IFN14_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA14: view

Function for IFNA14 Gene

Molecular function for IFNA14 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 14,leukocyte

Phenotypes From GWAS Catalog for IFNA14 Gene

Gene Ontology (GO) - Molecular Function for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding TAS 6163083
GO:0005132 type I interferon receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IFNA14: view
genes like me logo Genes that share phenotypes with IFNA14: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA14 Gene

Localization for IFNA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA14 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA14 gene
Compartment Confidence
extracellular 5
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA14 Gene

Pathways & Interactions for IFNA14 Gene

genes like me logo Genes that share pathways with IFNA14: view

Pathways by source for IFNA14 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA14 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA14 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway

Gene Ontology (GO) - Biological Process for IFNA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA14: view

No data available for SIGNOR curated interactions for IFNA14 Gene

Drugs & Compounds for IFNA14 Gene

No Compound Related Data Available

Transcripts for IFNA14 Gene

mRNA/cDNA for IFNA14 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA14

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA14 Gene

No ASD Table

Relevant External Links for IFNA14 Gene

GeneLoc Exon Structure for
IFNA14

Expression for IFNA14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA14 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA14 Gene

This gene is overexpressed in Kidney - Cortex (x38.0), Cervix - Ectocervix (x5.8), and Testis (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA14

SOURCE GeneReport for Unigene cluster for IFNA14 Gene:

Hs.93907
genes like me logo Genes that share expression patterns with IFNA14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA14 Gene

Orthologs for IFNA14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA14 30 31
  • 98.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ifna5 30
  • 73.37 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 63 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
IFNAG 31 31
  • 62 (a)
ManyToMany
-- 31
  • 62 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
-- 31
  • 61 (a)
ManyToMany
INFAF 31
  • 61 (a)
ManyToMany
IFNAH 31
  • 61 (a)
ManyToMany
IFNAA 31
  • 61 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Ifna13 31
  • 61 (a)
ManyToMany
Ifna6 31
  • 61 (a)
ManyToMany
Ifna9 31
  • 61 (a)
ManyToMany
Ifna5 31
  • 60 (a)
ManyToMany
Ifna12 31
  • 60 (a)
ManyToMany
Ifna1 31
  • 60 (a)
ManyToMany
Gm13280 31
  • 59 (a)
ManyToMany
Gm12597 31
  • 59 (a)
ManyToMany
Ifnab 31
  • 58 (a)
ManyToMany
Ifna2 31
  • 57 (a)
ManyToMany
Ifna11 31
  • 57 (a)
ManyToMany
Ifna14 31
  • 57 (a)
ManyToMany
Ifna7 31
  • 57 (a)
ManyToMany
Ifna4 31
  • 55 (a)
ManyToMany
Species where no ortholog for IFNA14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA14 Gene

ENSEMBL:
Gene Tree for IFNA14 (if available)
TreeFam:
Gene Tree for IFNA14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA14: view image

Paralogs for IFNA14 Gene

(19) SIMAP similar genes for IFNA14 Gene using alignment to 1 proteins:

  • IFN14_HUMAN
genes like me logo Genes that share paralogs with IFNA14: view

Variants for IFNA14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA14 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
788673 Benign: not provided 21,239,448(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for IFNA14 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFNA14 Gene

Variant ID Type Subtype PubMed ID
esv2764150 CNV gain+loss 21179565
esv3619956 CNV loss 21293372
esv3619957 CNV loss 21293372
nsv1035128 CNV gain 25217958
nsv968599 CNV duplication 23825009

Variation tolerance for IFNA14 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA14 Gene

Disorders for IFNA14 Gene

Additional Disease Information for IFNA14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for IFNA14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA14 Gene

Publications for IFNA14 Gene

  1. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 41
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 41
  3. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 41
  4. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang XR … Goldstein AM (Familial cancer 2010) 3 41
  5. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 41

Products for IFNA14 Gene

Sources for IFNA14 Gene