Aliases for IFNA13 Gene

Aliases for IFNA13 Gene

  • Interferon Alpha 13 2 3 5
  • Interferon Alpha-1/13 3 4
  • Interferon Alpha-D 3 4
  • IFN-Alpha-1/13 3 4
  • LeIF D 3 4
  • IFNA13 5

External Ids for IFNA13 Gene

Previous GeneCards Identifiers for IFNA13 Gene

  • GC09M021695
  • GC09M021568
  • GC09M021357

Summaries for IFNA13 Gene

GeneCards Summary for IFNA13 Gene

IFNA13 (Interferon Alpha 13) is a Protein Coding gene. Among its related pathways are JAK-STAT signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA1.

UniProtKB/Swiss-Prot Summary for IFNA13 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA13 Gene

Genomics for IFNA13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA13

Top Transcription factor binding sites by QIAGEN in the IFNA13 gene promoter:
  • Egr-2
  • Egr-3
  • Egr-4
  • IRF-7A
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for IFNA13 Gene

Latest Assembly
chr9:21,367,372-21,368,962
(GRCh38/hg38)
Size:
1,591 bases
Orientation:
Minus strand

Previous Assembly
chr9:21,367,371-21,368,056
(GRCh37/hg19 by Entrez Gene)
Size:
686 bases
Orientation:
Minus strand

chr9:21,367,371-21,368,075
(GRCh37/hg19 by Ensembl)
Size:
705 bases
Orientation:
Minus strand

Genomic View for IFNA13 Gene

Genes around IFNA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA13 Gene

Proteins for IFNA13 Gene

  • Protein details for IFNA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01562-IFNA1_HUMAN
    Recommended name:
    Interferon alpha-1/13
    Protein Accession:
    P01562
    Secondary Accessions:
    • D4Q9M8
    • Q14605
    • Q2M1L8
    • Q52LB8
    • Q5VYQ2
    • Q7M4Q1
    • Q8WZ68
    • Q9UMJ3

    Protein attributes for IFNA13 Gene

    Size:
    189 amino acids
    Molecular mass:
    21725 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Interferons alpha-1 and alpha-13 have identical protein sequences.

    Three dimensional structures from OCA and Proteopedia for IFNA13 Gene

neXtProt entry for IFNA13 Gene

Post-translational modifications for IFNA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein products for research

  • Novus Biologicals lysates for IFNA13
  • Abcam proteins for IFNA13

No data available for DME Specific Peptides for IFNA13 Gene

Domains & Families for IFNA13 Gene

Gene Families for IFNA13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IFNA13 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family

Suggested Antigen Peptide Sequences for IFNA13 Gene

GenScript: Design optimal peptide antigens:
  • Interferon alpha-D (IFNA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P01562

UniProtKB/Swiss-Prot:

IFNA1_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA13: view

Function for IFNA13 Gene

Molecular function for IFNA13 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 13,leukocyte

Phenotypes From GWAS Catalog for IFNA13 Gene

Gene Ontology (GO) - Molecular Function for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS,IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with IFNA13: view
genes like me logo Genes that share phenotypes with IFNA13: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFNA13 Gene

Localization for IFNA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA13 gene
Compartment Confidence
extracellular 5
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA13 Gene

Pathways & Interactions for IFNA13 Gene

genes like me logo Genes that share pathways with IFNA13: view

Pathways by source for IFNA13 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA13 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA13 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway

Gene Ontology (GO) - Biological Process for IFNA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA13: view

No data available for SIGNOR curated interactions for IFNA13 Gene

Drugs & Compounds for IFNA13 Gene

No Compound Related Data Available

Transcripts for IFNA13 Gene

mRNA/cDNA for IFNA13 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA13

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA13 Gene

No ASD Table

Relevant External Links for IFNA13 Gene

GeneLoc Exon Structure for
IFNA13

Expression for IFNA13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA13 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA13 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.3) and Brain - Hippocampus (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA13

SOURCE GeneReport for Unigene cluster for IFNA13 Gene:

Hs.533471

Evidence on tissue expression from TISSUES for IFNA13 Gene

  • Blood(4.3)
  • Nervous system(4.2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with IFNA13: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA13 Gene

Orthologs for IFNA13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA13 29
  • 99.29 (n)
-- 30
  • 98 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ifna6 30
  • 64 (a)
ManyToMany
Ifna9 30
  • 64 (a)
ManyToMany
Ifna13 30
  • 64 (a)
ManyToMany
Ifna5 30
  • 63 (a)
ManyToMany
Ifna12 30
  • 62 (a)
ManyToMany
Gm12597 30
  • 62 (a)
ManyToMany
Gm13280 30
  • 62 (a)
ManyToMany
Ifna1 30
  • 62 (a)
ManyToMany
Ifna14 30
  • 60 (a)
ManyToMany
Ifna7 30
  • 60 (a)
ManyToMany
Ifna4 30
  • 60 (a)
ManyToMany
Ifnab 30
  • 59 (a)
ManyToMany
Ifna11 30
  • 59 (a)
ManyToMany
Ifna2 30
  • 59 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia IFNAG 30 30
  • 63 (a)
ManyToMany
-- 30
  • 63 (a)
ManyToMany
INFAF 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
IFNAA 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
IFNAH 30
  • 61 (a)
ManyToMany
Species where no ortholog for IFNA13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA13 Gene

ENSEMBL:
Gene Tree for IFNA13 (if available)
TreeFam:
Gene Tree for IFNA13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA13: view image
Alliance of Genome Resources:
Additional Orthologs for IFNA13

Paralogs for IFNA13 Gene

(18) SIMAP similar genes for IFNA13 Gene using alignment to 2 proteins:

  • IFNA1_HUMAN
  • E9PB07_HUMAN
genes like me logo Genes that share paralogs with IFNA13: view

Variants for IFNA13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA13 Gene

IFNA1_HUMAN-P01562
Two forms exist; alpha-1a (shown here) and alpha-1b (PubMed:11032395).

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFNA13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFNA13 Gene

Variant ID Type Subtype PubMed ID
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
nsv972300 CNV duplication 23825009

Variation tolerance for IFNA13 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA13
Leiden Open Variation Database (LOVD)
IFNA13

SNP Genotyping and Copy Number Assays for research

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA13 Gene

Disorders for IFNA13 Gene

Additional Disease Information for IFNA13

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for IFNA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFNA13 Gene

Publications for IFNA13 Gene

  1. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 40
  2. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PMID: 20588308) Silva LK … Teixeira MG (European journal of human genetics : EJHG 2010) 3 40
  3. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PMID: 19258923) Siezen CL … Janssen R (The Pediatric infectious disease journal 2009) 3 40
  4. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PMID: 17703412) Janssen R … Hoebee B (The Journal of infectious diseases 2007) 3 40
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for IFNA13 Gene

Sources for IFNA13 Gene