This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane rec... See more...

Aliases for IFNA1 Gene

Aliases for IFNA1 Gene

  • Interferon Alpha 1 2 3 5
  • Interferon Alpha-1/13 3 4
  • Interferon Alpha 1b 2 3
  • Interferon Alpha-D 3 4
  • IFN-Alpha-1/13 3 4
  • IFN-AlphaD 2 3
  • IFN-ALPHA 2 3
  • IFNA13 2 3
  • LeIF D 3 4
  • IFNA@ 2 3
  • IFL 2 3
  • IFN 2 3
  • Interferon-Alpha1 3
  • IFN-Alpha 1b 2
  • IFNA1 5

External Ids for IFNA1 Gene

Previous GeneCards Identifiers for IFNA1 Gene

  • GC09P021768
  • GC09P021641
  • GC09P021430
  • GC09P021424
  • GC09P021427
  • GC09P021463
  • GC09P021461
  • GC09P021470
  • GC09P021478
  • GC09P021431
  • GC09P021434
  • GC09P021437
  • GC09P021441
  • GC09P021446
  • GC09P021449
  • GC09P021452
  • GC09P021459
  • GC09P021494
  • GC09P021503

Summaries for IFNA1 Gene

Entrez Gene Summary for IFNA1 Gene

  • This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia. [provided by RefSeq, Aug 2020]

GeneCards Summary for IFNA1 Gene

IFNA1 (Interferon Alpha 1) is a Protein Coding gene. Diseases associated with IFNA1 include Hepatitis and Cryoglobulinemia. Among its related pathways are JAK-STAT signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA13.

UniProtKB/Swiss-Prot Summary for IFNA1 Gene

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Gene Wiki entry for IFNA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFNA1 Gene

Genomics for IFNA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFNA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J021016 Enhancer 0.8 FANTOM5 Ensembl ENCODE 9.2 -423.6 -423638 4 MAFK SPI1 USF2 FOS CEBPB HACD4 IFNW1 IFNA1 IFNA6 FOCAD IFNA5 LOC105375989 lnc-IFNB1-2 piR-40176-033
GH09J021744 Enhancer 0.7 FANTOM5 Ensembl ENCODE 8.2 +304.8 304762 1.2 CEBPB MAX EP300 MTAP IFNA1 IFNA6 IFNA5 HSALNG0070383 LOC107987026 HSALNG0070380-002 HSALNG0070382 HSALNG0070380-001 ENSG00000264545
GH09J021653 Enhancer 0.4 FANTOM5 16.7 +213.1 213098 0.3 MAFF MAFK HSALNG0070376 IFNA1 IFNA6 KLHL9 HSALNG0070378 MTAP ENSG00000264545 IFNE
GH09J021573 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +143.5 143476 20.1 ZNF600 JUND ZNF580 ZIC2 ZBTB10 CEBPB DEK FEZF1 CTCF MAX MIR31 IFNW1 IFNA1 IFNA6 MIR31HG MIR31HG-002 HSALNG0070367 IFNE ENSG00000264545 MTAP
GH09J021901 Enhancer 0.5 FANTOM5 Ensembl 3.2 +462.6 462559 3.2 MAFK MTAP IFNA1 IFNA8 lnc-IFNA1-5 piR-59769-600 CDKN2A ENSG00000264545
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFNA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFNA1

Top Transcription factor binding sites by QIAGEN in the IFNA1 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • Sp1
  • STAT1
  • STAT3

Genomic Locations for IFNA1 Gene

Latest Assembly
chr9:21,440,439-21,441,316
(GRCh38/hg38)
Size:
878 bases
Orientation:
Plus strand

Previous Assembly
chr9:21,440,438-21,441,315
(GRCh37/hg19 by Entrez Gene)
Size:
878 bases
Orientation:
Plus strand

chr9:21,440,440-21,441,315
(GRCh37/hg19 by Ensembl)
Size:
876 bases
Orientation:
Plus strand

Genomic View for IFNA1 Gene

Genes around IFNA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFNA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFNA1 Gene

Proteins for IFNA1 Gene

  • Protein details for IFNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01562-IFNA1_HUMAN
    Recommended name:
    Interferon alpha-1/13
    Protein Accession:
    P01562
    Secondary Accessions:
    • D4Q9M8
    • Q14605
    • Q2M1L8
    • Q52LB8
    • Q5VYQ2
    • Q7M4Q1
    • Q8WZ68
    • Q9UMJ3

    Protein attributes for IFNA1 Gene

    Size:
    189 amino acids
    Molecular mass:
    21725 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Interferons alpha-1 and alpha-13 have identical protein sequences.

    Three dimensional structures from OCA and Proteopedia for IFNA1 Gene

neXtProt entry for IFNA1 Gene

Post-translational modifications for IFNA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFNA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFNA1 Gene

Domains & Families for IFNA1 Gene

Gene Families for IFNA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IFNA1 Gene

InterPro:
Blocks:
  • Interferon alpha, beta and delta family

Graphical View of Domain Structure for InterPro Entry

P01562

UniProtKB/Swiss-Prot:

IFNA1_HUMAN :
  • Belongs to the alpha/beta interferon family.
Family:
  • Belongs to the alpha/beta interferon family.
genes like me logo Genes that share domains with IFNA1: view

No data available for Suggested Antigen Peptide Sequences for IFNA1 Gene

Function for IFNA1 Gene

Molecular function for IFNA1 Gene

UniProtKB/Swiss-Prot Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GENATLAS Biochemistry:
interferon type I,alpha 1,leukocyte

Phenotypes From GWAS Catalog for IFNA1 Gene

Gene Ontology (GO) - Molecular Function for IFNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005126 cytokine receptor binding IEA --
GO:0005132 type I interferon receptor binding TAS,IBA 21873635
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with IFNA1: view
genes like me logo Genes that share phenotypes with IFNA1: view

miRNA for IFNA1 Gene

miRTarBase miRNAs that target IFNA1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IFNA1 Gene

Localization for IFNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFNA1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFNA1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
mitochondrion 3
nucleus 3
endosome 3
cytosol 3
lysosome 3
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IFNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
genes like me logo Genes that share ontologies with IFNA1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFNA1 Gene

Pathways & Interactions for IFNA1 Gene

genes like me logo Genes that share pathways with IFNA1: view

Pathways by source for IFNA1 Gene

2 GeneGo (Thomson Reuters) pathways for IFNA1 Gene
  • Immune response IFN alpha/beta signaling pathway
  • Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
4 Qiagen pathways for IFNA1 Gene
  • all-trans-Retinoic Acid Mediated Apoptosis
  • Cytokine Network
  • Interferon Pathway
  • JAK-STAT Pathway
1 Cell Signaling Technology pathway for IFNA1 Gene
1 GeneTex pathway for IFNA1 Gene

SIGNOR curated interactions for IFNA1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IFNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA 21873635
GO:0002286 T cell activation involved in immune response IBA 21873635
GO:0002323 natural killer cell activation involved in immune response IBA 21873635
GO:0006952 defense response IEA --
GO:0006959 humoral immune response IBA 21873635
genes like me logo Genes that share ontologies with IFNA1: view

Drugs & Compounds for IFNA1 Gene

(81) Drugs for IFNA1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(47) Additional Compounds for IFNA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IFNA1: view

Transcripts for IFNA1 Gene

mRNA/cDNA for IFNA1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFNA1

Alternative Splicing Database (ASD) splice patterns (SP) for IFNA1 Gene

No ASD Table

Relevant External Links for IFNA1 Gene

GeneLoc Exon Structure for
IFNA1

Expression for IFNA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFNA1 Gene

mRNA differential expression in normal tissues according to GTEx for IFNA1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.9) and Brain - Cerebellum (x7.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFNA1

SOURCE GeneReport for Unigene cluster for IFNA1 Gene:

Hs.37026

Evidence on tissue expression from TISSUES for IFNA1 Gene

  • Blood(4.7)
  • Nervous system(4.5)
  • Spleen(3.4)
  • Kidney(3.2)
  • Lymph node(3.1)
  • Lung(3)
  • Liver(2.8)
  • Bone marrow(2.7)
  • Intestine(2.7)
  • Skin(2.6)
  • Heart(2.5)
  • Muscle(2.5)
  • Stomach(2.4)
  • Thyroid gland(2.4)
  • Bone(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with IFNA1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFNA1 Gene

Orthologs for IFNA1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IFNA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFNA13 29
  • 99.12 (n)
-- 30
  • 98 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ifna6 30
  • 65 (a)
ManyToMany
Ifna13 30
  • 65 (a)
ManyToMany
Ifna9 30
  • 64 (a)
ManyToMany
Ifna5 30
  • 63 (a)
ManyToMany
Gm13280 30
  • 63 (a)
ManyToMany
Ifna1 30
  • 63 (a)
ManyToMany
Gm12597 30
  • 62 (a)
ManyToMany
Ifna12 30
  • 62 (a)
ManyToMany
Ifna7 30
  • 61 (a)
ManyToMany
Ifna14 30
  • 60 (a)
ManyToMany
Ifna4 30
  • 60 (a)
ManyToMany
Ifnab 30
  • 60 (a)
ManyToMany
Ifna11 30
  • 59 (a)
ManyToMany
Ifna2 30
  • 59 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 63 (a)
ManyToMany
IFNAG 30 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
-- 30
  • 62 (a)
ManyToMany
IFNAA 30
  • 61 (a)
ManyToMany
INFAF 30
  • 61 (a)
ManyToMany
IFNAH 30
  • 61 (a)
ManyToMany
-- 30
  • 61 (a)
ManyToMany
Species where no ortholog for IFNA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IFNA1 Gene

ENSEMBL:
Gene Tree for IFNA1 (if available)
TreeFam:
Gene Tree for IFNA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFNA1: view image
Alliance of Genome Resources:
Additional Orthologs for IFNA1

Paralogs for IFNA1 Gene

(18) SIMAP similar genes for IFNA1 Gene using alignment to 2 proteins:

  • IFNA1_HUMAN
  • L0N195_HUMAN

Pseudogenes.org Pseudogenes for IFNA1 Gene

genes like me logo Genes that share paralogs with IFNA1: view

Variants for IFNA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFNA1 Gene

IFNA1_HUMAN-P01562
Two forms exist; alpha-1a (shown here) and alpha-1b (PubMed:11032395).

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFNA1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1758567 Benign: not provided 21,440,536(+) T/Cp.Val10Ala
NM_024013.3(IFNA1):c.29T>C (p.Val10Ala)
MISSENSE
rs2230050 Benign: not provided 21,440,917(+) C/Tp.Ala137Val
NM_024013.3(IFNA1):c.410C>T (p.Ala137Val)
MISSENSE
rs28383794 Benign: not provided 21,440,995(+) C/Gp.Ala163Gly
NM_024013.3(IFNA1):c.488C>G (p.Ala163Gly)
MISSENSE
rs34278127 Benign: not provided 21,440,549(+) C/T
NM_024013.3(IFNA1):c.42C>T (p.Leu14=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IFNA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IFNA1 Gene

Variant ID Type Subtype PubMed ID
esv2752289 CNV gain 17911159
esv2764150 CNV gain+loss 21179565
nsv466297 CNV gain 19166990
nsv613758 CNV gain 21841781
nsv982203 CNV duplication 23825009

Variation tolerance for IFNA1 Gene

Residual Variation Intolerance Score: 64.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.57; 72.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFNA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFNA1
Leiden Open Variation Database (LOVD)
IFNA1

SNP Genotyping and Copy Number Assays for research

Disorders for IFNA1 Gene

MalaCards: The human disease database

(176) MalaCards diseases for IFNA1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
hepatitis
  • acute and subacute liver necrosis
cryoglobulinemia
  • cryoimmunoglobulinaemia
newcastle disease
  • newcastle's disease
viral infectious disease
  • viral disease
hepatitis c
  • chronic hepatitis c
- elite association - COSMIC cancer census association via MalaCards
Search IFNA1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IFNA1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IFNA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFNA1 Gene

Publications for IFNA1 Gene

  1. Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group. (PMID: 11315919) Donn RP … Thomson W (Arthritis and rheumatism 2001) 3 22 40
  2. Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia. (PMID: 1385305) Olopade OI … Diaz MO (Genomics 1992) 2 3 22
  3. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. (PMID: 20112359) Salloum R … Niewold TB (Arthritis and rheumatism 2010) 3 22
  4. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 40
  5. Interferon-alpha and interleukin-6 in SLE serum induce the differentiation and maturation of dendritic cells derived from CD34+ hematopoietic precursor cells. (PMID: 20303780) Zhang R … Jiang P (Cytokine 2010) 3 22

Products for IFNA1 Gene

Sources for IFNA1 Gene