Aliases for IFNA1 Gene
External Ids for IFNA1 Gene
Previous GeneCards Identifiers for IFNA1 Gene
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia. [provided by RefSeq, Aug 2020]
GeneCards Summary for IFNA1 Gene
IFNA1 (Interferon Alpha 1) is a Protein Coding gene. Diseases associated with IFNA1 include Hepatitis and Cryoglobulinemia. Among its related pathways are JAK-STAT signaling pathway and Toll-Like receptor Signaling Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNA13.
UniProtKB/Swiss-Prot Summary for IFNA1 Gene
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.