The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has no... See more...

Aliases for IFITM3 Gene

Aliases for IFITM3 Gene

  • Interferon Induced Transmembrane Protein 3 2 3 5
  • Dispanin Subfamily A Member 2b 2 3 4
  • Interferon-Induced Transmembrane Protein 3 3 4
  • Interferon-Inducible Protein 1-8U 3 4
  • DSPA2b 3 4
  • Interferon Induced Transmembrane Protein 3 (1-8U) 2
  • 1-8U 3
  • IP15 3

External Ids for IFITM3 Gene

Previous GeneCards Identifiers for IFITM3 Gene

  • GC11U990191
  • GC08P9A0176
  • GC11P000877
  • GC11M000309
  • GC11M000137

Summaries for IFITM3 Gene

Entrez Gene Summary for IFITM3 Gene

  • The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]

GeneCards Summary for IFITM3 Gene

IFITM3 (Interferon Induced Transmembrane Protein 3) is a Protein Coding gene. Diseases associated with IFITM3 include Influenza, Severe and Influenza. Among its related pathways are Innate Immune System and Interferon gamma signaling. An important paralog of this gene is IFITM2.

UniProtKB/Swiss-Prot Summary for IFITM3 Gene

  • IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.

Gene Wiki entry for IFITM3 Gene

Additional gene information for IFITM3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFITM3 Gene

Genomics for IFITM3 Gene

GeneHancer (GH) Regulatory Elements for IFITM3 Gene

Promoters and enhancers for IFITM3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFITM3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFITM3

Top Transcription factor binding sites by QIAGEN in the IFITM3 gene promoter:
  • Cart-1
  • GATA-3
  • GR
  • GR-alpha
  • Pax-5
  • STAT1
  • STAT3

Genomic Locations for IFITM3 Gene

Genomic Locations for IFITM3 Gene
chr11:319,673-327,537
(GRCh38/hg38)
Size:
7,865 bases
Orientation:
Minus strand
chr11:319,669-327,537
(GRCh37/hg19)
Size:
7,869 bases
Orientation:
Minus strand

Genomic View for IFITM3 Gene

Genes around IFITM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFITM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFITM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM3 Gene

Proteins for IFITM3 Gene

  • Protein details for IFITM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01628-IFM3_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 3
    Protein Accession:
    Q01628
    Secondary Accessions:
    • Q53Y76
    • Q96HK8
    • Q96J15

    Protein attributes for IFITM3 Gene

    Size:
    133 amino acids
    Molecular mass:
    14632 Da
    Quaternary structure:
    • Interacts with ATP6V0B and CD81 (By similarity). Interacts with SPP1; the interaction reduces OPN expression. Interacts with VAPA.

neXtProt entry for IFITM3 Gene

Post-translational modifications for IFITM3 Gene

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
  • Not glycosylated.
  • Polyubiquitinated with both 'Lys-48' and 'Lys-63' linkages. Ubiquitination negatively regulates antiviral activity. Lys-24 is the most prevalent ubiquitination site.
  • Ubiquitination at Lys24, Lys83, Lys88, and Lys104
  • Modification sites at PhosphoSitePlus

Other Protein References for IFITM3 Gene

Protein Products

No data available for DME Specific Peptides for IFITM3 Gene

Domains & Families for IFITM3 Gene

Gene Families for IFITM3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for IFITM3 Gene

Blocks:
  • Interferon-induced transmembrane protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFITM3 Gene

GenScript: Design optimal peptide antigens:
  • Interferon-inducible protein 1-8U (IFM3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q01628

UniProtKB/Swiss-Prot:

IFM3_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with IFITM3: view

Function for IFITM3 Gene

Molecular function for IFITM3 Gene

UniProtKB/Swiss-Prot Function:
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.
UniProtKB/Swiss-Prot Induction:
By IFN-alpha and IFNG/IFN-gamma.

Phenotypes From GWAS Catalog for IFITM3 Gene

Gene Ontology (GO) - Molecular Function for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18486613
genes like me logo Genes that share ontologies with IFITM3: view
genes like me logo Genes that share phenotypes with IFITM3: view

Animal Models for IFITM3 Gene

MGI Knock Outs for IFITM3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFITM3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFITM3 Gene

Localization for IFITM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM3 Gene

Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFITM3 gene
Compartment Confidence
plasma membrane 5
endosome 5
lysosome 5
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IFITM3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFITM3 Gene

Pathways & Interactions for IFITM3 Gene

genes like me logo Genes that share pathways with IFITM3: view

Pathways by source for IFITM3 Gene

Gene Ontology (GO) - Biological Process for IFITM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 1906403
GO:0009615 response to virus IDA 20943977
GO:0032897 negative regulation of viral transcription IDA 20943977
GO:0034341 response to interferon-gamma IDA,IBA 21253575
GO:0035455 response to interferon-alpha IDA 22479637
genes like me logo Genes that share ontologies with IFITM3: view

No data available for SIGNOR curated interactions for IFITM3 Gene

Drugs & Compounds for IFITM3 Gene

No Compound Related Data Available

Transcripts for IFITM3 Gene

mRNA/cDNA for IFITM3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFITM3

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM3 Gene

No ASD Table

Relevant External Links for IFITM3 Gene

GeneLoc Exon Structure for
IFITM3

Expression for IFITM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFITM3 Gene

Protein differential expression in normal tissues from HIPED for IFITM3 Gene

This gene is overexpressed in Esophagus (14.3), Placenta (12.9), Stomach (7.8), and Fetal testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFITM3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFITM3

SOURCE GeneReport for Unigene cluster for IFITM3 Gene:

Hs.374650

Evidence on tissue expression from TISSUES for IFITM3 Gene

  • Nervous system(4.8)
  • Heart(4.4)
  • Lung(3.9)
  • Liver(3.7)
  • Eye(3.4)
  • Pancreas(3.3)
  • Intestine(3)
  • Skin(2.9)
  • Spleen(2.9)
  • Stomach(2.9)
  • Kidney(2.6)
  • Lymph node(2.5)
  • Gall bladder(2.4)
  • Adrenal gland(2.1)
  • Muscle(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with IFITM3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFITM3 Gene

Orthologs for IFITM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFITM3 31 30
  • 98.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ifitm3 17 31 30
  • 73.96 (n)
Ifitm1 31
  • 66 (a)
ManyToMany
Ifitm2 31
  • 59 (a)
ManyToMany
Gm7676 31
  • 57 (a)
ManyToMany
Gm2840 31
  • 54 (a)
ManyToMany
Ifitm7 31
  • 52 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ifitm3 30
  • 73.7 (n)
cow
(Bos Taurus)
Mammalia IFITM3 31
  • 64 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 33 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 31
  • 32 (a)
ManyToMany
Species where no ortholog for IFITM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM3 Gene

ENSEMBL:
Gene Tree for IFITM3 (if available)
TreeFam:
Gene Tree for IFITM3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFITM3: view image

Paralogs for IFITM3 Gene

Paralogs for IFITM3 Gene

(4) SIMAP similar genes for IFITM3 Gene using alignment to 6 proteins:

  • IFM3_HUMAN
  • E9PS44_HUMAN
  • H9NKY4_HUMAN
  • H9NL12_HUMAN
  • H9NL19_HUMAN
  • R4GNG9_HUMAN
genes like me logo Genes that share paralogs with IFITM3: view

Variants for IFITM3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IFITM3 Gene

IFM3_HUMAN-Q01628
Genetic variations in IFITM3 are responsible for susceptibility to severe influenza virus infection [MIM:614680].

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFITM3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12252 Risk Factor: Influenza 320,772(-) A/G NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs1136853 - p.His3Gln

Additional dbSNP identifiers (rs#s) for IFITM3 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFITM3 Gene

Variant ID Type Subtype PubMed ID
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
esv3891905 CNV gain 25118596
nsv435976 OTHER inversion 17901297
nsv527327 CNV loss 19592680
nsv552765 CNV gain 21841781
nsv552768 CNV loss 21841781
nsv7212 OTHER inversion 18451855

Variation tolerance for IFITM3 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFITM3 Gene

Human Gene Mutation Database (HGMD)
IFITM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFITM3

Disorders for IFITM3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for IFITM3 Gene - From: OMIM, ClinVar, GTR, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
influenza, severe
  • influenza, severe, susceptibility to
influenza
  • flu
west nile virus
  • west nile virus, susceptibility to
dengue virus
  • dengue virus, susceptibility to
stomatitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IFITM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFITM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFITM3 Gene

Publications for IFITM3 Gene

  1. Molecular analysis of a human interferon-inducible gene family. (PMID: 1906403) Lewin AR … Kerr IM (European journal of biochemistry 1991) 2 3 4 23 54
  2. Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis. (PMID: 19946179) Seo GS … Choi SC (Experimental & molecular medicine 2010) 3 23 41 54
  3. The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry. (PMID: 23601107) Amini-Bavil-Olyaee S … Jung JU (Cell host & microbe 2013) 3 4 54
  4. IFITM3 restricts the morbidity and mortality associated with influenza. (PMID: 22446628) Everitt AR … Kellam P (Nature 2012) 3 4 54
  5. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 54

Products for IFITM3 Gene

Sources for IFITM3 Gene