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Aliases for IFITM2 Gene

Aliases for IFITM2 Gene

  • Interferon Induced Transmembrane Protein 2 2 3 5
  • Dispanin Subfamily A Member 2c 2 3 4
  • Interferon-Inducible Protein 1-8D 3 4
  • DSPA2c 3 4
  • Interferon Induced Transmembrane Protein 2 (1-8D) 2
  • Interferon-Induced Transmembrane Protein 2 3
  • 1-8D 3

External Ids for IFITM2 Gene

Previous GeneCards Identifiers for IFITM2 Gene

  • GC11P000530
  • GC11P000351
  • GC11M000889
  • GC11P000298
  • GC11P000299
  • GC11P000127

Summaries for IFITM2 Gene

GeneCards Summary for IFITM2 Gene

IFITM2 (Interferon Induced Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with IFITM2 include Influenza and Dengue Virus. Among its related pathways are Innate Immune System and Interferon gamma signaling. An important paralog of this gene is IFITM3.

UniProtKB/Swiss-Prot for IFITM2 Gene

  • IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.

Additional gene information for IFITM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFITM2 Gene

Genomics for IFITM2 Gene

GeneHancer (GH) Regulatory Elements for IFITM2 Gene

Promoters and enhancers for IFITM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000303 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 693.6 +5.0 4984 17.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A YY1 POLR2B ZNF766 IFITM2 IFITM3 ENSG00000254910 IFITM1 TMEM80 PGGHG PIDD1 PHRF1 ENSG00000270030 BET1L
GH11J000266 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 34.3 -37.6 -37579 6.8 HDGF PKNOX1 FOXA2 SMAD1 ARNT IRF4 YY1 POLR2B ZNF766 CBX5 PIR53591 RIC8A TMEM80 BET1L PHRF1 IFITM2 PSMD13 SNORA52 PIDD1 SIRT3
GH11J000352 Enhancer 1.6 FANTOM5 Ensembl ENCODE 5 +47.0 46955 4.7 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B YBX1 DMAP1 YY1 IFITM1 ENSG00000251661 PGGHG TSPAN4 IFITM3 LOC105376505 ENSG00000255089 ENSG00000254910 TMEM80 ENSG00000255026
GH11J000745 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.3 +440.4 440378 5.1 HDGF FOXA2 ARID4B SIN3A POLR2B ZNF143 NFYC ZHX2 MXD4 REST TALDO1 ENSG00000255108 RPLP2 IRF7 LOC171391 DEAF1 TMEM80 IFITM2 GC11P000742 LOC105376509
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFITM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IFITM2 gene promoter:
  • STAT3
  • STAT1
  • c-Ets-1
  • E47
  • Tal-1beta
  • ZID
  • Elk-1
  • deltaCREB

Genomic Locations for IFITM2 Gene

Genomic Locations for IFITM2 Gene
chr11:307,631-315,272
(GRCh38/hg38)
Size:
7,642 bases
Orientation:
Plus strand
chr11:307,631-315,272
(GRCh37/hg19)
Size:
7,642 bases
Orientation:
Plus strand

Genomic View for IFITM2 Gene

Genes around IFITM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFITM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFITM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM2 Gene

Proteins for IFITM2 Gene

  • Protein details for IFITM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01629-IFM2_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 2
    Protein Accession:
    Q01629
    Secondary Accessions:
    • Q6FH82
    • Q96DA8

    Protein attributes for IFITM2 Gene

    Size:
    132 amino acids
    Molecular mass:
    14632 Da
    Quaternary structure:
    • Interacts with CD81.

neXtProt entry for IFITM2 Gene

Post-translational modifications for IFITM2 Gene

  • Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFITM2 Gene

Antibody Products

  • Abcam antibodies for IFITM2
  • Boster Bio Antibodies for IFITM2

No data available for DME Specific Peptides for IFITM2 Gene

Domains & Families for IFITM2 Gene

Gene Families for IFITM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for IFITM2 Gene

Suggested Antigen Peptide Sequences for IFITM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q01629

UniProtKB/Swiss-Prot:

IFM2_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with IFITM2: view

Function for IFITM2 Gene

Molecular function for IFITM2 Gene

UniProtKB/Swiss-Prot Function:
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.
UniProtKB/Swiss-Prot Induction:
By IFN-alpha and IFNG/IFN-gamma. Down-regulated by p53/TP53.

Phenotypes From GWAS Catalog for IFITM2 Gene

genes like me logo Genes that share phenotypes with IFITM2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFITM2 Gene

Localization for IFITM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFITM2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endosome 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IFITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFITM2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFITM2 Gene

Pathways & Interactions for IFITM2 Gene

genes like me logo Genes that share pathways with IFITM2: view

Pathways by source for IFITM2 Gene

Gene Ontology (GO) - Biological Process for IFITM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 1906403
GO:0009607 response to biotic stimulus IEA --
GO:0009615 response to virus IDA 20943977
GO:0034341 response to interferon-gamma IDA 21253575
GO:0035455 response to interferon-alpha IDA 22479637
genes like me logo Genes that share ontologies with IFITM2: view

No data available for SIGNOR curated interactions for IFITM2 Gene

Drugs & Compounds for IFITM2 Gene

No Compound Related Data Available

Transcripts for IFITM2 Gene

mRNA/cDNA for IFITM2 Gene

Unigene Clusters for IFITM2 Gene

Interferon induced transmembrane protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM2 Gene

No ASD Table

Relevant External Links for IFITM2 Gene

GeneLoc Exon Structure for
IFITM2
ECgene alternative splicing isoforms for
IFITM2

Expression for IFITM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFITM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFITM2 Gene

This gene is overexpressed in Whole Blood (x28.9).

Protein differential expression in normal tissues from HIPED for IFITM2 Gene

This gene is overexpressed in Skin (45.8) and CD8 Tcells (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFITM2 Gene



Protein tissue co-expression partners for IFITM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IFITM2 Gene:

IFITM2

SOURCE GeneReport for Unigene cluster for IFITM2 Gene:

Hs.709321

Evidence on tissue expression from TISSUES for IFITM2 Gene

  • Lung(4.7)
  • Heart(3.7)
  • Liver(3.5)
  • Muscle(3.3)
  • Intestine(3.2)
  • Stomach(3.2)
  • Blood(3.1)
  • Nervous system(3.1)
  • Kidney(3)
  • Eye(2.7)
  • Spleen(2.4)
  • Bone marrow(2.3)
  • Gall bladder(2.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with IFITM2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFITM2 Gene

Orthologs for IFITM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IFITM2 34 33
  • 97.98 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifitm2 33
  • 77.24 (n)
mouse
(Mus musculus)
Mammalia Ifitm2 16 34 33
  • 75 (n)
Ifitm1 34
  • 63 (a)
ManyToMany
Ifitm3 34
  • 61 (a)
ManyToMany
Gm7676 34
  • 55 (a)
ManyToMany
Gm2840 34
  • 53 (a)
ManyToMany
Ifitm7 34
  • 50 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 58 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 51 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 35 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 34
  • 30 (a)
ManyToMany
Species where no ortholog for IFITM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM2 Gene

ENSEMBL:
Gene Tree for IFITM2 (if available)
TreeFam:
Gene Tree for IFITM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFITM2: view image

Paralogs for IFITM2 Gene

Paralogs for IFITM2 Gene

(4) SIMAP similar genes for IFITM2 Gene using alignment to 5 proteins:

  • IFM2_HUMAN
  • E9PQN9_HUMAN
  • H0YCL2_HUMAN
  • H7BYV1_HUMAN
  • Q6IBB0_HUMAN
genes like me logo Genes that share paralogs with IFITM2: view

Variants for IFITM2 Gene

Sequence variations from dbSNP and Humsavar for IFITM2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000384658 -- 309,486(+) G/A downstream_transcript_variant
rs1000437124 -- 309,660(+) A/G downstream_transcript_variant
rs1004493042 -- 307,373(+) G/A upstream_transcript_variant
rs1004642244 -- 307,646(+) C/T upstream_transcript_variant
rs1005698430 -- 306,527(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFITM2 Gene

Variant ID Type Subtype PubMed ID
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
esv3891905 CNV gain 25118596
nsv527327 CNV loss 19592680
nsv552765 CNV gain 21841781
nsv7212 OTHER inversion 18451855
nsv975869 CNV duplication 23825009

Variation tolerance for IFITM2 Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFITM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFITM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFITM2 Gene

Disorders for IFITM2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IFITM2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
dengue virus
  • dengue virus, susceptibility to
west nile virus
  • west nile virus, susceptibility to
stomatitis
asthenopia
  • accommodative strain
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IFITM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IFITM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFITM2 Gene

Publications for IFITM2 Gene

  1. Molecular analysis of a human interferon-inducible gene family. (PMID: 1906403) Lewin AR … Kerr IM (European journal of biochemistry 1991) 2 3 4 22 58
  2. The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene. (PMID: 19544527) Daniel-Carmi V … Eisenbach L (International journal of cancer 2009) 3 4 22 58
  3. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 58
  4. IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. (PMID: 22479637) Chan YK … Farzan M (PloS one 2012) 3 4 58
  5. The IFITM proteins inhibit HIV-1 infection. (PMID: 21177806) Lu J … Liang C (Journal of virology 2011) 3 4 58

Products for IFITM2 Gene

Sources for IFITM2 Gene

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