Aliases for IFITM2 Gene
External Ids for IFITM2 Gene
Previous GeneCards Identifiers for IFITM2 Gene
GeneCards Summary for IFITM2 Gene
IFITM2 (Interferon Induced Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with IFITM2 include Cycloplegia and Influenza. Among its related pathways are Innate Immune System and Interferon gamma signaling. An important paralog of this gene is IFITM3.
UniProtKB/Swiss-Prot Summary for IFITM2 Gene
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.