Aliases for IFITM10 Gene

Aliases for IFITM10 Gene

  • Interferon Induced Transmembrane Protein 10 2 3 5
  • Dispanin Subfamily A Member 3 2 3 4
  • Interferon-Induced Transmembrane Protein 10 3 4
  • DSPA3 3 4

External Ids for IFITM10 Gene

Previous GeneCards Identifiers for IFITM10 Gene

  • GC11M001755

Summaries for IFITM10 Gene

GeneCards Summary for IFITM10 Gene

IFITM10 (Interferon Induced Transmembrane Protein 10) is a Protein Coding gene. Diseases associated with IFITM10 include Osteogenesis Imperfecta, Type V. An important paralog of this gene is IFITM3.

Additional gene information for IFITM10 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFITM10 Gene

Genomics for IFITM10 Gene

GeneHancer (GH) Regulatory Elements for IFITM10 Gene

Promoters and enhancers for IFITM10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFITM10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFITM10

Genomic Locations for IFITM10 Gene

Genomic Locations for IFITM10 Gene
chr11:1,732,406-1,750,595
(GRCh38/hg38)
Size:
18,190 bases
Orientation:
Minus strand
chr11:1,753,640-1,771,824
(GRCh37/hg19)
Size:
18,185 bases
Orientation:
Minus strand

Genomic View for IFITM10 Gene

Genes around IFITM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFITM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFITM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM10 Gene

Proteins for IFITM10 Gene

  • Protein details for IFITM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMD0-IFM10_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 10
    Protein Accession:
    A6NMD0
    Secondary Accessions:
    • A6NEU7

    Protein attributes for IFITM10 Gene

    Size:
    228 amino acids
    Molecular mass:
    24599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAF82263.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for IFITM10 Gene

Post-translational modifications for IFITM10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFITM10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFITM10 Gene

Domains & Families for IFITM10 Gene

Gene Families for IFITM10 Gene

Protein Domains for IFITM10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFITM10 Gene

GenScript: Design optimal peptide antigens:
  • Interferon-induced transmembrane protein 10 (IFM10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMD0

UniProtKB/Swiss-Prot:

IFM10_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with IFITM10: view

Function for IFITM10 Gene

Phenotypes From GWAS Catalog for IFITM10 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFITM10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFITM10 Gene

Localization for IFITM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFITM10 gene
Compartment Confidence
plasma membrane 4
endosome 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IFITM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFITM10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFITM10 Gene

Pathways & Interactions for IFITM10 Gene

PathCards logo

SuperPathways for IFITM10 Gene

No Data Available

Interacting Proteins for IFITM10 Gene

;

Gene Ontology (GO) - Biological Process for IFITM10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IFITM10 Gene

Drugs & Compounds for IFITM10 Gene

No Compound Related Data Available

Transcripts for IFITM10 Gene

mRNA/cDNA for IFITM10 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFITM10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM10 Gene

No ASD Table

Relevant External Links for IFITM10 Gene

GeneLoc Exon Structure for
IFITM10

Expression for IFITM10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFITM10 Gene

mRNA differential expression in normal tissues according to GTEx for IFITM10 Gene

This gene is overexpressed in Adrenal Gland (x6.9) and Artery - Aorta (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFITM10

SOURCE GeneReport for Unigene cluster for IFITM10 Gene:

Hs.121575

Evidence on tissue expression from TISSUES for IFITM10 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IFITM10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFITM10 Gene

Orthologs for IFITM10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 31
  • 98 (a)
OneToMany
LOC613464 30
  • 92.33 (n)
dog
(Canis familiaris)
Mammalia IFITM10 30
  • 91.71 (n)
-- 31
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ifitm10 30
  • 88.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifitm10 31
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFITM10 30
  • 79.02 (n)
-- 31
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ifitm10 30
  • 70.28 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 31
  • 26 (a)
ManyToMany
Species where no ortholog for IFITM10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM10 Gene

ENSEMBL:
Gene Tree for IFITM10 (if available)
TreeFam:
Gene Tree for IFITM10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFITM10: view image

Paralogs for IFITM10 Gene

Paralogs for IFITM10 Gene

(3) SIMAP similar genes for IFITM10 Gene using alignment to 2 proteins:

  • IFM10_HUMAN
  • H0Y3H0_HUMAN
genes like me logo Genes that share paralogs with IFITM10: view

Variants for IFITM10 Gene

Additional dbSNP identifiers (rs#s) for IFITM10 Gene

Structural Variations from Database of Genomic Variants (DGV) for IFITM10 Gene

Variant ID Type Subtype PubMed ID
esv2403037 CNV deletion 18987734
esv3370062 CNV duplication 20981092
nsv1121470 CNV deletion 24896259
nsv1129154 CNV insertion 24896259
nsv1137983 CNV deletion 24896259
nsv1140466 CNV tandem duplication 24896259
nsv467645 CNV gain 19166990
nsv553047 CNV gain 21841781
nsv7642 CNV insertion 18451855
nsv832049 CNV loss 17160897

Variation tolerance for IFITM10 Gene

Gene Damage Index Score: 2.08; 37.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFITM10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFITM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFITM10 Gene

Disorders for IFITM10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IFITM10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type v
  • oi5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IFITM10

genes like me logo Genes that share disorders with IFITM10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IFITM10 Gene

Publications for IFITM10 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 54
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 54

Products for IFITM10 Gene

  • Signalway ELISA kits for IFITM10
  • Signalway Proteins for IFITM10

Sources for IFITM10 Gene