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Aliases for IFITM10 Gene

Aliases for IFITM10 Gene

  • Interferon Induced Transmembrane Protein 10 2 3 5
  • Dispanin Subfamily A Member 3 3 4
  • DSPA3 3 4
  • Interferon-Induced Transmembrane Protein 10 3

External Ids for IFITM10 Gene

Previous GeneCards Identifiers for IFITM10 Gene

  • GC11M001755

Summaries for IFITM10 Gene

GeneCards Summary for IFITM10 Gene

IFITM10 (Interferon Induced Transmembrane Protein 10) is a Protein Coding gene. An important paralog of this gene is IFITM2.

Additional gene information for IFITM10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFITM10 Gene

Genomics for IFITM10 Gene

GeneHancer (GH) Regulatory Elements for IFITM10 Gene

Promoters and enhancers for IFITM10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I001748 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 563.4 0.0 -25 4.8 NFIB ZNF335 ZFHX2 GLIS2 POLR2A PATZ1 VEZF1 ZNF600 RCOR1 EGR2 IFITM10 ENSG00000235027 RPLP2 CTSD ENSG00000250644
GH11I001770 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.9 -21.4 -21354 3.8 HDGF PKNOX1 CLOCK ATF1 ARNT NEUROD1 SIN3A ZBTB7B ARID2 FOS SNORA52 TSPAN4 PIDD1 IFITM10 TNNI2 ENSG00000255142 SYT8 KRTAP5-6 LOC100505570 FAM99B
GH11I001837 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -91.3 -91254 9.5 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 YBX1 IRF4 YY1 ZNF207 TNNI2 IFITM10 LSP1 LINC01219 C11orf21 GC11P001831 SYT8
GH11I001705 Enhancer 0.7 FANTOM5 22.7 +44.7 44670 0.4 SMARCE1 PKNOX1 ESRRA ZNF687 NEUROD1 DPF2 E2F1 ZNF217 CTBP1 GATA3 IFITM10 KRTAP5-5 KRTAP5-6 GC11M001718
GH11I001671 Enhancer 1.4 FANTOM5 Ensembl ENCODE 10.6 +75.7 75726 6 ELF3 FOXA2 MLX ZNF48 ZSCAN9 RAD21 RARA YY1 CREM MIXL1 GC11M001664 GC11P001673 KRTAP5-5 LSP1 IFITM10 FAM99B LOC100505570 ASCL2 KRTAP5-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IFITM10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IFITM10 Gene

Genomic Locations for IFITM10 Gene
chr11:1,732,410-1,750,594
(GRCh38/hg38)
Size:
18,185 bases
Orientation:
Minus strand
chr11:1,753,640-1,771,824
(GRCh37/hg19)

Genomic View for IFITM10 Gene

Genes around IFITM10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFITM10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFITM10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFITM10 Gene

Proteins for IFITM10 Gene

  • Protein details for IFITM10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMD0-IFM10_HUMAN
    Recommended name:
    Interferon-induced transmembrane protein 10
    Protein Accession:
    A6NMD0
    Secondary Accessions:
    • A6NEU7

    Protein attributes for IFITM10 Gene

    Size:
    228 amino acids
    Molecular mass:
    24599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAF82263.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IFITM10 Gene

Post-translational modifications for IFITM10 Gene

No Post-translational modifications

Other Protein References for IFITM10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFITM10 Gene

Domains & Families for IFITM10 Gene

Gene Families for IFITM10 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for IFITM10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IFITM10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMD0

UniProtKB/Swiss-Prot:

IFM10_HUMAN :
  • Belongs to the CD225/Dispanin family.
Family:
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with IFITM10: view

Function for IFITM10 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IFITM10 Gene

Localization for IFITM10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFITM10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFITM10 gene
Compartment Confidence
plasma membrane 4
peroxisome 2
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IFITM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IFITM10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IFITM10 Gene

Pathways & Interactions for IFITM10 Gene

SuperPathways for IFITM10 Gene

No Data Available

Interacting Proteins for IFITM10 Gene

Gene Ontology (GO) - Biological Process for IFITM10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with IFITM10: view

No data available for Pathways by source and SIGNOR curated interactions for IFITM10 Gene

Drugs & Compounds for IFITM10 Gene

No Compound Related Data Available

Transcripts for IFITM10 Gene

mRNA/cDNA for IFITM10 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IFITM10 Gene

Interferon induced transmembrane protein 10:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for IFITM10 Gene

No ASD Table

Relevant External Links for IFITM10 Gene

GeneLoc Exon Structure for
IFITM10
ECgene alternative splicing isoforms for
IFITM10

Expression for IFITM10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IFITM10 Gene

mRNA differential expression in normal tissues according to GTEx for IFITM10 Gene

This gene is overexpressed in Adrenal Gland (x6.9) and Artery - Aorta (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of IFITM10 Gene:

IFITM10

SOURCE GeneReport for Unigene cluster for IFITM10 Gene:

Hs.121575

Evidence on tissue expression from TISSUES for IFITM10 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IFITM10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFITM10 Gene

Orthologs for IFITM10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFITM10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
OneToMany
LOC613464 33
  • 92.33 (n)
dog
(Canis familiaris)
Mammalia IFITM10 33
  • 91.71 (n)
-- 34
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ifitm10 33
  • 88.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 84 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ifitm10 34
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves IFITM10 33
  • 79.02 (n)
-- 34
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ifitm10 33
  • 70.28 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-226m8.7 34
  • 26 (a)
ManyToMany
Species where no ortholog for IFITM10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IFITM10 Gene

ENSEMBL:
Gene Tree for IFITM10 (if available)
TreeFam:
Gene Tree for IFITM10 (if available)

Paralogs for IFITM10 Gene

Paralogs for IFITM10 Gene

(3) SIMAP similar genes for IFITM10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IFITM10: view

Variants for IFITM10 Gene

Sequence variations from dbSNP and Humsavar for IFITM10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000306608 -- 1,733,667(-) TCTTCTTCT/TCTTCT 3_prime_UTR_variant
rs1000588534 -- 1,738,799(-) G/T intron_variant
rs1000676064 -- 1,744,933(-) T/G intron_variant
rs1000734176 -- 1,749,904(-) C/G intron_variant
rs1000884542 -- 1,751,610(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IFITM10 Gene

Variant ID Type Subtype PubMed ID
esv2403037 CNV deletion 18987734
esv3370062 CNV duplication 20981092
nsv1121470 CNV deletion 24896259
nsv1129154 CNV insertion 24896259
nsv1137983 CNV deletion 24896259
nsv1140466 CNV tandem duplication 24896259
nsv467645 CNV gain 19166990
nsv553047 CNV gain 21841781
nsv7642 CNV insertion 18451855
nsv832049 CNV loss 17160897

Variation tolerance for IFITM10 Gene

Gene Damage Index Score: 2.08; 37.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFITM10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFITM10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFITM10 Gene

Disorders for IFITM10 Gene

Additional Disease Information for IFITM10

No disorders were found for IFITM10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFITM10 Gene

Publications for IFITM10 Gene

  1. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sällman Almén M … Schiöth HB (PloS one 2012) 3 4 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for IFITM10 Gene

Sources for IFITM10 Gene

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