Aliases for IFITM1 Gene
External Ids for IFITM1 Gene
Previous HGNC Symbols for IFITM1 Gene
Previous GeneCards Identifiers for IFITM1 Gene
GeneCards Summary for IFITM1 Gene
IFITM1 (Interferon Induced Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with IFITM1 include Influenza and West Nile Virus. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is IFITM3.
UniProtKB/Swiss-Prot Summary for IFITM1 Gene
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.