Aliases for IFIT5 Gene
- Interferon Induced Protein With Tetratricopeptide Repeats 5 2 3 5
- Interferon-Induced Protein With Tetratricopeptide Repeats 5 2 3 4
- Retinoic Acid- And Interferon-Inducible 58 KDa Protein 3 4
- Retinoic Acid- And Interferon-Inducible Protein (58kD) 2 3
- Interferon-Induced 58 KDa Protein 3 4
- IFIT-5 3 4
- ISG58 3 4
- RI58 3 4
- P58 3 4
External Ids for IFIT5 Gene
Previous GeneCards Identifiers for IFIT5 Gene
GeneCards Summary for IFIT5 Gene
IFIT5 (Interferon Induced Protein With Tetratricopeptide Repeats 5) is a Protein Coding gene. Diseases associated with IFIT5 include Chronic Interstitial Cystitis and Benign Familial Neonatal Epilepsy. Gene Ontology (GO) annotations related to this gene include tRNA binding. An important paralog of this gene is IFIT1.
UniProtKB/Swiss-Prot Summary for IFIT5 Gene
Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375).