Aliases for IFIT1B Gene

Aliases for IFIT1B Gene

  • Interferon Induced Protein With Tetratricopeptide Repeats 1B 2 3 5
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1B 2 3 4
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like Protein 3 4
  • BA149I23.6 2 3
  • IFIT1L 3 4
  • Interferon-Induced Protein With Tetratricopeptide Repeats 1-Like 2
  • IFIT1B 5

External Ids for IFIT1B Gene

Previous HGNC Symbols for IFIT1B Gene

  • IFIT1L

Previous GeneCards Identifiers for IFIT1B Gene

  • GC10P091137
  • GC10P084771

Summaries for IFIT1B Gene

GeneCards Summary for IFIT1B Gene

IFIT1B (Interferon Induced Protein With Tetratricopeptide Repeats 1B) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway. An important paralog of this gene is IFIT1.

Additional gene information for IFIT1B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IFIT1B Gene

Genomics for IFIT1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IFIT1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J089378 Promoter/Enhancer 0.8 EPDnew Ensembl 600.7 -0.4 -355 2.6 REST ZIC2 EHMT2 CBFA2T3 IFIT1B IFIT5 IFIT6P LIPA IFIT3
GH10J089245 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -129.1 -129115 7.5 HNRNPL GATAD2A ZNF629 REST ZNF692 POLR2A RCOR2 FOXA1 LARP7 PRDM1 LIPA ENSG00000235100 IFIT1B ENSG00000232110 FAS piR-36588-047 IFIT2 MN309102 CH25H
GH10J089300 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.9 -75.6 -75609 4.7 PRDM10 REST POLR2A FOXA1 STAT3 PRDM1 IRF2 FOXJ2 PKNOX1 EED LOC105378419 IFIT2 IFIT1B IFIT5 piR-48553-044 IFIT3 lnc-CH25H-1 lnc-CH25H-2 LIPA
GH10J089330 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.7 -45.3 -45339 5.2 SP1 GATAD2A REST TFE3 RCOR2 POLR2A BACH1 STAT3 RELA NR2C1 IFIT3 lnc-CH25H-1 IFIT5 IFIT2 IFIT1B ENSG00000232110 IFIT1 MN296998 lnc-CH25H-2 LOC101926887
GH10J089413 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 +36.9 36931 3.2 HNRNPL ZNF692 POLR2A BACH1 LARP7 ZSCAN4 RBFOX2 PATZ1 IRF2 ZNF501 IFIT5 LIPA piR-51137-016 KIF20B IFIT1B LOC107984251 SLC16A12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IFIT1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IFIT1B

Genomic Locations for IFIT1B Gene

Genomic Locations for IFIT1B Gene
chr10:89,378,056-89,385,205
(GRCh38/hg38)
Size:
7,150 bases
Orientation:
Plus strand
chr10:91,137,813-91,144,962
(GRCh37/hg19)
Size:
7,150 bases
Orientation:
Plus strand

Genomic View for IFIT1B Gene

Genes around IFIT1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFIT1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFIT1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIT1B Gene

Proteins for IFIT1B Gene

  • Protein details for IFIT1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T764-IFT1B_HUMAN
    Recommended name:
    Interferon-induced protein with tetratricopeptide repeats 1B
    Protein Accession:
    Q5T764
    Secondary Accessions:
    • A7E245

    Protein attributes for IFIT1B Gene

    Size:
    474 amino acids
    Molecular mass:
    54993 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IFIT1B Gene

Post-translational modifications for IFIT1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIT1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IFIT1B Gene

Domains & Families for IFIT1B Gene

Gene Families for IFIT1B Gene

Protein Domains for IFIT1B Gene

Suggested Antigen Peptide Sequences for IFIT1B Gene

GenScript: Design optimal peptide antigens:
  • Interferon-induced protein with tetratricopeptide repeats 1-like protein (IFT1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T764

UniProtKB/Swiss-Prot:

IFT1B_HUMAN :
  • Belongs to the IFIT family.
Family:
  • Belongs to the IFIT family.
genes like me logo Genes that share domains with IFIT1B: view

Function for IFIT1B Gene

Phenotypes From GWAS Catalog for IFIT1B Gene

Gene Ontology (GO) - Molecular Function for IFIT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA 21873635
GO:0005515 protein binding IPI 21642987
genes like me logo Genes that share ontologies with IFIT1B: view
genes like me logo Genes that share phenotypes with IFIT1B: view

Animal Models for IFIT1B Gene

MGI Knock Outs for IFIT1B:
  • Ifit1 Ifit1<tm1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFIT1B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IFIT1B Gene

Localization for IFIT1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IFIT1B gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
cytoskeleton 0

Gene Ontology (GO) - Cellular Components for IFIT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with IFIT1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for IFIT1B Gene

Pathways & Interactions for IFIT1B Gene

PathCards logo

SuperPathways for IFIT1B Gene

SuperPathway Contained pathways
1 Toll-like Receptor Signaling Pathway
genes like me logo Genes that share pathways with IFIT1B: view

Pathways by source for IFIT1B Gene

1 KEGG pathway for IFIT1B Gene

Gene Ontology (GO) - Biological Process for IFIT1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051607 defense response to virus IBA 21873635
genes like me logo Genes that share ontologies with IFIT1B: view

No data available for SIGNOR curated interactions for IFIT1B Gene

Drugs & Compounds for IFIT1B Gene

No Compound Related Data Available

Transcripts for IFIT1B Gene

mRNA/cDNA for IFIT1B Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IFIT1B

Alternative Splicing Database (ASD) splice patterns (SP) for IFIT1B Gene

No ASD Table

Relevant External Links for IFIT1B Gene

GeneLoc Exon Structure for
IFIT1B

Expression for IFIT1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IFIT1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IFIT1B Gene

This gene is overexpressed in Whole Blood (x48.3).

Protein differential expression in normal tissues from HIPED for IFIT1B Gene

This gene is overexpressed in Plasma (39.3) and Serum (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IFIT1B Gene



Protein tissue co-expression partners for IFIT1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IFIT1B

SOURCE GeneReport for Unigene cluster for IFIT1B Gene:

Hs.500491

Evidence on tissue expression from TISSUES for IFIT1B Gene

  • Blood(2.6)
genes like me logo Genes that share expression patterns with IFIT1B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IFIT1B Gene

Orthologs for IFIT1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IFIT1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IFIT1B 31
  • 99 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ifit1 30
  • 71.63 (n)
Mouse
(Mus musculus)
Mammalia Ifit1 30 17 31
  • 71.13 (n)
OneToMany
Gm14446 31
  • 58 (a)
OneToMany
2010002M12Rik 31
  • 56 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 55 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 54 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
-- 31
  • 52 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 52 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 45 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 28 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CR759879.1 31
  • 32 (a)
ManyToMany
si:dkey-26g8.11 31
  • 32 (a)
ManyToMany
si:dkey-26g8.10 31
  • 31 (a)
ManyToMany
ifit5 31
  • 31 (a)
ManyToMany
zgc:123282 31
  • 29 (a)
ManyToMany
ifit2 31
  • 24 (a)
ManyToMany
si:dkey-116m16.3 31
  • 23 (a)
ManyToMany
si:ch211-240h7.2 31
  • 23 (a)
ManyToMany
Species where no ortholog for IFIT1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IFIT1B Gene

ENSEMBL:
Gene Tree for IFIT1B (if available)
TreeFam:
Gene Tree for IFIT1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IFIT1B: view image

Paralogs for IFIT1B Gene

Paralogs for IFIT1B Gene

(4) SIMAP similar genes for IFIT1B Gene using alignment to 1 proteins:

  • IFT1B_HUMAN

Pseudogenes.org Pseudogenes for IFIT1B Gene

genes like me logo Genes that share paralogs with IFIT1B: view

Variants for IFIT1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IFIT1B Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
720003 Benign: not provided 89,383,876(+) T/C MISSENSE_VARIANT
rs778626965 Uncertain Significance: Severe Myopia 89,384,466(+) G/A MISSENSE_VARIANT
rs7072728 - p.Leu188Pro

Additional dbSNP identifiers (rs#s) for IFIT1B Gene

Structural Variations from Database of Genomic Variants (DGV) for IFIT1B Gene

Variant ID Type Subtype PubMed ID
esv34085 CNV loss 18971310

Variation tolerance for IFIT1B Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IFIT1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IFIT1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIT1B Gene

Disorders for IFIT1B Gene

Additional Disease Information for IFIT1B

No disorders were found for IFIT1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IFIT1B Gene

Publications for IFIT1B Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. The broad-spectrum antiviral functions of IFIT and IFITM proteins. (PMID: 23237964) Diamond MS … Farzan M (Nature reviews. Immunology 2013) 3
  4. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PMID: 21642987) Pichlmair A … Superti-Furga G (Nature immunology 2011) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for IFIT1B Gene

Sources for IFIT1B Gene